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Article ; Online: Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2.

Wu, Chung-Pu / Hsiao, Sung-Han / Wu, Yu-Shan

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

2023 Volume 71, Page(s) 101011

Abstract: The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is a common mechanism involved in developing multidrug resistance (MDR). Unfortunately, there are currently no approved drugs specifically designed to treat multidrug- ...

Abstract	The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is a common mechanism involved in developing multidrug resistance (MDR). Unfortunately, there are currently no approved drugs specifically designed to treat multidrug-resistant cancers, making MDR a significant obstacle to successful chemotherapy. Despite over two decades of research, developing transporter-specific inhibitors for clinical use has proven to be a challenging endeavor. As an alternative approach, drug repurposing has gained traction as a more practical method to discover clinically effective modulators of drug transporters. This involves exploring new indications for already-approved drugs, bypassing the lengthy process of developing novel synthetic inhibitors. In this context, we will discuss the mechanisms of ABC drug transporters ABCB1 and ABCG2, their roles in cancer MDR, and the inhibitors that have been evaluated for their potential to reverse MDR mediated by these drug transporters. Our focus will be on providing an up-to-date report on approved drugs tested for their inhibitory activities against these drug efflux pumps. Lastly, we will explore the challenges and prospects of repurposing already approved medications for clinical use to overcome chemoresistance in patients with high tumor expression of ABCB1 and/or ABCG2.
MeSH term(s)	Humans ; Drug Repositioning ; ATP-Binding Cassette Transporters/genetics ; Neoplasms/drug therapy ; Neoplasms/genetics ; Membrane Transport Proteins ; Drug Resistance, Multiple ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Neoplasm Proteins/genetics ; ATP Binding Cassette Transporter, Subfamily B/genetics
Chemical Substances	ATP-Binding Cassette Transporters ; Membrane Transport Proteins ; ABCG2 protein, human ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Neoplasm Proteins ; ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B
Language	English
Publishing date	2023-10-10
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1474513-6
ISSN	1532-2084 ; 1368-7646
ISSN (online)	1532-2084
ISSN	1368-7646
DOI	10.1016/j.drup.2023.101011
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Article ; Online: Correction: Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome in initiating ART among HIV-Infected patients in China-risk factors and management.

Yang, Honghong / Liu, Qian / Wu, Yushan / He, Kun / Zeng, Qin / Liu, Min

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 272

Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Published Erratum
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-024-09080-y
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Article ; Online: Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome in initiating ART among HIV-Infected patients in China-risk factors and management.

Yang, Honghong / Liu, Qian / Wu, Yushan / He, Kun / Zeng, Qin / Liu, Min

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 5

Abstract: Background: China is a country burdened with a high incidence of both tuberculosis (TB) and HIV, Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an important early complication in TB and HIV co-infected ... ...

Abstract	Background: China is a country burdened with a high incidence of both tuberculosis (TB) and HIV, Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an important early complication in TB and HIV co-infected patients, but data from China are limited. Additionally, as an integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) regimen becomes the first-line treatment, concerns have arisen regarding the potential increase in the incidence of paradoxical TB-IRIS. Nevertheless, the existing data are inconclusive and contradictory. Methods: We conducted a retrospective study at Chongqing Public Health Clinical Center from January 2018 to December 2021. We collected demographic and clinical data of HIV/TB co-infected patients who initiated ART. We described the patient characteristics, identified predictors for TB-IRIS, and determined clinical outcomes. The Statistical Package for Social Science (SPSS 25) was used to analyse the data. Continuous variables were compared using Student's t-test or rank sum test. Counting data were compared using the chi-square test or Fisher's exact test. The variables with statistical significance in the univariate analysis were added to the binary logistic regression. A p-value less than 0.05 was considered statistically significant. Results: A total of 384 patients co-infected with naive HIV and pulmonary TB (PTB) who were given ATT and ART combination were included. 72 patients (18.8%) developed paradoxical TB-IRIS with a median of 15 (12, 21) days after initiating ART. Baseline age ≤ 40years, CD4 + T-cell counts ≤ 50cells/µL, HIV viral load ≥ 500,000 copies/mL were found to be significantly associated with development of paradoxical TB-IRIS. Mortality rates were similar in the TB-IRIS (n = 5, 6.9%) group and non-TB-IRIS (n = 13, 4.2%) group. Interestingly, CD4 Conclusion: Paradoxical TB-IRIS, while often leading to clinical deterioration and hospitalization, is generally manageable. It appears to have a positive impact on the recovery of CD4 + T-cell counts over time. Importantly, our data suggest that INSTI-based ART regimens do not elevate the risk of TB-IRIS. Thus, paradoxical TB-IRIS should not be considered an impediment to initiating ART in adults with advanced immunodeficiency, except in the case of tuberculous meningitis (TBM).
MeSH term(s)	Adult ; Humans ; Retrospective Studies ; Immune Reconstitution Inflammatory Syndrome/epidemiology ; Immune Reconstitution Inflammatory Syndrome/etiology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Risk Factors ; China/epidemiology ; Tuberculosis, Meningeal/complications
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08897-3
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Article ; Online: Trial Selection Tensor Canonical Correlation Analysis (TSTCCA) for Depression Recognition with Facial Expression and Pupil Diameter.

Yang, Minqiang / Wu, Yushan / Tao, Yongfeng / Hu, Xiping / Hu, Bin

IEEE journal of biomedical and health informatics

2023 Volume PP

Abstract: Facial expressions have been widely used for depression recognition because it is intuitive and convenient to access. Pupil diameter contains rich emotional information that is already reflected in facial video streams. However, the spatiotemporal ... ...

Abstract	Facial expressions have been widely used for depression recognition because it is intuitive and convenient to access. Pupil diameter contains rich emotional information that is already reflected in facial video streams. However, the spatiotemporal correlation between pupillary changes and facial behavior changes induced by emotional stimuli has not been explored in existing studies. This paper presents a novel multimodal fusion algorithm - Trial Selection Tensor Canonical Correlation Analysis (TSTCCA) to optimize the feature space and build a more robust depression recognition model, which innovatively combines the spatiotemporal relevance and complementarity between facial expression and pupil diameter features. TSTCCA explores the interaction between trials and obtains an effective fusion representation of two modalities from a trial subset related to depression. The experimental results show that TSTCCA achieves the highest accuracy of 78.81% with the subset of 25 trials.
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2023.3322271
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Article ; Online: Rapid quantitative

Wu, Yu-Shan / Li, Bai-Xiang / Long, Ying-Yun

RSC advances

2022 Volume 12, Issue 9, Page(s) 5349–5356

Abstract: Two dimensional (2D) ...

Abstract	Two dimensional (2D)
Language	English
Publishing date	2022-02-14
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra08423b
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Article ; Online: Estimates of inpatient admission rates and associated costs for infants before and after China's universal two-child policy.

Shen, Menghan / Liang, Xiaoxia / Wu, Yushan / Fang, Shixin

BMC health services research

2022 Volume 22, Issue 1, Page(s) 163

Abstract: Background: China implemented a universal two-child policy in 2015. It is important to understand infants' medical utilization in the context of this policy to inform health policies and resource allocation.: Methods: This study utilized a 20% random ...

Abstract	Background: China implemented a universal two-child policy in 2015. It is important to understand infants' medical utilization in the context of this policy to inform health policies and resource allocation. Methods: This study utilized a 20% random sample of administrative data from China's Urban and Rural Basic Medical Insurance (URBMI) in one of the largest southern Chinese cities from January 2015 to June 2018. Ordinary least squares models were used to estimate changes in inpatient admission rates and costs for infants between 0 and 6 months old after the implementation of China's universal two-child policy. Results: The overall inpatient admission rate was 27.2% in 2015 and 31.3% in 2017. Compared with 2015, there was an increase in inpatient admission rates for infants 1 month old or younger (coef = 0.038, 95% CI = 0.029 to 0.047, p < .001) and infants 6 months old or younger (coef = 0.041, 95% CI = 0.030 to 0.052, p < .001) in 2017. The increase was larger for male infants than for female ones. The average inpatient admission cost was 8412.3 RMB ($1320.61) (SD = 15,088.2). There was no increase in inpatient admission costs overall. The average length of hospital stay was 7.3 days, the probability of going to a tertiary hospital was 76.2%, and the share of out-of-pocket costs was 53.0% for all diseases. Conclusion: After the implementation of the universal two-child policy in China, there was a significant increase in inpatient admission rates, especially for male infants. The overall associated costs did not change, but the increase in admission rates caused additional economic burdens for families and for social health insurance. Understanding the healthcare utilization of infants in the universal two-child period can provide insight for healthcare resource allocation in a time of dramatic changes in population policy.
MeSH term(s)	China ; Female ; Health Policy ; Humans ; Infant ; Infant, Newborn ; Inpatients ; Insurance, Health ; Male ; Urban Population
Language	English
Publishing date	2022-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-022-07571-9
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Article ; Online: Quantification of the Cumulative Shading Capacity in a Maize-Soybean Intercropping System Using an Unmanned Aerial Vehicle.

Li, Min / Hu, Pengcheng / He, Di / Zheng, Bangyou / Guo, Yan / Wu, Yushan / Duan, Tao

Plant phenomics (Washington, D.C.)

2023 Volume 5, Page(s) 95

Abstract: In intercropping systems, higher crops block direct radiation, resulting in inevitable shading on the lower crops. Cumulative shading capacity ( ...

Abstract	In intercropping systems, higher crops block direct radiation, resulting in inevitable shading on the lower crops. Cumulative shading capacity (
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ISSN	2643-6515
ISSN (online)	2643-6515
DOI	10.34133/plantphenomics.0095
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Article ; Online: Hukou-based rural-urban disparities in maternal health service utilization and delivery modes in two Chinese cities in Guangdong Province.

Shen, Menghan / Wu, Yushan / Xiang, Xin

International journal for equity in health

2021 Volume 20, Issue 1, Page(s) 145

Abstract: Background: Most existing research on rural-urban health inequalities focuses on disparities in service access and health outcomes based on region. This paper examines rural-urban disparities in maternal healthcare utilization and delivery modes based ... ...

Abstract	Background: Most existing research on rural-urban health inequalities focuses on disparities in service access and health outcomes based on region. This paper examines rural-urban disparities in maternal healthcare utilization and delivery modes based on household registration (hukou) status to understand the role of state institutions in producing healthcare disparities in China. Methods: Utilizing administrative data from the Public Maternal Health Insurance scheme, we analyzed 54,733 live births in City A (2015-2019) and 25,849 live births in City B (2018-2019) in Guangdong Province in China. We constructed regression models using hukou status (rural versus urban) as the explanatory variable. Results: While there is no statistically significant difference in rural and urban mothers' probability of obtaining the minimum recommended number of prenatal care checkups in City A (OR = 0.990 [0.950, 1.032]), mothers with rural hukou status have a lower probability of obtaining the minimum recommended number of visits in City B than their counterparts with urban hukou (OR = 0.781 [0.740, 0.825]). The probability of delivering in tertiary hospital is lower among mothers with rural hukou than among those with urban hukou in both cities (City A: OR = 0.734 [0.701, 0.769]; City B: OR = 0.336 [0.319, 0.354]). Mothers with rural hukou are more likely to have a Cesarean section than those with urban hukou in both cities (City A: OR = 1.065 [1.027, 1.104]; City B: OR = 1.127 [1.069, 1.189]). Compared with mothers with urban hukou, mothers with rural hukou incurred 4 % (95 % CI [-0.046, -0.033]) and 9.4 % (95 % CI [-0.120, -0.068]) less in total medical costs for those who delivered via Cesarean section and 7.8 % (95 % CI [-0.085, -0.071]) and 19.9 % (95 % CI [-0.221, -0.177]) less for those who delivered via natural delivery in City A and City B, respectively. Conclusions: Rural hukou status is associated with younger age, no difference or lower probability of having a minimum number of prenatal checkups, higher likelihood of delivering in nontertiary hospitals, increased Cesarean delivery rates, and lower medical cost for delivery in these two Chinese cities. Evaluating how hukou status influences maternal healthcare in Chinese cities is important for devising targeted public policies to promote more equitable maternal health services.
MeSH term(s)	Cesarean Section ; China ; Cities ; Female ; Healthcare Disparities ; Humans ; Maternal Health Services ; Pregnancy ; Rural Population ; Urban Population
Language	English
Publishing date	2021-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2092056-8
ISSN	1475-9276 ; 1475-9276
ISSN (online)	1475-9276
ISSN	1475-9276
DOI	10.1186/s12939-021-01485-4
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Article: Photosynthetic Acclimation of Shade-Grown Soybean Seedlings to a High-Light Environment.

Su, Yahan / Yang, Huan / Wu, Yushan / Gong, Wanzhuo / Gul, Hina / Yan, Yanhong / Yang, Wenyu

Plants (Basel, Switzerland)

2023 Volume 12, Issue 12

Abstract: Soybean in relay intercropping is initially exposed to a shade environment, followed by exposure to full sunlight after the harvesting of primary crops, e.g., maize. Therefore, soybean's ability to acclimate to this changing light environment determines ... ...

Abstract	Soybean in relay intercropping is initially exposed to a shade environment, followed by exposure to full sunlight after the harvesting of primary crops, e.g., maize. Therefore, soybean's ability to acclimate to this changing light environment determines its growth and yield formation. However, the changes in soybean photosynthesis under such light alternations in relay intercropping are poorly understood. This study compared the photosynthetic acclimation of two soybean varieties with contrasting shade tolerance, i.e.,
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12122324
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Article ; Online: Risk of Dementia Among Patients With Diabetes in a Multidisciplinary, Primary Care Management Program.

Wang, Kailu / Zhao, Shi / Lee, Eric Kam-Pui / Yau, Susan Zi-May / Wu, Yushan / Hung, Chi-Tim / Yeoh, Eng-Kiong

JAMA network open

2024 Volume 7, Issue 2, Page(s) e2355733

Abstract: Importance: Although poorly controlled diabetes is associated with a higher incidence of dementia, few studies have examined the association of diabetes management interventions with dementia incidence.: Objective: To examine the association of ... ...

Abstract	Importance: Although poorly controlled diabetes is associated with a higher incidence of dementia, few studies have examined the association of diabetes management interventions with dementia incidence. Objective: To examine the association of receiving a multidisciplinary diabetes management program (the Risk Assessment and Management Program-Diabetes Mellitus [RAMP-DM]) that enables better glycemic control with subsequent risk of dementia incidence and the association of dementia with glycemic control. Design, setting, and participants: This territory-wide, retrospective, matched cohort study with more than 8 years of follow-up was conducted using electronic health care records from all the patients who used public health care services in Hong Kong from 2011 to 2019. Eligible participants included all patients with type 2 diabetes (T2D) who were managed in primary care settings. Patients who received RAMP-DM were matched in a 1:1 ratio with patients who received usual care only. Data analysis occurred from April 2023 to July 2023. Exposures: Diagnosis of T2D, hemoglobin A1C (HbA1C) level, and attendance at a general outpatient clinic or family medicine clinic. Patients received either RAMP-DM or usual care. Main outcomes and measures: Incidence of all-cause dementia and subtypes of dementia were compared between the RAMP-DM and usual care participants using a Cox proportional hazard model with other baseline characteristics, biomarkers, and medication history adjusted. HbA1C levels were measured as a secondary outcome. Results: Among the 55 618 matched participants (mean [SD] age, 62.28 [11.90] years; 28 561 female [51.4%]; 27 057 male [48.6%]), including the 27 809 patients in the RAMP-DM group and 27 809 patients in the usual care group, patients had been diagnosed with T2D for a mean (SD) of 5.90 (4.20) years. During a median (IQR) follow-up period of 8.4 (6.8-8.8) years, 1938 patients in the RAMP-DM group (6.97%) and 2728 patients in the usual care group (9.81%) received a diagnosis of dementia. Compared with those receiving usual care, RAMP-DM participants had a lower risk of developing all-cause dementia (adjusted hazard ratio [aHR], 0.72; 95% CI, 0.68-0.77; P < .001), Alzheimer disease (aHR, 0.85; 95% CI, 0.76-0.96; P = .009), vascular dementia (aHR, 0.61; 95% CI, 0.51-0.73; P < .001), and other or unspecified dementia (aHR, 0.71; 95% CI, 0.66-0.77; P < .001). Compared with having a mean HbA1C level during the first 3 years after cohort entry between 6.5% and 7.5%, a higher risk of dementia incidence was detected for patients with a 3-year mean HbA1C level greater than 8.5% (aHR, 1.54; 95% CI, 1.31-1.80]), between 7.5% and 8.5% (aHR, 1.33; 95% CI, 1.19-1.48), between 6% and 6.5% (aHR, 1.17; 95% CI, 1.07-1.29), and 6% or less (aHR, 1.39; 95% CI, 1.24-1.57). Conclusions and relevance: In this cohort study of patients with T2D, the findings strengthened evidence of an association of glycemic control with dementia incidence, and revealed that a multidisciplinary primary care diabetes management program was associated with beneficial outcomes for T2D patients against dementia and its major subtypes. A moderate glycemic control target of HbA1C between 6.5% and 7.5% was associated with lower dementia incidence.
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/therapy ; Cohort Studies ; Glycated Hemoglobin ; Retrospective Studies ; Primary Health Care ; Dementia/epidemiology ; Dementia/therapy ; Dementia/complications
Chemical Substances	Glycated Hemoglobin
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.55733
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