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  1. Article: Physiologie für die Ärztin/den Arzt in der Anästhesiologie. Physiology for the physician in anaesthesiology

    Wunder, C.

    Anästhesiologie & Intensivmedizin

    2023  Volume 64, Issue Jan, Page(s) 20

    Language German
    Document type Article
    ZDB-ID 134392-0
    ISSN 0170-5334
    Database Current Contents Medicine

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    Zs.B 1017: Show issues Location:
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  2. Book ; Audio / Video ; Thesis: Systematische Untersuchungen zur Problematik postmortaler Insulin-Instabilität

    Wunder, Cora

    2011  

    Author's details von Cora Wunder
    Language German
    Size 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2011
    HBZ-ID HT017032630
    Database Catalogue ZB MED Medicine, Health

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    2011 MO 670 order for loan Magazin

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  3. Article: Nosokomiale Infektionen in der Intensivmedizin. Nosocomial infections in intensive care medicine

    Wunder, C.

    Anästhesiologie & Intensivmedizin

    2020  Volume 61, Issue Juni, Page(s) 215

    Language German
    Document type Article
    ZDB-ID 134392-0
    ISSN 0170-5334
    Database Current Contents Medicine

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  4. Article ; Online: Deciphering the impact of microenvironmental factors on cuticular hydrocarbon degradation in Lucilia sericata empty Puparia: Bridging ecological and forensic entomological perspectives using machine learning models.

    Sharif, Swaima / Wunder, Cora / Amendt, Jens / Qamar, Ayesha

    The Science of the total environment

    2024  Volume 913, Page(s) 169719

    Abstract: Blow flies (Calliphoridae) play essential ecological roles in nutrient recycling by consuming decaying organic matter. They serve as valuable bioindicators in ecosystem management and forensic entomology, with their unique feeding behavior leading to the ...

    Abstract Blow flies (Calliphoridae) play essential ecological roles in nutrient recycling by consuming decaying organic matter. They serve as valuable bioindicators in ecosystem management and forensic entomology, with their unique feeding behavior leading to the accumulation of environmental pollutants in their cuticular hydrocarbons (CHCs), making them potential indicators of exposure history. This study focuses on CHC degradation dynamics in empty puparia of Lucilia sericata under different environmental conditions for up to 90 days. The three distinct conditions were considered: outdoor-buried, outdoor-above-ground, and indoor environments. Five predominant CHCs, n-Pentacosane (n-C25), n-Hexacosane (n-C26), n-Heptacosane (n-C27), n-Octacosane (n-C28), and n-Nonacosane (n-C29), were analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). The findings revealed variations in CHC concentrations over time, influenced by environmental factors, with significant differences at different time points. Correlation heatmap analysis indicated negative correlations between weathering time and certain CHCs, suggesting decreasing concentrations over time. Machine learning techniques Support Vector Machine (SVM), Multilayer Perceptron (MLP), and eXtreme Gradient Boosting (XGBoost) models explored the potential of CHCs as age indicators. SVM achieved an R-squared value of 0.991, demonstrating high accuracy in age estimation based on CHC concentrations. MLP also exhibited satisfactory performance in outdoor conditions, while SVM and MLP yielded unsatisfactory results indoors due to the lack of significant CHC variations. After comprehensive model selection and performance evaluations, it was found that the XGBoost model excelled in capturing the patterns in all three datasets. This study bridges the gap between baseline and ecological/forensic use of empty puparia, offering valuable insights into the potential of CHCs in environmental monitoring and investigations. Understanding CHCs' stability and degradation enhances blow flies' utility as bioindicators for pollutants and exposure history, benefiting environmental monitoring and forensic entomology.
    MeSH term(s) Animals ; Forensic Entomology ; Ecosystem ; Environmental Biomarkers ; Diptera ; Hydrocarbons/analysis
    Chemical Substances Environmental Biomarkers ; Hydrocarbons
    Language English
    Publishing date 2024-01-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.169719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vom Verständnis zur Therapie der perioperativen Inflammation.

    Wunder, Christian

    Der Anaesthesist

    2019  Volume 68, Issue 7, Page(s) 419–420

    Title translation From comprehension to treatment of perioperative inflammation.
    MeSH term(s) Comprehension ; Humans ; Inflammation/drug therapy ; Perioperative Care
    Language German
    Publishing date 2019-05-24
    Publishing country Germany
    Document type Editorial
    ZDB-ID 260-4
    ISSN 1432-055X ; 0003-2417
    ISSN (online) 1432-055X
    ISSN 0003-2417
    DOI 10.1007/s00101-019-0608-9
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  6. Book ; Thesis: Flexible designs in oncological clinical trials allowing for inclusion of prognostic factors

    Wunder, Christina

    2011  

    Author's details vorgelegt von Christina Wunder
    Language English
    Size 180 S., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2011
    HBZ-ID HT017029284
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Rolle der Echokardiografie bei Notfällen und hämodynamischer Instabilität.

    Bierbaum, Dominik Michael / Wunder, Christian

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

    2022  Volume 57, Issue 5, Page(s) 320–332

    Abstract: Echocardiography is an imaging method in anaesthesia and intensive care medicine which adds a new dimension to hemodynamic monitoring: the direct visualization of the cardiac function and its disruptions. The review article shows the advantages and ... ...

    Title translation Echocardiography as a Diagnostic Tool in Emergencies and Hemodynamic Instability.
    Abstract Echocardiography is an imaging method in anaesthesia and intensive care medicine which adds a new dimension to hemodynamic monitoring: the direct visualization of the cardiac function and its disruptions. The review article shows the advantages and limitations of recent transthoracic (TTE) and transesophageal (TEE) echocardiography in the diagnostic course of hemodynamic instability. For TTE and TEE focused examination techniques and sequences are illustrated with regards to their fast applicability to hemodynamic monitoring.
    MeSH term(s) Critical Care ; Echocardiography/methods ; Echocardiography, Transesophageal/methods ; Emergencies ; Hemodynamics ; Humans
    Language German
    Publishing date 2022-05-18
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1065682-0
    ISSN 1439-1074 ; 0939-2661
    ISSN (online) 1439-1074
    ISSN 0939-2661
    DOI 10.1055/a-1530-4919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Vom Verständnis zur Therapie der perioperativen Inflammation

    Wunder, Christian

    Der Anästhesist

    2019  Volume 68, Issue 07, Page(s) 419–420

    Language German
    Document type Article
    ZDB-ID 260-4
    ISSN 1432-055X ; 0003-2417
    ISSN (online) 1432-055X
    ISSN 0003-2417
    Database bibnet.org

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  9. Article ; Online: "Dosis facit venenum": Sauerstofftherapie in der Anästhesie und Intensivmedizin.

    Wunder, C

    Der Anaesthesist

    2011  Volume 60, Issue 4, Page(s) 289

    Title translation "Dosis facit venenum": Oxygen therapy in anesthesia and intensive care medicine.
    MeSH term(s) Anesthesia ; Capillaries ; Cells/metabolism ; Critical Care ; Humans ; Myocardial Infarction/physiopathology ; Myocardial Infarction/therapy ; Oxygen/administration & dosage ; Oxygen/blood ; Oxygen Consumption/physiology ; Oxygen Inhalation Therapy/adverse effects
    Chemical Substances Oxygen (S88TT14065)
    Language German
    Publishing date 2011-04-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 260-4
    ISSN 1432-055X ; 0003-2417
    ISSN (online) 1432-055X
    ISSN 0003-2417
    DOI 10.1007/s00101-011-1897-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Endocytic Roles of Glycans on Proteins and Lipids.

    Johannes, Ludger / Shafaq-Zadah, Massiullah / Dransart, Estelle / Wunder, Christian / Leffler, Hakon

    Cold Spring Harbor perspectives in biology

    2024  Volume 16, Issue 1

    Abstract: Most cell surface proteins are decorated by glycans, and the plasma membrane is rich in glycosylated lipids. The mechanisms by which the enormous complexity of these glycan structures on proteins and lipids is exploited to control glycoprotein activity ... ...

    Abstract Most cell surface proteins are decorated by glycans, and the plasma membrane is rich in glycosylated lipids. The mechanisms by which the enormous complexity of these glycan structures on proteins and lipids is exploited to control glycoprotein activity by setting their cell surface residence time and the ways by which they are taken up into cells are still under active investigation. Here, two mechanisms are presented, termed galectin lattices and glycolipid-lectin (GL-Lect)-driven endocytosis, which are among the most prominent to establish a link between glycan information and endocytosis. Types of glycans on glycoproteins and glycolipids are reviewed from the angle of their interaction with glycan-binding proteins that are at the heart of galectin lattices and GL-Lect-driven endocytosis. Examples are given to show how these mechanisms affect cellular functions ranging from cell migration and signaling to vascularization and immune modulation. Finally, outstanding challenges on the link between glycosylation and endocytosis are discussed.
    MeSH term(s) Polysaccharides/chemistry ; Endocytosis/physiology ; Cell Membrane/metabolism ; Galectins/chemistry ; Galectins/metabolism ; Lipids
    Chemical Substances Polysaccharides ; Galectins ; Lipids
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a041398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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