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  1. Article ; Online: Weight loss associated with exenatide in an obese man with diabetes commenced on clozapine.

    Siskind, Dan / Wysoczanski, Daniel / Russell, Anthony / Ashford, Mark

    The Australian and New Zealand journal of psychiatry

    2016  Volume 50, Issue 7, Page(s) 702–703

    MeSH term(s) Adult ; Clozapine/adverse effects ; Diabetes Mellitus, Type 2/chemically induced ; Humans ; Male ; Peptides/adverse effects ; Schizophrenia/drug therapy ; Venoms/adverse effects ; Weight Loss/drug effects
    Chemical Substances Peptides ; Venoms ; exenatide (9P1872D4OL) ; Clozapine (J60AR2IKIC)
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 221140-3
    ISSN 1440-1614 ; 0004-8674
    ISSN (online) 1440-1614
    ISSN 0004-8674
    DOI 10.1177/0004867416636243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 856: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Fever, confusion, acute kidney injury: is this atypical neuroleptic malignant syndrome following polypharmacy with clozapine and risperidone?

    Cherry, Scott / Siskind, Dan / Spivak, Valeria / Wysoczanski, Daniel / Halangoda, Priyangika

    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

    2016  Volume 24, Issue 6, Page(s) 602–603

    Abstract: Objective: Clozapine is the gold-standard antipsychotic medication for treatment-refractory schizophrenia (TRS). However, one potentially lethal side effect of clozapine, as with other antipsychotics, is neuroleptic malignant syndrome (NMS) which could ... ...

    Abstract Objective: Clozapine is the gold-standard antipsychotic medication for treatment-refractory schizophrenia (TRS). However, one potentially lethal side effect of clozapine, as with other antipsychotics, is neuroleptic malignant syndrome (NMS) which could present differently in clozapine therapy. 'Atypical NMS' is a recognised variant of NMS with less rigidity and delayed elevation of creatine kinase; this variant is associated with clozapine.
    Method: A case from the author's clinical practice was reviewed.
    Results: A 67-year-old man with TRS was treated with clozapine. Unfortunately, his physical condition deteriorated and he presented with atypical NMS, which initially was treated as presumable urinary tract infection.
    Conclusions: Atypical NMS is associated with clozapine. This case exposes the potential difficulties in diagnosis, and highlights the importance of considering less common diagnoses in acutely unwell psychiatric patients.
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2213198-X
    ISSN 1440-1665 ; 1039-8562
    ISSN (online) 1440-1665
    ISSN 1039-8562
    DOI 10.1177/1039856216649768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6220: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 581: Show issues

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  3. Article ; Online: Lithium augmentation as an alternative to maintenance electroconvulsive therapy for recurrent major depressive disorder in older adults.

    Wysoczanski, Daniel / Cherry, Scott / Spivak, Valeria / Lie, David / Brisbane, Dan Siskind

    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

    2017  Volume 25, Issue 1, Page(s) 84

    MeSH term(s) Aged ; Aged, 80 and over ; Antidepressive Agents/therapeutic use ; Depressive Disorder, Major/therapy ; Depressive Disorder, Treatment-Resistant/therapy ; Drug Therapy, Combination ; Electroconvulsive Therapy ; Female ; Humans ; Lithium/therapeutic use ; Male ; Treatment Outcome
    Chemical Substances Antidepressive Agents ; Lithium (9FN79X2M3F)
    Language English
    Publishing date 2017-03-23
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 2213198-X
    ISSN 1440-1665 ; 1039-8562
    ISSN (online) 1440-1665
    ISSN 1039-8562
    DOI 10.1177/1039856216658825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6220: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 581: Show issues

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  4. Article ; Online: Metformin for Clozapine Associated Obesity: A Systematic Review and Meta-Analysis.

    Siskind, Dan J / Leung, Janni / Russell, Anthony W / Wysoczanski, Daniel / Kisely, Steve

    PloS one

    2016  Volume 11, Issue 6, Page(s) e0156208

    Abstract: Background: Although clozapine is the gold-standard for treatment refractory schizophrenia, it has the worst metabolic profile of all antipsychotics. This is partly mediated by clozapine's impact on glucagon-like peptide (GLP-1). There is an absence of ... ...

    Abstract Background: Although clozapine is the gold-standard for treatment refractory schizophrenia, it has the worst metabolic profile of all antipsychotics. This is partly mediated by clozapine's impact on glucagon-like peptide (GLP-1). There is an absence of robust evidence for effective treatments for clozapine associated weight gain and metabolic syndrome. Metformin, with its role in increasing GLP-1 may aid weight loss among people on clozapine.
    Methods: We conducted a systematic-review and meta-analysis of metformin versus placebo for change in weight and metabolic syndrome for people on clozapine without diabetes mellitus. We searched the Cochrane Schizophrenia Group's trial register, Pubmed and Embase, as well as the following Chinese databases: the Chinese Biomedical Literature Service System and China Knowledge Resource Integrated Database. This was supplemented by hand searches of key papers.
    Results: Eight studies, of which three were from Chinese databases, with 478 participants were included. We found that metformin was superior to placebo in terms of weight loss (-3.12kg, 95%CI -4.88kg to -1.37kg) and BMI (-1.18kg/m2, 95%CI -1.76kg/m2 to -0.61kg/m2). Metformin significantly improved three of the five components of metabolic syndrome; waist circumference, fasting glucose and triglycerides. Sensitivity analysis on study quality and duration did not greatly impact results.
    Conclusions: Metformin led to clinically meaningful weight loss among people on clozapine, and may reduce the rates of metabolic syndrome. Inclusion of metformin into the treatment protocols of people on clozapine, as tolerated, should be considered.
    Trial registration: PROSPERO registration number: CRD42015029723.
    MeSH term(s) Antipsychotic Agents/adverse effects ; Blood Glucose/metabolism ; Body Mass Index ; Body Weight/drug effects ; Clozapine/adverse effects ; Fasting/blood ; Humans ; Hypoglycemic Agents/therapeutic use ; Metabolic Syndrome/blood ; Metabolic Syndrome/prevention & control ; Metformin/therapeutic use ; Obesity/chemically induced ; Obesity/drug therapy ; Randomized Controlled Trials as Topic ; Schizophrenia/drug therapy ; Treatment Outcome ; Triglycerides/blood ; Waist Circumference/drug effects ; Weight Gain/drug effects
    Chemical Substances Antipsychotic Agents ; Blood Glucose ; Hypoglycemic Agents ; Triglycerides ; Metformin (9100L32L2N) ; Clozapine (J60AR2IKIC)
    Language English
    Publishing date 2016-06-15
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0156208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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