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  1. Article: Case Report: A Rare Case of Acute Anterior Myocardial Infarction Simultaneously Associated With Aortic Mural Thrombosis Due to Essential Thrombocytosis.

    Ye, Sheng / Xia, Wu-Jie / Chen, Peng

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 840906

    Abstract: Background: Essential thrombocytosis (ET) simultaneously complicated with acute myocardial infarction and aortic thrombosis is extremely rare and associated with poor outcomes.: Case: A 54-year-old female was admitted to our emergency department with ...

    Abstract Background: Essential thrombocytosis (ET) simultaneously complicated with acute myocardial infarction and aortic thrombosis is extremely rare and associated with poor outcomes.
    Case: A 54-year-old female was admitted to our emergency department with abdominal pain for 3 h. ST-segment elevation in leads V1-V3 on electrocardiography led to the diagnosis of acute anterior myocardial infarction. Coronary angiography demonstrated total occlusion of the proximal left anterior descending artery, and the patient was treated with angioplasty and placement of a drug-eluting stent. CT angiography revealed a massive mural thrombus located in the descending aorta. Bone marrow biopsy confirmed the diagnosis of ET. The patient was successfully treated with antithrombotic therapy and hydroxyurea.
    Conclusion: At present, the clinical diagnosis and treatment of ET complicated with acute myocardial infarction and aortic thrombosis are mostly based on literature reports. Early target vessel revascularization, antiplatelet and anticoagulant combined with cytoreductive therapy may improve the prognosis. Clinicians should consider the risk of bleeding and thrombosis and create individualized treatment strategies for these patients.
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.840906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Relaxin-3 Ameliorates Diabetic Cardiomyopathy by Inhibiting Endoplasmic Reticulum Stress.

    Pan, Li-Ya / Zhang, Xiao-Hui / Xia, Wu-Jie / Pan, Jia-Lin

    publication RETRACTED

    Computational and mathematical methods in medicine

    2022  Volume 2022, Page(s) 9380283

    Abstract: Background: This study is aimed at investigating whether relaxin-3 exhibits protective effects against cardiomyopathy in diabetic rats by suppressing ERS.: Methods: Eighty male SD rats were randomly divided into two groups: controls (: Results: (1) ...

    Abstract Background: This study is aimed at investigating whether relaxin-3 exhibits protective effects against cardiomyopathy in diabetic rats by suppressing ERS.
    Methods: Eighty male SD rats were randomly divided into two groups: controls (
    Results: (1) HE and Masson staining indicated that relaxin-3 could attenuate myocardial lesions and myocardial collagen volume fraction. (2) BNP, TnI, and myoglobin in the DM group at four and eight weeks were significantly higher than in the controls (
    Conclusions: Exogenous relaxin-3 ameliorates diabetic cardiomyopathy by inhibiting ERS in diabetic rats.
    MeSH term(s) Animals ; Apoptosis ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Cardiomyopathies/drug therapy ; Diabetic Cardiomyopathies/pathology ; Endoplasmic Reticulum Stress ; Eosine Yellowish-(YS)/pharmacology ; Eosine Yellowish-(YS)/therapeutic use ; Glucose ; Hematoxylin/pharmacology ; Hematoxylin/therapeutic use ; Interleukin-17/pharmacology ; Interleukin-17/therapeutic use ; Male ; Myoglobin/pharmacology ; Myoglobin/therapeutic use ; Natriuretic Peptide, Brain/pharmacology ; Natriuretic Peptide, Brain/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Relaxin/pharmacology ; Relaxin/therapeutic use ; Streptozocin/pharmacology ; Streptozocin/therapeutic use ; Troponin/pharmacology ; Troponin/therapeutic use ; Tumor Necrosis Factor-alpha
    Chemical Substances Interleukin-17 ; Myoglobin ; Troponin ; Tumor Necrosis Factor-alpha ; Natriuretic Peptide, Brain (114471-18-0) ; Streptozocin (5W494URQ81) ; Relaxin (9002-69-1) ; Glucose (IY9XDZ35W2) ; Eosine Yellowish-(YS) (TDQ283MPCW) ; Hematoxylin (YKM8PY2Z55)
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2252430-7
    ISSN 1748-6718 ; 1748-670X ; 1027-3662
    ISSN (online) 1748-6718
    ISSN 1748-670X ; 1027-3662
    DOI 10.1155/2022/9380283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6373: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: MG-132 attenuates cardiac deterioration of viral myocarditis via AMPK pathway.

    Zhang, Xin-Min / Li, Yue-Chun / Chen, Peng / Ye, Sheng / Xie, Shang-He / Xia, Wu-Jie / Yang, Jun-Hua

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2020  Volume 126, Page(s) 110091

    Abstract: Background: Coxsackievirus B3 (CVB3) is the primary cause of infectious myocarditis. Aggressive immunological activation and apoptosis of myocytes contributes to progressive dysfunction of cardiac contraction and poor prognosis. MG-132, a proteasome ... ...

    Abstract Background: Coxsackievirus B3 (CVB3) is the primary cause of infectious myocarditis. Aggressive immunological activation and apoptosis of myocytes contributes to progressive dysfunction of cardiac contraction and poor prognosis. MG-132, a proteasome inhibitor, regulates mitochondrial-mediated intrinsic myocardial apoptosis and downregulates NF-κB-mediated inflammation. Here, we determined whether AMPK pathway participates in MG-132-mediated myocardial protection in viral-induced myocarditis.
    Methods and results: Acute viral myocarditis models were established by intraperitoneal inoculation of CVB3 in male BALB/c mice. Myocarditis and age-matched control mice were administered MG-132 and/or BML-275 dihydrochloride (BML) (AMPK antagonist) intraperitoneally daily from the day following CVB3 inoculation. MG-132 improved hemodynamics and inhibited the structural remodeling of the ventricle in mice with myocarditis, while BML largely blunted these effects. TUNEL staining and immunochemistry suggested that MG-132 exerts anti-apoptotic and anti-inflammatory effects against CVB3-induced myocardial injuries. BML attenuated the effects of MG-132 on anti-apoptosis and anti-inflammation.
    Conclusion: MG-132 modulated apoptosis and inflammation, improved hemodynamics, and inhibited the structural remodeling of ventricles in a myocarditis mouse model via regulation of the AMPK signal pathway.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Biomarkers ; Biopsy ; Cysteine Proteinase Inhibitors/pharmacology ; Cytokines/metabolism ; Disease Models, Animal ; Echocardiography ; Enterovirus B, Human ; Heart Function Tests ; Hemodynamics/drug effects ; Humans ; Immunohistochemistry ; Inflammation Mediators/metabolism ; Leupeptins/pharmacology ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Myocarditis/drug therapy ; Myocarditis/metabolism ; Myocarditis/physiopathology ; Myocarditis/virology ; Prognosis ; Virus Replication/drug effects
    Chemical Substances Antineoplastic Agents ; Biomarkers ; Cysteine Proteinase Inhibitors ; Cytokines ; Inflammation Mediators ; Leupeptins ; benzyloxycarbonylleucyl-leucyl-leucine aldehyde (RF1P63GW3K)
    Language English
    Publishing date 2020-04-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2020.110091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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