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  1. Article ; Online: Advances in the applications of polymer biomaterials for in vitro follicle culture.

    Xiang, Du / Liu, Yang / Zhou, Encheng / Wang, Yanfeng

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2021  Volume 140, Page(s) 111422

    Abstract: The ovarian reserve (OR) indicates ovarian function by representing the quantity and quality of ovarian follicles, and it gradually decreases with increasing age. With the prolongation of women's lives, the protection provided by estrogen is lost for ... ...

    Abstract The ovarian reserve (OR) indicates ovarian function by representing the quantity and quality of ovarian follicles, and it gradually decreases with increasing age. With the prolongation of women's lives, the protection provided by estrogen is lost for decades in postmenopausal women, and the related cardiovascular and cerebrovascular diseases, osteoporosis, and decreased immunity are the main risk factors affecting women's quality of life and longevity. Pharmacologic hormone replacement therapy (PHRT) has been controversial, and the construction of artificial ovary (AO) has attracted increasing attention. The most critical step of AO generation is the establishment of an in vitro culture (IVC) system to support the development of isolated follicles. This article mainly compares the advantages and disadvantages of different polymer biomaterials for use in follicle IVC, provides theoretical support for the development and construction of the follicle IVC system using natural biological materials, and provides a theoretical basis for establishing mature AO technology.
    MeSH term(s) Animals ; Biocompatible Materials/administration & dosage ; Female ; Humans ; Ovarian Follicle/drug effects ; Ovary/drug effects ; Polymers/administration & dosage ; Quality of Life ; Tissue Culture Techniques/methods
    Chemical Substances Biocompatible Materials ; Polymers
    Language English
    Publishing date 2021-06-05
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2021.111422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anisotropic Strain-Tailoring Nonlinear Optical Response in van der Waals NbOI

    Wang, Han / Chen, Quan / Cao, Yi / Sang, Weihui / Tan, Feixia / Li, Honghong / Wang, Tinghao / Gan, Yang / Xiang, Du / Liu, Tao

    Nano letters

    2024  Volume 24, Issue 11, Page(s) 3413–3420

    Abstract: Two-dimensional (2D) ... ...

    Abstract Two-dimensional (2D) NbOI
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.4c00039
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  3. Article ; Online: Prevention of STAT3-related pathway in SK-N-SH cells by natural product astaxanthin

    Shao-Qian Sun / Feng-Xiang Du / Li-Hua Zhang / Hao-Shi / Fu-Ying Gu / Yu-Lin Deng / Yi-Zhi Ji

    BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Abstract Purpose Neuroblastoma (NB) is the most common solid malignancy in children. Despite current intensive treatment, the long-term event-free survival rate is less than 50% in these patients. Thus, patients with NB urgently need more valid treatment ...

    Abstract Abstract Purpose Neuroblastoma (NB) is the most common solid malignancy in children. Despite current intensive treatment, the long-term event-free survival rate is less than 50% in these patients. Thus, patients with NB urgently need more valid treatment strategies. Previous research has shown that STAT3 may be an effective target in high-risk NB patients. However, there are no effective inhibitors in clinical evaluation with low toxicity and few side effects. Astaxanthin is a safe and natural anticancer product. In this study, we investigated whether astaxanthin could exert antitumor effects in the SK-N-SH neuroblastoma cancer cell line. Method MTT and colony formation assays were used to determine the effect of astaxanthin on the proliferation and colony formation of SK-N-SH cells. Flow cytometry assays were used to detect the apoptosis of SK-N-SH cells. The migration and invasion ability of SK-N-SH cells were detected by migration and invasion assays. Western blot and RT-PCR were used to detect the protein and mRNA levels. Animal experiments were carried out and cell apoptosis in tissues were assessed using a TUNEL assay. Result We confirmed that astaxanthin repressed proliferation, clone formation ability, migration and invasion and induced apoptosis in SK-N-SH cells through the STAT3 pathway. Furthermore, the highest inhibitory effect was observed when astaxanthin was combined with si-STAT3. The reason for this may be that the combination of astaxanthin and si-STAT3 can lower STAT3 expression further than astaxanthin or si-STAT3 alone. Conclusion Astaxanthin can exert anti-tumor effect on SK-N-SH cells. The inhibitory effect was the higher when astaxanthin was combined with si-STAT3.
    Keywords Neuroblastoma ; Astaxanthin ; STAT3 ; Cell proliferation ; Apoptosis ; Cell migration inhibition ; Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Dielectric Engineered Two-Dimensional Neuromorphic Transistors.

    Xiang, Du / Liu, Tao / Zhang, Xumeng / Zhou, Peng / Chen, Wei

    Nano letters

    2021  Volume 21, Issue 8, Page(s) 3557–3565

    Abstract: Two-dimensional (2D) materials, which exhibit planar-wafer technique compatibility and pure electrically triggered communication, have established themselves as potential candidates in neuromorphic architecture integration. However, the current 2D ... ...

    Abstract Two-dimensional (2D) materials, which exhibit planar-wafer technique compatibility and pure electrically triggered communication, have established themselves as potential candidates in neuromorphic architecture integration. However, the current 2D artificial synapses are mainly realized at a single-device level, where the development of 2D scalable synaptic arrays with complementary metal-oxide-semiconductor compatibility remains challenging. Here, we report a 2D transition metal dichalcogenide-based synaptic array fabricated on commercial silicon-rich silicon nitride (sr-SiN
    MeSH term(s) Neural Networks, Computer ; Oxides ; Semiconductors ; Synapses
    Chemical Substances Oxides
    Language English
    Publishing date 2021-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.1c00492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress.

    Xiang, Du / Liu, Yang / Zhou, Shujun / Zhou, Encheng / Wang, Yanfeng

    Oxidative medicine and cellular longevity

    2021  Volume 2021, Page(s) 5523516

    Abstract: Perimenopause is an important stage of female senescence. Epidemiological investigation has shown that the incidence of cardiovascular disease in premenopausal women is lower than that in men, and the incidence of cardiovascular disease in postmenopausal ...

    Abstract Perimenopause is an important stage of female senescence. Epidemiological investigation has shown that the incidence of cardiovascular disease in premenopausal women is lower than that in men, and the incidence of cardiovascular disease in postmenopausal women is significantly higher than that in men. This phenomenon reveals that estrogen has a definite protective effect on the cardiovascular system. In the cardiovascular system, oxidative stress is considered important in the pathogenesis of atherosclerosis, myocardial dysfunction, cardiac hypertrophy, heart failure, and myocardial ischemia. From the perspective of oxidative stress, estrogen plays a regulatory role in the cardiovascular system through the estrogen receptor, providing strategies for the treatment of menopausal women with cardiovascular diseases.
    MeSH term(s) Cardiovascular Diseases/drug therapy ; Estrogens/pharmacology ; Estrogens/therapeutic use ; Female ; Humans ; Oxidative Stress/drug effects
    Chemical Substances Estrogens
    Language English
    Publishing date 2021-06-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2021/5523516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Artificially created interfacial states enabled van der Waals heterostructure memory device.

    Xiang, Du / Cao, Yi / Wang, Kun / Han, Zichao / Liu, Tao / Chen, Wei

    Nanotechnology

    2022  Volume 33, Issue 17

    Abstract: Two-dimensional (2D) interface plays a predominate role in determining the performance of a device that is configured as a van der Waals heterostructure (vdWH). Intensive efforts have been devoted to suppressing the emergence of interfacial states during ...

    Abstract Two-dimensional (2D) interface plays a predominate role in determining the performance of a device that is configured as a van der Waals heterostructure (vdWH). Intensive efforts have been devoted to suppressing the emergence of interfacial states during vdWH stacking process, which facilitates the charge interaction and transfer between the heterostructure layers. However, the effective generation and modulation of the vdWH interfacial states could give rise to a new design and architecture of 2D functional devices. Here, we report a 2D non-volatile vdWH memory device enabled by the artificially created interfacial states between hexagonal boron nitride (hBN) and molybdenum ditelluride (MoTe
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ac4b2f
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  7. Article ; Online: Two dimensional semiconducting materials for ultimately scaled transistors.

    Wei, Tianyao / Han, Zichao / Zhong, Xinyi / Xiao, Qingyu / Liu, Tao / Xiang, Du

    iScience

    2022  Volume 25, Issue 10, Page(s) 105160

    Abstract: Two dimensional (2D) semiconductors have been established as promising candidates to break through the short channel effect that existed in Si metal-oxide-semiconductor field-effect-transistor (MOSFET), owing to their unique atomically layered structure ... ...

    Abstract Two dimensional (2D) semiconductors have been established as promising candidates to break through the short channel effect that existed in Si metal-oxide-semiconductor field-effect-transistor (MOSFET), owing to their unique atomically layered structure and dangling-bond-free surface. The last decade has witnessed the significant progress in the size scaling of 2D transistors by various approaches, in which the physical gate length of the transistors has shrank from micrometer to sub-one nanometer with superior performance, illustrating their potential as a replacement technology for Si MOSFETs. Here, we review state-of-the-art techniques to achieve ultra-scaled 2D transistors with novel configurations through the scaling of channel, gate, and contact length. We provide comprehensive views of the merits and drawbacks of the ultra-scaled 2D transistors by summarizing the relevant fabrication processes with the corresponding critical parameters achieved. Finally, we identify the key opportunities and challenges for integrating ultra-scaled 2D transistors in the next-generation heterogeneous circuitry.
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.105160
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  8. Article ; Online: Research on a Low Melting Point Al-Si-Cu (Ni) Filler Metal for 6063 Aluminum Alloy Brazing

    Chengyin Peng / Dandan Zhu / Kaifeng Li / Xiang Du / Fei Zhao / Mingpan Wan / Yuanbiao Tan

    Applied Sciences, Vol 11, Iss 4296, p

    2021  Volume 4296

    Abstract: A new type of low melting point Al-Si-Cu (Ni) filler metal for brazed 6063 aluminum alloy was designed, and the microstructure and properties of the filler metal were systematically studied. The results show that when the content of Cu in the Al-Si-Cu ... ...

    Abstract A new type of low melting point Al-Si-Cu (Ni) filler metal for brazed 6063 aluminum alloy was designed, and the microstructure and properties of the filler metal were systematically studied. The results show that when the content of Cu in the Al-Si-Cu filler metal increased from 10 wt.% to 20 wt.%, the liquidus temperature of the filler metal decreased from 587.8 °C to 533.4 °C. Its microstructures were mainly composed of the α-Al phase, a primary Si phase, and a θ(Al 2 Cu) phase. After a proper amount of Ni was added to the Al-Si-20Cu filler metal, its melting range was narrowed, the spreading wettability was improved, and the microstructure was refined. Its microstructure mainly includes α-Al solid solution, Si particles, and θ(Al 2 Cu) and δ(Al 3 Ni 2 ) intermetallic compounds. The results of the shear strength test indicate that the shear strength of the brazed joint with Al-6.5Si-20Cu-2.0Ni filler metal was 150.4 MPa, which was 28.32% higher than that of the brazed joint with Al-6.5Si-20Cu filler metal.
    Keywords 6063 aluminum alloy ; Al-Si-Cu (Ni) filler metals ; microstructure ; shear strength ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 669
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Short-term synaptic plasticity in emerging devices for neuromorphic computing.

    Li, Chao / Zhang, Xumeng / Chen, Pei / Zhou, Keji / Yu, Jie / Wu, Guangjian / Xiang, Du / Jiang, Hao / Wang, Ming / Liu, Qi

    iScience

    2023  Volume 26, Issue 4, Page(s) 106315

    Abstract: Neuromorphic computing is a promising computing paradigm toward building next-generation artificial intelligence machines, in which diverse types of synaptic plasticity play an active role in information processing. Compared to long-term plasticity (LTP) ...

    Abstract Neuromorphic computing is a promising computing paradigm toward building next-generation artificial intelligence machines, in which diverse types of synaptic plasticity play an active role in information processing. Compared to long-term plasticity (LTP) forming the foundation of learning and memory, short-term plasticity (STP) is essential for critical computational functions. So far, the practical applications of LTP have been widely investigated, whereas the implementation of STP in hardware is still elusive. Here, we review the development of STP by bridging the physics in emerging devices and biological behaviors. We explore the computational functions of various STP in biology and review their recent progress. Finally, we discuss the main challenges of introducing STP into synaptic devices and offer the potential approaches to utilize STP to enrich systems' capabilities. This review is expected to provide prospective ideas for implementing STP in emerging devices and may promote the construction of high-level neuromorphic machines.
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106315
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  10. Article ; Online: High-strength, antibacterial, antioxidant, hemostatic, and biocompatible chitin/PEGDE-tannic acid hydrogels for wound healing.

    Cao, Hankun / Xiang, Du / Zhou, Xin / Yue, Pengpeng / Zou, Yongkang / Zhong, Zibiao / Ma, Yongsheng / Wang, Lizhe / Wu, Shuangquan / Ye, Qifa

    Carbohydrate polymers

    2023  Volume 307, Page(s) 120609

    Abstract: Natural polymer hydrogels are widely used in various aspects of biomedical engineering, such as wound repair, owing to their abundance and biosafety. However, the low strength and the lack of function restricted their development and application scope. ... ...

    Abstract Natural polymer hydrogels are widely used in various aspects of biomedical engineering, such as wound repair, owing to their abundance and biosafety. However, the low strength and the lack of function restricted their development and application scope. Herein, we fabricated novel multifunctional chitin/PEGDE-tannic acid (CPT) hydrogels through chemical- and physical-crosslinking strategies, using chitin as the base material, polyethylene glycol diglycidyl ether (PEGDE) and tannic acid (TA) as crosslinking agents, and 90 % ethanol as the regenerative bath. CPT hydrogels maintained a stable three-dimensional porous structure with suitable water contents and excellent biocompatibility. The mechanical properties of hydrogels were greatly improved (tensile stress up to 5.43 ± 1.14 MPa). Moreover, CPT hydrogels had good antibacterial, antioxidant, and hemostatic activities and could substantially promote wound healing in a rat model of full-thickness skin defect by regulating inflammatory responses and promoting collagen deposition and blood vessel formation. Therefore, this work provides a useful strategy to fabricate novel multifunctional CPT hydrogels with excellent mechanical, antibacterial, antioxidant, hemostatic, and biocompatible properties. CPT hydrogels could be promising candidates for wound healing.
    MeSH term(s) Rats ; Animals ; Hemostatics/pharmacology ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Wound Healing/physiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Chitin/pharmacology
    Chemical Substances Hemostatics ; Antioxidants ; Hydrogels ; Anti-Bacterial Agents ; Chitin (1398-61-4)
    Language English
    Publishing date 2023-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2023.120609
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