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Article ; Online: Association of Preoperative Subchondral Bone Marrow Oedema with Outcomes after Lateral Unicompartmental Knee Arthroplasty.

Jiang, Qilong / Bai, Xinwen / Deng, Yu / Xia, Huan

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2024 Volume 34, Issue 5, Page(s) 610–613

Abstract: Objective: To determine whether the presence of preoperative subchondral bone marrow oedema (SBME) is associated with inferior outcomes after lateral unicompartmental knee arthroplasty (LUKA).: Study design: Descriptive study. Place and Duration of ... ...

Abstract	Objective: To determine whether the presence of preoperative subchondral bone marrow oedema (SBME) is associated with inferior outcomes after lateral unicompartmental knee arthroplasty (LUKA). Study design: Descriptive study. Place and Duration of the Study: Department of Orthopaedic Surgery, Chongqing Orthopaedic Hospital of Traditional Chinese Medicine, Chongqing, China, from January 2019 to June 2022. Methodology: Data on patients treated with LUKA were obtained from the Medical Registry Database. Two groups were made based on the presence and absence of SBME on preoperative magnetic resonance imaging (MRI). The visual analogue scale (VAS), American Knee Society Scores (AKSS), and rate of patient satisfaction were compared between the two groups. Results: A total of 20 patients treated with LUKA were reviewed. The SBME was present in 9 cases and absent in 11 cases. Patients with SBME had inferior scores at preoperative evaluation and at 1, 3, and 6 months postoperatively. However, there was no significant difference between the groups at the 12-month follow-up. Eight (88.9%) patients with SBME were satisfied with the LUKA surgery versus 9 (81.8%) patients without SBME, showing no significant differences between groups. Conclusion: Presence of preoperative SBME is associated with inferior functional outcomes after LUKA within six months of follow-up. Key words: Bone marrow, Oedema, Knee, Arthroplasty, Outcome, Patient satisfaction.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Knee/methods ; Male ; Female ; Middle Aged ; Edema/etiology ; Aged ; Bone Marrow Diseases/surgery ; Treatment Outcome ; Magnetic Resonance Imaging ; Patient Satisfaction ; Osteoarthritis, Knee/surgery ; Retrospective Studies ; Knee Joint/surgery ; Preoperative Period ; Bone Marrow/pathology ; China/epidemiology
Language	English
Publishing date	2024-05-09
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2024.05.610
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Article ; Online: Design and key construction technology of steel-concrete-steel sandwich composite pylon for a large span cable-stayed bridge.

Pei, Bida / Chong, Aixiu / Xia, Huan / Kang, Xueyun

Scientific reports

2023 Volume 13, Issue 1, Page(s) 6626

Abstract: This paper introduces a new type of steel-concrete composite pylon that has been applied to Nanjing Fifth Yangtze River Bridge (a three-pylon cable-stayed bridge with a main span of 600 m). For this new type of pylon, the steel shells are connected with ... ...

Abstract	This paper introduces a new type of steel-concrete composite pylon that has been applied to Nanjing Fifth Yangtze River Bridge (a three-pylon cable-stayed bridge with a main span of 600 m). For this new type of pylon, the steel shells are connected with concrete through PBL shear connectors and studs, and the inner steel shells are connected with the outer steel shells by angle steels. Numerical analysis and full-scale model tests show that the pylon structure exhibits excellent mechanical properties and construction performance. The application of BIM technology, the research and development of special spreaders and construction platforms ensure the precise installation of structures. Highly factory-manufactured modular assembly of the reinforced steel shell structure can effectively reduce the intensity and difficulty of on-site operations, and improve the quality of the project, with low construction risks. Whereas, the successful application of this steel-concrete-steel sandwich composite pylon marks the formation of a complete set of construction technology of steel-concrete-steel sandwich composite pylon, which can be widely used in similar bridges.
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-33316-7
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Article ; Online: Retraction notice to "Long noncoding RNA HOXD-AS1 promotes non-small cell lung cancer migration and invasion through regulating miR-133b/MMP9 axis" [Biomed. Pharmacother. 106 (2018) 156-162].

Xia, Huan / Jing, Hongyu / Li, Yang / Lv, Xiaohong

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 169, Page(s) 115376

Language	English
Publishing date	2023-11-27
Publishing country	France
Document type	Journal Article ; Retraction of Publication
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115376
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Article ; Online: The role of HLA-DR on plasmacytoid dendritic cells in mediating the effects of Butyrivibrio gut microbiota on Parkinson's disease.

Wang, Zihao / Xia, Huan / Feng, Tingting / Aibibuli, Adilai / Zhang, Mingyang / Yang, Xinling

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2024

Abstract: Background: Parkinson's disease (PD) is viewed as a progressively deteriorating neurodegenerative disorder, the exact etiology of which remains not fully deciphered to this date. The gut microbiota could play a crucial role in PD development by ... ...

Abstract	Background: Parkinson's disease (PD) is viewed as a progressively deteriorating neurodegenerative disorder, the exact etiology of which remains not fully deciphered to this date. The gut microbiota could play a crucial role in PD development by modulating the human immune system. Objective: This study aims to explore the relationship between gut microbiota and PD, focusing on how immune characteristics may both directly and indirectly influence their interaction. Methods: Utilizing cumulative data from genome-wide association studies (GWAS), our research conducted a two-sample Mendelian randomization (MR) analysis to clarify the association between the gut microbiome and PD. Additionally, by employing a two-step MR approach, we assessed the impact of gut microbiota on PD development via immune characteristics and quantified HLA-DR mediation effect on plasmacytoid dendritic cells (pDCs). Results: We discovered significant associations between PD and microbiota, comprising one class, one order, two families, and two genera. Furthermore, we explored the extent to which HLA-DR on pDCs mediates the effect of Butyrivibrio gut microbiota on PD. Conclusion: Our study emphasizes the complex interactions between the gut microbiota, immune characteristics, and PD. The relationships and intermediary roles identified in our research provide important insights for developing potential therapies that target the gut microbiome to alleviate symptoms in PD patients.
Language	English
Publishing date	2024-03-19
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-024-07467-y
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Article ; Online: A new resorcylic acid lactone from the endophytic fungus

Wang, Min / Xia, Gui-Yang / Liang, Yong-Xin / Xia, Huan / Lin, Peng-Cheng / Lin, Sheng

Journal of Asian natural products research

2024 , Page(s) 1–8

Abstract: A new 14-membered resorcylic acid lactone ( ... ...

Abstract	A new 14-membered resorcylic acid lactone (RAL
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2024.2335254
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Article ; Online: Rapid Initiation of Antiretroviral Therapy Under the Treat-All Policy Reduces Loss to Follow-Up and Virological Failure in Routine Human Immunodeficiency Virus Care Settings in China: A Retrospective Cohort Study (2016-2022).

Xia, Huan / Li, Lei / Wu, Yue / Gao, Liying / Zhang, Defa / Ma, Ping

AIDS patient care and STDs

2024 Volume 38, Issue 4, Page(s) 168–176

Abstract: Following the World Health Organization's guidelines for rapid antiretroviral therapy (ART) initiation [≤7 days after human immunodeficiency virus (HIV) diagnosis], China implemented Treat-All in 2016 and has made significant efforts to provide timely ... ...

Abstract	Following the World Health Organization's guidelines for rapid antiretroviral therapy (ART) initiation [≤7 days after human immunodeficiency virus (HIV) diagnosis], China implemented Treat-All in 2016 and has made significant efforts to provide timely ART since 2017. This study included newly diagnosed HIV adults from Tianjin, China, between 2016 and 2022. Our primary outcome was loss to follow-up (LTFU) at 12 months after enrollment. The secondary outcome was 12-month virological failure. The association between rapid ART and LTFU, as well as virological failure, was assessed
MeSH term(s)	Humans ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV Infections/epidemiology ; Female ; Male ; China/epidemiology ; Adult ; Retrospective Studies ; Anti-HIV Agents/therapeutic use ; Anti-HIV Agents/administration & dosage ; Viral Load ; Middle Aged ; Lost to Follow-Up ; CD4 Lymphocyte Count ; Treatment Failure ; Antiretroviral Therapy, Highly Active/methods ; Time Factors ; Time-to-Treatment/statistics & numerical data
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1326868-5
ISSN	1557-7449 ; 0893-5068 ; 1087-2914
ISSN (online)	1557-7449
ISSN	0893-5068 ; 1087-2914
DOI	10.1089/apc.2024.0045
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Article: Study on Dynamic Crack Expansion and Size Effect of Back-Filling Concrete under Uniaxial Compression.

Gao, Xicai / Xia, Huan / Fan, Kai / Yi, Leilei / Yin, Jianhui

Materials (Basel, Switzerland)

2023 Volume 16, Issue 23

Abstract: With the continuous expansion of the application range of gob-side entry retaining technology, the depth, height, and advancing speed of coal seams also increase, which brings great problems to the stability control of surrounding rock structures of gob- ... ...

Abstract	With the continuous expansion of the application range of gob-side entry retaining technology, the depth, height, and advancing speed of coal seams also increase, which brings great problems to the stability control of surrounding rock structures of gob-side entry retaining. As one of the main bearing structures of the surrounding rock, the stability of the roadway-side support body is a key factor for the success of gob-side entry retaining. In order to study the deformation characteristics and instability mechanism of roadway-side support body, based on the roadway-side support materials of gob-side entry retaining, the dynamic expansion test of back-filling concrete cracks under uniaxial compression was carried out. The YOLOv5 algorithm was applied to establish the fine identification and quantitative characterization method of macroscopic cracks of the samples, and the dynamic expansion rule of roadway-side support body cracks and its dimensional effect were revealed by combining the fractal theory. The results show that the F1 value and average precision mean of the intelligent dynamic crack identification model reached 75% and 71%, respectively, the GIoU loss value tends to fit around 0.038, and the model reached the overall optimal solution. During the uniaxial compression process, micro cracks on the surface of the back-filling concrete first initiated at the end, and after reaching the yield stress, the macroscopic cracks developed significantly. Moreover, several secondary cracks expanded, pooled, and connected from the middle of the specimen to the two ends, inducing the overall instability of the specimen. The surface crack expansion rate, density, and fractal dimension all show stage change characteristics with the increase in stress, and the main crack expansion rate has obvious precursor characteristics. With the increase in the size, the decrease in crack density after back-filling concrete failures gradually decreases from 93.19% to 4.08%, the surface crack network develops from complex to simple, and the failure mode transits from tensile failure to shear failure. The above research results provide a basic experimental basis for design optimization and instability prediction of a roadway-side support body for engineering-scale applications.
Language	English
Publishing date	2023-12-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16237503
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Article ; Online: Pretreatment integrase strand transfer inhibitor resistance in Tianjin, China.

Xia, Huan / Ge, Zhangwen / Zhang, Defa / Wu, Yue / Ma, Ping

Chinese medical journal

2023 Volume 136, Issue 22, Page(s) 2735–2737

MeSH term(s)	Humans ; HIV Infections ; HIV-1 ; Integrases ; China ; Drug Resistance, Viral ; Mutation
Chemical Substances	Integrases (EC 2.7.7.-)
Language	English
Publishing date	2023-11-03
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000002898
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Ua VI Zs.425: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Co-immobilization of β-xylosidase and endoxylanase on zirconium based metal-organic frameworks for improving xylosidase activity at high temperature and in acetone.

Li, Na / Xia, Huan / Jiang, Yanbin / Xiong, Jun / Lou, Wenyong

Bioresource technology

2023 Volume 383, Page(s) 129240

Abstract: Improving the activity of β-xylosidase at high temperature and organic solvents is important for the conversion of xylan, phytochemicals and some hydroxyl-containing substances to produce xylose and bioactive substances. In this study, a β-xylosidase ... ...

Abstract	Improving the activity of β-xylosidase at high temperature and organic solvents is important for the conversion of xylan, phytochemicals and some hydroxyl-containing substances to produce xylose and bioactive substances. In this study, a β-xylosidase R333H and an endoxylanase were simultaneously co-immobilized on the metal-organic framework UiO-66-NH
MeSH term(s)	Endo-1,4-beta Xylanases ; Zirconium ; Temperature ; Xylans ; Acetone ; Metal-Organic Frameworks ; Enzymes, Immobilized ; Hydrogen-Ion Concentration ; Xylosidases/chemistry
Chemical Substances	exo-1,4-beta-D-xylosidase (EC 3.2.1.37) ; Endo-1,4-beta Xylanases (EC 3.2.1.8) ; Zirconium (C6V6S92N3C) ; Xylans ; Acetone (1364PS73AF) ; Metal-Organic Frameworks ; Enzymes, Immobilized ; Xylosidases (EC 3.2.1.-)
Language	English
Publishing date	2023-05-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129240
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Article ; Online: β-Xylosidase mutant immobilization on UiO-66-NH2 for continuous production of ginsenoside Rg1 and selective production of furfural from notoginsenoside R1

Li, Na / Xia, Huan / Liu, Shiyuan / Teng, Junjiang / Jiang, Yanbin

Industrial Crops & Products. 2023 July, v. 197 p.116563-

2023

Abstract: In order to improve the activity and reusability of β-xylosidase, the β-xylosidase mutant S160N-R333H (R333H) which could convert notoginsenoside R1 to ginsenoside Rg1 and xylose was immobilized on the metal-organic framework (MOF) UiO-66-NH₂. The ... ...

Abstract	In order to improve the activity and reusability of β-xylosidase, the β-xylosidase mutant S160N-R333H (R333H) which could convert notoginsenoside R1 to ginsenoside Rg1 and xylose was immobilized on the metal-organic framework (MOF) UiO-66-NH₂. The physical and biochemical properties of immobilized β-xylosidase (R333H@UiO-66-NH₂) were studied in detail. The results showed improved performances, i.e. the high immobilization yield of 93% and recovery activity of 192.8%, better stability under acidic or trypsin-containing conditions, the higher activity in the reaction containing ions, and the improved catalytic efficiency (was 1.37-fold than that of free R333H). Importantly, the ginsenoside Rg1 yields remained more than 80% after six recycles in McIlvaine buffer and pure water. The UiO-66-NH₂ could catalyze xylose dehydration to produce furfural and the yield reached 69%. Thus this study provides a promising method for production of bioactive or platform chemicals via continuous conversion of xyloylated substrates using nanocatalyst synthesized by β-xylosidase and MOF.
Keywords	catalytic activity ; coordination polymers ; furfural ; ginsenosides ; mutants ; nanocatalysts ; xylose ; Ginsenoside Rg1 ; β-xylosidase ; Immobilization ; Metal-organic framework
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2023.116563
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