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Article ; Online: Research on the Behavioral Dynamics Motion Planning Method of the Human-Vehicle Social Force Model.

Han, Gaining / Wu, Zongsheng / Zhang, Wei / Wang, Wei

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 3154532

Abstract: The interactive motion planning between unmanned vehicles and pedestrians in urban road environments is the key to realizing the autonomous motion of unmanned vehicles in hybrid traffic scenarios. The problem of human-vehicle interaction motion planning ... ...

Abstract	The interactive motion planning between unmanned vehicles and pedestrians in urban road environments is the key to realizing the autonomous motion of unmanned vehicles in hybrid traffic scenarios. The problem of human-vehicle interaction motion planning modeling at complex intersections is studied for an unmanned vehicle in this article. First, the motion planning of pedestrians and the unmanned vehicles is established according to the social force model and the behavioral dynamics model. Then, the autonomous vehicle is added to the crowd, and the human-vehicle interaction force is established. The virtual force is added to the social force model and the behavioral dynamics model, respectively, and the improved social force model and the behavioral dynamics model are used for the motion planning of pedestrians and unmanned vehicles. In this way, the established model solves the problems of simple pedestrian interaction motion planning in the social force model and single-body motion planning in the behavioral dynamics and thus provides a strong support for multibody motion planning. Finally, through the interactive motion planning trajectory of pedestrians and unmanned vehicles in different scenes, the vehicle and pedestrian motion planning trajectory can effectively avoid overlapping or crossing, so as to avoid the collision, which verifies the effectiveness and feasibility of the proposed model.
MeSH term(s)	Humans ; Accidents, Traffic/prevention & control ; Safety ; Pedestrians ; Walking
Language	English
Publishing date	2022-10-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/3154532
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Article ; Online: Knowledge graph analysis and visualization of AI technology applied in COVID-19

Wu, Zongsheng / Xue, Ru / Shao, Meiyun

Environ Sci Pollut Res. 2022 Apr., v. 29, no. 18 p.26396-26408

2022

Abstract: With the global outbreak of coronavirus disease (COVID-19) all over the world, artificial intelligence (AI) technology is widely used in COVID-19 and has become a hot topic. In recent 2 years, the application of AI technology in COVID-19 has developed ... ...

Abstract	With the global outbreak of coronavirus disease (COVID-19) all over the world, artificial intelligence (AI) technology is widely used in COVID-19 and has become a hot topic. In recent 2 years, the application of AI technology in COVID-19 has developed rapidly, and more than 100 relevant papers are published every month. In this paper, we combined with the bibliometric and visual knowledge map analysis, used the WOS database as the sample data source, and applied VOSviewer and CiteSpace analysis tools to carry out multi-dimensional statistical analysis and visual analysis about 1903 pieces of literature of recent 2 years (by the end of July this year). The data is analyzed by several terms with the main annual article and citation count, major publication sources, institutions and countries, their contribution and collaboration, etc. Since last year, the research on the COVID-19 has sharply increased; especially the corresponding research fields combined with the AI technology are expanding, such as medicine, management, economics, and informatics. The China and USA are the most prolific countries in AI applied in COVID-19, which have made a significant contribution to AI applied in COVID-19, as the high-level international collaboration of countries and institutions is increasing and more impactful. Moreover, we widely studied the issues: detection, surveillance, risk prediction, therapeutic research, virus modeling, and analysis of COVID-19. Finally, we put forward perspective challenges and limits to the application of AI in the COVID-19 for researchers and practitioners to facilitate future research on AI applied in COVID-19.
Keywords	COVID-19 infection ; artificial intelligence ; databases ; economics ; medicine ; monitoring ; prediction ; risk ; statistical analysis ; therapeutics ; viruses ; China
Language	English
Dates of publication	2022-04
Size	p. 26396-26408.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-17800-z
Database	NAL-Catalogue (AGRICOLA)

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Article: New Frontiers of Extracorporeal Shock Wave Medicine in Urology from Bench to Clinical Studies.

Chen, Po-Yen / Cheng, Jai-Hong / Wu, Zong-Sheng / Chuang, Yao-Chi

Biomedicines

2022 Volume 10, Issue 3

Abstract: A shock wave (SW), which carries energy and propagates through a medium, is a type of continuous transmitted sonic wave that can achieve rapid energy transformations. SWs have been applied for many fields of medical science in various treatment settings. ...

Abstract	A shock wave (SW), which carries energy and propagates through a medium, is a type of continuous transmitted sonic wave that can achieve rapid energy transformations. SWs have been applied for many fields of medical science in various treatment settings. In urology, high-energy extracorporeal SWs have been used to disintegrate urolithiasis for 30 years. However, at lower energy levels, SWs enhance the expression of vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), proliferating cell nuclear antigen (PCNA), chemoattractant factors, and the recruitment of progenitor cells, and inhibit inflammatory molecules. Low energy extracorporeal shock wave (LESW) therapy has been used in urology for treating chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), interstitial cystitis/bladder pain syndrome (IC/BPS), overactive bladder, stress urinary incontinence, and erectile dysfunction through the mechanisms of anti-inflammation, neovascularization, and tissue regeneration. Additionally, LESW have been proven to temporarily increase tissue permeability and facilitate intravesical botulinum toxin delivery for treating overactive bladders in animal studies and in a human clinical trial. LESW assisted drug delivery was also suggested to have a synergistic effect in combination with cisplatin to improve the anti-cancer effect for treating urothelial cancer in an in vitro and in vivo study. LESW assisted drug delivery in uro-oncology is an interesting suggestion, but no comprehensive clinical trials have been conducted as of yet. Taken together, LESW is a promising method for the treatment of various diseases in urology. However, further investigation with a large scale of clinical studies is necessary to confirm the real role of LESW in clinical use. This article provides information on the basics of SW physics, mechanisms of action on biological systems, and new frontiers of SW medicine in urology.
Language	English
Publishing date	2022-03-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10030675
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Article ; Online: Knowledge graph analysis and visualization of AI technology applied in COVID-19.

Wu, Zongsheng / Xue, Ru / Shao, Meiyun

Environmental science and pollution research international

2021 Volume 29, Issue 18, Page(s) 26396–26408

Abstract	With the global outbreak of coronavirus disease (COVID-19) all over the world, artificial intelligence (AI) technology is widely used in COVID-19 and has become a hot topic. In recent 2 years, the application of AI technology in COVID-19 has developed rapidly, and more than 100 relevant papers are published every month. In this paper, we combined with the bibliometric and visual knowledge map analysis, used the WOS database as the sample data source, and applied VOSviewer and CiteSpace analysis tools to carry out multi-dimensional statistical analysis and visual analysis about 1903 pieces of literature of recent 2 years (by the end of July this year). The data is analyzed by several terms with the main annual article and citation count, major publication sources, institutions and countries, their contribution and collaboration, etc. Since last year, the research on the COVID-19 has sharply increased; especially the corresponding research fields combined with the AI technology are expanding, such as medicine, management, economics, and informatics. The China and USA are the most prolific countries in AI applied in COVID-19, which have made a significant contribution to AI applied in COVID-19, as the high-level international collaboration of countries and institutions is increasing and more impactful. Moreover, we widely studied the issues: detection, surveillance, risk prediction, therapeutic research, virus modeling, and analysis of COVID-19. Finally, we put forward perspective challenges and limits to the application of AI in the COVID-19 for researchers and practitioners to facilitate future research on AI applied in COVID-19.
MeSH term(s)	Artificial Intelligence ; COVID-19 ; Humans ; Pattern Recognition, Automated ; SARS-CoV-2 ; Technology
Language	English
Publishing date	2021-12-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-17800-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Local Magnesium Sulfate Administration Ameliorates Nociception, Peripheral Inflammation, and Spinal Sensitization in a Rat Model of Incisional Pain.

Wen, Zhi-Hong / Wu, Zong-Sheng / Huang, Shi-Ying / Chou, Tung-Lin / Cheng, Hao-Jung / Lo, Yi-Hao / Jean, Yen-Hsuan / Sung, Chun-Sung

Neuroscience

2024

Abstract: Objective: Postoperative pain remains one of the most common complaints after surgery, and appropriate treatments are limited.: Methods: We therefore investigated the effect of the anti-nociceptive properties of magnesium sulfate (MgSO: Results: ... ...

Abstract	Objective: Postoperative pain remains one of the most common complaints after surgery, and appropriate treatments are limited. Methods: We therefore investigated the effect of the anti-nociceptive properties of magnesium sulfate (MgSO Results: We found that local MgSO Conclusion: Locally administered MgSO
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2024.03.033
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Article: Platelet Lysate Therapy Attenuates Hypoxia Induced Apoptosis in Human Uroepithelial SV-HUC-1 Cells through Regulating the Oxidative Stress and Mitochondrial-Mediated Intrinsic Apoptotic Pathway.

Wu, Zong-Sheng / Luo, Hou-Lun / Chuang, Yao-Chi / Lee, Wei-Chia / Wang, Hung-Jen / Chancellor, Michael B

Biomedicines

2023 Volume 11, Issue 3

Abstract: 1) Background: Ischemia/hypoxia plays an important role in interstitial cystitis/bladder pain syndrome (IC/BPS). Platelet-rich plasma (PRP) has been shown to relieve symptoms of IC/BPS by regulating new inflammatory processes and promoting tissue repair. ...

Abstract	(1) Background: Ischemia/hypoxia plays an important role in interstitial cystitis/bladder pain syndrome (IC/BPS). Platelet-rich plasma (PRP) has been shown to relieve symptoms of IC/BPS by regulating new inflammatory processes and promoting tissue repair. However, the mechanism of action of PRP on the IC/BPS bladder remains unclear. We hypothesize that PRP might protect the urothelium during ischemia/hypoxia by decreasing apoptosis. (2) Methods: SV-HUC-1 cells were cultured under hypoxia for 3 h and treated with or without 2% PLTGold
Language	English
Publishing date	2023-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11030935
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Article ; Online: Low-Energy Shock Wave Suppresses Prostatic Pain and Inflammation by Modulating Mitochondrial Dynamics Regulators on a Carrageenan-Induced Prostatitis Model in Rats.

Wu, Zong-Sheng / Wang, Hung-Jen / Lee, Wei-Chia / Luo, Hou Lun / Lin, Tsu-Kung / Chuang, Yao-Chi

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: A low-energy shock wave (LESW) has therapeutic effects on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); however, its mechanism of action remains unclear. We explored the effects of LESW on the prostate and mitochondrial dynamics regulators ... ...

Abstract	A low-energy shock wave (LESW) has therapeutic effects on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); however, its mechanism of action remains unclear. We explored the effects of LESW on the prostate and mitochondrial dynamics regulators in a rat model of carrageenan-induced prostatitis. The imbalance of mitochondrial dynamics regulators may affect the inflammatory process and molecules and contribute to CP/CPPS. Male Sprague-Dawley rats received intraprostatic 3% or 5% carrageenan injections. The 5% carrageenan group also received LESW treatment at 24 h, 7 days, and 8 days. Pain behavior was evaluated at baseline, 1 week, and 2 weeks after a saline or carrageenan injection. The bladder and the prostate were harvested for immunohistochemistry and quantitative reverse-transcription polymerase chain reaction analysis. Intraprostatic carrageenan injection induced inflammatory reaction in the prostate and the bladder, decreased the pain threshold, and resulted in the upregulation of Drp-1, MFN-2, NLRP3 (mitochondrial integrity markers), substance P, and CGRP-RCP, whose effects were maintained for 1-2 weeks. LESW treatment suppressed carrageenan-induced prostatic pain, inflammatory reaction, mitochondrial integrity markers, and expression of sensory molecules. These findings support a link between the anti-neuroinflammatory effects of LESW in CP/CPPS and the reversal of cellular perturbations caused by imbalances in mitochondrial dynamics in the prostate.
MeSH term(s)	Animals ; Humans ; Male ; Rats ; Carrageenan ; Disease Models, Animal ; Inflammation/metabolism ; Mitochondrial Dynamics ; Pelvic Pain/chemically induced ; Pelvic Pain/therapy ; Prostatitis/chemically induced ; Prostatitis/therapy ; Rats, Sprague-Dawley ; Ultrasonic Waves ; Ultrasonic Therapy
Chemical Substances	Carrageenan (9000-07-1)
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043898
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Article ; Online: CIRP increases Foxp3

Wu, Zongsheng / Liu, Xu / Huang, Wei / Chen, Jing / Li, Songli / Chao, Jie / Xie, Jianfeng / Liu, Ling / Yang, Yi / Wu, Xiaojing / Qiu, Haibo

International immunopharmacology

2024 Volume 132, Page(s) 111924

Abstract: Background: T helper (Th) cell imbalances have been associated with the pathophysiology of sepsis, including the Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Cold-inducible RNA-binding protein (CIRP), a novel damage-associated molecular pattern ...

Abstract	Background: T helper (Th) cell imbalances have been associated with the pathophysiology of sepsis, including the Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Cold-inducible RNA-binding protein (CIRP), a novel damage-associated molecular pattern (DAMP) was reported that could induce T cell activation, and skew CD4 Methods: A prospective exploratory study including patients with sepsis was conducted. Blood samples were collected from patients on days 0, 3 and 7 on admission. The serum CIRP and peripheral blood Treg/Th17 percentage was determined by ELISA and flow cytometry. CD4 Results: A total of 19 patients with sepsis finally completed the study. Serum CIRP levels remained high in the majority of patients up to 1 week after admittance was closely associated with high Treg/Th17 ratio of peripheral blood and poor outcome. A univariate logistic analysis demonstrated that higher CIRP concentration at Day 7 is an independent risk factor for Treg/Th17 ratio increasing. CIRP promotes Treg development and suppresses Th17 differentiation was found both in vivo and in vitro. Pretreated with C23 not only alleviated the majority of negative effect of CIRP on Th17 differentiation, but also inhibited Treg differentiation, to some extent. Tlr4 deficiency could abolish almost all downstream effects of rmCIRP. Furthermore, IL-2 is proved a key downstream molecules of the effect CIRP, which also could amplify the activated CD4 Conclusions: Persistent high circulating CIRP level may lead to Treg/Th17 ratio elevated through TLR4 and subsequent active IL-2 signaling which contribute to immunosuppression during late phases of sepsis.
Language	English
Publishing date	2024-03-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111924
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Article ; Online: IFIH1

Zhang, Shi / Chu, Cuilin / Wu, Zongsheng / Liu, Feng / Xie, Jianfeng / Yang, Yi / Qiu, Haibo

Frontiers in immunology

2021 Volume 11, Page(s) 580838

Abstract: Accumulated evidence has demonstrated that the macrophage phenotypic switch from M0 to M1 is crucial in the initiation of the inflammatory process of acute respiratory distress syndrome (ARDS). Better insight into the molecular control of M1 macrophages ... ...

Abstract	Accumulated evidence has demonstrated that the macrophage phenotypic switch from M0 to M1 is crucial in the initiation of the inflammatory process of acute respiratory distress syndrome (ARDS). Better insight into the molecular control of M1 macrophages in ARDS may identify potential therapeutic targets. In the current study, 36 candidate genes associated with the severity of ARDS and simultaneously involved in M1-polarized macrophages were first screened through a weighted network algorithm on all gene expression profiles from the 26 ARDS patients and empirical Bayes analysis on the gene expression profiles of macrophages.
MeSH term(s)	Animals ; Cell Differentiation ; Cells, Cultured ; Cytokines/metabolism ; Humans ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Interferon-Induced Helicase, IFIH1/genetics ; Interferon-Induced Helicase, IFIH1/metabolism ; Macrophage Activation ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred C57BL ; RAW 264.7 Cells ; Respiratory Distress Syndrome/immunology ; Th1 Cells/immunology
Chemical Substances	Cytokines ; IRF3 protein, human ; Interferon Regulatory Factor-3 ; IFIH1 protein, human (EC 3.6.1.-) ; Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13)
Language	English
Publishing date	2021-01-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.580838
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Article ; Online: Correction: Overexpressing TGF-β1 in mesenchymal stem cells attenuates organ dysfunction during CLP-induced septic mice by reducing macrophage-driven.

Liu, Feng / Xie, Jianfeng / Zhang, Xiwen / Wu, Zongsheng / Zhang, Shi / Xue, Ming / Chen, Jianxiao / Yang, Yi / Qiu, Haibo

Stem cell research & therapy

2022 Volume 13, Issue 1, Page(s) 362

Language	English
Publishing date	2022-07-27
Publishing country	England
Document type	Published Erratum
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-022-03078-6
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