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  1. Article ; Online: The Proteostasis of Thymic Stromal Cells in Health and Diseases.

    Liu, Ting / Xia, Sheng

    The protein journal

    2024  

    Abstract: The thymus is the key immune organ for the development of T cells. Different populations of thymic stromal cells interact with T cells, thereby controlling the dynamic development of T cells through their differentiation and function. Proteostasis ... ...

    Abstract The thymus is the key immune organ for the development of T cells. Different populations of thymic stromal cells interact with T cells, thereby controlling the dynamic development of T cells through their differentiation and function. Proteostasis represents a balance between protein expression, folding, and modification and protein clearance, and its fluctuation usually depends at least partially on related protein regulatory systems for further survival and effects. However, in terms of the substantial requirement for self-antigens and their processing burden, increasing evidence highlights that protein regulation contributes to the physiological effects of thymic stromal cells. Impaired proteostasis may expedite the progression of thymic involution and dysfunction, accompanied by the development of autoimmune diseases or thymoma. Hence, in this review, we summarize the regulation of proteostasis within different types of thymic stromal cells under physiological and pathological conditions to identify potential targets for thymic regeneration and immunotherapy.
    Language English
    Publishing date 2024-04-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2143071-8
    ISSN 1875-8355 ; 1572-3887
    ISSN (online) 1875-8355
    ISSN 1572-3887
    DOI 10.1007/s10930-024-10197-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: NK-like CD8 T Cell: One Potential Evolutionary Continuum between Adaptive Memory and Innate Immunity.

    Wang, Qiulei / Chen, Shaodan / Guo, Zhenhong / Xia, Sheng / Zhang, Minghui

    Clinical and experimental immunology

    2024  

    Abstract: CD8 T cells are crucial adaptive immune cells with cytotoxicity to fight against pathogens or abnormal self-cells via major histocompatibility complex class I-dependent priming pathways. The composition of the memory CD8 T cell pool is influenced by ... ...

    Abstract CD8 T cells are crucial adaptive immune cells with cytotoxicity to fight against pathogens or abnormal self-cells via major histocompatibility complex class I-dependent priming pathways. The composition of the memory CD8 T cell pool is influenced by various factors. Physiological aging, chronic viral infection, and autoimmune diseases promote the accumulation of CD8 T cells with highly differentiated memory phenotypes. Accumulating studies have shown that some of these memory CD8 T cells also exhibit innate-like cytotoxicity and upregulate the expression of receptors associated with natural killer (NK) cells. Further analysis shows that these NK-like CD8 T cells have transcriptional profiles of both NK and CD8 T cells, suggesting the transformation of CD8 T cells into NK cells. However, the specific induction mechanism underlying NK-like transformation and the implications of this process for CD8 T cells are still unclear. This review aimed to deduce the possible differentiation model of NK-like CD8 T cells, summarize the functions of major NK cell receptors expressed on these cells and provide a new perspective for exploring the role of these CD8 T cells in health and disease.
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1093/cei/uxae038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 337: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: New-Onset Arthritis Following COVID-19 Vaccination: A Systematic Review of Case Reports.

    Liu, Jie / Wu, Hui / Xia, Sheng-Li

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: Coronavirus disease 2019 (COVID-19) vaccine has effectively suppressed the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and alleviated its symptoms, but there are also many adverse events. Joint diseases caused by COVID-19 ... ...

    Abstract Coronavirus disease 2019 (COVID-19) vaccine has effectively suppressed the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and alleviated its symptoms, but there are also many adverse events. Joint diseases caused by COVID-19 vaccine have been reported in many studies. Some are well-controlled arthritis patients who developed arthritis after COVID-19 vaccination, while others are new-onset joint pain and swelling problems after COVID-19 vaccination. The purpose of this systematic review is to examine the literature reports in existing databases and analyze the incidence of new-onset arthritis after COVID-19 vaccination. We included 31 eligible articles and described 45 patients, ranging in age from 17 to over 90, with more females than males. The majority (84.4%) of patients received the adenovirus vector vaccine (ChAdOx1) and the mRNA-based vaccine (BNT126b2 and mRNA-1273). Most (64.4%) patients developed joint-related symptoms after the first dose of vaccine, and 66.7% developed symptoms within the first week of vaccination. The joint symptoms involved were mainly joint swelling, joint pain, limited range of motion, and so on. A total of 71.1% of the patients involved multiple joints, both large and small; 28.9% of patients involved only a single joint. Some (33.3%) patients were confirmed by imaging, and the most common diagnoses were bursitis and synovitis. Two nonspecific inflammatory markers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were monitored in almost all cases, and all patients showed varying degrees of increase in these two markers. Most of the patients received the treatment of glucocorticoid drugs or nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical symptoms markedly improved in most patients, with 26.7% making a full recovery and no relapse after a few months of follow-up. To determine whether there is a causal relationship between COVID-19 vaccination and the triggering of arthritis, large-scale and well-controlled research studies are needed in the future to verify this relationship and to further study its pathogenesis in detail. Clinicians should raise awareness of this complication with a view to early diagnosis and appropriate treatment.
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Endoplasmic reticulum stress in T cell-mediated diseases.

    Chen, Shaodan / Wang, Qiulei / Wang, Hui / Xia, Sheng

    Scandinavian journal of immunology

    2023  Volume 98, Issue 3, Page(s) e13307

    Abstract: T cells synthesize a large number of proteins during their development, activation, and differentiation. The build-up of misfolded and unfolded proteins in the endoplasmic reticulum, however, causes endoplasmic reticulum (ER) stress. Thus, T cells can ... ...

    Abstract T cells synthesize a large number of proteins during their development, activation, and differentiation. The build-up of misfolded and unfolded proteins in the endoplasmic reticulum, however, causes endoplasmic reticulum (ER) stress. Thus, T cells can maintain ER homeostasis via endoplasmic reticulum-associated degradation, unfolded protein response, and autophagy. In T cell-mediated diseases, such as rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, type 1 diabetes and vitiligo, ER stress caused by changes in the internal microenvironment can cause disease progression by affecting T cell homeostasis. This review discusses ER stress in T cell formation, activation, differentiation, and T cell-mediated illnesses, and may offer new perspectives on the involvement of T cells in autoimmune disorders and cancer.
    MeSH term(s) Humans ; Endoplasmic Reticulum-Associated Degradation ; T-Lymphocytes ; Endoplasmic Reticulum Stress ; Autoimmune Diseases ; Arthritis, Rheumatoid
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 120476-2
    ISSN 1365-3083 ; 0300-9475
    ISSN (online) 1365-3083
    ISSN 0300-9475
    DOI 10.1111/sji.13307
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 806: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: First-Principle Study of Rh-Doped Nitrogen Vacancy Boron Nitride Monolayer for Scavenging and Detecting SF

    Shi, Zhen / Xia, Sheng-Yuan

    Polymers

    2021  Volume 13, Issue 20

    Abstract: The scavenging and detection of sulfur hexafluoride ( ... ...

    Abstract The scavenging and detection of sulfur hexafluoride (SF
    Language English
    Publishing date 2021-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13203507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Quantitative fluorescence resonance energy transfer-based immunoassay for activated complement C1s.

    Ye, Jun / Xu, Jie / Zhang, Chuanmeng / Zhu, Li / Xia, Sheng

    Frontiers in immunology

    2023  Volume 14, Page(s) 1081793

    Abstract: Objectives: C1s activation is associated with the pathogenesis of various diseases, indicating the potential value of C1s activation detection in clinic. Here we aimed to establish fluorescence resonance energy transfer (FRET)-based immunoassay for the ... ...

    Abstract Objectives: C1s activation is associated with the pathogenesis of various diseases, indicating the potential value of C1s activation detection in clinic. Here we aimed to establish fluorescence resonance energy transfer (FRET)-based immunoassay for the quantitative detection of activated C1s in serum.
    Methods: FRET-based fluorogenic peptides, sensitive to the enzymatic activity of activated C1s, were prepared and labeled with the fluorophore ortho-aminobenzoic acid (Abz) and quencher 2,4-dinitrophenyl (Dnp), and then were further selected depending on its Kcat/Km value. C1s in the samples was captured and separated using anti-C1s-conjugated magnetic microbeads. Next, enzymatic activity of activated C1s in samples and standards was examined using fluorescent quenched substrate assays. Limit of detection (LOD), accuracy, precision, and specificity of FRET-based immunoassay were also investigated.
    Results: This method presented a linear quantification range for the enzymatic activity of activated C1s up to 10 μmol min
    Conclusions: One anti-C1s-based FRET immunoassay for activated C1s detection in serum samples were established, and it will be useful to explore the role of C1s activation in the pathogenesis, diagnosis and treatment in complement-related diseases.
    MeSH term(s) Humans ; Complement C1s ; Complement C1r ; Fluorescence Resonance Energy Transfer ; Immunoassay ; Peptides ; Mannose-Binding Protein-Associated Serine Proteases
    Chemical Substances Complement C1s (EC 3.4.21.42) ; Complement C1r (EC 3.4.21.41) ; Peptides ; MASP2 protein, human (EC 3.4.21.-) ; Mannose-Binding Protein-Associated Serine Proteases (EC 3.4.21.-)
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1081793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: HDAC6 and ERK/ADAM17 Regulate VEGF-Induced NOTCH Signaling in Lung Endothelial Cells.

    Xia, Sheng / Menden, Heather L / Mabry, Sherry M / Sampath, Venkatesh

    Cells

    2023  Volume 12, Issue 18

    Abstract: Angiogenesis plays a critical role in various physiological and pathological processes and is regulated by VEGF. Histone Deacetylase 6 (HDAC6) is a class IIB HDAC that regulates cytoplasmic signaling through deacetylation and is emerging as a target for ... ...

    Abstract Angiogenesis plays a critical role in various physiological and pathological processes and is regulated by VEGF. Histone Deacetylase 6 (HDAC6) is a class IIB HDAC that regulates cytoplasmic signaling through deacetylation and is emerging as a target for modulating angiogenesis. We investigated the hypothesis that VEGF-induced endothelial cell (EC) NOTCH signaling is regulated by HDAC6 through acetylation of NOTCH intracellular cytoplasmic domain (NICD). In pulmonary endothelial cells (EC), VEGF-induced activation of the NICD transcriptional response was regulated by ERK1/2 and ADAM 17 and required DLL4. While HDAC6 inhibition induced the acetylation of NICD and stabilized NICD, it repressed NICD-SNW1 binding required for the NOTCH transcriptional responses. In vitro experiments showed that HDAC6 inhibition inhibited lung EC angiogenesis, and neonatal mice treated with a systemic HDAC6 inhibitor had significantly altered angiogenesis and alveolarization. These findings shed light on the role of HDAC6 in modulating VEGF-induced angiogenesis through acetylation and repression of the transcriptional regulators, NICD and SNW1.
    Language English
    Publishing date 2023-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12182231
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  8. Article ; Online: Clinical efficacy analysis of repairing the medial malleolus canal combined with double incision on the plantar surface for ankle-related ganglion cysts.

    Tian, Haoran / Xia, Sheng / Zong, Bangyong / Li, Peng / Chai, Leizi

    Minerva medica

    2023  Volume 114, Issue 6, Page(s) 891–892

    MeSH term(s) Humans ; Ankle/surgery ; Ganglion Cysts/surgery ; Ankle Joint/surgery ; Treatment Outcome ; Tibia ; Fracture Fixation, Internal
    Language English
    Publishing date 2023-06-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.23.08717-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Does Corporate Financialization Have a Non-Linear Impact on Sustainable Total Factor Productivity? Perspectives of Cash Holdings and Technical Innovation

    Hui Wang / Qing Wang / Xia Sheng

    Sustainability, Vol 13, Iss 5, p

    2021  Volume 2533

    Abstract: This study explores the conditions under which financialization may foster sustainable total factor productivity (TFP). We examine the inverted U-shaped relationship between corporate financialization and TFP by employing a panel threshold model using ... ...

    Abstract This study explores the conditions under which financialization may foster sustainable total factor productivity (TFP). We examine the inverted U-shaped relationship between corporate financialization and TFP by employing a panel threshold model using microeconomic non-financial panel data from Chinese firms in the 2007 to 2018 period. Our results suggest that the turning point is more significant in holding short-term financial assets and state-owned enterprises. The threshold effect suggests that technical innovation determines the optimal threshold at which TFP is affected by financialization. Further, financialization is considered an alternative to cash in order to increase the value of capital, leading to a positive effect on TFP. Contrary to their positive effects below the optimal thresholds, financialization exceeds a certain level, displaces technical innovation, and becomes detrimental to TFP. Our analysis thus establishes the importance of sustainable growth of TFP and minimize the adverse effect of financialization.
    Keywords circular economy ; sustainability strategy ; resilience ; financialization ; TFP ; innovation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 339
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Complement C1s as a diagnostic marker and therapeutic target: Progress and propective.

    Ye, Jun / Yang, Peng / Yang, Yili / Xia, Sheng

    Frontiers in immunology

    2022  Volume 13, Page(s) 1015128

    Abstract: The molecules of the complement system connect the effectors of innate and adaptive immunity and play critical roles in maintaining homeostasis. Among them, the C1 complex, composed of C1q, C1r, and C1s ( ... ...

    Abstract The molecules of the complement system connect the effectors of innate and adaptive immunity and play critical roles in maintaining homeostasis. Among them, the C1 complex, composed of C1q, C1r, and C1s (C1qr
    MeSH term(s) Complement C1s/metabolism ; Complement C1r ; Complement C1q/metabolism ; Complement Activation/physiology ; Peptides ; Antibodies, Monoclonal
    Chemical Substances Complement C1s (EC 3.4.21.42) ; Complement C1r (EC 3.4.21.41) ; Complement C1q (80295-33-6) ; Peptides ; Antibodies, Monoclonal
    Language English
    Publishing date 2022-10-06
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1015128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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