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Article ; Online: Rotary F

Li, Yue / Liu, Jun / Wu, Yingjie / He, Qiang

Journal of the American Chemical Society

2024

Abstract: We report the hierarchical assembly of a chloroplast-derived rotary ... ...

Abstract	We report the hierarchical assembly of a chloroplast-derived rotary F
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.4c00334
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Article ; Online: Recent advances in targeted drug delivery for the treatment of glioblastoma.

Mao, Meng / Wu, Yingjie / He, Qiang

Nanoscale

2024

Abstract: Glioblastoma multiforme (GBM) is one of the highly malignant brain tumors characterized by significant morbidity and mortality. Despite the recent advancements in the treatment of GBM, major challenges persist in achieving controlled drug delivery to ... ...

Abstract	Glioblastoma multiforme (GBM) is one of the highly malignant brain tumors characterized by significant morbidity and mortality. Despite the recent advancements in the treatment of GBM, major challenges persist in achieving controlled drug delivery to tumors. The management of GBM poses considerable difficulties primarily due to unresolved issues in the blood-brain barrier (BBB)/blood-brain tumor barrier (BBTB) and GBM microenvironment. These factors limit the uptake of anti-cancer drugs by the tumor, thus limiting the therapeutic options. Current breakthroughs in nanotechnology provide new prospects concerning unconventional drug delivery approaches for GBM treatment. Specifically, swimming nanorobots show great potential in active targeted delivery, owing to their autonomous propulsion and improved navigation capacities across biological barriers, which further facilitate the development of GBM-targeted strategies. This review presents an overview of technological progress in different drug administration methods for GBM. Additionally, the limitations in clinical translation and future research prospects in this field are also discussed. This review aims to provide a comprehensive guideline for researchers and offer perspectives on further development of new drug delivery therapies to combat GBM.
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d4nr01056f
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Article ; Online: Confined Synthesis of Noble Metal Clusters Assisted by Liquid Film for Photocatalytic CO

Gong, Dongkun / Wu, Yingjie / Jiang, Hao / Li, Chunzhong / Hu, Yanjie

Langmuir : the ACS journal of surfaces and colloids

2024 Volume 40, Issue 14, Page(s) 7492–7501

Abstract: The important concept of confined synthesis is considered a promising strategy for the design and synthesis of definable nanostructured materials with controllable compositions and specific morphology, such as highly loaded single-atom catalysts capable ... ...

Abstract	The important concept of confined synthesis is considered a promising strategy for the design and synthesis of definable nanostructured materials with controllable compositions and specific morphology, such as highly loaded single-atom catalysts capable of providing abundant active sites for photocatalytic reactions. In recent years, researchers have been working on developing new confined reaction systems and searching for new confined spaces. Here, we present for the first time the concept of a bubble liquid film as a novel confined space. The liquid film has a typical sandwich structure consisting of a water layer, sandwiched between the upper and lower surfactant layers, with the thickness of the intermediate water layer at the micro- and nanometer scales, which can serve as a good confinement. Based on the above understanding and combined with the photodeposition method, we successfully confined synthesized Ag/TiO
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c04020
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Article ; Online: Branched-Chain Amino Acids Metabolism and Their Roles in Retinopathy: From Relevance to Mechanism.

Zhang, Xiaonan / Xia, Mengxue / Wu, Yingjie / Zhang, Fang

Nutrients

2023 Volume 15, Issue 9

Abstract: Retinopathy is one of the leading causes of irreversible blindness and vision loss worldwide. Imbalanced nutrients play important roles in the pathogenesis and pathophysiology of retinal diseases. Branched-Chain Amino Acids (BCAAs), as essential amino ... ...

Abstract	Retinopathy is one of the leading causes of irreversible blindness and vision loss worldwide. Imbalanced nutrients play important roles in the pathogenesis and pathophysiology of retinal diseases. Branched-Chain Amino Acids (BCAAs), as essential amino acids, perform a variety of biological functions, including protein synthesis, glucose metabolism, lipid metabolism, inflammation, and oxidative stress in metabolic tissues of diabetes and aging-related diseases. Recently, it has been shown that BCAAs are highly related to neuroprotection, oxidative stress, inflammatory and glutamate toxicity in the retina of retinopathy. Therefore, this review summarizes the alterations of BCAA levels in retinopathy, especially diabetic retinopathy and aging-related macular disease, and the genetics, functions, and mechanisms of BCAAs in the retina as well as other metabolic tissues for reference. All of these efforts aim to provide fundamental knowledge of BCAAs for further discoveries and research on retina health based on the sensing and signaling of essential amino acids.
MeSH term(s)	Humans ; Retinal Diseases/etiology ; Retina ; Amino Acids, Branched-Chain ; Amino Acids, Essential ; Blindness ; Glutamic Acid
Chemical Substances	Amino Acids, Branched-Chain ; Amino Acids, Essential ; Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2023-04-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15092161
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Article: Considering Climatic Factors, Time Lag, and Cumulative Effects of Climate Change and Human Activities on Vegetation NDVI in Yinshanbeilu, China.

Wang, Sinan / Liu, Xiaomin / Wu, Yingjie

Plants (Basel, Switzerland)

2023 Volume 12, Issue 18

Abstract: Climate and human activities are the basic driving forces that control and influence the spatial distribution and change of vegetation. Using trend analysis, the Hurst index, correlation analysis, the Moran index, path analysis, residual analysis, and ... ...

Abstract	Climate and human activities are the basic driving forces that control and influence the spatial distribution and change of vegetation. Using trend analysis, the Hurst index, correlation analysis, the Moran index, path analysis, residual analysis, and other methods, the effects of human activities and climate factors on vegetation change were analyzed. The results show that: (1) The research area's normalized difference vegetation index (NDVI) exhibited a substantial upward trend from 2001 to 2020, increasing at a rate of 0.003/a, and the vegetation cover was generally healthy. The generally constant NDVI region made up 78.45% of the entire area, and the grassland, cultivated land, and forest land showed the most visible NDVI aggregation features. (2) The Vegetation is mainly promoted by water and heat, particularly precipitation, have a major impact on plants, with the direct influence of precipitation on vegetation growth being much greater than the indirect effect through the temperature. (3) The trend of NDVI residuals showed obvious spatial variability, presenting a distribution characteristic of high in the south and low in the north. The results of this study can provide a basis for the scientific layout of ecological protection and restoration projects in the Yinshanbeilu area.
Language	English
Publishing date	2023-09-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12183312
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Article ; Online: Self-calibration phase demodulation scheme for stabilization based on an auxiliary reference fiber-optic interferometer and ellipse fitting algorithm.

Wu, Yingjie / Li, Churui / Wang, Chao / Jia, Bo

Optics express

2023 Volume 31, Issue 3, Page(s) 4639–4651

Abstract: To solve the problem of light source jitter and asymmetric 3 × 3 coupler, a phase demodulation method with the combination of an auxiliary reference interferometer and elliptic fitting algorithm is proposed, which is verified by simulation and experiment. ...

Abstract	To solve the problem of light source jitter and asymmetric 3 × 3 coupler, a phase demodulation method with the combination of an auxiliary reference interferometer and elliptic fitting algorithm is proposed, which is verified by simulation and experiment. By introducing additional phase modulation in the auxiliary reference interferometer, the parameters of the sensing arm can be calibrated in real time, which ensures the effective operation of elliptic fitting algorithm in small signal measurement. Consequently, the experiments show that the self-calibration scheme enables a higher signal to noise and distortion ratio with an average increase of 1.65 dB and 10.47 dB compared with the traditional Arctan and cross multiplication differential, respectively. Meanwhile, the self-calibration scheme can also effectively suppress the harmonic distortion, with a total harmonic distortion of -33.64 dB in the case of small signal.
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.480428
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Article: Ring-finger protein 5 attenuates oxygen-glucose deprivation and reperfusion-induced mitochondrial dysfunction and inflammation in cardiomyocytes by inhibiting the S100A8/MYD88/NF-κB axis.

Chen, Xuesi / Wu, Yingjie / Bao, Yingchun

The Chinese journal of physiology

2023 Volume 66, Issue 4, Page(s) 228–238

Abstract: Mitochondrial dysfunction is closely intertwined with the progression of heart failure (HF). Ring-finger protein 5 (RNF5) is an E3 ubiquitin ligase, whose deletion induces the enhanced S100A8 expression. S100A8 regulates the mitochondrial dysfunction and ...

Abstract	Mitochondrial dysfunction is closely intertwined with the progression of heart failure (HF). Ring-finger protein 5 (RNF5) is an E3 ubiquitin ligase, whose deletion induces the enhanced S100A8 expression. S100A8 regulates the mitochondrial dysfunction and S100A8/myeloid differentiation factor 88 (MYD88)/nuclear factor-kappa B (NF-κB) pathway promotes an inflammatory response; however, whether RNF5 modulated mitochondrial dysregulation and inflammation through the S100A8/MYD88/NF-κB axis remains unknown. Here, H9c2 cells were stimulated with oxygen-glucose deprivation/reperfusion (OGD/R) to build a HF model in vitro. RNF5 level was assessed in gene expression omnibus database and in OGD/R-induced H9c2 cells with reverse transcriptase quantitative polymerase chain reaction and western blot. The RNF5 level was overexpressed via transfecting RNF5 overexpression plasmids into H9c2 cells. The role and mechanism of RNF5 in OGD/R-elicited H9c2 cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, spectrophotometry, flow cytometry, mitochondrial membrane potential (MMP) measurement, enzyme-linked immunosorbent assay and western blot assays. The RNF5 expression was downregulated both in silico and in OGD/R-stimulated H9c2 cells. OGD/R treatment caused a decrease in the cell viability, the MMP level, and the translational expression of mito-cyt-c and NF-κB-cyto, and an elevation in the concentrations of lactate dehydrogenase and creatine kinase myocardial band, the apoptosis rate, the inflammatory factor release, and the relative protein expression of cyto-cyt-c, S100A8, MYD88 and NF-κB-nuc in H9c2 cells. Upregulation of RNF5 reversed these indicators in OGD/R-stimulated H9c2 cells. Altogether, based on these outcomes, we concluded that RNF5 impeded mitochondrial dysfunction and inflammation through attenuating the S100A8/MYD88/NF-κB axis in OGD/R-stimulated H9c2 cells.
MeSH term(s)	Humans ; NF-kappa B/metabolism ; Oxygen/metabolism ; Myeloid Differentiation Factor 88/metabolism ; Signal Transduction ; Myocytes, Cardiac/metabolism ; Glucose/metabolism ; Apoptosis ; Reperfusion ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Mitochondria ; Inflammation
Chemical Substances	NF-kappa B ; Oxygen (S88TT14065) ; Myeloid Differentiation Factor 88 ; Glucose (IY9XDZ35W2) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2023-08-27
Publishing country	India
Document type	Journal Article
ZDB-ID	966112-8
ISSN	0304-4920 ; 0300-8525
ISSN	0304-4920 ; 0300-8525
DOI	10.4103/cjop.CJOP-D-22-00140
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Article ; Online: scBCR-seq revealed a special and novel IG H&L V(D)J allelic inclusion rearrangement and the high proportion dual BCR expressing B cells.

Zhu, Lanwei / Peng, Qi / Wu, Yingjie / Yao, Xinsheng

Cellular and molecular life sciences : CMLS

2023 Volume 80, Issue 11, Page(s) 319

Abstract: Since the initial report of V (D) J "allelic exclusion/inclusion" (allelic exclusion rearrangement or allelic inclusion rearrangement) and the concept of the "dual B cell receptor (BCR)" in 1961, despite ongoing discoveries, the precise proportion and ... ...

Abstract	Since the initial report of V (D) J "allelic exclusion/inclusion" (allelic exclusion rearrangement or allelic inclusion rearrangement) and the concept of the "dual B cell receptor (BCR)" in 1961, despite ongoing discoveries, the precise proportion and source mechanism of dual BCR under physiological conditions have been puzzling immuologists. This study takes advantage of the single cell B cell receptor sequencing (scBCR-seq) technology, which can perfectly match the heavy and light chains of BCR at the level of a single B cell, and obtain the full length mRNA sequence of the complementary determining region 3 (CDR3). Through analyzing the pairing of functional IGH (immunoglobulin heavy chain) and IGL (immunoglobulin light chain) in single B cell from both human and mouse bone marrow and peripheral blood, it was observed that dual BCR B cells exhibit stable and high levels of expression. Among them, the human bone marrow and peripheral blood contain about 10% dual (or multiple) BCR B cells, while in mouse peripheral blood and bone marrow memory B cells, this proportion reaches around 20%. At the same time, we innovatively found that in each research sample of humans and mice, there are three (or more) functional rearrangements (mRNA level) of a single chain in a single B cell. By analyzing the position, direction and other compositional characteristics of the V(D)J gene family, we found that at least two (or more) of them are derived from over two (or more) specific allelic inclusion rearrangements of a single chromosome (mRNA molecular level evidence), our findings also highlighted the necessity of classified single cell sequencing data based on single, dual (or multiple) and cannot be assembled into BCR when analyzing the B cell repertoire. The results of this article provides new methods and modeling references for evaluating the proportion and source mechanisms of dual BCR B cells, as well as potential significance of allelic inclusion (exclusion escape) of V(D)J rearrangement.
MeSH term(s)	Mice ; Humans ; Animals ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/metabolism ; B-Lymphocytes/metabolism ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/metabolism ; RNA, Messenger/genetics
Chemical Substances	Receptors, Antigen, B-Cell ; Immunoglobulin Heavy Chains ; RNA, Messenger
Language	English
Publishing date	2023-10-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-023-04973-8
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Article ; Online: Estimation of surface soil moisture by combining a structural equation model and an artificial neural network (SEM-ANN).

Wang, Sinan / Li, Ruiping / Wu, Yingjie / Wang, Wenjun

The Science of the total environment

2023 Volume 876, Page(s) 162558

Abstract: Soil moisture is an important variable of the environment that directly affects hydrological, ecological, and climatic processes. However, owing to the influence of soil type, soil structure, topography, vegetation, and human activities, the distribution ...

Abstract	Soil moisture is an important variable of the environment that directly affects hydrological, ecological, and climatic processes. However, owing to the influence of soil type, soil structure, topography, vegetation, and human activities, the distribution of soil water content is spatially heterogeneous. It is difficult to accurately monitor the distribution of soil moisture over large areas. To investigate the direct or indirect influence of various factors on soil moisture and obtain accurate soil moisture inversion results, we used structural equation models (SEMs) to determine the structural relationships between these factors and the degree of their influence on soil moisture. These models were subsequently transformed into the topology of artificial neural networks (ANN). Finally, a structural equation model coupled with an artificial neural network was constructed (SEM-ANN) for soil moisture inversion. The results showed the following: (1) The most important predictor of the spatial variability of soil moisture in the April was the temperature-vegetation dryness index, while land surface temperature was the most important predictor in the August; (2) After the ANN model was improved, the inversion accuracy of surface soil moisture by SEM-ANN model was improved, and the R
Language	English
Publishing date	2023-03-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162558
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Article ; Online: Comprehensive RNA-seq profiling to evaluate the rabbit mammary gland transcriptome after mastitis.

Wu, Yingjie / Zhao, Lihua / Qin, Yinghe

Journal of animal science

2023 Volume 101

Abstract: Mastitis is a relatively common disease in rabbit does. The aim of this study was to investigate a relationship between the severity of clinical signs and pathological observations and to analyze differentially expressed genes (DEGs) in the mammary gland ...

Abstract	Mastitis is a relatively common disease in rabbit does. The aim of this study was to investigate a relationship between the severity of clinical signs and pathological observations and to analyze differentially expressed genes (DEGs) in the mammary gland with mastitis versus healthy mammary gland. The result showed that rectal temperatures of the rabbits with both mild mastitis and severe mastitis were higher than that of control. Cell counting results showed that the somatic cell count (SCC) only in milk of the rabbit with severe mastitis was significantly higher than that in the control group. However, the number of heterophils in the histological sections of mammary glands with mild mastitis was significantly higher than that of control. A total of 1,096 DEGs between the control and mastitis mammary glands was identified by RNA-sequencing (RNA-seq). Gene ontology (GO) showed that most of up-regulated genes were enriched in terms such as response to stimulus, signal transduction, and cell communication. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that these genes were mostly enriched in the pathways such as Rap1 signaling pathway, proteoglycans in cancer, and PI3K-Akt signaling pathway. However, the downregulated genes were mainly enriched in metabolic processes and significantly involved in metabolic pathways. The data provides useful information to further dissect the molecular genetic mechanisms underlying rabbit mastitis, which is a prerequisite for designing effective intervention strategies.
MeSH term(s)	Female ; Rabbits ; Animals ; Transcriptome ; Gene Expression Profiling/veterinary ; Phosphatidylinositol 3-Kinases/genetics ; RNA-Seq/veterinary ; Mastitis/veterinary
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skad110
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