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  1. Article ; Online: Survival outcomes in HER2-low versus HER2-zero breast cancer after neoadjuvant chemotherapy: a meta-analysis.

    Xia, Lin-Yu / Cao, Xu-Chen / Yu, Yue

    World journal of surgical oncology

    2024  Volume 22, Issue 1, Page(s) 106

    Abstract: Background: The survival outcomes in HER2-low versus HER2-zero breast cancer (BC) after neoadjuvant chemotherapy (NACT) remain unclear. The meta-analysis was conducted to summarize current evidence about the survival outcomes in HER2-low versus HER2- ... ...

    Abstract Background: The survival outcomes in HER2-low versus HER2-zero breast cancer (BC) after neoadjuvant chemotherapy (NACT) remain unclear. The meta-analysis was conducted to summarize current evidence about the survival outcomes in HER2-low versus HER2-zero BC.
    Methods: We conducted a systematic search in PubMed and EMBASE databases to identify relevant studies.
    Results: A total of 14 studies with 53,714 patients were included. Overall, 34,037 patients (63.37%) were HER2-low, and 19,677 patients (36.63%) were HER2-zero. Patients with HER2-low tumors had a significantly lower pathological complete response (pCR) rate than patients with HER2-zero tumors, regardless of the hormone receptor status. Compared with HER2-zero breast cancer, the overall survival (OS) and disease-free survival (DFS) of HER2-low BC were longer in the overall cohort (HR = 0.72; 95% CI = 0.61-0.85; P < 0.0001; HR = 0.83; 95% CI = 0.75-0.92; P = 0.0002); however, no differences were observed in terms of OS and DFS between HER2-low and HER2-zero BC in the HR-negative group. In the HR-positive group, HER2-low status had no significant impact on OS, while significantly associated with increased DFS (HR = 0.85; 95% CI = 0.76-0.96; P = 0.007).
    Conclusion: These results suggest that although HER2-low BC has a poor response to NACT, it is correlated with favorable OS and DFS after NACT in the overall cohort as well as longer DFS in the HR-positive group.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Neoadjuvant Therapy ; Receptor, ErbB-2 ; Disease-Free Survival ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2024-04-20
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-024-03382-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytokine-Like Protein 1 (CYTL1) as a Key Target of M-Stage Immune Infiltration in Stomach Adenocarcinoma

    Fang Zhou / QianXia Lin / ZiHan Zheng

    BioMed Research International, Vol

    2023  Volume 2023

    Abstract: Background. Stomach adenocarcinoma (STAD) has an extremely high fatality rate worldwide, and survival after metastasis is extremely poor. Cytokine-like protein 1 (CYTL1) has prognostic significance in various tumors. We aimed to explore the impact and ... ...

    Abstract Background. Stomach adenocarcinoma (STAD) has an extremely high fatality rate worldwide, and survival after metastasis is extremely poor. Cytokine-like protein 1 (CYTL1) has prognostic significance in various tumors. We aimed to explore the impact and underlying molecular mechanisms of CYTL1 in STAD through bioinformatics analysis. Methods. We used R software to analyze CYTL1 expression in STAD samples (n=375) and normal samples (n=32) in The Cancer Genome Atlas database. Kaplan–Meier analysis was used to verify the relationship between CYTL1 expression and overall survival (OS) and disease-specific survival (DSS) based on the clinical characteristics and subgroups of patients with STAD. Furthermore, univariate and multivariate Cox regression analyses were used to verify the outcome variables of OS and DSS in patients with STAD. Receiver operating characteristic curves were used to test the predictive power of CYTL1. The biological functions and signaling pathways of CYTL1 were determined using gene set enrichment analysis (GSEA), and the immune infiltration patterns of CYTL1 and correlation of immune-related markers were analyzed using single-sample GSEA (ssGSEA) and an estimate algorithm. Results. In our research, low CYTL1 expression (tumor vs. normal) was noted in patients with STAD. High CYTL1 expression was detrimental to OS and DSS and had good diagnostic performance (AUC=0.731). In the subtype analysis of STAD, T3 and T4 stages, N0 and N1 stages, M0 stage, gender (female), and age (≤65 years) showed different performances between OS and DSS. Univariate and multivariate Cox analyses identified CYTL1 as an independent factor, and logistic regression analysis indicated that CYTL1 was associated with M stage (OR=3.406) and sex (OR=1.535). GSEA of the differential genes of CYTL1 showed the possible involvement of immunity. ssGSEA and estimation algorithms were used to further evaluate whether immune cells were closely related to CYTL1 expression, and many markers of immune cells also had statistical ...
    Keywords Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Identification and verification of ferroptosis-related genes in the synovial tissue of osteoarthritis using bioinformatics analysis.

    Xia, Lin / Gong, Ningji

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 992044

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.992044
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  4. Article ; Online: Metabolism Serves as a Bridge Between Cardiomyocytes and Immune Cells in Cardiovascular Diseases.

    Hang, Lixiao / Zhang, Ying / Zhang, Zheng / Jiang, Haiqiang / Xia, Lin

    Cardiovascular drugs and therapy

    2024  

    Abstract: Metabolic disorders of cardiomyocytes play an important role in the progression of various cardiovascular diseases. Metabolic reprogramming can provide ATP to cardiomyocytes and protect them during diseases, but this transformation also leads to adverse ... ...

    Abstract Metabolic disorders of cardiomyocytes play an important role in the progression of various cardiovascular diseases. Metabolic reprogramming can provide ATP to cardiomyocytes and protect them during diseases, but this transformation also leads to adverse consequences such as oxidative stress, mitochondrial dysfunction, and eventually aggravates myocardial injury. Moreover, abnormal accumulation of metabolites induced by metabolic reprogramming of cardiomyocytes alters the cardiac microenvironment and affects the metabolism of immune cells. Immunometabolism, as a research hotspot, is involved in regulating the phenotype and function of immune cells. After myocardial injury, both cardiac resident immune cells and heart-infiltrating immune cells significantly contribute to the inflammation, repair and remodeling of the heart. In addition, metabolites generated by the metabolic reprogramming of immune cells can further affect the microenvironment, thereby affecting the function of cardiomyocytes and other immune cells. Therefore, metabolic reprogramming and abnormal metabolite levels may serve as a bridge between cardiomyocytes and immune cells, leading to the development of cardiovascular diseases. Herein, we summarize the metabolic relationship between cardiomyocytes and immune cells in cardiovascular diseases, and the effect on cardiac injury, which could be therapeutic strategy for cardiovascular diseases, especially in drug research.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-024-07545-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intelligent

    Wang, Qi / Li, Yutao / Xiao, Jianbin / Xia, Lin

    Polymers

    2023  Volume 15, Issue 5

    Abstract: ... ...

    Abstract Intelligent
    Language English
    Publishing date 2023-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15051182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Correction to: LncRNA WDFY3-AS2 promotes cisplatin resistance and the cancer stem cell in ovarian cancer by regulating hsa-miR-139-5p/SDC4 axis.

    Wu, Yue / Wang, Ting / Xia, Lin / Zhang, Mei

    Cancer cell international

    2023  Volume 23, Issue 1, Page(s) 176

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2091573-1
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-023-03029-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Insights into the roles of IL-10-producing regulatory B cells in cardiovascular disorders: recent advances and future perspectives.

    Zheng, Huiqin / Cao, Pei / Su, Zhaoliang / Xia, Lin

    Journal of leukocyte biology

    2023  Volume 114, Issue 4, Page(s) 315–324

    Abstract: Interleukin-10-producing regulatory B (B10) cells mediate the immunomodulatory functions of biosystems by secreting anti-inflammatory factors, thus playing vital roles in cardiovascular diseases such as viral myocarditis, myocardial infarction, and ... ...

    Abstract Interleukin-10-producing regulatory B (B10) cells mediate the immunomodulatory functions of biosystems by secreting anti-inflammatory factors, thus playing vital roles in cardiovascular diseases such as viral myocarditis, myocardial infarction, and ischemia-reperfusion injury. However, several challenges hinder B10 cells from regulating the immunoreactivity of organisms in specific cardiovascular diseases, such as atherosclerotic disease. Regarding the regulatory mechanisms of B10 cells, the interplay between B10 cells and the cardiovascular and immune systems is complex and requires clarification. In this study, we summarize the roles of B10 cells in bacterial and aseptic heart injuries, address their regulatory functions in different stages of cardiovascular disorders, and discuss their challenges and opportunities in addressing cardiovascular diseases from bench to bedside.
    MeSH term(s) Humans ; B-Lymphocytes, Regulatory ; Cardiovascular Diseases ; Immunity ; Interleukin-10 ; Myocarditis
    Chemical Substances Interleukin-10 (130068-27-8) ; IL10 protein, human
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiad066
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
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  8. Article ; Online: Sunken Upper Eyelid Deformity Correction by Orbital Fat Pad Repositioning and Orbicularis Oculi Muscle Folding in Blepharoplasty.

    Li, XiuQi / Xia, Lin / Ma, Ling

    The Journal of craniofacial surgery

    2023  Volume 34, Issue 2, Page(s) 704–707

    Abstract: Background: Sunken upper eyelid deformity results in an aged and unnatural appearance and is common among Asians along with the single eyelid. The upper eyelid volume restoration is as important as the creation of a supratarsal fold for patients with ... ...

    Abstract Background: Sunken upper eyelid deformity results in an aged and unnatural appearance and is common among Asians along with the single eyelid. The upper eyelid volume restoration is as important as the creation of a supratarsal fold for patients with sunken eyelids. In the present study, the combination of orbital fat pad repositioning and orbicularis oculi muscle flap folding was established to correct the upper eyelid depression during blepharoplasty.
    Methods: A retrospective study was conducted on patients who underwent the orbital fat pad repositioning and orbicularis oculi muscle flap folding to correct the upper eyelid depression between July 2020 and October 2021. The preoperative and postoperative sunken depths were calculated and compared, and overall patient satisfaction was performed to evaluate the operation efficiency.
    Results: There were 40 patients, including 39 females and 1 male, who underwent surgery with an average age of 25.4 years. During the mean follow-up period of 12.7 months, the sunken depth improved from 3.2 mm preoperatively to 1.5 mm postoperatively with a statistical significance. Satisfactory results were achieved without major complication.
    Conclusions: For patients with mild to moderate sunken upper eyelids, the combination of orbital fat pad repositioning and orbicularis oculi muscle folding has been proved efficient and consistent to restore the upper eyelid volume and helpful to build esthetic double eyelids.
    MeSH term(s) Female ; Humans ; Male ; Aged ; Adult ; Blepharoplasty/methods ; Retrospective Studies ; Esthetics, Dental ; Eyelids/surgery ; Facial Muscles/surgery ; Adipose Tissue/transplantation
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000009174
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    Zs.MO 175: Show issues

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  9. Article ; Online: The Initial Experience of Laparoscopic Management for Type VI Choledochal Cyst in Children.

    Li, Bing / Chen, Bing Wei / Xia, Lin Shun

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2023  Volume 34, Issue 3, Page(s) 280–283

    Abstract: Purposes: ...

    Abstract Purposes:
    MeSH term(s) Child ; Humans ; Choledochal Cyst/surgery ; Anastomosis, Roux-en-Y/methods ; Liver/surgery ; Dilatation, Pathologic/surgery ; Laparoscopy/methods ; Cholecystectomy, Laparoscopic
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2023.0229
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  10. Article ; Online: Laparoscopic Kasai Procedure of Treating Biliary Atresia with an Aberrant Right Hepatic Artery.

    Li, Bing / Chen, Bing Wei / Xia, Lin Shun

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2023  Volume 33, Issue 9, Page(s) 904–908

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Infant ; Child ; Humans ; Biliary Atresia/surgery ; Portoenterostomy, Hepatic/adverse effects ; Hepatic Artery/surgery ; Treatment Outcome ; Laparoscopy/methods ; Cholangitis/etiology ; Bilirubin ; Retrospective Studies
    Chemical Substances Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2022.0596
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