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Article ; Online: The Legal Landscape of Surrogacy in China.

Wu, Yingying

2023 Volume 42, Issue 3-4, Page(s) 87–110

Abstract: Surrogacy has increased globally due to the development of medical technology. In light of the abolition of the one-child policy in China, demand for surrogacy among Chinese citizens has increased, especially in single-child families that would like a ... ...

Abstract	Surrogacy has increased globally due to the development of medical technology. In light of the abolition of the one-child policy in China, demand for surrogacy among Chinese citizens has increased, especially in single-child families that would like a second child but worry about childbearing at an advanced age. Meanwhile, highly educated women tend to have children at an advanced age. Hence, the need for surrogacy has risen. However, current policies and laws in China prohibit surrogacy, resulting in a domestic black market and people seeking international surrogacy. This article surveys legal and judicial practices in China and attempts to forecast whether China is likely to explicitly prohibit or legitimize surrogacy in the short term.
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	604915-1
ISSN	1521-057X ; 0194-7648
ISSN (online)	1521-057X
ISSN	0194-7648
DOI	10.1080/01947648.2023.2238563
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Article ; Online: The role and progress of EIA in environmental protection in China

Wu Yingying

E3S Web of Conferences, Vol 236, p

2021 Volume 03002

Abstract: The Environmental Impact Assessment system, referred to as the EIA system, is to evaluate the impact of the implementation of the plan or the construction and operation of the project on the environment, combine the surrounding environmental quality ... ...

Abstract	The Environmental Impact Assessment system, referred to as the EIA system, is to evaluate the impact of the implementation of the plan or the construction and operation of the project on the environment, combine the surrounding environmental quality status, propose ecological or environmental protection measures,then evaluate the effectiveness of the measures, and draw a conclusion on the feasibility of the project(planning) in terms of environmental protection.This article summarizes the role and progress in environmental protection in the two aspects of planning and construction projects in recent years.Comprehensively selected cases found that both planning or construction project environmental assessment have played an important role in predicting the possible impact of planning or construction projects on the environment and ecology, and proposed feasible and effective environmental protection measures.After the planning or construction project adopts the conclusions and suggestions, as long as the "Three Simultaneous" regulations are followed, the impact of the planning or construction project on the environment or ecology can be prevented or effectively reduced. When it is necessary to conduct postevaluation of environmental impact, verify the actual conditions of the construction project, such as emissions and actual production processes.
Keywords	Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Microglia-Astrocyte Communication in Alzheimer's Disease.

Wu, Yingying / Eisel, Ulrich L M

Journal of Alzheimer's disease : JAD

2023 Volume 95, Issue 3, Page(s) 785–803

Abstract: Microglia and astrocytes are regarded as active participants in the central nervous system under various neuropathological conditions, including Alzheimer's disease (AD). Both microglia and astrocyte activation have been reported to occur with a ... ...

Abstract	Microglia and astrocytes are regarded as active participants in the central nervous system under various neuropathological conditions, including Alzheimer's disease (AD). Both microglia and astrocyte activation have been reported to occur with a spatially and temporarily distinct pattern. Acting as a double-edged sword, glia-mediated neuroinflammation may be both detrimental and beneficial to the brain. In a variety of neuropathologies, microglia are activated before astrocytes, which facilitates astrocyte activation. Yet reactive astrocytes can also prevent the activation of adjacent microglia in addition to helping them become activated. Studies describe changes in the genetic profile as well as cellular and molecular responses of these two types of glial cells that contribute to dysfunctional immune crosstalk in AD. In this paper, we construct current knowledge of microglia-astrocyte communication, highlighting the multifaceted functions of microglia and astrocytes and their role in AD. A thorough comprehension of microglia-astrocyte communication could hasten the creation of novel AD treatment approaches.
MeSH term(s)	Humans ; Alzheimer Disease/pathology ; Astrocytes/pathology ; Microglia/pathology ; Central Nervous System/pathology ; Communication
Language	English
Publishing date	2023-08-28
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-230199
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Article ; Online: USP3: Key deubiquitylation enzyme in human diseases.

Zhang, Hongyan / Liu, Wenjing / Wu, Yingying / Chen, Ceshi

Cancer science

2024

Abstract: Ubiquitination and deubiquitylation are pivotal posttranslational modifications essential for regulating cellular protein homeostasis and are implicated in the development of human diseases. Ubiquitin-specific protease 3 (USP3), a member of the ubiquitin- ...

Abstract	Ubiquitination and deubiquitylation are pivotal posttranslational modifications essential for regulating cellular protein homeostasis and are implicated in the development of human diseases. Ubiquitin-specific protease 3 (USP3), a member of the ubiquitin-specific protease family, serves as a key deubiquitylation enzyme, playing a critical role in diverse cellular processes including the DNA damage response, cell cycle regulation, carcinogenesis, tumor cell proliferation, migration, and invasion. Despite notable research efforts, our current understanding of the intricate and context-dependent regulatory networks governing USP3 remains incomplete. This review aims to comprehensively synthesize existing published works on USP3, elucidating its multifaceted roles, functions, and regulatory mechanisms, while offering insights for future investigations. By delving into the complexities of USP3, this review strives to provide a foundation for a more nuanced understanding of its specific roles in various cellular processes. Furthermore, the exploration of USP3's regulatory networks may uncover novel therapeutic strategies targeting this enzyme in diverse human diseases, thereby holding promising clinical implications. Overall, an in-depth comprehension of USP3's functions and regulatory pathways is crucial for advancing our knowledge and developing targeted therapeutic approaches for human diseases.
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.16178
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Article ; Online: Parents' knowledge and attitudes towards extracorporeal membrane oxygenation and their post-traumatic stress symptoms.

Sun, Yuyan / Wang, Huanhuan / Wu, Yingying / Luo, Leng / Shi, Caixiao

Scientific reports

2024 Volume 14, Issue 1, Page(s) 10700

Abstract: This cross-sectional study, conducted between January 2020 and July 2023, aimed to assess the knowledge, attitude, and post-traumatic stress symptoms (PTSS) among parents with children undergoing extracorporeal membrane oxygenation (ECMO) treatment. Out ... ...

Abstract	This cross-sectional study, conducted between January 2020 and July 2023, aimed to assess the knowledge, attitude, and post-traumatic stress symptoms (PTSS) among parents with children undergoing extracorporeal membrane oxygenation (ECMO) treatment. Out of 201 valid questionnaires collected, the median knowledge score was 3.00, the mean attitude score was 27.00 ± 3.20, and the mean PTSS score was 3.50 ± 1.54. Logistic regression identified associations between PTSS and parents with lower education levels, particularly junior high school and high school/technical secondary school education, as well as those occupied as housewives. Structural equation modeling highlighted direct effects, such as the impact of residence on education, education on employment status, and associations between knowledge, attitude, PTSS, employment status, monthly income, and parental demographics. The findings indicated inadequate knowledge and suboptimal attitudes among parents, especially those with lower education levels, emphasizing the need for educational resources. Furthermore, addressing parental PTSS through psychosocial support and screening was deemed essential, providing valuable insights for tailored interventions in this context.
MeSH term(s)	Humans ; Female ; Male ; Parents/psychology ; Extracorporeal Membrane Oxygenation ; Health Knowledge, Attitudes, Practice ; Stress Disorders, Post-Traumatic/therapy ; Stress Disorders, Post-Traumatic/psychology ; Adult ; Cross-Sectional Studies ; Surveys and Questionnaires ; Middle Aged ; Child ; Educational Status
Language	English
Publishing date	2024-05-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60880-3
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Article: Case report: A case of anti-glycine receptor encephalomyelitis triggered by post-transplant or COVID-19 infection?

Zhang, Zhengxue / Zhang, Xiang / Dai, Mingming / Wu, Yingying / You, Yong

Frontiers in neurology

2024 Volume 15, Page(s) 1356691

Abstract: Even though long-term immunosuppressant drugs (ISD) are employed to inhibit immune system activity, enhancing graft functionality and patient survival in solid organ transplantation (SOT), these transplants often lead to immune complications, with post- ... ...

Abstract	Even though long-term immunosuppressant drugs (ISD) are employed to inhibit immune system activity, enhancing graft functionality and patient survival in solid organ transplantation (SOT), these transplants often lead to immune complications, with post-transplant autoimmune diseases of the central nervous system (CNS) being uncommon. Here, we detail the case of a 66-year-old woman who underwent a renal transplantation 8 months prior, who was admitted with subacute onset of encephalomyelitis, accompanied by headaches, paraplegia, weakness, vomiting, and abdominal pain, with a positive COVID-19 nasopharyngeal swab test 1 month before admission. MRI scans of the brain revealed multiple lesions in the white matter of the bilateral deep frontal lobe, the left temporal lobe and insula lobe. Additionally, there were multiple short segment lesions in the spinal cord and subdural hematoma at T1, T6-T7 posterior. The serum revealed a positive result for GlyR-IgG. Following the administration of corticosteroid and intravenous immunoglobulin, there was a significant improvement in the patient's symptoms within 2 weeks, and her brain MRI showed a reduction in the lesion. Despite its rarity, we believe this to be the inaugural documentation of anti-GlyR encephalomyelitis occurring during renal transplantation. A full panel of antibodies for autoimmune encephalomyelitis is the key leading to the diagnosis.
Language	English
Publishing date	2024-04-18
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1356691
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Article ; Online: Research progress on ubiquitin-specific proteases in regulation of bone remodeling

ZHANG Guorui / WU Yingying / XIONG Yi

口腔疾病防治, Vol 30, Iss 11, Pp 832-

2022 Volume 836

Abstract: Maintaining bone homeostasis relies on the balance between bone remodeling involving bone resorption by osteoclasts and bone formation by osteoblasts under physiological conditions. An increasing number of studies have shown that the ubiquitin-proteasome ...

Abstract	Maintaining bone homeostasis relies on the balance between bone remodeling involving bone resorption by osteoclasts and bone formation by osteoblasts under physiological conditions. An increasing number of studies have shown that the ubiquitin-proteasome system plays an important role in bone remodeling. The ubiquitination process is reversible through the action of deubiquitinase (DUB), and ubiquitin-specific proteases (USPs) are the largest of the DUB families. This article summarizes the mechanisms by which USPs regulate bone homeostasis, including USP4 and USP7, by affecting bone formation through signaling pathways such as Wnt/β-catenin and cylindromatosis (CYLD) and regulating bone resorption through signaling pathways such as nuclear factor-kappa B (NF-κB). In addition to affecting bone resorption and bone formation during bone reconstruction, the effect of USPs on bone is also reflected in the osteogenic differentiation of human periodontal membrane stem cells and implant bone binding. Future research should determine whether USPs have a greater regulatory effect on bone reconstruction and the specific mechanism of their regulatory effect to provide more approaches for the treatment of bone diseases.
Keywords	bone remodeling ; periodontitis ; implant bone bonding ; ubiquitination ; ubiquitin-specific proteases (usps) ; osteoblasts ; osteoclasts ; mechanism ; wnt signaling ; nf-κb signaling ; Medicine ; R
Subject code	616
Language	Chinese
Publishing date	2022-11-01T00:00:00Z
Publisher	Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Fast needling combined with occupational therapy for hand dysfunction of spastic cerebral palsy : a randomized controlled trial.

Wu, Juanmei / Yin, Linlin / Huang, Xinping / Chen, Fangchuan / Wu, Yingying / Meng, Rui / Xie, Hongxiang

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2024 Volume 44, Issue 2, Page(s) 149–152

Abstract: Objectives: To compare the clinical effect of fast needling (without needle retaining), needle retaining acupuncture combined with occupational therapy and simple occupational therapy for hand dysfunction of spastic cerebral palsy in children.: ... ...

Title translation	快针结合作业疗法治疗痉挛型脑瘫患儿手功能障碍：随机对照试验.
Abstract	Objectives: To compare the clinical effect of fast needling (without needle retaining), needle retaining acupuncture combined with occupational therapy and simple occupational therapy for hand dysfunction of spastic cerebral palsy in children. Methods: A total of 75 children with spastic cerebral palsy were randomly divided into an occupational therapy group (25 cases), a fast needling group (25 cases, 1 case dropped out) and a needle retaining group (25 cases, 1 case dropped out). The patients in the occupational therapy group were only treated with occupational therapy for 20 min each time. The patients in the fast needling group were treated with acupuncture (without needle retaining) combined with occupational therapy, and the needle retaining group was treated with acupuncture (needle retaining) combined with occupational therapy, and acupuncture was taken at Hegu (LI 4), Houxi (SI 3), Yuji (LU 10), Waiguan (SJ 5), Jianyu (LI 15) and so on. The needles were retained for 30 min in patients of the needle retaining group. All the above treatments were performed once a day, 5 times a week for 12 weeks. The scores of fine motor function measure (FMFM) and Peabody developmental motor scale 2 (PDMS-2) were observed in patients of the three groups before and after treatment, and the safety of the fast needling group and the needle retaining group was compared. Results: After treatment, the scores of FMFM and PDMS-2 in patients of the three groups were higher than those before treatment ( Conclusions: Acupuncture combined with occupational therapy has better clinical effect than occupational therapy alone in improving hand dysfunction in children with spastic cerebral palsy, and there is no statistical difference in effect between fast needling acupuncture and needle retaining acupuncture, but fast needling has better safety than needle retaining acupuncture.
MeSH term(s)	Child ; Humans ; Occupational Therapy ; Cerebral Palsy/therapy ; Percutaneous Collagen Induction ; Upper Extremity ; Hand ; Acupuncture Therapy ; Treatment Outcome ; Acupuncture Points
Language	Chinese
Publishing date	2024-02-12
Publishing country	China
Document type	Randomized Controlled Trial ; Journal Article
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.20230420-k0004
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Article ; Online: Reconstructing Randomly Masked Spectra Helps DNNs Identify Discriminant Wavenumbers.

Wu, Yingying / Liu, Jinchao / Wang, Yan / Gibson, Stuart / Osadchy, Margarita / Fang, Yongchun

IEEE transactions on pattern analysis and machine intelligence

2024 Volume 46, Issue 5, Page(s) 3845–3861

Abstract: Nondestructive detection methods, based on vibrational spectroscopy, are vitally important in a wide range of applications including industrial chemistry, pharmacy and national defense. Recently, deep learning has been introduced into vibrational ... ...

Abstract	Nondestructive detection methods, based on vibrational spectroscopy, are vitally important in a wide range of applications including industrial chemistry, pharmacy and national defense. Recently, deep learning has been introduced into vibrational spectroscopy showing great potential. Different from images, text, etc. that offer large labeled data sets, vibrational spectroscopic data is very limited, which requires novel concepts beyond transfer and meta learning. To tackle this, we propose a task-enhanced augmentation network (TeaNet). The key component of TeaNet is a reconstruction module that inputs randomly masked spectra and outputs reconstructed samples that are similar to the original ones, but include additional variations learned from the domain. These augmented samples are used to train the classification model. The reconstruction and prediction parts are trained simultaneously, end-to-end with back-propagation. Results on both synthetic and real-world datasets verified the superiority of the proposed method. In the most difficult synthetic scenarios TeaNet outperformed CNN by 17%. We visualized and analysed the neuron responses of TeaNet and CNN, and found that TeaNet's ability to identify discriminant wavenumbers was excellent compared to CNN. Our approach is general and can be easily adapted to other domains, offering a solution to more accurate and interpretable few-shot learning.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ISSN	1939-3539
ISSN (online)	1939-3539
DOI	10.1109/TPAMI.2023.3347617
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Article ; Online: The effects of environmental factors on the synthesis of water-soluble Monascus red pigments via submerged fermentation: a review.

Li, Ping / Zhou, Yin / Wu, Yingying / Jiang, Xiao / Wang, Xuan / Shi, Xinyun / Wang, Weiping

Journal of the science of food and agriculture

2024

Abstract: Monascus pigments (MPs) have been used as natural food pigments for many years. There is a high demand for Monascus red pigments (MRPs) to enhance color and for antibacterial and cancer prevention therapies in food and medicine. Most MRPs are not water ... ...

Abstract	Monascus pigments (MPs) have been used as natural food pigments for many years. There is a high demand for Monascus red pigments (MRPs) to enhance color and for antibacterial and cancer prevention therapies in food and medicine. Most MRPs are not water soluble, and the yield of water-soluble MRPs is naturally low. On the other hand, water-soluble MRP is more cost effective for application in industrial mass production. Therefore, it is important to improve the yield of water-soluble MRPs. Environmental factors have a significant influence on the synthesis of water-soluble MRPs, which is crucial for the development of industrial production of water-soluble MRPs. This review introduces the biosynthetic pathways of water-soluble MRPs and summarizes the effects of environmental factors on the yield of water-soluble MRPs. Acetyl coenzyme A (acetyl-CoA) is a precursor for MPs synthesis. Carbon and nitrogen sources and the carbon/nitrogen ratio can impact MP production by regulating the metabolic pathway of acetyl-CoA. Optimization of fermentation conditions to change the morphology of Monascus can stimulate the synthesis of MPs. The appropriate choice of nitrogen sources and pH values can promote the synthesis of MRPs from MPs. Additives such as metal ions and non-ionic surfactants can affect the fluidity of Monascus cell membrane and promote the transformation of MRPs into water-soluble MRPs. This review will lay the foundation for the industrial production of water-soluble MRPs. © 2024 Society of Chemical Industry.
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.13517
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