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  1. Article ; Online: Ping-Pong Gaze in Sporadic Creutzfeldt-Jakob Disease.

    Yang, Yuan / Tan, Hua / Xiang, Shuli / Chen, Xiu / Guo, Xiaoyan

    Movement disorders clinical practice

    2024  Volume 11, Issue 3, Page(s) 301–302

    MeSH term(s) Humans ; Creutzfeldt-Jakob Syndrome/diagnosis ; Nystagmus, Pathologic
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acute quadriplegia and epileptic seizures in a 47-year-old man.

    Yang, Yuan / Guo, Xiaoyan / Tang, Xingjiang / Tan, Hua / Xiang, Shuli / Li, Zuoxiao

    Clinical medicine (London, England)

    2022  Volume 22, Issue 6, Page(s) 578–579

    Abstract: We present a case of a cerebral and spinal infarction caused by paradoxical embolism following traveller's thrombosis in a patient with a low activity of protein S. ...

    Abstract We present a case of a cerebral and spinal infarction caused by paradoxical embolism following traveller's thrombosis in a patient with a low activity of protein S.
    MeSH term(s) Male ; Humans ; Middle Aged ; Epilepsy ; Quadriplegia/etiology ; Seizures/etiology
    Language English
    Publishing date 2022-11-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2022-0419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: [Immunopathological evidence of terminal residues containing sialic acid in Campylobacter jejuni lipopolysaccharide as the critical antigen to induce peripheral neuropathy].

    Xiang, Shu-li / Cai, Fang-cheng / Zhang, Xiao-ping / Deng, Bing

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2005  Volume 43, Issue 9, Page(s) 665–670

    Abstract: Objective: To explore the important role of the terminal residues containing sialic acid (SA) in Campylobacter jejuni (CJ) lipopolysaccharide (LPS) as the critical antigen to induce nerve damage, and also to identify immunopathological evidence for the ... ...

    Abstract Objective: To explore the important role of the terminal residues containing sialic acid (SA) in Campylobacter jejuni (CJ) lipopolysaccharide (LPS) as the critical antigen to induce nerve damage, and also to identify immunopathological evidence for the hypothesis of molecular mimicry and cross-immunity between CJ LPS and gangliosides.
    Methods: A mutant of Pen O:19 CJ with neuB1 gene inactivated and LPS outer core terminal residues losing SA was to be constructed. PCR and RT-PCR were used to confirm the mutant. Capability of CJ LPS binding to cholera toxin B subunit (CTB) was tested. Guinea pigs were systematically immunized with LPS of the wild and the mutant strains, respectively. Titers of anti-LPS and anti-ganglioside GM(1) IgG antibodies in sera of immunized guinea pigs were detected by ELISA. Pathological study for sciatic nerves of both Guinea pigs either immunized systematically or perineural injection with their immunized serum was finished.
    Results: (1) The mutant of CJ O:19 strain with inactivated neuB1 gene was successfully constructed and lost transcriptional activity of neuB1 gene in the mutant strain was confirmed by PCR and RT-PCR. SA was well demonstrated by both acidic ninhydrin reaction and periodate-resorcinol reaction in the LPS of wild strain but not in the mutant LPS; (2) Compared with the titers before immunization, the titers of anti-GM(1) IgG antibody increased in sera of guinea pigs immunized with LPS of the wild strain. However there were no detectable anti-GM(1) IgG antibody in sera of the animals immunized with mutant LPS and PBS. (3) The incidence of pathological fibers of sciatic nerves in wild CJ LPS group (17.3%) was significantly higher than the mutant CJ LPS group (chi(2) = 125, P < 0.01); the difference between the mutant CJ LPS group and control group was not statistically significant (chi(2) = 1.633, P > 0.05). (4) After perineural injection with immunized serum, the incidence of pathological fibers of sciatic nerves in wild strain group (67.8%) was also significantly higher than the incidence of mutant group (P < 0.01).
    Conclusion: A mutant of CJ O:19 strain neuB1 gene inactivated and SA component of terminal structure of LPS lost was successfully constructed. And it no longer expressed SA component which is the normal terminal structure of LPS in wild strain. The capability of the wild strain to induce increased titers of anti-GM(1) antibody and immune-mediated nerve damage was simultaneously lost for the mutant strain. It could be a strong immunopathologic evidence to identify the molecular mimicry hypothesis between CJ LPS and ganglioside epitope in nerve on the pathogenesis of CJ related GBS. The terminal residues containing SA should be as the basic GM1-like structure in CJ LPS.
    MeSH term(s) Animals ; Antibodies, Bacterial/blood ; Antibodies, Bacterial/immunology ; Antigens, Bacterial/genetics ; Antigens, Bacterial/immunology ; Campylobacter jejuni/genetics ; Campylobacter jejuni/immunology ; G(M1) Ganglioside/immunology ; Guinea Pigs ; Lipopolysaccharides/chemistry ; Lipopolysaccharides/immunology ; Molecular Mimicry ; Mutagenesis ; N-Acetylneuraminic Acid/chemistry ; N-Acetylneuraminic Acid/immunology ; Peripheral Nervous System Diseases/immunology ; Peripheral Nervous System Diseases/microbiology
    Chemical Substances Antibodies, Bacterial ; Antigens, Bacterial ; Lipopolysaccharides ; G(M1) Ganglioside (37758-47-7) ; N-Acetylneuraminic Acid (GZP2782OP0)
    Language Chinese
    Publishing date 2005-09
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3292: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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