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Article ; Online: Corrigendum to "Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose-sodium alginate composite sponges for accelerated wound healing" [International Journal of Biological Macromolecules volume 191 (2021) 27-39/10.1016/IJBIOMAC-D-21-05321].

Xie, Hongxia / Xia, Haoyang / Huang, Lin / Zhong, Zibiao / Ye, Qifa / Zhang, Lina / Lu, Ang

International journal of biological macromolecules

2023 Volume 249, Page(s) 126046

Language	English
Publishing date	2023-08-05
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.126046
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Article ; Online: Serum hsa-miR-98-5p and RORC may be new biomarkers related to esophageal cancer

Zhou Zheyu / Wang Yinyu / Li Wenwen / Xia Haoyang / Han Gaohua

E3S Web of Conferences, Vol 271, p

2021 Volume 03049

Abstract: This study aims to use bioinformatics methods to discover new serum miRNA markers for esophageal cancer, and provide a theoretical basis for early diagnosis of esophageal cancer. We used GEO2R to analyze the differential serum miRNAs in esophageal cancer ...

Abstract	This study aims to use bioinformatics methods to discover new serum miRNA markers for esophageal cancer, and provide a theoretical basis for early diagnosis of esophageal cancer. We used GEO2R to analyze the differential serum miRNAs in esophageal cancer based on GSE112264 from the GEO database. Then target genes of top 10 differential miRNAs were predicted. Obtain RNA-Seq data of esophageal cancer from the TCGA database, and use R software for analysis of differential expression. Overlap the predicted target genes with the differentially down-regulated genes, then perform analysis of GO and KEGG enrichment. Use GEPIA and UALCAN databases to perform verification of expression and prognostic analysis of key genes in the pathway. The results showed there are 2565 differential miRNAs in the serum of esophageal cancer patients. The top 10 up-regulated miRNAs predicted 1676 target genes, then 63 overlapped genes were obtained from target genes and 1642 down-regulated genes. GO enrichment obtained 14 biological processes, and KEGG enrichment obtained the circadian rhythm pathway. Only RORC is related to the poor prognosis of patients with esophageal cancer. Our study concluded serum hsa-miR-98-5p and its target gene RORC may be new biological markers for early diagnosis and treatment of esophageal cancer.
Keywords	Environmental sciences ; GE1-350
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing

Xie, Hongxia / Xia, Haoyang / Huang, Lin / Zhong, Zibiao / Ye, Qifa / Zhang, Lina / Lu, Ang

International journal of biological macromolecules. 2021 Nov. 30, v. 191

2021

Abstract: Bacterial infection has become one of the most challenges for wound healing, which causes serious inflammatory response and delays the healing process. Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties ... ...

Abstract	Bacterial infection has become one of the most challenges for wound healing, which causes serious inflammatory response and delays the healing process. Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn²⁺ was reported. The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding endowed the sponges with enhanced mechanical property. The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn²⁺ release and quaternary ammonium group. In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration. Overall, the novel sponge demonstrated great potentials in bacteria-associated wound management.
Keywords	anti-inflammatory activity ; antibacterial properties ; bacterial infections ; biocompatibility ; cellulose ; chelation ; collagen ; crosslinking ; electrostatic interactions ; epithelium ; hydrogen ; inflammation ; mechanical properties ; quaternary ammonium compounds ; sodium alginate ; wound treatment ; zinc
Language	English
Dates of publication	2021-1130
Size	p. 27-39.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2021.09.047
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing.

Xie, Hongxia / Xia, Haoyang / Huang, Lin / Zhong, Zibiao / Ye, Qifa / Zhang, Lina / Lu, Ang

International journal of biological macromolecules

2021 Volume 191, Page(s) 27–39

Abstract	Bacterial infection has become one of the most challenges for wound healing, which causes serious inflammatory response and delays the healing process. Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn
MeSH term(s)	Alginates/chemistry ; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Bandages, Hydrocolloid ; Cell Line ; Cellulose/analogs & derivatives ; Cross-Linking Reagents/chemistry ; Mice ; Nanogels/chemistry ; Quaternary Ammonium Compounds/chemistry ; Rats ; Rats, Sprague-Dawley ; Staphylococcus aureus/drug effects ; Wound Healing ; Zinc/chemistry
Chemical Substances	Alginates ; Anti-Bacterial Agents ; Anti-Inflammatory Agents ; Cross-Linking Reagents ; Nanogels ; Quaternary Ammonium Compounds ; Cellulose (9004-34-6) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2021-09-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2021.09.047
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Article ; Online: Effect of Matrix Metalloproteinase 23 Accelerating Wound Healing Induced by Hydroxybutyl Chitosan.

Xia, Haoyang / Hu, Qianchao / Yang, Yi / Yuan, Haoran / Cai, Yan / Liu, Zhongzhong / Xu, Zhigao / Xiong, Yan / Zhou, Jinping / Ye, Qifa / Zhong, Zibiao

ACS applied bio materials

2023 Volume 6, Issue 4, Page(s) 1460–1470

Abstract: Skin wounds may cause severe financial and social burden due to the difficulties in wound healing. Original inert dressings cannot meet multiple needs in the process of wound healing. Therefore, the development of materials to accelerate healing progress ...

Abstract	Skin wounds may cause severe financial and social burden due to the difficulties in wound healing. Original inert dressings cannot meet multiple needs in the process of wound healing. Therefore, the development of materials to accelerate healing progress is essential and urgent. In the previous study, we found that the homogeneously synthesized hydroxybutyl chitosan (HBCS) had an effective performance in promoting wound healing. Proteomic analysis of the same specimen suggested that matrix metalloproteinase 23 (MMP23) may play a key role in HBCS expediting the progress of wound healing. In this work, we aim to reveal the underlying mechanism of MMP23 in the dynamic process of cutaneous proliferation and repair period. In order to regulate the expression level of MMP23 in the local wound area, we leaded in adeno-associated virus (AAV) to specifically decreased expression quantity of MMP23 in rat skin. In contrast to the negative control groups, we found that the wound closed faster and the collagen fibers and neovascularization were significantly increased in AAV groups. These findings highlighted that MMP23 was involved in wound healing after traumatic injury, and managing the expression of MMP23 could be a potential intervention target to accelerate wound healing.
MeSH term(s)	Animals ; Rats ; Chitosan/pharmacology ; Proteomics ; Skin ; Wound Healing ; Metalloendopeptidases/metabolism
Chemical Substances	Chitosan (9012-76-4) ; hydroxybutyl chitosan ; Metalloendopeptidases (EC 3.4.24.-)
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.2c01008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Vagus Nerve Stimulation Alleviates Hepatic Ischemia and Reperfusion Injury by Regulating Glutathione Production and Transformation.

Xia, Haoyang / Liu, Zhongzhong / Liang, Wenjin / Zeng, Xianpeng / Yang, Yi / Chen, Pu / Zhong, Zibiao / Ye, Qifa

Oxidative medicine and cellular longevity

2020 Volume 2020, Page(s) 1079129

Abstract: Inflammation and oxidative stress are pivotal mechanisms for the pathogenesis of ischemia and reperfusion injury (IRI). Vagus nerve stimulation (VNS) may participate in maintaining oxidative homeostasis and response to external stimulus or injury. We ... ...

Abstract	Inflammation and oxidative stress are pivotal mechanisms for the pathogenesis of ischemia and reperfusion injury (IRI). Vagus nerve stimulation (VNS) may participate in maintaining oxidative homeostasis and response to external stimulus or injury. We investigated whether the
MeSH term(s)	Animals ; Antioxidants/metabolism ; Apoptosis/genetics ; Cytokines/metabolism ; Glutathione/biosynthesis ; Glutathione/blood ; Glutathione/metabolism ; Glutathione Peroxidase/blood ; Glutathione Synthase/genetics ; Glutathione Synthase/metabolism ; Glutathione Transferase/genetics ; Glutathione Transferase/metabolism ; Hepatocytes/enzymology ; Hepatocytes/metabolism ; Liver/enzymology ; Liver/injuries ; Liver/metabolism ; Liver/pathology ; Liver Diseases/enzymology ; Liver Diseases/metabolism ; Liver Diseases/pathology ; Liver Diseases/therapy ; Male ; Oxidative Stress ; Proteomics ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/enzymology ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Reperfusion Injury/therapy ; Signal Transduction/genetics ; Vagus Nerve Stimulation
Chemical Substances	Antioxidants ; Cytokines ; Glutathione Peroxidase (EC 1.11.1.9) ; Glutathione Transferase (EC 2.5.1.18) ; Glutathione Synthase (EC 6.3.2.3) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2020-01-21
Publishing country	United States
Document type	Journal Article
ISSN	1942-0994
ISSN (online)	1942-0994
DOI	10.1155/2020/1079129
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Homogeneously Synthesized Hydroxybutyl Chitosans in Alkali/Urea Aqueous Solutions as Potential Wound Dressings.

Cai, Yan / Zhong, Zibiao / He, Chen / Xia, Haoyang / Hu, Qianchao / Wang, Yanfeng / Ye, Qifa / Zhou, Jinping

ACS applied bio materials

2019 Volume 2, Issue 10, Page(s) 4291–4302

Abstract: Wound healing is a clinical challenge, and nontoxic, nonadherent wound dressings that promote healing are urgently needed. Herein, hydroxybutyl chitosans (HBCSs) with the degree of substitution (DS) from 0.41 to 1.38 were synthesized in alkali/urea ... ...

Abstract	Wound healing is a clinical challenge, and nontoxic, nonadherent wound dressings that promote healing are urgently needed. Herein, hydroxybutyl chitosans (HBCSs) with the degree of substitution (DS) from 0.41 to 1.38 were synthesized in alkali/urea aqueous solutions, from which sponge-like dressings were prepared by freeze-drying. The pore size of the sponges was in the range of 14.8-18.4 μm, and the porosity was about 98-99%. The compressive strength of the sponges decreased with increasing DS of HBCS. Cytocompatibility studies with normal human dermal fibroblast (NHDF) cells demonstrated that HBCSs were nontoxic and could even promote the growth of fibroblasts. Further tests revealed that HBCS-3 (DS = 0.85) and HBCS-5 (DS = 1.38) exhibited better hemocompatibility and a low blood-clotting index (BCI). Therefore, these two samples were selected as model dressings for
Language	English
Publishing date	2019-10-01
Publishing country	United States
Document type	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.9b00553
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Construction of cellulose nanofibers/quaternized chitin/organic rectorite composites and their application as wound dressing materials.

Gao, Huimin / Zhong, Zibiao / Xia, Haoyang / Hu, Qianchao / Ye, Qifa / Wang, Yanfeng / Chen, Lingyun / Du, Yumin / Shi, Xiaowen / Zhang, Lina

Biomaterials science

2019 Volume 7, Issue 6, Page(s) 2571–2581

Abstract: Traumatic injury is a major cause of mortality, and poor wound healing affects millions of people. Thus, the development of effective wound dressings is essential for speeding up wound healing and decreasing mortality. In this study, a suspension of ... ...

Abstract	Traumatic injury is a major cause of mortality, and poor wound healing affects millions of people. Thus, the development of effective wound dressings is essential for speeding up wound healing and decreasing mortality. In this study, a suspension of carboxylated brown algae cellulose nanofibers (BACNFs) with a high aspect ratio was freeze dried to prepare a sponge. The sponge showed high porosity and water absorption capacity; thus, it can absorb wound exudates when used as a wound dressing. In addition, quaternized β-chitin (QC) with antibacterial properties was intercalated into the interlayer space of the organic rectorite (OREC) via electrostatic interactions to obtain composite suspensions (QCRs) with improved antimicrobial activity compared to that of QC alone. Subsequently, the BACNF sponge was soaked in the QCR suspension to absorb QCRs via electrostatic interactions and hydrogen bonding from which cellulose nanofiber/quaternized chitin/organic rectorite composite (BACNF/QCR) sponges were constructed via freeze-drying. The in vivo animal tests demonstrated that the BACNF/QCR sponges rapidly induced hemostasis in a rat tail amputation test, making them superior to the traditional hemostatic materials. Furthermore, BACNFs/QCRs could substantially promote collagen synthesis and neovascularization, thereby accelerating wound healing 3 days earlier than gauze. This multi-functional biomedical material, fabricated using natural substances, shows great potential to be used for wound healing.
MeSH term(s)	Aluminum Silicates/chemistry ; Animals ; Bandages/microbiology ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Cell Line ; Cellulose/chemistry ; Chitin/chemistry ; Escherichia coli/drug effects ; Freeze Drying ; Hemostasis/drug effects ; Humans ; Male ; Materials Testing ; Minerals/chemistry ; Nanocomposites/chemistry ; Nanofibers/chemistry ; Rats ; Rats, Sprague-Dawley ; Staphylococcus aureus/drug effects ; Wound Healing/drug effects
Chemical Substances	Aluminum Silicates ; Biocompatible Materials ; Minerals ; rectorite ; Chitin (1398-61-4) ; Cellulose (9004-34-6)
Language	English
Publishing date	2019-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/c9bm00288j
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction: Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury.

Zhou, Wei / Zhong, Zibiao / Lin, Danni / Liu, Zhongzhong / Zhang, Qiuyan / Xia, Haoyang / Peng, Sheng / Liu, Anxiong / Lu, Zhongshan / Wang, Yanfeng / Ye, Shaojun / Ye, Qifa

Cell death & disease

2021 Volume 12, Issue 6, Page(s) 567

Language	English
Publishing date	2021-06-02
Publishing country	England
Document type	Published Erratum
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-021-03840-3
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Article ; Online: Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury.

Zhou, Wei / Zhong, Zibiao / Lin, Danni / Liu, Zhongzhong / Zhang, Qiuyan / Xia, Haoyang / Peng, Sheng / Liu, Anxiong / Lu, Zhongshan / Wang, Yanfeng / Ye, Shaojun / Ye, Qifa

Cell death & disease

2021 Volume 12, Issue 2, Page(s) 211

Abstract: Ischemia-reperfusion injury (IRI) is an inevitable and serious clinical problem in donations after heart death (DCD) liver transplantation. Excessive sterile inflammation plays a fateful role in liver IRI. Hypothermic oxygenated perfusion (HOPE), as an ... ...

Abstract	Ischemia-reperfusion injury (IRI) is an inevitable and serious clinical problem in donations after heart death (DCD) liver transplantation. Excessive sterile inflammation plays a fateful role in liver IRI. Hypothermic oxygenated perfusion (HOPE), as an emerging organ preservation technology, has a better preservation effect than cold storage (CS) for reducing liver IRI, in which regulating inflammation is one of the main mechanisms. HECTD3, a new E3 ubiquitin ligase, and TRAF3 have an essential role in inflammation. However, little is known about HECTD3 and TRAF3 in HOPE-regulated liver IRI. Here, we aimed to investigate the effects of HOPE on liver IRI in a DCD rat model and explore the roles of HECTD3 and TRAF3 in its pathogenesis. We found that HOPE significantly improved liver damage, including hepatocyte and liver sinusoidal endothelial cell injury, and reduced DCD liver inflammation. Mechanistically, both the DOC and HECT domains of HECTD3 directly interacted with TRAF3, and the catalytic Cys (C832) in the HECT domain promoted the K63-linked polyubiquitination of TRAF3 at Lys138. Further, the ubiquitinated TRAF3 at Lys138 increased oxidative stress and activated the NF-κB inflammation pathway to induce liver IRI in BRL-3A cells under hypoxia/reoxygenation conditions. Finally, we confirmed that the expression of HECTD3 and TRAF3 was obviously increased in human DCD liver transplantation specimens. Overall, these findings demonstrated that HOPE can protect against DCD liver transplantation-induced-liver IRI by reducing inflammation via HECTD3-mediated TRAF3 K63-linked polyubiquitination. Therefore, HOPE regulating the HECTD3/TRAF3 pathway is a novel target for improving IRI in DCD liver transplantation.
MeSH term(s)	Animals ; Cell Hypoxia ; Cell Line ; Disease Models, Animal ; Hepatectomy ; Humans ; Hypothermia, Induced ; Inflammation Mediators/metabolism ; Liver/blood supply ; Liver/metabolism ; Liver/pathology ; Liver/surgery ; Liver Circulation ; Liver Transplantation ; Male ; Organ Preservation ; Oxidative Stress ; Perfusion ; Rats, Sprague-Dawley ; Reperfusion Injury/genetics ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Reperfusion Injury/prevention & control ; TNF Receptor-Associated Factor 3/genetics ; TNF Receptor-Associated Factor 3/metabolism ; Tissue and Organ Harvesting ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; Rats
Chemical Substances	Inflammation Mediators ; TNF Receptor-Associated Factor 3 ; TRAF3 protein, human ; Hectd3 protein, human (EC 2.3.2.26) ; Hectd3 protein, rat (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2021-02-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-021-03493-2
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