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Article: Clinical learning environment for nursing students in operating rooms: Development of an evaluation scale.

Zhang, Rui / Wu, Yuqi / Li, Li

2024 Volume 10, Issue 3, Page(s) e24553

Abstract: Aim: To develop a measurement tool to evaluate the clinical learning environment for nursing students in operating rooms.: Background: In this study, a scale for evaluating the clinical learning environment for nursing students in operating rooms was ...

Abstract	Aim: To develop a measurement tool to evaluate the clinical learning environment for nursing students in operating rooms. Background: In this study, a scale for evaluating the clinical learning environment for nursing students in operating rooms was developed and subjected to reliability and validity tests. Design: A cross-sectional, methodological study. Methods: Qualitative interviews, the Delphi method, a literature review and pilot testing were employed to develop the scale. A purposive sampling method was used to select September 2021 through May 2022; a total of 227 nursing students with internship experience in operating rooms at several teaching hospitals in North China were selected to evaluate the reliability and validity of the scale. Results: The 32-item, four-dimensional evaluation scale was developed through two rounds of consultation with 17 experts. The reliability and validity test showed that the overall Cronbach's alpha was 0.984 and 0.96. The split-half reliability for the total scale was 0.937, indicating good reliability. Conclusion: The proposed scale has high reliability and validity in evaluating the clinical learning environment of nursing students in operating rooms and improving clinical nursing education.
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24553
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Article ; Online: The Applications of CRISPR/Cas9 System for Urinary System Tumor.

Li, Shulin / Wu, Yuqi / Wang, Xiangwei

Current topics in medicinal chemistry

2023 Volume 23, Issue 10, Page(s) 897–906

Abstract: Tumors of the urinary system include those in the urinary and reproductive systems, of which tumors of the prostate, bladder, and kidney have the highest incidence. In recent years, due to changes in dietary structure, prostate cancer has become the most ...

Abstract	Tumors of the urinary system include those in the urinary and reproductive systems, of which tumors of the prostate, bladder, and kidney have the highest incidence. In recent years, due to changes in dietary structure, prostate cancer has become the most common type of male genitourinary system cancer. Furthermore, due to tobacco consumption, increases in industrialization, and the age of the population, the incidence of bladder cancer in both males and females in both urban and rural areas, has shown an increasing trend. The incidence and mortality of kidney cancer have also increased and negatively affected the lives and health of all residents. While surgery, radiotherapy, and chemotherapy have greatly improved the cure and survival rates of patients with urinary tumors, we lack methods for early detection and effective long-term treatment. New tools and methods for diagnosis and treatment are thus urgently needed. Recently, CRISPR/Cas9 has become an efficient method to alter the genome in many organisms. It can be used to activate or inhibit gene expression, which greatly facilitates the editing of targeted genes, both in vivo and in vitro. It provides a powerful scientific research tool to analyze the mechanisms of disease occurrence and development and to develop advanced targeted drug delivery. The diagnosis and treatment of human tumors will consequently be improved as this technology will surely accelerate cancer research. In this article, we discuss how CRISPR/Cas9 technology can be used to research and treat genitourinary system tumors will consequently be improved as this technology will surely accelerate cancer research. Here, we review the current applications of CRISPR/Cas9 technology for genitourinary system tumor research and therapy.
MeSH term(s)	Humans ; Male ; CRISPR-Cas Systems/genetics ; Gene Editing/methods ; Prostatic Neoplasms
Language	English
Publishing date	2023-05-07
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/1568026623666230504100706
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Article ; Online: A systematic review on automated clinical depression diagnosis.

Mao, Kaining / Wu, Yuqi / Chen, Jie

Npj mental health research

2023 Volume 2, Issue 1, Page(s) 20

Abstract: Assessing mental health disorders and determining treatment can be difficult for a number of reasons, including access to healthcare providers. Assessments and treatments may not be continuous and can be limited by the unpredictable nature of psychiatric ...

Abstract	Assessing mental health disorders and determining treatment can be difficult for a number of reasons, including access to healthcare providers. Assessments and treatments may not be continuous and can be limited by the unpredictable nature of psychiatric symptoms. Machine-learning models using data collected in a clinical setting can improve diagnosis and treatment. Studies have used speech, text, and facial expression analysis to identify depression. Still, more research is needed to address challenges such as the need for multimodality machine-learning models for clinical use. We conducted a review of studies from the past decade that utilized speech, text, and facial expression analysis to detect depression, as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline. We provide information on the number of participants, techniques used to assess clinical outcomes, speech-eliciting tasks, machine-learning algorithms, metrics, and other important discoveries for each study. A total of 544 studies were examined, 264 of which satisfied the inclusion criteria. A database has been created containing the query results and a summary of how different features are used to detect depression. While machine learning shows its potential to enhance mental health disorder evaluations, some obstacles must be overcome, especially the requirement for more transparent machine-learning models for clinical purposes. Considering the variety of datasets, feature extraction techniques, and metrics used in this field, guidelines have been provided to collect data and train machine-learning models to guarantee reproducibility and generalizability across different contexts.
Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Journal Article ; Review
ISSN	2731-4251
ISSN (online)	2731-4251
DOI	10.1038/s44184-023-00040-z
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Article ; Online: Prevalence and predictors of depression and anxiety in patients with chronic rhinosinusitis: a systematic review and meta-analysis.

Fan, Hongli / Han, Zhoutong / Gong, Xinru / Wu, Yuqi / Fu, Yijie / Zhu, Tianmin / Li, Hui

BMJ open

2024 Volume 14, Issue 3, Page(s) e079273

Abstract: Background: Chronic rhinosinusitis (CRS) is a persistent inflammation of the sinuses. As a result of long-term discomfort, patients may experience symptoms of common mental disorders such as anxiety and depression. This may affect the quality of life ... ...

Abstract	Background: Chronic rhinosinusitis (CRS) is a persistent inflammation of the sinuses. As a result of long-term discomfort, patients may experience symptoms of common mental disorders such as anxiety and depression. This may affect the quality of life and disease progression. However, there is still uncertainty about the extent of the problem. Objective: This meta-analysis aimed to determine the prevalence of depression and anxiety symptoms in patients with CRS. Search strategy: We searched PubMed, Embase, Web of Science, Cochrane Library, and CBM databases for relevant studies published before 15 July 2022 in patients with CRS with concomitant depression and anxiety symptoms. Data collection and analysis: Two authors independently performed screening and quality assessment using validated tools. Extraction of data using predefined standardised data collection spreadsheets. Heterogeneity and inconsistency were checked using the Results: The meta-analysis included 32 articles involving 56 933 patients. The prevalence of depression and anxiety symptoms was estimated at 24.7% (95% CI, 21.3% to 28. 1%) and 29.7% (95% CI, 19.3% to 40.2%). Subgroup analysis revealed the following: (1) CRS without nasal polyps (CRSsNP): 26.2% (95% CI, 21.9% to 30.5%), CRS with nasal polyps(CRSwNP): 20% (95% CI, 15.9% to 24%); (2) Female patients: 36. 1% (95% CI, 25.3% to 46.9%), male patients: 24.3% (95% CI, 12. 1% to 36.6%); and (3) The average age≤50 years patients: 29.8% (95% CI, 21.3% to 38.2%), the average age>50 years patients: 22. 1% (95% CI, 17.1% to 27%). Conclusion: A significant proportion of people with CRS have symptoms of depression and anxiety, and early screening for depression and anxiety in people with CRS is critical. And, more attention needs to be given to females and patients with CRSsNP during screening. Prospero registration number: CRD42022345959).
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Depression/epidemiology ; Prevalence ; Nasal Polyps/complications ; Nasal Polyps/epidemiology ; Quality of Life ; Rhinosinusitis ; Anxiety/epidemiology ; Sinusitis/complications ; Sinusitis/epidemiology ; Chronic Disease ; Rhinitis/complications ; Rhinitis/epidemiology
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-079273
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Article ; Online: Multiple myeloma initially manifesting as a solitary deep ulcer on the tongue: a case study and literature review.

Zhang, You / Wu, Yuqi / Yao, Lihong / Feng, Xiaodong / Luo, Xiaobo / Chen, Qianming

European journal of dermatology : EJD

2024 Volume 33, Issue 6, Page(s) 618–623

Abstract: Multiple myeloma (MM) is a malignant disease associated with clonal plasma cell proliferative disorder, characterized by extensive infiltration of clonal plasma cells in the bone marrow, for which a proportion of patients suffer poor outcome and exhibit ... ...

Abstract	Multiple myeloma (MM) is a malignant disease associated with clonal plasma cell proliferative disorder, characterized by extensive infiltration of clonal plasma cells in the bone marrow, for which a proportion of patients suffer poor outcome and exhibit no obvious symptoms in the early stages. Amyloidosis is a rare condition caused by MM. Immunoglobulin light chain amyloidosis (AL) is caused by the secretion of specific toxic light chain proteins from proliferating clonal B cells or plasma cells. These light chain proteins accumulate in human tissues and cause organ dysfunction and failure. Oral manifestations of amyloidosis include macroglossia, prominent lingual margins, coloured papules, purpura, and nodular protrusions. To describe and summarize the oral manifestations associated with AL amyloidosis in order to achieve an accurate clinical diagnosis. We present a case of AL amyloidosis associated with multiple myeloma and review the literature on other related cases identified from the inception of Medline. A female patient visited our clinic with a deep tongue ulcer. After oral biopsy and tissue staining, combined with the examination results from the Department of Haematology, the patient was diagnosed with oral AL amyloidosis related to multiple myeloma. This is the first case study of AL amyloidosis secondary to latent MM presenting as a solitary tongue ulcer. Chronic oral refractory ulcers may be associated with systemic diseases and should be considered in future clinical practice.
MeSH term(s)	Humans ; Female ; Multiple Myeloma/complications ; Multiple Myeloma/diagnosis ; Multiple Myeloma/pathology ; Immunoglobulin Light-chain Amyloidosis/pathology ; Ulcer/complications ; Amyloidosis/complications ; Tongue/pathology ; Paraproteinemias/complications ; Tongue Diseases/etiology ; Tongue Diseases/pathology
Language	English
Publishing date	2024-03-11
Publishing country	France
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2023.4628
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Zs.A 3484: Show issues

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Article ; Online: Parental Autonomy Granting, Peer Attachment and Problematic Internet Use Among Chinese Adolescents: The Moderating Effect of School Climate.

Wu, Yu-Qi / Chen, Pei / Li, Sheng-Nan / Huang, Xin-Yi / Nie, Yan-Gang

Child psychiatry and human development

2024

Abstract: While the correlation between parental autonomy granting and adolescents' problematic Internet use (PIU) has been confirmed, the processes underlying this connection have not been thoroughly investigated. Drawing on the ecological systems theory, this ... ...

Abstract	While the correlation between parental autonomy granting and adolescents' problematic Internet use (PIU) has been confirmed, the processes underlying this connection have not been thoroughly investigated. Drawing on the ecological systems theory, this study sought to investigate the mediating mechanism of peer attachment and the moderating mechanism of school climate that link parental autonomy granting to PIU. A two-wave longitudinal design was employed with a time interval of six months. The participants were 852 adolescents who attended three middle schools located in Guangdong Province, China. Self-report questionnaires were used to obtain data on demographics, parental autonomy granting, peer attachment, school climate, and PIU. The findings indicated that peer attachment significantly mediated the link between parental autonomy granting and adolescent PIU. A positive school climate significantly moderated the influence of parental autonomy granting on peer attachment and the influence of peer attachment on PIU. Specifically, the association between parental autonomy granting and peer attachment and the association between peer attachment and PIU were more pronounced when the school climate was perceived to be positive. This research underscores the possible significance of peer attachment in the association between parental autonomy granting and PIU and offers valuable insights for mitigating the negative outcomes of PIU.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	223895-0
ISSN	1573-3327 ; 0009-398X
ISSN (online)	1573-3327
ISSN	0009-398X
DOI	10.1007/s10578-024-01687-1
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Zs.A 772: Show issues

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Article: Anaerobic co-digestion of waste activated sludge and fish waste: Methane production performance and mechanism analysis

Wu, Yuqi / Song, Kang

Journal of cleaner production. 2021 Jan. 10, v. 279

2021

Abstract: The performances of anaerobic co-digestion (AcD) of waste activated sludge (WAS) and fish waste (FW) were studied through mesophilic biochemical methane potential test. Mixtures of various compositions (0, 1.5, 3, 6 and 10% of FW on the volume basis) ... ...

Abstract	The performances of anaerobic co-digestion (AcD) of waste activated sludge (WAS) and fish waste (FW) were studied through mesophilic biochemical methane potential test. Mixtures of various compositions (0, 1.5, 3, 6 and 10% of FW on the volume basis) were tested as the AcD substrates. Experimental results showed that 1.5% and 3% of FW addition could enhance the cumulative methane production remarkably, increasing from 212.3 mL CH₄/g VSfₑd (100% WAS) to 410.1 mL CH₄/g VSfₑd and 683.8 mL CH₄/g VSfₑd, respectively. However, methane producing was inhibited severely with more than 6% of FW addition, whose cumulative methane production dramatically decreased to approximately 51 mL CH₄/g VSfₑd. Mechanism analysis showed that large amounts of fatty acids accumulation occurred during the AcD with FW addition above 6%, leading to methanogenesis process failure. Microbial community analysis showed that methane producing during AcD was dominated by hydrogenotrophic and methylotrophic methanogenesis pathways led by Methanobacterium and Methanomassiliicoccus.
Keywords	Methanobacterium ; activated sludge ; anaerobic digestion ; fatty acids ; fish waste ; methane ; methane production ; microbial communities
Language	English
Dates of publication	2021-0110
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2020.123678
Database	NAL-Catalogue (AGRICOLA)

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Article: Pathogenesis and treatment of chronic rhinosinusitis from the perspective of sinonasal epithelial dysfunction.

He, Yuanqiong / Fu, Yijie / Wu, Yuqi / Zhu, Tianmin / Li, Hui

Frontiers in medicine

2023 Volume 10, Page(s) 1139240

Abstract: Background: Chronic rhinosinusitis (CRS) is a clinical syndrome primarily characterized by long-term mucosal inflammation of the nasal cavity and sinuses. The pathogenesis of CRS is still unclear due to its high heterogeneity. A number of studies have ... ...

Abstract	Background: Chronic rhinosinusitis (CRS) is a clinical syndrome primarily characterized by long-term mucosal inflammation of the nasal cavity and sinuses. The pathogenesis of CRS is still unclear due to its high heterogeneity. A number of studies have recently focused on the sinonasal epithelium. Thus, there has been a quantum leap in awareness of the role of the sinonasal epithelium, which is now understood as an active functional organ rather than simply an inert mechanical barrier. Undoubtedly, epithelial dysfunction plays a vital role in the onset and development of CRS. Objective: In this article, we discuss the potential contribution of sinonasal epithelium dysfunction to CRS pathogenesis and explore a few current and developing therapeutic options targeting the sinonasal epithelium. Results: Impaired mucociliary clearance (MCC) and an abnormal sinonasal epithelial barrier are usually considered to be the main causative factors in CRS. Epithelial-derived bioactive substances, such as cytokines, exosomes, and complements, play a vital role in the regulation of innate and adaptive immunity and contribute to the pathophysiological alterations of CRS. The phenomena of epithelial-mesenchymal transition (EMT), mucosal remodeling, and autophagy observed in CRS offer some novel insights into the pathogenesis of this disease. In addition, existing treatment options targeting disorder of sinonasal epithelium can help to relieve the main symptoms associated with CRS to some extent. Conclusion: The presence of a normal epithelium is fundamental for maintaining homeostasis in the nasal and paranasal sinuses. Here, we describe various aspects of the sinonasal epithelium and highlight the contributions of epithelial dysfunction to CRS pathogenesis. Our review provides sound evidence of the need for in-depth study of the pathophysiological alterations of this disease and for the development of novel epithelium-targeting alternative treatments.
Language	English
Publishing date	2023-04-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1139240
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Article ; Online: Racial Disparities in Utilization of Emergency Medical Services and Related Impact on Poststroke Disability.

Wu, Yuqi / Xirasagar, Sudha / Nan, Zixiao / Heidari, Khosrow / Sen, Souvik

Medical care

2023 Volume 61, Issue 11, Page(s) 796–804

Abstract: Background: Prompt seeking of emergency medical services (EMS) assistance at stroke onset is critical to minimize poststroke disability.: Objective: The aim was to study how racial differences in EMS decision-relevant factors and EMS use impact ... ...

Abstract	Background: Prompt seeking of emergency medical services (EMS) assistance at stroke onset is critical to minimize poststroke disability. Objective: The aim was to study how racial differences in EMS decision-relevant factors and EMS use impact stroke care and disability outcomes. Design: A prospective observational study. Participants: A total of 1168 acute ischemic stroke patients discharged from April 2016 to October 2017 at a safety net hospital were included; 108 patients were surveyed before discharge. Measures: (1) Prehospital delay: EMS use, timely hospital arrival; (2) Stroke care: alteplase receipt and inpatient rehab; (3) Outcomes: Functional improvement at discharge (admission minus discharge scores on National Institutes of Health Stroke Scale), 90-day modified Rankin Scale; (4) EMS decision-relevant factors: Stroke symptom knowledge, source of knowledge, unfavorable past EMS/care experiences, and financial barriers to EMS use. Results: Despite more Black patients using EMS than Whites/Asians (56% vs. 48%, P =0.003), their timely hospital arrival was 30% less likely. Adjusted for stroke severity, receipt of alteplase, and inpatient rehab were similar, but Black patients fared worse on functional improvement at discharge (among severe strokes, 2.4 National Institutes of Health Stroke Scale points less improvement, P <0.01), and on functional normalcy at 90 days (modified Rankin Scale score 0-1 being 60% less likely across severity categories) ( P <0.01). Fewer Black patients knew any stroke symptoms before the stroke (72% vs. 87%, P =0.03), and fewer learned about stroke from providers ( P =0.01). Financial barriers and provider mistrust were similar. Conclusions: Black patients had less knowledge of stroke symptoms, more care-seeking delay, and poorer outcomes. Including stroke education as a standard of chronic disease care may mitigate stroke outcome disparities.
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	411646-x
ISSN	1537-1948 ; 0025-7079
ISSN (online)	1537-1948
ISSN	0025-7079
DOI	10.1097/MLR.0000000000001926
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Zs.MO 63: Show issues

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Article ; Online: Systematic review of machine learning in PTSD studies for automated diagnosis evaluation.

Wu, Yuqi / Mao, Kaining / Dennett, Liz / Zhang, Yanbo / Chen, Jie

Npj mental health research

2023 Volume 2, Issue 1, Page(s) 16

Abstract: Post-traumatic stress disorder (PTSD) is frequently underdiagnosed due to its clinical and biological heterogeneity. Worldwide, many people face barriers to accessing accurate and timely diagnoses. Machine learning (ML) techniques have been utilized for ... ...

Abstract	Post-traumatic stress disorder (PTSD) is frequently underdiagnosed due to its clinical and biological heterogeneity. Worldwide, many people face barriers to accessing accurate and timely diagnoses. Machine learning (ML) techniques have been utilized for early assessments and outcome prediction to address these challenges. This paper aims to conduct a systematic review to investigate if ML is a promising approach for PTSD diagnosis. In this review, statistical methods were employed to synthesize the outcomes of the included research and provide guidance on critical considerations for ML task implementation. These included (a) selection of the most appropriate ML model for the available dataset, (b) identification of optimal ML features based on the chosen diagnostic method, (c) determination of appropriate sample size based on the distribution of the data, and (d) implementation of suitable validation tools to assess the performance of the selected ML models. We screened 3186 studies and included 41 articles based on eligibility criteria in the final synthesis. Here we report that the analysis of the included studies highlights the potential of artificial intelligence (AI) in PTSD diagnosis. However, implementing AI-based diagnostic systems in real clinical settings requires addressing several limitations, including appropriate regulation, ethical considerations, and protection of patient privacy.
Language	English
Publishing date	2023-09-27
Publishing country	England
Document type	Journal Article ; Review
ISSN	2731-4251
ISSN (online)	2731-4251
DOI	10.1038/s44184-023-00035-w
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