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  1. Article ; Online: The internal structure of handwriting proficiency in beginning writers.

    Truxius, Lidia / Maurer, Michelle N / Sägesser Wyss, Judith / Roebers, Claudia M

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0296096

    Abstract: Fluent and automatized handwriting frees cognitive resources for more complex elements of writing (i.e., spelling or text generation) or even math tasks (i.e., operating) and is therefore a central objective in primary school years. Most previous ... ...

    Abstract Fluent and automatized handwriting frees cognitive resources for more complex elements of writing (i.e., spelling or text generation) or even math tasks (i.e., operating) and is therefore a central objective in primary school years. Most previous research has focused on the development of handwriting automaticity across the school years and characteristics of handwriting difficulties in advanced writers. However, the relative and absolute predictive power of the different kinematic aspects for typically developing beginning handwriting remains unclear. The purpose of the present study was to investigate whether and to what extent different kinematic aspects contribute to handwriting proficiency in typically developing beginning handwriters. Further, we investigated whether gender, socioeconomic background, or interindividual differences in executive functions and visuomotor integration contribute to children's acquisition of handwriting. Therefore, 853 first-grade children aged seven copied words on a digitized tablet and completed cognitive performance tasks. We used a confirmatory factor analysis to investigate how predefined kinematic aspects of handwriting, specifically the number of inversions in velocity (NIV), pen stops, pen lifts, and pressure on the paper, are linked to an underlying handwriting factor. NIV, pen stops, and pen lifts showed the highest factor loadings and therefore appear to best explain handwriting proficiency in beginning writers. Handwriting proficiency was superior in girls than boys but, surprisingly, did not differ between children from low versus high socioeconomic backgrounds. Handwriting proficiency was related to working memory but unrelated to inhibition, shifting, and visuomotor integration. Overall, these findings highlight the importance of considering different kinematic aspects in children who have not yet automatized pen movements. Results are also important from an applied perspective, as the early detection of handwriting difficulties has not yet received much research attention, although it is the base for tailoring early interventions for children at risk for handwriting difficulties.
    MeSH term(s) Male ; Child ; Female ; Humans ; Handwriting ; Early Intervention, Educational ; Executive Function ; Factor Analysis, Statistical ; Inhibition, Psychological
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Letter to the editor regarding, "Management of lumbar spondylolysis in the adolescent athlete: a review of over 200 cases" by Choi et al.

    Wyss, James / Casey, Ellen / Moley, Peter / Cheng, Jennifer

    The spine journal : official journal of the North American Spine Society

    2023  Volume 23, Issue 6, Page(s) 922–923

    MeSH term(s) Humans ; Adolescent ; Spondylolysis/therapy ; Athletes ; Lumbosacral Region ; Lumbar Vertebrae
    Language English
    Publishing date 2023-02-19
    Publishing country United States
    Document type Review ; Letter ; Comment
    ZDB-ID 2037072-6
    ISSN 1878-1632 ; 1529-9430
    ISSN (online) 1878-1632
    ISSN 1529-9430
    DOI 10.1016/j.spinee.2023.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Continuous timely monitoring of core temperature with two wearable devices in pediatric patients undergoing chemotherapy for cancer - a comparison study.

    Koenig, Christa / Ammann, Roland A / Schneider, Christine / Wyss, Johanna / Roessler, Jochen / Brack, Eva

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2024  Volume 32, Issue 3, Page(s) 188

    MeSH term(s) Child, Preschool ; Adolescent ; Humans ; Child ; Temperature ; Body Temperature ; Neoplasms/drug therapy ; Wearable Electronic Devices ; Prospective Studies
    Language English
    Publishing date 2024-02-24
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-024-08366-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Treatment of Interspinous Pain With Extracorporeal Shockwave Therapy: A Case Report.

    Leupold, Olivia / Cheng, Jennifer / Barcavage, Christine / Press, Joel / Wyss, James

    American journal of physical medicine & rehabilitation

    2023  Volume 103, Issue 3, Page(s) e23–e25

    Abstract: Abstract: The interspinous region is an atypical source of low back pain, and it can often be difficult to identify. There are many structural components in the interspinous region that can contribute to interspinous pain, including the interspinous ... ...

    Abstract Abstract: The interspinous region is an atypical source of low back pain, and it can often be difficult to identify. There are many structural components in the interspinous region that can contribute to interspinous pain, including the interspinous ligament, which plays a role in providing stabilization to the spine. Successful treatments of interspinous pain have not been well characterized in the literature. This case presents the first documentation of the use of extracorporeal shockwave therapy as a noninvasive treatment for refractory interspinous-related low back pain. Extracorporeal shockwave therapy has previously been shown to facilitate regeneration and tissue healing in tendons and ligaments but has not previously been used to treat interspinous pain. A 24-yr-old former collegiate softball player presented with 5 mos of low back pain; the interspinous ligament was clinically suspected as a pain generator, and this was confirmed via an ultrasound-guided injection. She underwent a course of physical therapy that improved function but did not improve pain, and nonsteroidal anti-inflammatory drugs only provided minimal and temporary relief. Three consecutive extracorporeal shockwave therapy treatment sessions provided 90% improvement in pain and function, and she was able to return to exercise and recreational sports. At more than 6 mos after extracorporeal shockwave therapy treatment, she reported no recurrences or functional limitations.
    MeSH term(s) Female ; Humans ; Low Back Pain ; Extracorporeal Shockwave Therapy ; Ligaments, Articular ; Sports ; Spine
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000002353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: From Scribbles to Script: Graphomotor Skills' Impact on Spelling in Early Primary School.

    Maurer, Michelle N / Truxius, Lidia / Sägesser Wyss, Judith / Eckhart, Michael

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 12

    Abstract: The acquisition of handwriting skills is a crucial goal in early primary school. Yet our comprehension of handwriting development, encompassing graphomotor skills and spelling, remains fragmented. The identification of predictors for handwriting skills ... ...

    Abstract The acquisition of handwriting skills is a crucial goal in early primary school. Yet our comprehension of handwriting development, encompassing graphomotor skills and spelling, remains fragmented. The identification of predictors for handwriting skills is essential for providing early support. This longitudinal study aimed to explore the predictive roles of gender, working memory, and motivation to handwrite for graphomotor skills six months later and spelling skills one year later. Paper-and-pencil tasks (graphomotor skills, spelling), a tablet task (working memory), and a questionnaire (teachers' ratings of children's handwriting motivation) were employed. This study included 363 first-grade children (49.8% girls) aged 6-9 years. Results from a structural equation model, controlling for age and socioeconomic background, revealed that girls exhibited superior performance in graphomotor skills, while boys tended to spell more accurately. Furthermore, working memory predicted graphomotor skills but not spelling. Additionally, motivation to handwrite predicted both first-grade graphomotor skills and second-grade spelling. This study extends contemporary evidence, demonstrating that graphomotor skills predict spelling while considering gender and motivation. The findings underscore the pivotal role of graphomotor skills in spelling acquisition and suggest their contribution to spelling difficulties.
    Language English
    Publishing date 2023-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10121886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Speech understanding in noise for cochlear implant recipients using a spatial noise reduction setting in an off the ear sound processor with directional microphones.

    Jones, Marian / Warren, Chris / Mashal, Marjan / Greenham, Paula / Wyss, Josie

    Cochlear implants international

    2023  Volume 24, Issue 6, Page(s) 311–324

    Abstract: Purpose: Cochlear implant (CI) recipients struggle to hear in competing background noise. ForwardFocus is a spatial noise reduction setting from Cochlear Ltd. (Sydney) that can simultaneously attenuate noise from multiple sources behind the listener. ... ...

    Abstract Purpose: Cochlear implant (CI) recipients struggle to hear in competing background noise. ForwardFocus is a spatial noise reduction setting from Cochlear Ltd. (Sydney) that can simultaneously attenuate noise from multiple sources behind the listener. This study assessed hearing performance with ForwardFocus in an off-the-ear (OTE) sound processor.
    Method: Twenty-two experienced adult CI recipients participated. Speech reception data was collected in fixed noise acutely in the clinic. After three to five weeks take home experience, subjective impressions were recorded, and evaluations were conducted for speech reception in quiet and roving noise.
    Results: Group mean speech reception thresholds (SRT) were below 0 dB in two spatially-separated noise test conditions when using ForwardFocus in the OTE sound processor. SRT were -8.5 dB (SD 2.9) in 4-talker babble roving in a rear hemi-field (S0Nrearhemi) and -3.9 dB (SD 3.3) in 12-talker babble presented laterally and behind (S0N3). Results in S0N3 were significantly better with ForwardFocus On (
    Conclusions: ForwardFocus provides significant benefits for speech recognition in competing background noise in an OTE sound processor. These results support clinicians in counselling CI recipients on potential sound processor options to consider.
    MeSH term(s) Adult ; Humans ; Cochlear Implants ; Cochlear Implantation/methods ; Speech ; Speech Perception ; Noise
    Language English
    Publishing date 2023-08-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2079515-4
    ISSN 1754-7628 ; 1467-0100
    ISSN (online) 1754-7628
    ISSN 1467-0100
    DOI 10.1080/14670100.2023.2233203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Tale of Bilateral Rapidly Progressive Osteoarthritis of the Hip-It Is Not Always the Steroid Injection: A Case Report.

    Cheng, Jennifer / Barcavage, Christine / Leupold, Olivia / Tsai, Jefferson / Wyss, James

    American journal of physical medicine & rehabilitation

    2023  Volume 103, Issue 5, Page(s) e51–e53

    Abstract: Abstract: Rapidly progressive osteoarthritis of the hip is an unusual subset of hip osteoarthritis in which a >2 mm/yr rate of joint space narrowing occurs. Rapidly progressive osteoarthritis of the hip has been associated with intra-articular steroid ... ...

    Abstract Abstract: Rapidly progressive osteoarthritis of the hip is an unusual subset of hip osteoarthritis in which a >2 mm/yr rate of joint space narrowing occurs. Rapidly progressive osteoarthritis of the hip has been associated with intra-articular steroid injection, with the incidence of rapidly progressive osteoarthritis of the hip after intra-articular steroid injection ranging from 2.8% to 21%. The occurrence of rapidly progressive osteoarthritis of the hip unrelated to intra-articular steroid injection is rare, and not frequently reported. This report presents a unique case of rapidly progressive osteoarthritis of the hip in the bilateral hips of one patient. The first hip developed rapidly progressive osteoarthritis of the hip within 6 mos after an intra-articular steroid injection. Three years later, the second hip developed rapidly progressive osteoarthritis of the hip within 4 mos without any injection or use of systemic steroid medication. The etiology of rapidly progressive osteoarthritis of the hip in the absence of intra-articular steroid injection is unclear, and this case presents the opportunity to observe the development of rapidly progressive osteoarthritis of the hip due to different causes within the same individual.
    MeSH term(s) Humans ; Osteoarthritis, Hip/diagnostic imaging ; Osteoarthritis, Hip/drug therapy ; Steroids/therapeutic use ; Injections, Intra-Articular ; Treatment Outcome
    Chemical Substances Steroids
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000002391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Long-Term Follow-Up of Pediatric CNS Tumor Survivors-A Selection of Relevant Long-Term Issues.

    Otth, Maria / Wyss, Johanna / Scheinemann, Katrin

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 4

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-03-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9040447
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  9. Article: Novel Pharmacological Treatment Options in Pediatric Glioblastoma-A Systematic Review.

    Wyss, Johanna / Frank, Nicole Alexandra / Soleman, Jehuda / Scheinemann, Katrin

    Cancers

    2022  Volume 14, Issue 11

    Abstract: Background: Pediatric glioblastoma (GBM) is an aggressive central nervous system tumor in children that has dismal prognosis. Standard of care is surgery with subsequent irradiation and temozolomide. We aimed to outline currently available data on novel ...

    Abstract Background: Pediatric glioblastoma (GBM) is an aggressive central nervous system tumor in children that has dismal prognosis. Standard of care is surgery with subsequent irradiation and temozolomide. We aimed to outline currently available data on novel pharmacological treatments for pediatric GBM.
    Methods: We conducted a systematic literature search in PubMed and Embase, including reports published in English from 2010 to 2021. We included randomized trials, cohort studies and case series. Phase I trials were not analyzed. We followed PRISMA guidelines, assessed the quality of the eligible reports using the Newcastle-Ottawa scale (NOS) and the RoB-2 tool and registered the protocol on PROSPERO.
    Results: We included 6 out of 1122 screened reports. All six selected reports were prospective, multicenter phase II trials (five single-arm and one randomized controlled trial). None of the investigated novel treatment modalities showed any benefit regarding overall or progression free survival.
    Conclusions: To date, the role of pharmacological approaches regarding pediatric GBM remains unclear, since no novel treatment approach could provide a significant impact on overall or progression free survival. Further research should aim to combine different treatment strategies in large international multicenter trials with central comprehensive diagnostics regarding subgrouping. These novel treatment approaches should include targeted and immunotherapeutic treatments, potentially leading to a more successful outcome.
    Language English
    Publishing date 2022-06-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14112814
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  10. Article ; Online: Development of non-alcoholic steatohepatitis is associated with gut microbiota but not with oxysterol enzymes CH25H, EBI2, or CYP7B1 in mice.

    Wyss, Jacqueline / Raselli, Tina / Wyss, Annika / Telzerow, Anja / Rogler, Gerhard / Krupka, Niklas / Yilmaz, Bahtiyar / Schmidt, Thomas S B / Misselwitz, Benjamin

    BMC microbiology

    2024  Volume 24, Issue 1, Page(s) 69

    Abstract: Liver steatosis is the most frequent liver disorder and its advanced stage, non-alcoholic steatohepatitis (NASH), will soon become the main reason for liver fibrosis and cirrhosis. The "multiple hits hypothesis" suggests that progression from simple ... ...

    Abstract Liver steatosis is the most frequent liver disorder and its advanced stage, non-alcoholic steatohepatitis (NASH), will soon become the main reason for liver fibrosis and cirrhosis. The "multiple hits hypothesis" suggests that progression from simple steatosis to NASH is triggered by multiple factors including the gut microbiota composition. The Epstein Barr virus induced gene 2 (EBI2) is a receptor for the oxysterol 7a, 25-dihydroxycholesterol synthesized by the enzymes CH25H and CYP7B1. EBI2 and its ligand control activation of immune cells in secondary lymphoid organs and the gut. Here we show a concurrent study of the microbial dysregulation and perturbation of the EBI2 axis in a mice model of NASH.We used mice with wildtype, or littermates with CH25H
    MeSH term(s) Animals ; Mice ; Non-alcoholic Fatty Liver Disease/pathology ; Oxysterols ; Gastrointestinal Microbiome ; Epstein-Barr Virus Infections/pathology ; Herpesvirus 4, Human ; Liver/pathology ; Diet, High-Fat/adverse effects ; Mice, Inbred C57BL ; Disease Models, Animal
    Chemical Substances Oxysterols
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041505-9
    ISSN 1471-2180 ; 1471-2180
    ISSN (online) 1471-2180
    ISSN 1471-2180
    DOI 10.1186/s12866-024-03195-7
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