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Article ; Online: Prognostic significance of a pathological response in metastatic lymph nodes of patients with gastric cancer who underwent neoadjuvant chemotherapy followed by surgery.

Chen, Fengju / Xian, Jia / Huo, Junjie

2024

Abstract: Purpose: To grade the pathological response of lymph nodes (LNs) to neoadjuvant chemotherapy (NAC) in patients with locally advanced gastric cancer (LAGC) and investigate its prognostic significance.: Methods: This retrospective study included 196 ... ...

Abstract	Purpose: To grade the pathological response of lymph nodes (LNs) to neoadjuvant chemotherapy (NAC) in patients with locally advanced gastric cancer (LAGC) and investigate its prognostic significance. Methods: This retrospective study included 196 patients who underwent NAC, followed by radical gastrectomy for LAGC between January 2010 and October 2019. Pathological responses were evaluated based on the proportion of residual tumor cells within the tumor area in the primary tumor (PT) and LNs and included the following categories: 1a (0%), 1b (< 10%), 2 (10-50%), and 3 (> 50%). Results: Among 166 patients with clinically node-positive disease, 38/27/39/62 were classified as having LN regression grade (LRG) 1a/1b/2/3, respectively. Compared to LN non-responders (LRG 2 or 3), LN responders (LRG 1a or 1b) had significantly higher 5-year overall survival (72.5% vs. 19.0%, P < 0.001) and recurrence-free survival rates (67.8% vs. 22.2%, P < 0.001), irrespective of PT response. Furthermore, a multivariate analysis revealed that the LN response was an independent risk factor for the overall survival (hazard ratio [HR] 0.417, 95% confidence interval [CI] 0.181-0.962, P = 0.040) and recurrence-free survival (HR 0.490, 95% CI 0.242-0.991, P = 0.047), but not the PT response (P > 0.05). Conclusions: The pathological LN response may be a reliable prognostic prediction tool in patients with LAGC who received NAC.
Language	English
Publishing date	2024-04-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1115435-4
ISSN	1436-2813 ; 0941-1291
ISSN (online)	1436-2813
ISSN	0941-1291
DOI	10.1007/s00595-024-02829-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Exploring the diagnostic value of CLR and CPR in differentiating Kawasaki disease from other infectious diseases based on clinical predictive modeling.

Liao, Jin-Wen / Guo, Xin / Li, Xu-Xia / Xian, Jia-Ming / Chen, Cheng / Xu, Ming-Guo

Frontiers in pediatrics

2024 Volume 12, Page(s) 1345141

Abstract: Background: Kawasaki disease (KD) is an important cause of acquired heart disease in children and adolescents worldwide. KD and infectious diseases can be easily confused when the clinical presentation is inadequate or atypical, leading to misdiagnosis ... ...

Abstract	Background: Kawasaki disease (KD) is an important cause of acquired heart disease in children and adolescents worldwide. KD and infectious diseases can be easily confused when the clinical presentation is inadequate or atypical, leading to misdiagnosis or underdiagnosis of KD. In turn, misdiagnosis or underdiagnosis of KD can lead to delayed use of intravenous immunoglobulin (IVIG), increasing the risk of drug resistance and coronary artery lesions (CAL). Objectives: The purpose of this study was to develop a predictive model for identifying KD and infectious diseases in children in the hope of helping pediatricians develop timely and accurate treatment plans. Methods: The data Patients diagnosed with KD from January 2018 to July 2022 in Shenzhen Longgang District Maternity & Child Healthcare Hospital, and children diagnosed with infectious diseases in the same period will be included in this study as controls. We collected demographic information, clinical presentation, and laboratory data on KD before receiving IVIG treatment. All statistical analyses were performed using R-4.2.1 (https://www.rproject.org/). Logistic regression and Least Absolute Shrinkage with Selection Operator (LASSO) regression analyses were used to build predictive models. Calibration curves and C-index were used to validate the accuracy of the prediction models. Results: A total of 1,377 children were enrolled in this study, 187 patients with KD were included in the KD group and 1,190 children with infectious diseases were included in the infected group. We identified 15 variables as independent risk factors for KD by LASSO analysis. Then by logistic regression we identified 7 variables for the construction of nomogram including white blood cell (WBC), Monocyte (MO), erythrocyte sedimentation rate (ESR), alanine transaminase (ALT), albumin (ALB), C-reactive protein to procalcitonin ratio (CPR) and C-reactive protein to lymphocyte ratio (CLR). The calibration curve and C-index of 0.969 (95% confidence interval: 0.960-0.978) validated the model accuracy. Conclusion: Our predictive model can be used to discriminate KD from infectious diseases. Using this predictive model, it may be possible to provide an early determination of the use of IVIG and the application of antibiotics as soon as possible.
Language	English
Publishing date	2024-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2024.1345141
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Article: Changes in neurotransmitter levels, brain structural characteristics, and their correlation with PANSS scores in patients with first-episode schizophrenia.

Xu, Xian-Jia / Liu, Tang-Long / He, Liang / Pu, Ben

World journal of clinical cases

2023 Volume 11, Issue 22, Page(s) 5215–5223

Abstract: Background: In patients with schizophrenia, the brain structure and neurotransmitter levels change, which may be related to the occurrence and progression of this disease.: Aim: To explore the relationships between changes in neurotransmitters, brain ...

Abstract	Background: In patients with schizophrenia, the brain structure and neurotransmitter levels change, which may be related to the occurrence and progression of this disease. Aim: To explore the relationships between changes in neurotransmitters, brain structural characteristics, and the scores of the Positive and Negative Symptom Scale (PANSS) in patients with first-episode schizophrenia. Methods: The case group comprised 97 patients with schizophrenia, who were evaluated using the Canadian Neurological Scale and confirmed by laboratory tests at Ningbo Mental Hospital from January 2020 to July 2022. The control group comprised 100 healthy participants. For all participants, brain structural characteristics were explored by measuring brain dopamine (DA), glutamic acid (Glu), and gamma-aminobutyric acid (GABA) levels, with magnetic resonance imaging. The case group was divided into negative and positive symptom subgroups using PANSS scores for hierarchical analysis. Linear correlation analysis was used to analyze the correlations between neurotransmitters, brain structural characteristics, and PANSS scores. Results: Patients in the case group had higher levels of DA and lower levels of Glu and GABA, greater vertical and horizontal distances between the corpus callosum and the inferior part of the fornix and larger ventricle area than patients in the control group ( Conclusion: In patients with first-episode schizophrenia, DA levels increased, Glu and GABA levels decreased, the thickness of the corpus callosum increased, and these variables were correlated with PANSS scores.
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i22.5215
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Article ; Online: Temporal and spatial trends in road traffic fatalities from 2001 to 2019 in Shandong Province, China.

Tao Wang / Zhi-Ying Yao / Bao-Peng Liu / Cun-Xian Jia

PLoS ONE, Vol 18, Iss 7, p e

2023 Volume 0287988

Abstract: Objective This study explored the temporal and spatial trends in road traffic fatalities in Shandong Province from 2001 to 2019 and discusses the possible influencing factors. Methods We collected data from the statistical yearbooks of the China National ...

Abstract	Objective This study explored the temporal and spatial trends in road traffic fatalities in Shandong Province from 2001 to 2019 and discusses the possible influencing factors. Methods We collected data from the statistical yearbooks of the China National Bureau of Statistics and the Shandong Provincial Bureau of Statistics. Join-point Regression Program 4.9.0.0 and ArcGIS 10.8 software were used to analyze the temporal and spatial trends. Results The mortality rate of road traffic injuries in Shandong Province decreased from 2001 to 2019, with an average annual decrease of 5.8% (Z = -20.7, P < 0.1). The three key time points analyzed in the Join-point regression model roughly corresponded to the implementation times of traffic laws and regulations in China. The temporal trend in case fatality rate in Shandong Province from 2001 to 2019 was not statistically significant (Z = 2.8, P < 0.1). The mortality rate showed spatial autocorrelation (global Moran's I = 0.3889, Z = 2.2043, P = 0.028) and spatial clustering. No spatial autocorrelation was observed in the case fatality rate (global Moran's I = -0.0183, Z = 0.2308, P = 0.817). Conclusions The mortality rate in Shandong Province decreased significantly over the studied period, but the case fatality rate did not decline significantly and remains relatively high. Many factors influence road traffic fatalities, among which laws and regulations are the most important.
Keywords	Medicine ; R ; Science ; Q
Subject code	380
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Relationship between impulsivity and suicide among the rural elderly in China

Yunfang Zhou / Zhenyu Ma / Cun-Xian Jia / Liang Zhou

PeerJ, Vol 9, p e

a case-control psychological autopsy study

2021 Volume 11801

Abstract: Background The relationship between impulsivity and suicide is inconsistent in different populations. Hence, the relationship between impulsivity and suicide still needs to be studied among the elderly population. The present study intends to explore the ...

Abstract	Background The relationship between impulsivity and suicide is inconsistent in different populations. Hence, the relationship between impulsivity and suicide still needs to be studied among the elderly population. The present study intends to explore the relationship between impulsivity and suicide among the rural Chinese elderly. Methods A case-control psychological autopsy study was conducted from February 1, 2014 to December 18, 2015 among rural residents over the age of 60 who died by suicide. The sample consisted of 242 suicides as the case group and 242 living individuals as the control group. Data on demographic characteristics, impulsivity, previous history of suicide attempts, social support, negative life events, and suicidal behavior were collected. Results Our study found that impulsivity increased the risk of suicide. The case group showed a higher Barratt Impulsiveness Scale score compared with the control group (p < 0.001), which indicates that impulsivity was higher among the elderly suicides. In addition, regression analyses show that impulsivity (odds ratio: 1.03, 95% confidence interval: 1.01–1.06) is an independent risk factor of suicide, after controlling for the effects of marital status, education, family annual income, being left behind, social support, and negative life events. Finally, compared with elderly who do not have a history of attempted suicide, elderly with a history of attempted suicide showed higher impulsivity (p = 0.001).
Keywords	Case–control study ; Impulsivity ; Psychological autopsy ; Rural elderly ; Suicide ; Medicine ; R
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Coping Ability and Promotion Countermeasures of Medical and Health Institutions Reputation Crisis

Yang Liu / Xiaofang Li / Rui Ding / Tianrun He / Xian-jia Wang

Frontiers in Public Health, Vol

A Case Study in Hubei Province

2022 Volume 9

Abstract: At present, the doctor–patient relationships in Chinese medical and health institutions (MHI) are increasingly tense, and the reputation crisis challenges are being faced by MHI more frequently. However, the reputation crisis management level of the MHI ... ...

Abstract	At present, the doctor–patient relationships in Chinese medical and health institutions (MHI) are increasingly tense, and the reputation crisis challenges are being faced by MHI more frequently. However, the reputation crisis management level of the MHI is directly related to the future development and construction of the MHI and is an important management link that cannot be ignored. Therefore, how to quantify the impact of the relevant crisis on hospitals has become a major problem. First of all, this paper uses the situational crisis communication theory (SCCT) to combine the characteristics of hospital reputation crisis with the theory and classification of MHI reputation crisis from three perspectives: victim crisis, accidental crisis, and preventable crisis. Second, a more comprehensive analysis of MHI reputation crisis management model is conducted in the research cases, based on the relevant data of Union Hospital, Tongji Medical College Huazhong University of Science and Technology (UH), Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology (TJ), Zhongnan Hospital of Wuhan University (ZN), Renmin Hospital of Wuhan University (RM), and Maternal and Child Hospital of Hubei Province (MC). Third, we divide MHI reputation positioning into four types, namely robust, growth, fragile, and sensitive, and innovate SCCT to build a new MHI crisis classification type. Finally, this paper provides appropriate crisis management strategies for sample MHI based on the above examples and theories. Furthermore, we realize the lifecycle management of MHI reputation by identifying, evaluating and responding to reputation issues. This study provides a theoretical reference for the MHI reputation crisis management level and the adjustment of future management strategies.
Keywords	coping ability ; promotion countermeasures ; situational crisis communication theory ; medical and health institutions ; reputation crisis ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Impact of Physical Activity Intensity on the Dynamic Progression of Cardiometabolic Multimorbidity

Bao-Peng Liu / Jia-Hui Zhu / Li-Peng Wan / Zhen-Yu Zhao / Xinting Wang / Cun-Xian Jia

JMIR Public Health and Surveillance, Vol 9, p e

Prospective Cohort Study Using UK Biobank Data

2023 Volume 46991

Abstract: BackgroundAlthough many studies have reported on the associations between the amount of physical activity (PA) and the transitions of cardiometabolic multimorbidity (CMM), the evidence for PA intensity has not been fully evaluated. ObjectiveThis study ... ...

Abstract	BackgroundAlthough many studies have reported on the associations between the amount of physical activity (PA) and the transitions of cardiometabolic multimorbidity (CMM), the evidence for PA intensity has not been fully evaluated. ObjectiveThis study aimed to explore the impact of PA intensity on the dynamic progression of CMM. MethodsThe prospective cohort of this study using data from the UK Biobank included 359,773 participants aged 37-73 years who were recruited from 22 centers between 2006 and 2010. The diagnoses of CMM, which included the copresence of type 2 diabetes (T2D), ischemic heart disease, and stroke, were obtained from first occurrence fields provided by the UK Biobank, which included data from primary care, hospital inpatient record, self-reported medical condition, and death registers. The PA intensity was assessed by the proportion of vigorous PA (VPA) to moderate to vigorous PA (MVPA). Multistate models were used to evaluate the effect of PA intensity on the dynamic progression of CMM. The first model (model A) included 5 transitions, namely free of cardiometabolic disease (CMD) to first occurrence of CMD (FCMD), free of CMD to death, FCMD to CMM, FCMD to mortality, and CMM to mortality. The other model (model B) used specific CMD, namely T2D, ischemic heart disease, and stroke, instead of FCMD and included 11 transitions in this study. ResultsThe mean age of the included participants (N=359,773) was 55.82 (SD 8.12) years at baseline, and 54.55% (196,271/359,773) of the participants were female. Compared with the participants with no VPA, participants with intensity levels of >0.75 to <1 for VPA to MVPA had a 13% and 27% lower risk of transition from free of CMD to FCMD (hazard ratio [HR] 0.87, 95% CI 0.83-0.91) and mortality (HR 0.73, 95% CI 0.66-0.79) in model A, respectively. The HR for the participants with no moderate PA was 0.82 (95% CI 0.73-0.92) compared with no VPA. There was a substantially protective effect of higher PA intensity on the transitions from free of CMD to T2D ...
Keywords	Public aspects of medicine ; RA1-1270
Subject code	310
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: N-maleyl chitosan-supported palladium catalyst for Heck coupling reaction and reduction of 4-nitrophenol

Luo, Wenyi / Luo, Kun / Yang, Yi / Lin, XianJia / Li, Puwang / Wen, Yanmei

Colloids and surfaces. 2022 Nov. 05, v. 652

2022

Abstract: In this study, maleic anhydride-acylated chitosan (MAAC) was synthesized by modifying chitosan with maleic anhydride, and used to support palladium catalysts. N-maleyl chitosan-supported palladium (Pd/MAAC) was used as a heterogeneous catalyst for the ... ...

Abstract	In this study, maleic anhydride-acylated chitosan (MAAC) was synthesized by modifying chitosan with maleic anhydride, and used to support palladium catalysts. N-maleyl chitosan-supported palladium (Pd/MAAC) was used as a heterogeneous catalyst for the Heck coupling reaction and reduction of 4-nitrophenol (4-NP). The chemical structure of Pd/MAAC was characterized using FT-IR XPS, XRD, XPS, TEM, SEM/EDS, N₂-physisorption (adsorption–desorption), and ICP-MS. The as-synthesized catalyst exhibited high catalytic performance and could be reused up to nine runs to catalyze the cyclic reaction between iodobenzene and n-butyl acrylate with low leaching of palladium. Pd/MAAC was also used for the reduction of 4-NP to 4-aminophenol(4-AP) in 90 s at room temperature, and could be reused six times. The findings establish that Pd/MAAC catalyst is an efficient, economical, practical, and environment-friendly catalyst for the Heck reaction and reduction of 4-NP.
Keywords	Fourier transform infrared spectroscopy ; ambient temperature ; aminophenols ; catalysts ; catalytic activity ; chemical structure ; chitosan ; iodobenzenes ; maleic anhydrides ; p-nitrophenol ; palladium
Language	English
Dates of publication	2022-1105
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2022.129852
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Coping Ability and Promotion Countermeasures of Medical and Health Institutions Reputation Crisis: A Case Study in Hubei Province.

Liu, Yang / Li, Xiaofang / Ding, Rui / He, Tianrun / Wang, Xian-Jia

Frontiers in public health

2022 Volume 9, Page(s) 802004

Abstract: At present, the doctor-patient relationships in Chinese medical and health institutions (MHI) are increasingly tense, and the reputation crisis challenges are being faced by MHI more frequently. However, the reputation crisis management level of the MHI ... ...

Abstract	At present, the doctor-patient relationships in Chinese medical and health institutions (MHI) are increasingly tense, and the reputation crisis challenges are being faced by MHI more frequently. However, the reputation crisis management level of the MHI is directly related to the future development and construction of the MHI and is an important management link that cannot be ignored. Therefore, how to quantify the impact of the relevant crisis on hospitals has become a major problem. First of all, this paper uses the situational crisis communication theory (SCCT) to combine the characteristics of hospital reputation crisis with the theory and classification of MHI reputation crisis from three perspectives: victim crisis, accidental crisis, and preventable crisis. Second, a more comprehensive analysis of MHI reputation crisis management model is conducted in the research cases, based on the relevant data of Union Hospital, Tongji Medical College Huazhong University of Science and Technology (UH), Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology (TJ), Zhongnan Hospital of Wuhan University (ZN), Renmin Hospital of Wuhan University (RM), and Maternal and Child Hospital of Hubei Province (MC). Third, we divide MHI reputation positioning into four types, namely robust, growth, fragile, and sensitive, and innovate SCCT to build a new MHI crisis classification type. Finally, this paper provides appropriate crisis management strategies for sample MHI based on the above examples and theories. Furthermore, we realize the lifecycle management of MHI reputation by identifying, evaluating and responding to reputation issues. This study provides a theoretical reference for the MHI reputation crisis management level and the adjustment of future management strategies.
MeSH term(s)	Adaptation, Psychological ; Child ; Family ; Hospitals ; Humans ; Universities
Language	English
Publishing date	2022-02-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2021.802004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evolutionary game dynamics of the Wright-Fisher process with different selection intensities.

Wang, Xian-Jia / Gu, Cui-Ling / Quan, Ji

Journal of theoretical biology

2019 Volume 465, Page(s) 17–26

Abstract: Evolutionary game dynamics in finite populations can be described by a frequency-dependent, stochastic Wright-Fisher process. The fitness of individuals in a population is not only linked to environmental conditions but also tightly coupled to the types ... ...

Abstract	Evolutionary game dynamics in finite populations can be described by a frequency-dependent, stochastic Wright-Fisher process. The fitness of individuals in a population is not only linked to environmental conditions but also tightly coupled to the types and frequencies of competitors, leading to different types of individuals with different selection intensities. We studied a 2 × 2 symmetric game in a finite population and established a dynamic model of the Wright-Fisher process by introducing different selection intensities for different strategies. Thus, we provided another effective way to study the evolutionary dynamics of a finite population and obtained the analytical expressions of fixation probabilities under weak selection. The fixation probability of a strategy is not only related to a game matrix but also to different selection intensities. The conditions required for natural selection to favor one strategy and for that strategy to be an evolutionary stable strategy (ESS
MeSH term(s)	Algorithms ; Animals ; Biological Evolution ; Game Theory ; Genetic Fitness/genetics ; Genetics, Population/methods ; Humans ; Models, Theoretical ; Population Density ; Population Dynamics ; Selection, Genetic/genetics ; Stochastic Processes
Language	English
Publishing date	2019-01-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2972-5
ISSN	1095-8541 ; 0022-5193
ISSN (online)	1095-8541
ISSN	0022-5193
DOI	10.1016/j.jtbi.2019.01.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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