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  1. Book ; Thesis: Pharmakogenetik und Pharmakokinetik der antiretroviralen Substanzen - Einfluss der Aktivität von Cytochrom P450-Enzymen, P-Glykoprotein und Cytochrom P4502B6 Einzelnukleotid-Polymorphismen auf die Plasmaspiegel antiretroviraler Substanzen

    Wyen, Christoph

    = Pharmacogenetics and pharmacokinetics of antiretroviral drugs - Influence of activities of cytochrome P450 enzymes, P-glycoprotein and cytochrome P-450 2B6 single nucleotide polymorphisms on plasma levels of antiretroviral drugs

    2013  

    Title variant Pharmacogenetics and pharmacokinetics of antiretroviral drugs - Influence of activities of cytochrome P450 enzymes, P-glycoprotein and cytochrome P-450 2B6 single nucleotide polymorphisms on plasma levels of antiretroviral drugs
    Author's details vorgelegt von Christoph Wyen
    Language German
    Size 38 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Habil.-Schr., 2014
    Note Zsfassung in engl. Sprache
    HBZ-ID HT018240429
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2014 E 542 order for loan Magazin

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  2. Book ; Online: HIV-assoziierte Lymphome

    Hentrich, Marcus / Egle, Alexander / Hensel, Manfred / Hoffmann, Christian / Hübel, Kai / Mosthaf, Franz A. / Müller, Markus / Rossi, Davide / Siehl, Jan Michael / Wyen, Christoph

    Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

    (Onkopedia Leitlinien)

    2019  

    Abstract: HIV-assoziierte aggressive B-Zell-Lymphome zählen zu den AIDS-definierenden Neoplasien. Demgegenüber ist das Hodgkin Lymphom eines der häufigsten nicht-AIDS definierenden Malignome. Die Therapie HIV-assoziierter Lymphome orientiert sich sowohl an den ... ...

    Institution Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
    Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie
    Schweizerische Gesellschaft für Medizinische Onkologie
    Schweizerische Gesellschaft für Hämatologie
    Author's details DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V., OeGHO - Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, SSMO/SSOM/SGMO - Schweizerische Gesellschaft für Medizinische Onkologie, SGH-SSH - Schweizerische Gesellschaft für Hämatologie/Société Suisse d'Hématologie ; Autoren: Marcus Hentrich, Alexander Egle, Manfred Hensel, Christian Hoffmann, Kai Hübel, Franz A. Mosthaf, Markus Müller, Davide Rossi, Jan Michael Siehl, Christoph Wyen
    Series title Onkopedia Leitlinien
    Abstract HIV-assoziierte aggressive B-Zell-Lymphome zählen zu den AIDS-definierenden Neoplasien. Demgegenüber ist das Hodgkin Lymphom eines der häufigsten nicht-AIDS definierenden Malignome. Die Therapie HIV-assoziierter Lymphome orientiert sich sowohl an den Ergebnissen großer multizentrischer Studien bei HIV-negativen Patienten und entsprechenden nationalen und internationalen Leitlinien, wie auch an den Ergebnissen klinischer Studien, die bei HIV-positiven Patienten durchgeführt wurden. Die Empfehlungen "Therapy of HIV-associated lymphoma" wurde von der Kerngruppe Onkologie der Deutschen Arbeitsgemeinschaft niedergelassener Ärzte für die Versorgung HIV-Infizierter e.V. (DAGNÄ), in Kooperation mit der Deutschen AIDS-Gesellschaft e.V. (DAIG) erstellt [1]. Grundlagen sind eine systematische Literaturrecherche, die einheitliche Bewertung der Evidenzstärke [2] und ein Konsensfindungsprozess. Dies ist eine aktualisierte deutsche Version dieser Empfehlungen.
    Subject code 610
    Language German
    Size 1 Online-Ressource (19 Seiten), Diagramme
    Edition Stand: Juni 2019
    Publisher DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT020210808
    DOI 10.4126/FRL01-006416531
    Database Repository for Life Sciences

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  3. Book ; Thesis: Akute Effekte der Angiotensin-Converting-Enzaym (ACE) Hemmung auf die koronare Endothel-Dysfunktion

    Wyen, Christoph

    2002  

    Author's details vorgelegt von Christoph Wyen
    Language German
    Size 107 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2002
    HBZ-ID HT013474492
    Database Catalogue ZB MED Medicine, Health

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  4. Book ; Online: HIV-assoziierte Lymphome

    Hentrich, Marcus / Hensel, Manfred / Hoffmann, Christian / Mosthaf, Franz A. / Müller, Markus / Siehl, Jan Michael / Wyen, Christoph

    Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

    (Onkopedia Leitlinien)

    2014  

    Institution Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
    Author's details Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie ; Autoren: Marcus Hentrich, Manfred Hensel, Christian Hoffmann, Franz A. Mosthaf, Markus Müller, Jan Michael Siehl, Christoph Wyen
    Series title Onkopedia Leitlinien
    Subject code 610
    Language German
    Size 1 Online-Ressource (18 Seiten)
    Edition Stand: Oktober 2014
    Publisher DGHO Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online
    HBZ-ID HT019068740
    DOI 10.4126/FRL01-006400539
    Database Repository for Life Sciences

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  5. Book ; Online ; Thesis: Etablierung einer standardisierten Methode zur Identifizierung des HIV-Subtyps A6 und dessen epidemiologische und Resistenz-Analyse in Südrussland

    Schlösser, Madita [Verfasser] / Klein, Florian [Gutachter] / Wyen, Christoph J. [Gutachter]

    2023  

    Author's details Madita Schlösser ; Gutachter: Florian Klein, Christoph J. Wyen
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: Survival after cryptococcosis in Germany: A retrospective multicenter cohort study of patients diagnosed between 2004 and 2021.

    Kessel, Johanna / Rossaert, Anna-Catharina / Lingscheid, Tilman / Grothe, Jan / Harrer, Thomas / Wyen, Christoph / Tominski, Daniela / Bollinger, T / Kehr, Anna Katharina / Kalbitz, Sven / Hoffmann, Christian / Cornely, Oliver / Koppe, Uwe / Stephan, Christoph / Rickerts, Volker

    International journal of medical microbiology : IJMM

    2024  Volume 314, Page(s) 151614

    Abstract: Cryptococcosis is the most prevalent fungal infection of the central nervous system worldwide. We performed a retrospective multicenter cohort study to gain insights into the epidemiology of cryptococcosis in Germany. We describe the use of diagnostic ... ...

    Abstract Cryptococcosis is the most prevalent fungal infection of the central nervous system worldwide. We performed a retrospective multicenter cohort study to gain insights into the epidemiology of cryptococcosis in Germany. We describe the use of diagnostic tests, clinical management and patient outcome. We included 64 patients with underlying HIV infection (55%) or other predispositions. Molecular typing by MLST documented 20 individual sequence types among 42 typed isolates. A fatal outcome was documented in 14% of patients in the first two months after diagnosis.
    MeSH term(s) Humans ; Cryptococcus neoformans ; HIV Infections/complications ; HIV Infections/epidemiology ; Multilocus Sequence Typing ; Cohort Studies ; Cryptococcosis/diagnosis ; Cryptococcosis/epidemiology ; Cryptococcosis/microbiology ; Germany/epidemiology ; Retrospective Studies
    Language English
    Publishing date 2024-02-16
    Publishing country Germany
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2006518-8
    ISSN 1618-0607 ; 1438-4221
    ISSN (online) 1618-0607
    ISSN 1438-4221
    DOI 10.1016/j.ijmm.2024.151614
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    Zs.A 5333: Show issues Location:
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  7. Article ; Online: Malignant lymphoma in the HIV-positive patient.

    Meister, Anne / Hentrich, Marcus / Wyen, Christoph / Hübel, Kai

    European journal of haematology

    2018  Volume 101, Issue 1, Page(s) 119–126

    Abstract: The introduction of combination antiretroviral therapy (cART) drastically improved performance status, immune function, and life expectancy of HIV-infected individuals. In addition, incidence of opportunistic infections and of AIDS-defining malignancies ... ...

    Abstract The introduction of combination antiretroviral therapy (cART) drastically improved performance status, immune function, and life expectancy of HIV-infected individuals. In addition, incidence of opportunistic infections and of AIDS-defining malignancies declined. Nevertheless, aggressive non-Hodgkin's lymphoma still remains the leading cause of AIDS-related deaths. The availability of cART, however, significantly improved the therapeutic options for HIV-positive patients with lymphomas. Diffuse large B-cell lymphoma, Burkitt's lymphoma, or Hodgkin lymphoma has increasingly become curable diseases. In light of these favorable developments in the treatment of HIV and HIV-associated lymphomas, reduction in treatment-associated toxicities and further improvement of outcome of patients with advanced immune suppression are major requirements for future clinical trials. This review summarizes the current treatment landscape and gives an overview on future needs in HIV-positive patients with lymphoma.
    MeSH term(s) Anti-HIV Agents/therapeutic use ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Antiretroviral Therapy, Highly Active ; Burkitt Lymphoma/diagnosis ; Burkitt Lymphoma/drug therapy ; Burkitt Lymphoma/mortality ; Burkitt Lymphoma/virology ; Drug Administration Schedule ; Drug Dosage Calculations ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/mortality ; HIV Infections/virology ; Hodgkin Disease/diagnosis ; Hodgkin Disease/drug therapy ; Hodgkin Disease/mortality ; Hodgkin Disease/virology ; Humans ; Lymphoma, AIDS-Related/diagnosis ; Lymphoma, AIDS-Related/drug therapy ; Lymphoma, AIDS-Related/mortality ; Lymphoma, AIDS-Related/virology ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/mortality ; Lymphoma, Large B-Cell, Diffuse/virology ; Survival Analysis ; Treatment Outcome
    Chemical Substances Anti-HIV Agents ; Antineoplastic Agents
    Language English
    Publishing date 2018-05-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.13082
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    Zs.A 323: Show issues Location:
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  8. Article ; Online: Durable Efficacy of Switching From a 3- or 4-Drug Tenofovir Alafenamide-Based Regimen to the 2-Drug Regimen Dolutegravir/Lamivudine in the TANGO Study Through Week 196.

    De Wit, Stéphane / Bonnet, Fabrice / Osiyemi, Olayemi / Bisshop, Fiona / Olalla, Julian / Routy, Jean-Pierre / Wyen, Christoph / Moodley, Riya / Pappa, Keith / Wang, Ruolan / Oyee, James / Saggu, Parminder / Letang, Emilio / Wynne, Brian / Jones, Bryn / Smith, Kimberly Y / Ait-Khaled, Mounir

    Journal of acquired immune deficiency syndromes (1999)

    2024  

    Abstract: Background: Switching to the 2-drug regimen dolutegravir/lamivudine demonstrated durable non-inferior efficacy vs continuing 3- or 4-drug tenofovir alafenamide-based regimens for maintaining virologic suppression in people with HIV-1 through Week 144 in ...

    Abstract Background: Switching to the 2-drug regimen dolutegravir/lamivudine demonstrated durable non-inferior efficacy vs continuing 3- or 4-drug tenofovir alafenamide-based regimens for maintaining virologic suppression in people with HIV-1 through Week 144 in TANGO.
    Setting: 134 centers, 10 countries.
    Methods: Adults with HIV-1 RNA <50 copies/mL for >6 months and no history of virologic failure were randomized to switch from stable tenofovir alafenamide-based regimens to dolutegravir/lamivudine on Day 1 (early-switch group) for 196 weeks. Those randomized to continue tenofovir alafenamide-based regimens on Day 1 who maintained virologic suppression at Week 144 switched to dolutegravir/lamivudine at Week 148 (late-switch group). Efficacy, safety, and tolerability (including weight and biomarker changes) of dolutegravir/lamivudine in early-switch and late-switch groups were assessed through Week 196.
    Results: Overall, 369 participants switched to dolutegravir/lamivudine on Day 1 (early-switch) and 298 switched at Week 148 (late-switch). In the early-switch group, 83% (306/369) maintained virologic suppression through Year 4, and 3% (11/369) reported new adverse events between Weeks 144 and 196. The late-switch group at Week 196 and early-switch group at Week 48 had comparable proportions with virologic suppression (93% each) and similar safety profiles. No late-switch participants and 1 early-switch participant met confirmed virologic withdrawal criteria through Week 196, with no resistance-associated mutations observed. Treatment continued to be well tolerated long-term.
    Conclusion: Switching from tenofovir alafenamide-based regimens to dolutegravir/lamivudine showed durable efficacy, high barrier to resistance, and good tolerability through 4 years. These results support dolutegravir/lamivudine as a robust treatment for maintaining virologic suppression.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000003395
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    Zs.A 2442: Show issues Location:
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  9. Article ; Online: Drug Interactions in the Treatment of Malignancy in HIV-Infected Patients.

    Welz, Tanya / Wyen, Christoph / Hensel, Manfred

    Oncology research and treatment

    2017  Volume 40, Issue 3, Page(s) 120–127

    Abstract: The number of patients with HIV (human immunodeficiency virus) requiring treatment for malignancy is increasing worldwide. Concurrent treatment of HIV and malignancy is complicated by unpredictable drug-drug interactions, which can cause potentially life- ...

    Abstract The number of patients with HIV (human immunodeficiency virus) requiring treatment for malignancy is increasing worldwide. Concurrent treatment of HIV and malignancy is complicated by unpredictable drug-drug interactions, which can cause potentially life-threatening toxicities and ineffective treatment of either disease. This article aims to provide a practical approach to drug interactions and their management in this context to help deliver effective and safe treatment of both the malignancy and HIV.
    MeSH term(s) Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Drug Interactions ; Drug Therapy, Combination/adverse effects ; Drug Therapy, Combination/methods ; Drug Therapy, Combination/standards ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/etiology ; Drug-Related Side Effects and Adverse Reactions/prevention & control ; Evidence-Based Medicine ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/etiology ; Humans ; Medical Oncology/standards ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Neoplasms/etiology ; Practice Guidelines as Topic ; Treatment Outcome
    Chemical Substances Anti-HIV Agents ; Antineoplastic Agents
    Language English
    Publishing date 2017
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2760274-6
    ISSN 2296-5262 ; 2296-5270
    ISSN (online) 2296-5262
    ISSN 2296-5270
    DOI 10.1159/000458443
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    Zs.A 1414: Show issues Location:
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  10. Article ; Online: Immune response to mRNA-based COVID-19 booster vaccination in people living with HIV.

    Malin, Jakob J / Suárez, Isabelle / Biehl, Lena M / Schommers, Philipp / Knops, Elena / Di Cristanziano, Veronica / Heger, Eva / Pflieger, Eva / Wyen, Christoph / Bettin, Daniel / Rybniker, Jan / Fätkenheuer, Gerd / Lehmann, Clara

    HIV medicine

    2023  Volume 24, Issue 7, Page(s) 785–793

    Abstract: Objectives: Our objective was to assess immune responses and their influencing factors in people living with HIV after messenger RNA (mRNA)-based COVID-19 booster vaccination (third dose).: Methods: This was a retrospective cohort study of people ... ...

    Abstract Objectives: Our objective was to assess immune responses and their influencing factors in people living with HIV after messenger RNA (mRNA)-based COVID-19 booster vaccination (third dose).
    Methods: This was a retrospective cohort study of people living with HIV who received booster vaccination with BNT-162b2 or mRNA-1273 between October 2021 and January 2022. We assessed anti-spike receptor-binding domain (RBD) immunoglobulin G (IgG), virus neutralizing activity (VNA) titres reported as 100% inhibitory dilution (ID
    Results: Of 84 people living with HIV who received an mRNA-based booster vaccination, 76 were eligible for analysis. Participants were on effective antiretroviral therapy (ART) and had a median of 670 CD4
    Conclusions: People living with HIV with ≥500 CD4
    MeSH term(s) Humans ; Influenza, Human ; Retrospective Studies ; COVID-19/prevention & control ; HIV Infections ; Vaccination ; RNA, Messenger ; Immunity ; Immunoglobulin G ; Antibodies, Viral
    Chemical Substances RNA, Messenger ; Immunoglobulin G ; Antibodies, Viral
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001932-4
    ISSN 1468-1293 ; 1464-2662
    ISSN (online) 1468-1293
    ISSN 1464-2662
    DOI 10.1111/hiv.13481
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    Zs.A 5441: Show issues Location:
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