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Article ; Online: Study of stress-strain loops on cardiotoxicity related to immune checkpoint inhibitors.

Chunlan, Shi / Bing, Yue / Xi, Wei

2024 Volume 41, Issue 1, Page(s) e15746

Abstract: Objective: To evaluate the effect of immune checkpoint inhibitors (ICIs) on left ventricular myocardial work by pressure-strain loop (PSL).: Methods: Forty-three immunotherapy patients were enrolled in the case group, and another 43 healthy ... ...

Abstract	Objective: To evaluate the effect of immune checkpoint inhibitors (ICIs) on left ventricular myocardial work by pressure-strain loop (PSL). Methods: Forty-three immunotherapy patients were enrolled in the case group, and another 43 healthy volunteers were enrolled in the control group. They were examined by echocardiography before immunotherapy (T0 phase), after three cycles of treatment (T3 phase) and after six cycles of treatment (T6 phase). Conventional echocardiographic parameters, left ventricular global longitudinal strain (GLS), and myocardial work indices, including global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE), were collected for analysis to compare the results of the different immunotherapy cycles. Results: There were no statistically significant differences of baseline characteristics, conventional echocardiographic parameters, left ventricular strain, and myocardial work indices between T0 phase and control group (all p > .05). There were no statistically significant differences in LVEF between T0, T3, and T6 phase (all p > .05). GLS, GWI, GCW, and GWE were decreased and GWW was increased in T3 and T6 phase. There were no statistically significant difference between GLS in T3 and T0 phase (q = .9057, p > .05). The difference was statistically significant between GLS in T6 and T0 phase (q = 5.5651, p < .01). The difference was statistically significant between GLS in T3 and T6phase(q = 4.6594, p < .01). There were statistically significant difference in GWI, GCW, GWE, and GWW in the T3 and T6 phase compared with the T0 phase (p < .01). Conclusion: PSL can effectively evaluate the effect of ICIs on left ventricular myocardial work, to provide a new method for the early clinical detection of ICIs-related cardiotoxicity.
MeSH term(s)	Humans ; Cardiotoxicity/diagnostic imaging ; Cardiotoxicity/etiology ; Immune Checkpoint Inhibitors ; Myocardium ; Echocardiography ; Healthy Volunteers ; Ventricular Function, Left ; Stroke Volume
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.15746
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Article ; Online: Progress of Mine Land Reclamation and Ecological Restoration Research Based on Bibliometric Analysis

Ya Shao / Qinxue Xu / Xi Wei

Sustainability, Vol 15, Iss 10458, p

2023 Volume 10458

Abstract: The mining of mineral resources has caused serious damage to land and significant pressure on ecological environment. During the repairing of damaged land and degraded ecosystems, there have been many pieces of literature related to land reclamation and ... ...

Abstract	The mining of mineral resources has caused serious damage to land and significant pressure on ecological environment. During the repairing of damaged land and degraded ecosystems, there have been many pieces of literature related to land reclamation and ecological restoration (LRER) that have emerged. To understand the progress and prospect of LRER research, it is necessary to sort out such pieces of literature, analyze the current research status, and forecast the future research directions. Here, Bibliometrix R-package was used to analyze 2357 articles, which were derived from the core database of Web of Science, to explore the development of LRER from 1990 to 2022. The results are as follows. (1) The annual scientific output results show that both the number of articles published on LRER and the number of articles annually citied were increasing gradually from 1990 to 2022. (2) High-frequency keyword analysis indicates that heavy metal (Cd, Pb) pollution remediation is a research hotspot. The cluster analysis (CA) and multiple correspondence analysis (MCA) show that there are two clusters in the current research of LRER, in which one surrounds heavy metal pollution and the other focuses on ecological restoration of mining areas. The two clusters correspond to the remediation and ecological restoration (rehabilitation) stages of stepwise ecological restoration, respectively. Thematic evolution analysis shows that, for more than 30 years, mine drainage and heavy metal pollution treatment, soil reconstruction (soil profile reconstruction, soil improvement), and vegetation restoration have been the focus of research. (3) Future research should focus on the relationship between mine ecological restoration and carbon sequestration and the relationship between ecological restoration and biodiversity in mine areas. In addition, LRER technology exchange, international cooperation, and industrialization are also main directions of development. Generally, in this study, metrology software (Bibliometrix R-package 3.1.4) ...
Keywords	mine ; land reclamation and ecological restoration (LRER) ; research status ; research directions ; Web of Science ; Bibliometrix ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	001
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multivariate path analysis of factors influencing Larix principis-rupprechtii plantation regeneration in northern China

Wenjun Liang / Xi Wei

Ecological Indicators, Vol 129, Iss , Pp 107886- (2021)

2021

Abstract: Forest regeneration is a critical indicator of the overall health of forest ecosystems, and is considered to be a vital process in which old and senescent trees are replaced by young ones. The seed-to-seedling transition entails seedlings’ emergence from ...

Abstract	Forest regeneration is a critical indicator of the overall health of forest ecosystems, and is considered to be a vital process in which old and senescent trees are replaced by young ones. The seed-to-seedling transition entails seedlings’ emergence from seeds and their establishment, this phase being the most vulnerable to mortality effects from biotic and abiotic factors. Larix principis-rupprechtii is a typical tree species in northern China, where the natural regeneration of artificial forests dominated by this species is very limited. This study explored the limiting factors affecting the natural regeneration of Larix principis-rupprechtii forests via field surveys of large-scale sampling plots. Redundancy analysis and structural equation models were developed and applied to determine the relative importance of direct and indirect factors affecting the regeneration of Larix principis-rupprechtii plantations. We found a negative relationship between the regeneration index and stand structure, for which the path coefficient was –0.54, the strongest correlation. Conversely, the regeneration index was positively correlated with the herb index, soil index, and elevation, having path coefficients of 0.06, 0.07, and 0.32, respectively. The soil index was negative correlated with both elevation and herb index, with path coefficients of –0.31 and –0.53, respectively, while stand structure was negatively correlated with the herb index and positively correlated with elevation (respective path coefficients: –0.62 and 0.29). Stand density and tree height to crown base were the main factors representing stand structure and, accordingly, the most important factors influencing forest regeneration of the species. At a stand density of ca. 200 trees·hm−2, the number and quality of seedling regeneration were robust. In later stages of stand management and thinning, the proper adjustment of stand density and timely pruning interventions can promote this tree’s natural regeneration to achieve the sustainable development of forest resources.
Keywords	Forest regeneration ; Limiting factor ; Artificial disturbance ; Forest sustainability ; Ecology ; QH540-549.5
Subject code	910
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Biomaterial scaffolds in maxillofacial bone tissue engineering

Xiangya Huang / Yaxin Lou / Yihong Duan / He Liu / Jun Tian / Ya Shen / Xi Wei

Bioactive Materials, Vol 33, Iss , Pp 129-

A review of recent advances

2024 Volume 156

Abstract: Maxillofacial bone defects caused by congenital malformations, trauma, tumors, and inflammation can severely affect functions and aesthetics of maxillofacial region. Despite certain successful clinical applications of biomaterial scaffolds, ideal bone ... ...

Abstract	Maxillofacial bone defects caused by congenital malformations, trauma, tumors, and inflammation can severely affect functions and aesthetics of maxillofacial region. Despite certain successful clinical applications of biomaterial scaffolds, ideal bone regeneration remains a challenge in maxillofacial region due to its irregular shape, complex structure, and unique biological functions. Scaffolds that address multiple needs of maxillofacial bone regeneration are under development to optimize bone regeneration capacity, costs, operational convenience. etc. In this review, we first highlight the special considerations of bone regeneration in maxillofacial region and provide an overview of the biomaterial scaffolds for maxillofacial bone regeneration under clinical examination and their efficacy, which provide basis and directions for future scaffold design. Latest advances of these scaffolds are then discussed, as well as future perspectives and challenges. Deepening our understanding of these scaffolds will help foster better innovations to improve the outcome of maxillofacial bone tissue engineering.
Keywords	Biomaterial scaffolds ; Maxillofacial region ; Bone regeneration ; Tissue engineering ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2024-03-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Forest Gaps Modulate the Composition and Co-Occurrence Network of Soil Bacterial Community in Larix principis-rupprechtii Mayr Plantation

Yajie Niu / Wenjun Liang / Xi Wei / Youzhi Han

Agronomy, Vol 13, Iss 38, p

2022 Volume 38

Abstract: Forest gaps create a favorable microenvironment for the growth of the soil microbial community. This study aimed to explore the effects of gap-related microenvironmental heterogeneity on soil bacterial communities in Larix principis-rupprechtii Mayr ... ...

Abstract	Forest gaps create a favorable microenvironment for the growth of the soil microbial community. This study aimed to explore the effects of gap-related microenvironmental heterogeneity on soil bacterial communities in Larix principis-rupprechtii Mayr forest gaps. Therefore, the redundancy analysis (RDA) and structure equations modeling (SEM) of affecting elements were further used to test the significance of forest gaps’ effect on soil bacterial community composition and co-occurrence structure complexity. The formation of forest gaps increased canopy opening (CO) and significantly increased soil moisture content (SW), soil temperature (ST) and the accumulation of acid phosphatase (PHO) and sucrase (INV) in the soil, and the G250 (forest gap size: >250 m 2 ) was most conductive to the accumulation of light and soil total nutrient. G50, G70, and G100 (forest gap size: 50–70 m 2 , 70–100 m 2 , 100–125 m 2 ) were most favorable for the natural regeneration of the L. principis-rupprechtii Mayr plantation. The light properties under the forest gaps were the most significant factor that influenced the soil bacterial community composition, followed by the size of the forest gap, with standard path coefficients (Std. PCs) of 0.45 and −0.37, respectively. The canopy opening (CO), relative light intensity (RLA) and leaf area index (LAI) were considered to be the most important environmental factors affecting bacterial community composition (Std. PCs: 0.97, 0.99, and −0.93, respectively). The natural regeneration density under the forest gap was the most significant factor influencing the complexity of the soil bacterial community co-occurrence network, followed by soil nutrients (Std. PCs: 0.87 and −0.76, respectively).
Keywords	forest gap ; microenvironmental factors ; soil bacteria ; Larix principis-rupprechtii Mayr ; Agriculture ; S
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Relationships between ecosystems above and below ground including forest structure, herb diversity and soil properties in the mountainous area of Northern China

Wenjun Liang / Xi Wei

Global Ecology and Conservation, Vol 24, Iss , Pp e01228- (2020)

2020

Abstract: One hundred field plots of 20 m × 20 m were established in a typical secondary forest of Populus davidiana and Betula platyphylla Suk. in the mountainous area of northern China. The aim was to explore quantitative tree–herb–soil relationships at three ... ...

Abstract	One hundred field plots of 20 m × 20 m were established in a typical secondary forest of Populus davidiana and Betula platyphylla Suk. in the mountainous area of northern China. The aim was to explore quantitative tree–herb–soil relationships at three different soil depths, using a structural equation model (SEM) approach to reveal the connection between the above and below ground ecosystems. The corrected model (ratio of the chi-square degree of freedom <3, p-value >0.05, the root meant square error of approximation <0.05, and all the fix indexes were from 0.9 to 1.0) confirmed that the total effects between tree canopy stand structure and understory herb diversity were negative and significant, with standard path coefficients (Std. PCs) of −0.87, −0.84, and −0.98 from the topsoil down to the deepest layer. The positive relationship of soil properties with stand structure (Std. PCs: 0.90, 0.30, and 0.01, respectively) and herb diversity (Std. PCs: 0.54, 0.44, and 0.32, respectively) decreased with soil depth, and the effect was greatest in the 0–20 cm layer. Average DBH, stand density, and Simpson index were the major drivers of structure and diversity, with path coefficients more than 0.8 at all the soil depths. Total phosphorus (Std. PC: 0.83 at 0–20 cm), total nitrogen (Std. PC: 0.62 at 20–40 cm), and available potassium and organic matter (Std. PCs: 0.86 and 0.77, respectively at 40–60 cm) were significant to soil properties, and even to trees and herbs. Hence, management to improve both the overstory and understory of forest ecosystems in similar mountainous area of northern China should be more targeted towards optimization of soil properties, stand structure, and herb diversity simultaneously, by increasing litter thickness as well as soil microbial activity of the topsoil, optimizing stand density, and planting different grass seeds.
Keywords	Structural equation modeling ; Stand structure ; Herb diversity ; Soil characteristics ; Above ground and below ground ecosystem ; Ecology ; QH540-549.5
Subject code	630
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Factors promoting the natural regeneration of Larix principis-rupprechtii plantation in the Lvliang Mountains of central China

Wenjun Liang / Xi Wei

PeerJ, Vol 8, p e

2020 Volume 9339

Abstract: Given their complexity, targeted care and management of different areas and tree species are necessary for enhancing the natural regeneration of forests. Thus, an understanding of changes in the overstory and understory is essential for ensuring ... ...

Abstract	Given their complexity, targeted care and management of different areas and tree species are necessary for enhancing the natural regeneration of forests. Thus, an understanding of changes in the overstory and understory is essential for ensuring successful regeneration. Promoting the natural regeneration of Larix principis-rupprechtii plantations is considered challenging; indeed, regional sustainable development through natural regeneration of many stands has often been considered unattainable. Here, we studied several plots with varying extents of regeneration to identify the most important factors that affect regeneration. The plots were divided into three forest types based on the number of regenerating plants. For each type of plot, we measured various factors that might potentially affect regeneration. Representational difference analysis was used to identify the most important factors >9% contribution). Based on these factors, multiple corrections were made to construct a structural equation model of topography, stand structure, soil properties and litter to identify the most important factors driving variation in regeneration. Positive correlations were detected between regeneration with diameter at breast height (0.21) and litter thickness (0.57). Regeneration was negatively correlated with soil (−0.54) and slope (−0.48). Additionally, the number of regenerating plants and the height of regenerating plants were strongly positively correlated. However, there was no significant relationship between regeneration and litter accumulation, stand density, altitude, average tree height, total P and total N. Overall, our study showed that key factors for promoting natural regeneration include appropriate litter thickness, strong parent trees, a gentle slope and sufficient quantities of soil nutrients. Moreover, our findings provide a reference for the design of effective management and restoration plans.
Keywords	Forest plantations ; Natural regeneration ; Environmental factors ; Forest structure ; Soil nutrients ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	580 ; 571
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pd-Catalyzed Cascade Cyclization/Thiocarbonylation with Thioformates: Synthesis of Thioester-Functionalized Oxindoles.

Zhu, Xi-Wei / Ye, Hao / Pan, Yi-Yun / Wu, Yanan / Wu, Xin-Xing

The Journal of organic chemistry

2024 Volume 89, Issue 5, Page(s) 3471–3480

Abstract: A Pd-catalyzed thiocarbonylative cyclization of N-( ...

Abstract	A Pd-catalyzed thiocarbonylative cyclization of N-(
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c02898
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Article ; Online: A cluster-randomized controlled trial of a nurse-led artificial intelligence assisted prevention and management for delirium (AI-AntiDelirium) on delirium in intensive care unit: Study protocol.

Zhang, Shan / Cui, Wei / Ding, Shu / Li, Xiangyu / Zhang, Xi-Wei / Wu, Ying

PloS one

2024 Volume 19, Issue 2, Page(s) e0298793

Abstract: Background: Delirium is a common complication among intensive care unit (ICU) patients that is linked to negative clinical outcomes. However, adherence to the Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, ... ...

Abstract	Background: Delirium is a common complication among intensive care unit (ICU) patients that is linked to negative clinical outcomes. However, adherence to the Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU (PADIS guidelines), which recommend the use of the ABCDEF bundle, is sub-optimal in routine clinical care. To address this issue, AI-AntiDelirium, a nurse-led artificial intelligence-assisted prevention and management tool for delirium, was developed by our research team. Our pilot study yielded positive findings regarding the use of AI-AntiDelirium in preventing patient ICU delirium and improving activities of daily living and increasing intervention adherence by health care staff. Methods: The proposed large-scale pragmatic, open-label, parallel-group, cluster randomized controlled study will assess the impact of AI-AntiDelirium on the incidence of ICU delirium and delirium-related outcomes. Six ICUs in two tertiary hospitals in China will be randomized in a 1:1 ratio to an AI-AntiDelirium or a PADIS guidelines group. A target sample size of 1,452 ICU patients aged 50 years and older treated in the ICU for at least 24 hours will be included. The primary outcome evaluated will be the incidence of ICU delirium and the secondary outcomes will be the duration of ICU delirium, length of ICU and hospital stay, ICU and in-hospital mortality rates, patient cognitive function, patient activities of daily living, and ICU nurse adherence to the ABCDEF bundle. Discussion: If this large-scale trial provides evidence of the effectiveness of AI-AntiDelirium, an artificial intelligence-assisted system tool, in decreasing the incidence of ICU delirium, length of ICU and hospital stay, ICU and in-hospital mortality rates, patient cognitive function, and patient activities of daily living while increasing ICU nurse adherence to the ABCDEF bundle, it will have a profound impact on the management of ICU delirium in both research and clinical practice. Clinical trial registration: ChiCTR1900023711 (Chinese Clinical Trial Registry).
MeSH term(s)	Aged ; Humans ; Middle Aged ; Activities of Daily Living ; Artificial Intelligence ; Delirium/drug therapy ; Delirium/prevention & control ; Intensive Care Units ; Nurse's Role ; Pilot Projects ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298793
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Influence of health-related behaviors patterns on obesity among primary and secondary school students: A latent profile analysis.

Li, Yin / Xu, Chang / Ban, Yanjing / Xi, Wei / Han, Yu / Zhang, Xin / Gao, Lei

Public health nursing (Boston, Mass.)

2024

Abstract: Objective: To analyze the co-existing patterns of health-related behaviors among children and adolescents at different education stages and the association with obesity.: Design: Cross-sectional study.: Sample: A total of 5651 primary and ... ...

Abstract	Objective: To analyze the co-existing patterns of health-related behaviors among children and adolescents at different education stages and the association with obesity. Design: Cross-sectional study. Sample: A total of 5651 primary and secondary school students were drawn from the National Student Physical Health Survey in 2014 with an average age of 13.53 ± 2.87 years. Measurements: Physical measurements and questionnaires were completed, which concluded height, weight, and health-related behaviors (sleep, physical activity, dietary, and screen behavior et al.). Latent profile analysis (LPA) was conducted using Mplus 8.3 and SPSS 26.0 was used for other statistical analysis. Results: Three latent classes of health-related behaviors were fitted for each of the education stages. After adjustment for age, gender, and region, the high-screen behavior group were 2.217 (95%CI = 1.030-4.772, p = .042) times more likely to be obesity than the health-behavior group in primary school, and the poor-diet group and poor-diet and high-screen behavior group were 2.101 (95%CI = 1.396-3.396, p < .001) and 1.788 (95%CI = 1.003-3.190, p = .049) times more likely to be overweight than the health-behavior group in junior middle school respectively. Conclusion: Obesity is mainly influenced by screen behavior and dietary patterns among children and adolescents. Health-related behavior patterns should be accurately identified and comprehensive joint interventions should be carried out to prevent obesity.
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	632563-4
ISSN	1525-1446 ; 0737-1209
ISSN (online)	1525-1446
ISSN	0737-1209
DOI	10.1111/phn.13327
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