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  1. Article: Perinatal and Neonatal Outcomes Using Cardiotocography Versus STAN and Cardiotocography: a Systematic Review.

    Tsiligkeridou, Sofia / Bolou, Angeliki / Xanthos, Theodoros / Gourounti, Kleanthi

    Maedica

    2024  Volume 18, Issue 4, Page(s) 684–691

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-02-08
    Publishing country Romania
    Document type Editorial
    ZDB-ID 2399972-X
    ISSN 2069-6116 ; 1841-9038
    ISSN (online) 2069-6116
    ISSN 1841-9038
    DOI 10.26574/maedica.2023.18.4.684
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  2. Article ; Online: The Effects of IRL-1620 in Post-ischemic Brain Injury: A Systematic Review and Meta-analysis of Experimental Studies.

    Moustakas, Dimitris / Mani, Iliana / Pouliakis, Abraham / Iacovidou, Nikoletta / Xanthos, Theodoros

    Neurocritical care

    2024  

    Abstract: Background: Sovateltide (IRL-1620), an endothelin B receptor agonist, has previously demonstrated neuroprotective and neuroregenerative effects in animal models of acute ischemic stroke. Recently, clinical trials indicated that it could also be ... ...

    Abstract Background: Sovateltide (IRL-1620), an endothelin B receptor agonist, has previously demonstrated neuroprotective and neuroregenerative effects in animal models of acute ischemic stroke. Recently, clinical trials indicated that it could also be effective in humans with stroke. Here, we systematically investigate whether IRL-1620 may be used for the treatment of ischemia-induced brain injury.
    Methods: A systematic review was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. MEDLINE (PubMed) and Scopus databases were searched for eligible studies up to December 2022. The databases ClinicalTrials.gov and Pharmazz Inc. were screened for unpublished or ongoing trials. Only studies in English were evaluated for eligibility. Meta-analysis of the included studies was also conducted.
    Results: Finally, seven studies were included in the review, all in animal rat models because of scarcity of clinical trials. Six studies, all in middle cerebral artery occlusion (MCAO) models, were selected for meta-analysis. In the two studies assessing mortality, no deaths were reported in the IRL-1620 group 24 h after MCAO, whereas the vehicle group had almost a five times higher mortality risk (risk ratio 5.3, 95% confidence interval 0.7-40.1, I
    Conclusions: According to the above, in animal MCAO models, IRL-1620 enhanced neurogenesis and neuroprotection and improved outcome. Future studies are needed to expand our understanding of its effects in human study participants with acute ischemic stroke as well as in other common causes of cerebral ischemia including cardiac arrest.
    Language English
    Publishing date 2024-05-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-024-01994-4
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  3. Article: The Effect of Oral Iron Supplementation/Fortification on the Gut Microbiota in Infancy: A Systematic Review and Meta-Analysis.

    Karamantziani, Theoni / Pouliakis, Abraham / Xanthos, Theodoros / Ekmektzoglou, Konstantinos / Paliatsiou, Styliani / Sokou, Rozeta / Iacovidou, Nicoletta

    Children (Basel, Switzerland)

    2024  Volume 11, Issue 2

    Abstract: 1) Background: Iron is an essential metal for the proper growth and neurodevelopment of infants. To prevent and treat iron deficiency, iron supplementation or fortification is often required. It has been shown, though, that it affects the synthesis of ... ...

    Abstract (1) Background: Iron is an essential metal for the proper growth and neurodevelopment of infants. To prevent and treat iron deficiency, iron supplementation or fortification is often required. It has been shown, though, that it affects the synthesis of gut microbiota. (2) Methods: This paper is a systematic review and meta-analysis of the effect of oral iron supplementation/fortification on the gut microbiota in infancy. Studies in healthy neonates and infants who received per os iron with existing data on gut microbiota were included. Three databases were searched: PUBMED, Scopus, and Google Scholar. Randomized controlled trials (RCTs) were included. Quality appraisal was assessed using the ROB2Tool. (3) Results: A total of six RCTs met inclusion criteria for a systematic review, and four of them were included in the meta-analysis using both the fixed and random effects methods. Our results showed that there is very good heterogeneity in the iron group (I
    Language English
    Publishing date 2024-02-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children11020231
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  4. Article ; Online: Sovateltide (ILR-1620) Improves Motor Function and Reduces Hyperalgesia in a Rat Model of Spinal Cord Injury.

    Mavridis, Theodoros / Mavridi, Artemis / Karampela, Eleftheria / Galanos, Antonis / Gkiokas, George / Iacovidou, Nicoletta / Xanthos, Theodoros

    Neurocritical care

    2024  

    Abstract: Background: Spinal cord injury (SCI) presents a major global health challenge, with rising incidence rates and substantial disability. Although progress has been made in understanding SCI's pathophysiology and early management, there is still a lack of ... ...

    Abstract Background: Spinal cord injury (SCI) presents a major global health challenge, with rising incidence rates and substantial disability. Although progress has been made in understanding SCI's pathophysiology and early management, there is still a lack of effective treatments to mitigate long-term consequences. This study investigates the potential of sovateltide, a selective endothelin B receptor agonist, in improving clinical outcomes in an acute SCI rat model.
    Methods: Thirty male Sprague-Dawley rats underwent sham surgery (group A) or SCI and treated with vehicle (group B) or sovateltide (group C). Clinical tests, including Basso, Beattie, and Bresnahan scoring, inclined plane, and allodynia testing with von Frey hair, were performed at various time points. Statistical analyses assessed treatment effects.
    Results: Sovateltide administration significantly improved motor function, reducing neurological deficits and enhancing locomotor recovery compared with vehicle-treated rats, starting from day 7 post injury. Additionally, the allodynic threshold improved, suggesting antinociceptive properties. Notably, the sovateltide group demonstrated sustained recovery, and even reached preinjury performance levels, whereas the vehicle group plateaued.
    Conclusions: This study suggests that sovateltide may offer neuroprotective effects, enhancing neurogenesis and angiogenesis. Furthermore, it may possess anti-inflammatory and antinociceptive properties. Future clinical trials are needed to validate these findings, but sovateltide shows promise as a potential therapeutic strategy to improve functional outcomes in SCI. Sovateltide, an endothelin B receptor agonist, exhibits neuroprotective properties, enhancing motor recovery and ameliorating hyperalgesia in a rat SCI model. These findings could pave the way for innovative pharmacological interventions for SCI in clinical settings.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-024-01950-2
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  5. Article: Non-Typical Clinical Presentation of COVID-19 Patients in Association with Disease Severity and Length of Hospital Stay.

    Skourtis, Alexandros / Ekmektzoglou, Konstantinos / Xanthos, Theodoros / Stouraitou, Stella / Iacovidou, Nicoletta

    Journal of personalized medicine

    2023  Volume 13, Issue 1

    Abstract: Background: This study aimed to investigate the incidence of non-typical symptoms in ambulatory patients with mild-to-moderate COVID-19 infection and their potential association with disease progression.: Materials and methods: Data on the ... ...

    Abstract Background: This study aimed to investigate the incidence of non-typical symptoms in ambulatory patients with mild-to-moderate COVID-19 infection and their potential association with disease progression.
    Materials and methods: Data on the symptomatology of COVID-19 patients presenting to the fast-track emergency department were collected between March 2020 and March 2021. Fever, cough, shortness of breath, and fatigue-weakness were defined as "typical" symptoms, whereas all other symptoms such as nasal congestion, rhinorrhea, gastrointestinal symptoms, etc., were defined as "non-typical".
    Results: A total of 570 COVID-19 patients with a mean age of 42.25 years were included, the majority of whom were male (61.3%; N = 349), and were divided according to their symptoms into two groups. The mean length of hospital stay was found to be 9.5 days. A higher proportion of patients without non-typical symptoms were admitted to the hospital (
    Conclusion: With the possible exception of gastrointestinal symptoms, non-typical symptoms of COVID-19 at baseline appear to predispose to a milder disease.
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13010132
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  6. Article ; Online: 'Do not attempt cardiopulmonary resuscitation' or 'allowing natural death'? The time for resuscitation community to review its boundaries and its terminology.

    Xanthos, Theodoros

    Resuscitation

    2014  Volume 85, Issue 11, Page(s) 1644–1645

    MeSH term(s) Attitude to Death ; Cardiopulmonary Resuscitation/methods ; Cardiopulmonary Resuscitation/mortality ; Female ; Heart Arrest/classification ; Heart Arrest/mortality ; Heart Arrest/therapy ; Humans ; Male ; Needs Assessment ; Residence Characteristics ; Resuscitation Orders/ethics ; Resuscitation Orders/psychology ; Terminal Care/standards ; Terminal Care/trends ; Terminology as Topic ; United Kingdom
    Keywords covid19
    Language English
    Publishing date 2014-11
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2014.09.012
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  7. Article: The Effect of Statins on Ocular Disorders: A Systematic Review of Randomized Controlled Trials.

    Lymperopoulou, Charoula / Kandarakis, Stylianos A / Tzanaki, Ismini / Mylona, Ioanna / Xanthos, Theodoros / Agouridis, Aris P

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 5

    Abstract: Aim: Statins have been established in the market not only due to their ability to lower plasma cholesterol levels but also due to their pleiotropic effects. In the literature, there is a controversy regarding the role of statins in ophthalmology. We ... ...

    Abstract Aim: Statins have been established in the market not only due to their ability to lower plasma cholesterol levels but also due to their pleiotropic effects. In the literature, there is a controversy regarding the role of statins in ophthalmology. We aimed to systematically address the possible effect of statin therapy on ocular diseases and to identify if there is a beneficial relationship.
    Methods: We searched PubMed and Cochrane Library databases up to 31 December 2022 for studies evaluating the effect of statins on ocular diseases. We included all relevant Randomized Control Trials (RCTs) that have been conducted in the adult population. PROSPERO registration number: CRD42022364328.
    Results: Nineteen RCTs were finally considered eligible for this systematic review, with a total of 28,940 participants. Ten studies investigated the role of simvastatin, suggesting a lack of cataractogenic effect and a possible protective role in cataract formation, retinal vascular diseases, and especially diabetic retinopathy, age-related macular disease progression, and non-infectious uveitis. Four studies investigated lovastatin, showing no cataractogenic effect. Three studies examined atorvastatin, revealing conflicting results regarding diabetic retinopathy. Two studies examined rosuvastatin, indicating a possibly harmful effect on lenses and a significant protective effect on retinal microvasculature.
    Conclusions: Based on our findings, we believe that statins have no cataractogenic effect. There are indications that statins may have a protective role against cataract formation, AMD, diabetic retinopathy progression, and non-infectious uveitis. However, our results were insufficient for any robust conclusion. Future RCTs, with large sample sizes, on the current topic are therefore recommended to provide more solid evidence.
    Language English
    Publishing date 2023-05-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16050711
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  8. Article ; Online: The effects of upper limb exercise training on upper limb muscle strength in people with chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomized controlled trials.

    Karagiannis, Christos / Savva, Christos / Korakakis, Vasileios / Ploutarchou, George / Adamide, Tonia / Georgiou, Andreas / Xanthos, Theodoros

    Therapeutic advances in respiratory disease

    2023  Volume 17, Page(s) 17534666231170813

    Abstract: Background: Upper limb (UL) muscle dysfunction is a common extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD). UL muscle dysfunction is associated with muscle weakness, dyspnea, and exercise intolerance. Although upper limb ... ...

    Abstract Background: Upper limb (UL) muscle dysfunction is a common extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD). UL muscle dysfunction is associated with muscle weakness, dyspnea, and exercise intolerance. Although upper limb exercise training (ULET) is typically incorporated in pulmonary rehabilitation programs, its effects on UL muscle strength remains unclear.
    Objectives: The purpose of this systematic review was to investigate the effectiveness of ULET, in UL muscle strength of people with COPD.
    Design: This is systematic review and meta-analysis study.
    Data sources and methods: Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Protocols 2020 guidelines were used for this study. PubMed, Cochrane, CINAHL Plus and SPORTDiscus and clinicaltrials.gov registry were searched from inception to July 2022. Included studies were randomized controlled trials, assessing the effectiveness in muscle strength of ULET, compared with other types of upper or lower limb exercise or no exercise. The quality and risk of bias were assessed using the Physiotherapy Evidence Database (PEDro) scale and certainty of evidence with the Grading of Recommendations, Assessment, Development, and Evaluations approach. Treatment effects of ULET were calculated using standardized mean differences and 95% confidence intervals.
    Results: Twenty-four studies, with a total sample of 882 patients, were included. Most studies were of moderate quality and high risk of bias. Very low to low certainty evidence indicates a significant difference in UL muscle strength in favor of resistance ULET, compared with lower limb exercise alone or no exercise. No significant differences were found in different types of ULET comparisons.
    Conclusion: The results of this review showed that resistance ULET could improve UL muscle strength in people with COPD. Most studies, however, were of moderate quality and high risk of bias. Further studies with larger sample sizes, better methodological quality, and standardized training protocols are needed to confirm these findings.
    MeSH term(s) Humans ; Quality of Life ; Randomized Controlled Trials as Topic ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/therapy ; Pulmonary Disease, Chronic Obstructive/complications ; Exercise ; Physical Therapy Modalities ; Upper Extremity ; Muscle Strength/physiology
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2476459-0
    ISSN 1753-4666 ; 1753-4658
    ISSN (online) 1753-4666
    ISSN 1753-4658
    DOI 10.1177/17534666231170813
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  9. Article ; Online: Airway Pressure Monitoring May Improve Small Airway Flow, Hemodynamics, and Tissue Oxygenation.

    Chalkias, Athanasios / Xanthos, Theodoros

    American journal of respiratory and critical care medicine

    2019  Volume 199, Issue 7, Page(s) 928–929

    MeSH term(s) Carbon Dioxide ; Cardiopulmonary Resuscitation ; Hemodynamics ; Monitoring, Physiologic
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2019-01-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201811-2075LE
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  10. Article ; Online: New era in upper eyelid rejuvenation: A brief overview of non-surgical blepharoplasty techniques.

    Theodorelou-Charitou, Sofia-Andriani / Xanthos, Theodoros / Nikas, Ilias P / Ntinioti, Trisevgeni

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2021  Volume 74, Issue 7, Page(s) 1633–1701

    MeSH term(s) Blepharoplasty ; Cosmetic Techniques ; Eyelids ; Humans ; Outcome Assessment, Health Care ; Rejuvenation ; Skin Aging
    Language English
    Publishing date 2021-02-10
    Publishing country Netherlands
    Document type Letter ; Review
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2021.01.008
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