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  1. AU="Xavier Coumoul"
  2. AU="Lutterer, S."
  3. AU="A Gasset-Teixidor"
  4. AU="Brea, Ángel"
  5. AU="Mozaherul Hoque Abdul Hasnat"
  6. AU="Adeyemi, Oluwapelumi O"
  7. AU="Oyim, James"
  8. AU="Fu, Yuntian"
  9. AU="Spigland, N"
  10. AU="Blum, Jonathan"
  11. AU="Philips, Santosh"
  12. AU="Lin, Xingyu"
  13. AU=Ko C W AU=Ko C W
  14. AU="Yang, Shucai"
  15. AU="Orton, Jane"
  16. AU="Remer, Thomas"
  17. AU="Blanco Álvarez, Adoración"
  18. AU="Nestor Laurier, Engone Obiang"
  19. AU="Huberty, Fanny"
  20. AU="Ju, Beomsoo"
  21. AU="Yu, Jessica"
  22. AU="Yamada, Hiroyuki"
  23. AU="Uruski, Pawel"
  24. AU="Laranjeiro, Ricardo"
  25. AU="Ahmadi, Reza"
  26. AU="Hoet, Peter H.M."
  27. AU=Sengupta Sohini AU=Sengupta Sohini
  28. AU="Conlon, Dara"
  29. AU=Endeman Henrik AU=Endeman Henrik
  30. AU="New, Sophie E.P"

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  1. Artikel ; Online: The Aryl Hydrocarbon Receptor and the Nervous System

    Ludmila Juricek / Xavier Coumoul

    International Journal of Molecular Sciences, Vol 19, Iss 9, p

    2018  Band 2504

    Abstract: The aryl hydrocarbon receptor (or AhR) is a cytoplasmic receptor of pollutants. It translocates into the nucleus upon binding to its ligands, and forms a heterodimer with ARNT (AhR nuclear translocator). The heterodimer is a transcription factor, which ... ...

    Abstract The aryl hydrocarbon receptor (or AhR) is a cytoplasmic receptor of pollutants. It translocates into the nucleus upon binding to its ligands, and forms a heterodimer with ARNT (AhR nuclear translocator). The heterodimer is a transcription factor, which regulates the transcription of xenobiotic metabolizing enzymes. Expressed in many cells in vertebrates, it is mostly present in neuronal cell types in invertebrates, where it regulates dendritic morphology or feeding behavior. Surprisingly, few investigations have been conducted to unravel the function of the AhR in the central or peripheral nervous systems of vertebrates. In this review, we will present how the AhR regulates neural functions in both invertebrates and vertebrates as deduced mainly from the effects of xenobiotics. We will introduce some of the molecular mechanisms triggered by the well-known AhR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which impact on neuronal proliferation, differentiation, and survival. Finally, we will point out the common features found in mice that are exposed to pollutants, and in AhR knockout mice.
    Schlagwörter AhR ; nervous system ; endocrine disruptor ; TCDD ; dioxin ; neuron ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2018-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Endocrine disrupting chemicals and COVID-19 relationships

    Qier Wu / Xavier Coumoul / Philippe Grandjean / Robert Barouki / Karine Audouze

    Environment International, Vol 157, Iss , Pp 106232- (2021)

    A computational systems biology approach

    2021  

    Abstract: Background: Patients at high risk of severe forms of COVID-19 frequently suffer from chronic diseases, but other risk factors may also play a role. Environmental stressors, such as endocrine disrupting chemicals (EDCs), can contribute to certain chronic ... ...

    Abstract Background: Patients at high risk of severe forms of COVID-19 frequently suffer from chronic diseases, but other risk factors may also play a role. Environmental stressors, such as endocrine disrupting chemicals (EDCs), can contribute to certain chronic diseases and might aggravate the course of COVID-19. Objectives: To explore putative links between EDCs and COVID-19 severity, an integrative systems biology approach was constructed and applied. Methods: As a first step, relevant data sets were compiled from major data sources. Biological associations of major EDCs to proteins were extracted from the CompTox database. Associations between proteins and diseases known as important COVID-19 comorbidities were obtained from the GeneCards and DisGeNET databases. Based on these data, we developed a tripartite network (EDCs-proteins-diseases) and used it to identify proteins overlapping between the EDCs and the diseases. Signaling pathways for common proteins were then investigated by over-representation analysis. Results: We found several statistically significant pathways that may be dysregulated by EDCs and that may also be involved in COVID-19 severity. The Th17 and the AGE/RAGE signaling pathways were particularly promising. Conclusions: Pathways were identified as possible targets of EDCs and as contributors to COVID-19 severity, thereby highlighting possible links between exposure to environmental chemicals and disease development. This study also documents the application of computational systems biology methods as a relevant approach to increase the understanding of molecular mechanisms linking EDCs and human diseases, thereby contributing to toxicology prediction.
    Schlagwörter Endocrine disruptor ; Systems toxicology ; Integrative computational approach ; Network science ; OBERON ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Impact of mixtures of persistent organic pollutants on breast cancer aggressiveness

    Louise Benoit / Meriem Koual / Céline Tomkiewicz / Anne-Sophie Bats / Jean-Philippe Antignac / Xavier Coumoul / Robert Barouki / German Cano-Sancho

    Environment International, Vol 170, Iss , Pp 107615- (2022)

    2022  

    Abstract: Introduction: Breast cancer (BC) is frequent with a poor prognosis in case of metastasis. The role of the environment has been poorly evaluated in its progression. We searched to assess whether a mixture of pollutants could be responsible of BC ... ...

    Abstract Introduction: Breast cancer (BC) is frequent with a poor prognosis in case of metastasis. The role of the environment has been poorly evaluated in its progression. We searched to assess whether a mixture of pollutants could be responsible of BC aggressiveness. Methods: Patients undergoing surgery for their BC were prospectively included in the METAPOP cohort. Forty-two POPs were extracted, among them 17 dioxins (PCDD/F), 16 polychlorobiphenyls (PCB), 8 polybromodiphenylethers (PBDE) and 2,2′,4,4′,5,5′-hexabromobiphenyl (PBB153) were measured in the adipose tissue surrounding the tumor. BC aggressiveness was defined using tumor size and metastasis (distant or lymph nodes). Two complementary models were used to evaluate the impact of the mixture of pollutants: the BKMR (Bayesian Kernel machine regression) and WQS (weighted quantile sum regression) models. The WQS estimates the weight (positive or negative) of a certain chemical based on its quantile and the BKMR model applies a kernel-based approach to estimate posterior inclusion probabilities. The sub-group of patients with a body mass index (BMI) > 22 kg/ m2 was also analyzed. Results: Ninety-one patients were included. Of these, 38 patients presented a metastasis, and the mean tumor size was 25.4 mm. The mean BMI was 24.5 kg/m2 (+/- 4.1). No statistical association was found in the general population. However, in patients with a BMI > 22 kg/ m2, our mixture was positively associated with tumor size (OR: 9.73 95 %CI: 1.30–18.15) and metastasis (OR = 3.98 95 %CI = 1.09–17.53) using the WQS model. Moreover, using the BKMR model on chemical families, dioxin like chemicals and PCDD were associated with a higher risk of metastasis. Discussion: These novel findings identified a mixture associated with breast cancer aggressiveness in patients with a BMI > 22 kg/ m2.
    Schlagwörter Adipose tissue ; Mammary cancer ; Endocrine disrupting chemicals ; Environmental exposure ; Metastasis ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: COVID-19 and aerobic exercise

    Haidar Djemai / Rami Hammad / Ibrahim M. Dabayebeh / Saleh Hammad / Abdellah Merzouk / Xavier Coumoul / Philippe Noirez

    Archives of Public Health, Vol 80, Iss 1, Pp 1-

    possible role of angiotensin converting enzyme 2

    2022  Band 5

    Abstract: Highlights • Physical inactivity during COVID-19 lockdowns may damage health. • Risk of contamination by aerosols is higher during high-intensity urban outdoor exercise. • Angiotensin converting enzyme 2 (ACE2) could play key role in SARS-CoV-2 ... ...

    Abstract Highlights • Physical inactivity during COVID-19 lockdowns may damage health. • Risk of contamination by aerosols is higher during high-intensity urban outdoor exercise. • Angiotensin converting enzyme 2 (ACE2) could play key role in SARS-CoV-2 transmission during exercise. • How ACE2 serum concentration changes as function of exercise intensity and duration must be studied to elucidate role of this enzyme.
    Schlagwörter COVID-19 ; SARS-CoV-2 ; Physical activity ; Outdoor exercise ; Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Adverse outcome pathway from activation of the AhR to breast cancer-related death

    Louise Benoit / Florence Jornod / Elias Zgheib / Celine Tomkiewicz / Meriem Koual / Thibaut Coustillet / Robert Barouki / Karine Audouze / Mathieu Vinken / Xavier Coumoul

    Environment International, Vol 165, Iss , Pp 107323- (2022)

    2022  

    Abstract: Adverse outcome pathways (AOPs) are formalized and structured linear concepts that connect one molecular initiating event (MIE) to an adverse outcome (AO) via different key events (KE) through key event relationships (KER). They are mainly used in eco- ... ...

    Abstract Adverse outcome pathways (AOPs) are formalized and structured linear concepts that connect one molecular initiating event (MIE) to an adverse outcome (AO) via different key events (KE) through key event relationships (KER). They are mainly used in eco-toxicology toxicology, and regulatory health issues. AOPs must respond to specific guidelines from the Organization for Economic Co-operation and Development (OECD) to weight the evidence between each KE.Breast cancer is the deadliest cancer in women with a poor prognosis in case of metastatic breast cancer. The role of the environments in the formation of metastasis has been suggested. We hypothesized that activation of the AhR (MIE), a xenobiotic receptor, could lead to breast cancer related death (AO), through different KEs, constituting a new AOP.An artificial intelligence tool (AOP-helpfinder), which screens the available literature, was used to collect all existing scientific abstracts to build a novel AOP, using a list of key words. Four hundred and seven abstracts were found containing at least a word from our MIE list and either one word from our AO or KE list. A manual curation retained 113 pertinent articles, which were also screened using PubTator. From these analyses, an AOP was created linking the activation of the AhR to breast cancer related death through decreased apoptosis, inflammation, endothelial cell migration, angiogenesis, and invasion. These KEs promote an increased tumor growth, angiogenesis and migration which leads to breast cancer metastasis and breast cancer related death.The evidence of the proposed AOP was weighted using the tailored Bradford Hill criteria and the OECD guidelines. The confidence in our AOP was considered strong. An in vitro validation must be carried out, but our review proposes a strong relationship between AhR activation and breast cancer-related death with an innovative use of an artificial intelligence literature search.
    Schlagwörter Mammary metastasis ; Aryl hydrocarbon receptor ; Chemical toxicity ; Adverse outcome pathway ; Cancer development ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: The Ah Receptor from Toxicity to Therapeutics

    Gary H. Perdew / Charlotte Esser / Megan Snyder / David H. Sherr / Ellen H. van den Bogaard / Karen McGovern / Pedro M. Fernández-Salguero / Xavier Coumoul / Andrew D. Patterson

    International Journal of Molecular Sciences, Vol 24, Iss 5550, p

    Report from the 5th AHR Meeting at Penn State University, USA, June 2022

    2023  Band 5550

    Abstract: The aryl hydrocarbon receptor (AHR) is a sensor of low-molecular-weight molecule signals that originate from environmental exposures, the microbiome, and host metabolism. Building upon initial studies examining anthropogenic chemical exposures, the list ... ...

    Abstract The aryl hydrocarbon receptor (AHR) is a sensor of low-molecular-weight molecule signals that originate from environmental exposures, the microbiome, and host metabolism. Building upon initial studies examining anthropogenic chemical exposures, the list of AHR ligands of microbial, diet, and host metabolism origin continues to grow and has provided important clues as to the function of this enigmatic receptor. The AHR has now been shown to be directly involved in numerous biochemical pathways that influence host homeostasis, chronic disease development, and responses to toxic insults. As this field of study has continued to grow, it has become apparent that the AHR is an important novel target for cancer, metabolic diseases, skin conditions, and autoimmune disease. This meeting attempted to cover the scope of basic and applied research being performed to address possible applications of our basic knowledge of this receptor on therapeutic outcomes.
    Schlagwörter Ah receptor ; aryl hydrocarbon receptor ; cancer ; clinical trials ; OCT4 ; multiple sclerosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Benzo(a)pyrene and Cerium Dioxide Nanoparticles in Co-Exposure Impair Human Trophoblast Cell Stress Signaling

    Gaëlle Deval / Margaux Nedder / Séverine Degrelle / Jasmina Rogozarski / Marie-Léone Vignaud / Audrey Chissey / Stacy Colzin / Christelle Laguillier-Morizot / Xavier Coumoul / Sonja Boland / Thierry Fournier / Amal Zerrad-Saadi / Ioana Ferecatu

    International Journal of Molecular Sciences, Vol 24, Iss 5439, p

    2023  Band 5439

    Abstract: Human placenta is a multifunctional interface between maternal and fetal blood. Studying the impact of pollutants on this organ is crucial because many xenobiotics in maternal blood can accumulate in placental cells or pass into the fetal circulation. ... ...

    Abstract Human placenta is a multifunctional interface between maternal and fetal blood. Studying the impact of pollutants on this organ is crucial because many xenobiotics in maternal blood can accumulate in placental cells or pass into the fetal circulation. Benzo(a)pyrene (B a P) and cerium dioxide nanoparticles (CeO 2 NP), which share the same emission sources, are found in ambient air pollution and also in maternal blood. The aim of the study was to depict the main signaling pathways modulated after exposure to B a P or CeO 2 NP vs. co-exposure on both chorionic villi explants and villous cytotrophoblasts isolated from human term placenta. At nontoxic doses of pollutants, B a P is bioactivated by AhR xenobiotic metabolizing enzymes, leading to DNA damage with an increase in γ-H2AX, the stabilization of stress transcription factor p53, and the induction of its target p21. These effects are reproduced in co-exposure with CeO 2 NP, except for the increase in γ-H2AX, which suggests a modulation of the genotoxic effect of B a P by CeO 2 NP. Moreover, CeO 2 NP in individual and co-exposure lead to a decrease in Prx-SO 3 , suggesting an antioxidant effect. This study is the first to identify the signaling pathways modulated after co-exposure to these two pollutants, which are common in the environment.
    Schlagwörter human placenta ; chorionic villi ; villous cytotrophoblasts ; benzo(a)pyrene ; cerium dioxide nanoparticles ; AhR ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Merging the exposome into an integrated framework for “omics” sciences

    Elliott J. Price / Chiara M. Vitale / Gary W. Miller / Arthur David / Robert Barouki / Karine Audouze / Douglas I. Walker / Jean-Philippe Antignac / Xavier Coumoul / Vincent Bessonneau / Jana Klánová

    iScience, Vol 25, Iss 3, Pp 103976- (2022)

    2022  

    Abstract: Summary: The exposome concept encourages holistic consideration of the non-genetic factors (environmental exposures including lifestyle) that influence an individual’s health over their life course. However, disconnect between the concept and practical ... ...

    Abstract Summary: The exposome concept encourages holistic consideration of the non-genetic factors (environmental exposures including lifestyle) that influence an individual’s health over their life course. However, disconnect between the concept and practical application has promoted divergent interpretations of the exposome across disciplines and reinforced separation of the environmental (emphasizing exposures) and biological (emphasizing responses) research communities. In particular, while knowledge of biological responses can help to distinguish actual (i.e. experienced) from potential exposures, the inclusion of endogenous processes has generated confusion about the position of the exposome in a multi-omics systems biology context. We propose a reattribution of “exposome” to exclusively represent the totality of contact with external factors that a biological entity experiences, and introduce the term “functional exposomics” to denote the systematic study of exposure-phenotype interaction. This reoriented definition of the exposome allows a more readily integrable dataset for multi-omics and systems biology research.
    Schlagwörter Environmental health ; Exposure assessment ; Omics ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Mitochondrial Dysfunction as a Hallmark of Environmental Injury

    Carolina Duarte-Hospital / Arnaud Tête / François Brial / Louise Benoit / Meriem Koual / Céline Tomkiewicz / Min Ji Kim / Etienne B. Blanc / Xavier Coumoul / Sylvie Bortoli

    Cells, Vol 11, Iss 110, p

    2022  Band 110

    Abstract: Environmental factors including diet, sedentary lifestyle and exposure to pollutants largely influence human health throughout life. Cellular and molecular events triggered by an exposure to environmental pollutants are extremely variable and depend on ... ...

    Abstract Environmental factors including diet, sedentary lifestyle and exposure to pollutants largely influence human health throughout life. Cellular and molecular events triggered by an exposure to environmental pollutants are extremely variable and depend on the age, the chronicity and the doses of exposure. Only a fraction of all relevant mechanisms involved in the onset and progression of pathologies in response to toxicants has probably been identified. Mitochondria are central hubs of metabolic and cell signaling responsible for a large variety of biochemical processes, including oxidative stress, metabolite production, energy transduction, hormone synthesis, and apoptosis. Growing evidence highlights mitochondrial dysfunction as a major hallmark of environmental insults. Here, we present mitochondria as crucial organelles for healthy metabolic homeostasis and whose dysfunction induces critical adverse effects. Then, we review the multiple mechanisms of action of pollutants causing mitochondrial toxicity in link with chronic diseases. We propose the Aryl hydrocarbon Receptor (AhR) as a model of “exposome receptor”, whose activation by environmental pollutants leads to various toxic events through mitochondrial dysfunction. Finally, we provide some remarks related to mitotoxicity and risk assessment.
    Schlagwörter mitotoxicity ; xenobiotics ; environmental pollutants ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Alimentation, pesticides et pathologies neurologiques

    Juricek, Ludmila / Xavier Coumoul

    Société française de nutrition Cahiers de nutrition et de diététique. 2014 Apr., v. 49, no. 2

    2014  

    Abstract: A recent report from the Inserm brought out the involvement of occupational exposure to pesticides in the development of several diseases such as cancer, fertility problems and neurological diseases. These epidemiological studies have shown that some ... ...

    Abstract A recent report from the Inserm brought out the involvement of occupational exposure to pesticides in the development of several diseases such as cancer, fertility problems and neurological diseases. These epidemiological studies have shown that some pesticides can produce toxic effects on the nervous system with the occurrence of neurodegenerative diseases or the onset of cognitive impairment and depression. Firstly, the aim of this review is to introduce the cellular and molecular mechanisms underlying the neurotoxicity associated with this exposure, through a specific example, Parkinson's disease. In the second part, we discuss the problem of pesticide exposure during the critical period of development (in utero, childhood) by studying the association between organophosphate pesticides and neurodevelopmental disorders. Finally, we discuss the advantages and limitations of these studies (concentrations, route and duration of exposure, effects of mixtures...)
    Schlagwörter childhood ; cognitive disorders ; epidemiological studies ; neoplasms ; nervous system ; neurotoxicity ; nutrition ; occupational exposure ; organophosphorus pesticides ; Parkinson disease
    Sprache Englisch
    Erscheinungsverlauf 2014-04
    Umfang p. 74-80.
    Erscheinungsort Elsevier Masson SAS
    Dokumenttyp Artikel
    ZDB-ID 840946-8
    ISSN 0007-9960
    ISSN 0007-9960
    DOI 10.1016/j.cnd.2014.02.002
    Datenquelle NAL Katalog (AGRICOLA)

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