Article ; Online: Associations of dietary protein intake with all-cause, cardiovascular disease, and cancer mortality: A systematic review and meta-analysis of cohort studies.
Nutrition, metabolism, and cardiovascular diseases : NMCD
2020 Volume 30, Issue 7, Page(s) 1094–1105
Abstract: Background and aims: The relationships between dietary protein intake and risk of all-cause, cardiovascular disease (CVD), and cancer mortality are still unclear. We conducted a systematic review with meta-analysis of cohort studies to summarize the ... ...
| Abstract | Background and aims: The relationships between dietary protein intake and risk of all-cause, cardiovascular disease (CVD), and cancer mortality are still unclear. We conducted a systematic review with meta-analysis of cohort studies to summarize the evidence. Methods and results: We searched PubMed and Web of Science for relevant studies through February 2020. The associations of total, animal, and plant proteins with all-cause, CVD, and cancer mortality were evaluated. Study-specific relative risks (RR) were pooled using the fixed effect model when no significant heterogeneity was detected; otherwise the random effect model was employed. Twelve cohort studies were eligible for the study. Increased total protein showed no clear association with risk of all-cause, CVD, and cancer mortality. In the stratified analysis by protein sources, higher plant protein intake was associated with a reduced risk of all-cause mortality (highest vs lowest intake: RR = 0.92; 95% CI: 0.88, 0.96; each 3% increment of intake: RR = 0.97; 95% CI: 0.94, 0.99), and may be associated with a reduced risk of CVD mortality (highest vs lowest intake: RR = 0.90; 95% CI: 0.80, 1.01; each 3% increment of intake: RR = 0.95; 95% CI: 0.91, 0.99). Moreover, higher intake of animal protein may be associated with an increased risk of CVD mortality (highest vs lowest intake: RR = 1.11; 95% CI: 1.01, 1.22; each 3% increment of intake: RR = 1.02; 95% CI: 0.98, 1.06). Conclusion: This study demonstrates that higher plant protein intake is associated with a reduced risk of all-cause and CVD-related mortality. Persons should be encouraged to increase their plant protein intake to potentially decrease their risk of death. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control ; Cause of Death ; Diet, Healthy ; Female ; Humans ; Male ; Middle Aged ; Neoplasms/diagnosis ; Neoplasms/mortality ; Neoplasms/prevention & control ; Nutritive Value ; Plant Proteins, Dietary/administration & dosage ; Protective Factors ; Recommended Dietary Allowances ; Risk Assessment ; Risk Factors ; Risk Reduction Behavior ; Time Factors |
| Chemical Substances | Plant Proteins, Dietary |
| Language | English |
| Publishing date | 2020-03-17 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Meta-Analysis ; Systematic Review |
| ZDB-ID | 1067704-5 |
| ISSN | 1590-3729 ; 0939-4753 |
| ISSN (online) | 1590-3729 |
| ISSN | 0939-4753 |
| DOI | 10.1016/j.numecd.2020.03.008 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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