Article ; Online: Sex differences in brain excitability revealed by concurrent iTBS/fNIRS.
2024 Volume 96, Page(s) 104043
Abstract: Sex differences have been claimed an imperative factor in the optimization of psychiatric treatments. Intermittent theta-burst stimulation (iTBS), a patterned form of repetitive transcranial magnetic stimulation, is a promising non-invasive treatment ... ...
Abstract | Sex differences have been claimed an imperative factor in the optimization of psychiatric treatments. Intermittent theta-burst stimulation (iTBS), a patterned form of repetitive transcranial magnetic stimulation, is a promising non-invasive treatment option. Here, we investigated whether the real-time neural response to iTBS differs between men and women, and which mechanisms may mediate these differences. To this end, we capitalized on a concurrent iTBS/functional near-infrared spectroscopy setup over the left dorsolateral prefrontal cortex, a common clinical target, to test our assumptions. In a series of experiments, we show (1) a biological sex difference in absolute hemoglobin concentrations in the left dorsolateral prefrontal cortex in healthy participants; (2) that this sex difference is amplified by iTBS but not by cognitive tasks; and (3) that the sex difference amplified by iTBS is modulated by stimulation intensity. These results inform future stimulation treatment optimizations towards precision psychiatry. |
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Language | English |
Publishing date | 2024-04-03 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 2456678-0 |
ISSN | 1876-2026 ; 1876-2018 |
ISSN (online) | 1876-2026 |
ISSN | 1876-2018 |
DOI | 10.1016/j.ajp.2024.104043 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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