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  1. Article ; Online: Probing the Rotary Cycle of Amine-Substituted Molecular Motors.

    van Venrooy, Alexis / Wyderka, Aaron M / García-López, Víctor / Alemany, Lawrence B / Martí, Angel A / Tour, James M

    The Journal of organic chemistry

    2023  Volume 88, Issue 2, Page(s) 762–770

    Abstract: An understanding of the rotary cycle of molecular motors (MMs), a key component of an approach to opening cells using mechanical motion, is important in furthering the research. Nuclear magnetic resonance (NMR) spectroscopy was used ... ...

    Abstract An understanding of the rotary cycle of molecular motors (MMs), a key component of an approach to opening cells using mechanical motion, is important in furthering the research. Nuclear magnetic resonance (NMR) spectroscopy was used for
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c01457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Hemithioindigo-Based Visible Light-Activated Molecular Machines Kill Bacteria by Oxidative Damage.

    Santos, Ana L / van Venrooy, Alexis / Reed, Anna K / Wyderka, Aaron M / García-López, Víctor / Alemany, Lawrence B / Oliver, Antonio / Tegos, George P / Tour, James M

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2022  Volume 9, Issue 30, Page(s) e2203242

    Abstract: Antibiotic resistance is a growing health threat. There is an urgent and critical need to develop new antimicrobial modalities and therapies. Here, a set of hemithioindigo (HTI)-based molecular machines capable of specifically killing Gram-positive ... ...

    Abstract Antibiotic resistance is a growing health threat. There is an urgent and critical need to develop new antimicrobial modalities and therapies. Here, a set of hemithioindigo (HTI)-based molecular machines capable of specifically killing Gram-positive bacteria within minutes of activation with visible light (455 nm at 65 mW cm<sup>-2</sup> ) that are safe for mammalian cells is described. Importantly, repeated exposure of bacteria to HTI does not result in detectable development of resistance. Visible light-activated HTI kill both exponentially growing bacterial cells and antibiotic-tolerant persister cells of various Gram-positive strains, including methicillin-resistant S. aureus (MRSA). Visible light-activated HTI also eliminate biofilms of S. aureus and B. subtilis in as little as 1 h after light activation. Quantification of reactive oxygen species (ROS) formation and protein carbonyls, as well as assays with various ROS scavengers, identifies oxidative damage as the underlying mechanism for the antibacterial activity of HTI. In addition to their direct antibacterial properties, HTI synergize with conventional antibiotics in vitro and in vivo, reducing the bacterial load and mortality associated with MRSA infection in an invertebrate burn wound model. To the best of the authors' knowledge, this is the first report on the antimicrobial activity of HTI-based molecular machines.
    MeSH term(s) Animals ; Methicillin-Resistant Staphylococcus aureus ; Microbial Sensitivity Tests ; Staphylococcus aureus/metabolism ; Reactive Oxygen Species/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteria ; Light ; Oxidative Stress ; Mammals/metabolism
    Chemical Substances Reactive Oxygen Species ; hemithioindigo ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-08-24
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202203242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane.

    Santos, Ana L / Liu, Dongdong / Reed, Anna K / Wyderka, Aaron M / van Venrooy, Alexis / Li, John T / Li, Victor D / Misiura, Mikita / Samoylova, Olga / Beckham, Jacob L / Ayala-Orozco, Ciceron / Kolomeisky, Anatoly B / Alemany, Lawrence B / Oliver, Antonio / Tegos, George P / Tour, James M

    Science advances

    2022  Volume 8, Issue 22, Page(s) eabm2055

    Abstract: The increasing occurrence of antibiotic-resistant bacteria and the dwindling antibiotic research and development pipeline have created a pressing global health crisis. Here, we report the discovery of a distinctive antibacterial therapy that uses visible ...

    Abstract The increasing occurrence of antibiotic-resistant bacteria and the dwindling antibiotic research and development pipeline have created a pressing global health crisis. Here, we report the discovery of a distinctive antibacterial therapy that uses visible (405 nanometers) light-activated synthetic molecular machines (MMs) to kill Gram-negative and Gram-positive bacteria, including methicillin-resistant
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abm2055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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