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  1. AU="Xiangpeng Yuan"
  2. AU="Rajpoot, Akanksha"
  3. AU="Aragaw, Kassaye"
  4. AU="Nalesso, Giovanna"
  5. AU="Remzi, F"
  6. AU="Lely Solari"
  7. AU="Aldridge, Daniel L"
  8. AU=Gross Lissy Z F AU=Gross Lissy Z F
  9. AU="DeVita, Robert"
  10. AU=Berkenstock Meghan K
  11. AU=Saleh Mohammed
  12. AU="Ganesan, Anuradha"
  13. AU="Ye, Yi-Fan"
  14. AU="Astasov-Frauenhoffer, Monika"
  15. AU="Ferrer-Diaz, Alejandra I"
  16. AU="Iwata, Miko"

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Treffer 1 - 4 von insgesamt 4

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  1. Artikel ; Online: Thyroid Carcinoma

    Jinwei Hu / Isabella J. Yuan / Saied Mirshahidi / Alfred Simental / Steve C. Lee / Xiangpeng Yuan

    International Journal of Molecular Sciences, Vol 22, Iss 4, p

    Phenotypic Features, Underlying Biology and Potential Relevance for Targeting Therapy

    2021  Band 1950

    Abstract: Thyroid carcinoma consists a group of phenotypically heterogeneous cancers. Recent advances in biological technologies have been advancing the delineation of genetic, epigenetic, and non-genetic factors that contribute to the heterogeneities of these ... ...

    Abstract Thyroid carcinoma consists a group of phenotypically heterogeneous cancers. Recent advances in biological technologies have been advancing the delineation of genetic, epigenetic, and non-genetic factors that contribute to the heterogeneities of these cancers. In this review article, we discuss new findings that are greatly improving the understanding of thyroid cancer biology and facilitating the identification of novel targets for therapeutic intervention. We review the phenotypic features of different subtypes of thyroid cancers and their underlying biology. We discuss recent discoveries in thyroid cancer heterogeneities and the critical mechanisms contributing to the heterogeneity with emphases on genetic and epigenetic factors, cancer stemness traits, and tumor microenvironments. We also discuss the potential relevance of the intratumor heterogeneity in understanding therapeutic resistance and how new findings in tumor biology can facilitate designing novel targeting therapies for thyroid cancer.
    Schlagwörter thyroid carcinoma ; heterogeneity ; cancer stem cells ; tumor microenvironments ; genetics ; epigenetics ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Targeting Tumor Microenvironment Akt Signaling Represents a Potential Therapeutic Strategy for Aggressive Thyroid Cancer

    Saied Mirshahidi / Isabella J. Yuan / Alfred Simental / Steve C. Lee / Nathaniel R. Peterson / Pedro A. Andrade Filho / Thomas Murry / Penelope Duerksen-Hughes / Xiangpeng Yuan

    International Journal of Molecular Sciences, Vol 24, Iss 5471, p

    2023  Band 5471

    Abstract: Effects of the tumor microenvironment (TME) stromal cells on progression in thyroid cancer are largely unexplored. Elucidating the effects and underlying mechanisms may facilitate the development of targeting therapy for aggressive cases of this disease. ...

    Abstract Effects of the tumor microenvironment (TME) stromal cells on progression in thyroid cancer are largely unexplored. Elucidating the effects and underlying mechanisms may facilitate the development of targeting therapy for aggressive cases of this disease. In this study, we investigated the impact of TME stromal cells on cancer stem-like cells (CSCs) in patient-relevant contexts where applying in vitro assays and xenograft models uncovered contributions of TME stromal cells to thyroid cancer progression. We found that TME stromal cells can enhance CSC self-renewal and invasiveness mainly via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway. The disruption of Akt signaling could diminish the impact of TME stromal cells on CSC aggressiveness in vitro and reduce CSC tumorigenesis and metastasis in xenografts. Notably, disrupting Akt signaling did not cause detectable alterations in tumor histology and gene expression of major stromal components while it produced therapeutic benefits. In addition, using a clinical cohort, we discovered that papillary thyroid carcinomas with lymph node metastasis are more likely to have elevated Akt signaling compared with the ones without metastasis, suggesting the relevance of Akt-targeting. Overall, our results identify PI3K/Akt pathway-engaged contributions of TME stromal cells to thyroid tumor disease progression, illuminating TME Akt signaling as a therapeutic target in aggressive thyroid cancer.
    Schlagwörter Akt signaling ; cancer stem cell ; thyroid cancer ; tumor stromal cell ; targeting aggressive disease ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Neural stem cells--a promising potential therapy for brain tumors.

    Dwain, Irvin / Xiangpeng, Yuan / Zeng, Zhaohui / Patricia, Tunici / Joh S, Yu

    Current stem cell research & therapy

    2008  Band 1, Heft 1, Seite(n) 79–84

    Abstract: Brain tumors can be highly aggressive and debilitating for many patients and lead to an untimely death in just a few months. Unfortunately, due to the location of many brain tumors, therapy with ionizing radiation, chemotherapeutic agents and/or surgery ... ...

    Abstract Brain tumors can be highly aggressive and debilitating for many patients and lead to an untimely death in just a few months. Unfortunately, due to the location of many brain tumors, therapy with ionizing radiation, chemotherapeutic agents and/or surgery has limited rewards. In addition, the probability of totally removing highly infiltrative tumors, particularly gliomas, is extremely low and rarely provides a cure. The need for directed targeting and ablation of tumors with minimal damage to nearby healthy tissue has lead to the most recent findings and uses of neural stem cells for therapeutic treatment of brain tumors. Recently, some very promising studies have demonstrated that exogenous neural stem cells have the remarkable ability to migrate very long distances towards sites of metastasis after transplantation. These studies also show that intravascular injections of neural stem cells may lead to preferential migration towards central nervous system tumors. It has also been demonstrated that genetically modified neural stem cells, engineered to produce anti-tumor molecules, upon transplantation, have the ability to migrate towards tumors and reduce tumor mass directly or through a "bystander" effect. Here we review the current literature examining the promise of utilizing genetically modified neural stem cells as vehicles for CNS tumor therapy.
    Mesh-Begriff(e) Brain Neoplasms/therapy ; Cell Movement ; Humans ; Neurons/cytology ; Neurons/physiology ; Neurons/transplantation ; Signal Transduction ; Stem Cell Transplantation/adverse effects
    Sprache Englisch
    Erscheinungsdatum 2008-01-02
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2251937-3
    ISSN 1574-888X
    ISSN 1574-888X
    DOI 10.2174/157488806775269070
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Glioma Tropic Neural Stem Cells Consist of Astrocytic Precursors and Their Migratory Capacity Is Mediated by CXCR4

    Moneeb Ehtesham / Xiangpeng Yuan / Peter Kabos / Nancy H.C. Chung / Gentao Liu / Yasuharu Akasaki / Keith L. Black / John S. Yu

    Neoplasia : An International Journal for Oncology Research, Vol 6, Iss 3, Pp 287-

    2004  Band 293

    Abstract: Malignant gliomas spawn disseminated microsatellites, which are largely refractory to currently employed therapies, resulting in eventual tumor recurrence and death. The use of tumor-tropic neural stem cells (NSCs) as delivery vehicles for therapeutic ... ...

    Abstract Malignant gliomas spawn disseminated microsatellites, which are largely refractory to currently employed therapies, resulting in eventual tumor recurrence and death. The use of tumor-tropic neural stem cells (NSCs) as delivery vehicles for therapeutic gene products represents an attractive strategy specifically focused at treating these residual neoplastic foci. We wished to elucidate the biological cues governing NSC tropism for glioma. In this context, we describe that tumortropic NSCs comprise largely of astrocytic progenitors expressing chemokine receptor 4 (CXCR4). Blocking of CXCR4 significantly inhibits NSC migration toward the tumor. These findings define specific characteristics associated with the cell populations within transplanted NSCs that demonstrate glioma-tracking behavior.
    Schlagwörter Glioma/brain tumor ; neural stem cells ; migration ; CXCR4 ; SDF-1 ; Medicine ; R ; Internal medicine ; RC31-1245 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Erscheinungsdatum 2004-05-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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