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  1. Article ; Online: Flame-Retardant and Washable Finishing of Lyocell/Cotton Blended Fabrics Using Eco-Friendly Creatinine O-Phosphate

    Xuan Yang / Yunbo Zheng / Xiaohui Liu / Yuanlin Ren / Xianwen Yang / Qiuyan Zhang

    Journal of Natural Fibers, Vol 20, Iss

    2023  Volume 1

    Abstract: Creatinine O-phosphate (COP) containing phosphorus and nitrogen elements was used as eco-friendly flame-retardant for lyocell/cotton blended fabric (L/C fabric). The flame retardant fabrics are prepared by a simple and effective dip-dry-cure method. ... ...

    Abstract Creatinine O-phosphate (COP) containing phosphorus and nitrogen elements was used as eco-friendly flame-retardant for lyocell/cotton blended fabric (L/C fabric). The flame retardant fabrics are prepared by a simple and effective dip-dry-cure method. Fourier infrared spectroscopy (FTIR), scanning electron microscope (SEM), and X-ray photoelectron spectroscopy (XPS) analyses certified that COP has been successfully grafted onto the surface of the L/C fabric and distributed evenly. Compared with the control fabric, the thermogravimetric analysis (TG) results showed that the char residue rate of the flame-retardant fabric at 800°C increased by 229% (air atmosphere), indicating that it has excellent char-forming ability. Besides, cone calorimetry results showed that the PHRR and THR values of the treated L/C fabric were reduced by 88.83% and 76.65%, respectively. The volatile pyrolysis products of the treated L/C fabric were determined by thermogravimetric analysis coupled with Fourier transform infrared analysis (TG-IR). In general, these results indicated that the L/C fabric treated with COP had high flame retardancy, excellent washing resistance and thermal stability.
    Keywords lyocell/cotton blended fabric ; flame retardant ; eco-friendly material ; creatinine o-phosphate ; thermal decomposition ; combustion behavior ; Science ; Q ; Textile bleaching ; dyeing ; printing ; etc ; TP890-933
    Subject code 660
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Deep-sea-derived viridicatol relieves allergic response by suppressing MAPK and JAK-STAT signalling pathways of RBL-2H3 cells

    Yan Liu / Zhendan Shu / Yan Li / Huiying Chen / Hong Liu / Xianwen Yang / Guangming Liu / Qingmei Liu

    Food and Agricultural Immunology, Vol 34, Iss

    2023  Volume 1

    Abstract: ABSTRACTOur previous studies reported that viridicatol isolated from the deep-sea-derived fungus Penicillium griseofulvum could regulate the stabilisation of mast cells to relieve food allergy. To understand the molecular role of viridicatol in ... ...

    Abstract ABSTRACTOur previous studies reported that viridicatol isolated from the deep-sea-derived fungus Penicillium griseofulvum could regulate the stabilisation of mast cells to relieve food allergy. To understand the molecular role of viridicatol in stabilising mast cells, transcriptomes of viridicatol-treated RBL-2H3 cells were analysed by RNA-sequencing. There were 128 differentially expressed genes in activated RBL-2H3 cells with or without viridicatol treatment. The mast cell activation-related genes were significantly reduced by treatment with viridicatol through RT-qPCR analysis. Moreover, Kyoto Encyclopedia of Genes and Genomes enrichment analysis indicated that viridicatol was important in mast cell stabilisation by affecting MAPK and JAK-STAT signalling pathways. Additionally, molecular docking and western blot analysis revealed that the phosphorylated JNK, ERK, P38, and STAT6 proteins were inhibited by viridicatol. Taken together, viridicatol has the potential to be used as a new type of anti-food allergic functional material via controlling MAPK and JAK-STAT signalling pathways of mast cells.
    Keywords Anti-food allergy ; MAPK ; mast cells ; RNA sequencing ; viridicatol ; Agriculture (General) ; S1-972 ; Immunologic diseases. Allergy ; RC581-607
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Aberrant DNA Methylation in Acute Myeloid Leukemia and Its Clinical Implications

    Xianwen Yang / Molly Pui Man Wong / Ray Kit Ng

    International Journal of Molecular Sciences, Vol 20, Iss 18, p

    2019  Volume 4576

    Abstract: Acute myeloid leukemia (AML) is a heterogeneous disease that is characterized by distinct cytogenetic or genetic abnormalities. Recent discoveries in cancer epigenetics demonstrated a critical role of epigenetic dysregulation in AML pathogenesis. Unlike ... ...

    Abstract Acute myeloid leukemia (AML) is a heterogeneous disease that is characterized by distinct cytogenetic or genetic abnormalities. Recent discoveries in cancer epigenetics demonstrated a critical role of epigenetic dysregulation in AML pathogenesis. Unlike genetic alterations, the reversible nature of epigenetic modifications is therapeutically attractive in cancer therapy. DNA methylation is an epigenetic modification that regulates gene expression and plays a pivotal role in mammalian development including hematopoiesis. DNA methyltransferases (DNMTs) and Ten-eleven-translocation (TET) dioxygenases are responsible for the dynamics of DNA methylation. Genetic alterations of DNMTs or TETs disrupt normal hematopoiesis and subsequently result in hematological malignancies. Emerging evidence reveals that the dysregulation of DNA methylation is a key event for AML initiation and progression. Importantly, aberrant DNA methylation is regarded as a hallmark of AML, which is heralded as a powerful epigenetic marker in early diagnosis, prognostic prediction, and therapeutic decision-making. In this review, we summarize the current knowledge of DNA methylation in normal hematopoiesis and AML pathogenesis. We also discuss the clinical implications of DNA methylation and the current therapeutic strategies of targeting DNA methylation in AML therapy.
    Keywords Acute myeloid leukemia ; DNA methylation ; epigenetic biomarker ; therapeutics ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Chemical Constituents of Cassia abbreviata and Their Anti-HIV-1 Activity

    Xianwen Yang / Zhihui He / Yue Zheng / Ning Wang / Martin Mulinge / Jean-Claude Schmit / André Steinmetz / Carole Seguin-Devaux

    Molecules, Vol 26, Iss 2455, p

    2021  Volume 2455

    Abstract: Three new ( 1 – 3 ) and 25 known compounds were isolated from the crude extract of Cassia abbreviata . The chemical structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone ( 1 ) ... ...

    Abstract Three new ( 1 – 3 ) and 25 known compounds were isolated from the crude extract of Cassia abbreviata . The chemical structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone ( 1 ) is the first heterodimer of guibourtinidol and planchol A. Compound 2 was a new chalcane, while 3 was a new naphthalene. Cassiabrevone ( 1 ), guibourtinidol-(4α→8)-epiafzelechin ( 4 ), taxifolin ( 8 ), oleanolic acid ( 17 ), piceatannol ( 22 ), and palmitic acid ( 28 ), exhibited potent anti-HIV-1 activity with IC 50 values of 11.89 µM, 15.39 µM, 49.04 µM, 7.95 µM, 3.58 µM, and 15.97 µM, respectively.
    Keywords Cassia abbreviata ; Fabaceae ; anti-HIV ; heterodimer ; flavonoid ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Viridicatol Isolated from Deep-Sea Penicillium Griseofulvum Alleviates Anaphylaxis and Repairs the Intestinal Barrier in Mice by Suppressing Mast Cell Activation

    Zhendan Shu / Qingmei Liu / Cuiping Xing / Yafen Zhang / Yu Zhou / Jun Zhang / Hong Liu / Minjie Cao / Xianwen Yang / Guangming Liu

    Marine Drugs, Vol 18, Iss 517, p

    2020  Volume 517

    Abstract: Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food ... ...

    Abstract Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were established to explore the anti-allergic properties of viridicatol. On the basis of the mouse model, we found viridicatol to alleviate the allergy symptoms; decrease the levels of specific immunoglobulin E, mast cell protease-1, histamine, and tumor necrosis factor-α; and promote the production of interleukin-10 in the serum. The treatment of viridicatol also downregulated the population of B cells and mast cells (MCs), as well as upregulated the population of regulatory T cells in the spleen. Moreover, viridicatol alleviated intestinal villi injury and inhibited the degranulation of intestinal MCs to promote intestinal barrier repair in mice. Furthermore, the accumulation of Ca 2+ in RBL-2H3 cells was significantly suppressed by viridicatol, which could block the activation of MCs. Taken together, these data indicated that deep-sea viridicatol may represent a novel therapeutic for allergic diseases.
    Keywords food allergy ; deep-sea-derived viridicatol ; X-ray single crystal ; intestinal barrier ; mast cell ; calcium influx ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp.

    Ying Liu / Shizhe Zhao / Wanjing Ding / Pinmei Wang / Xianwen Yang / Jinzhong Xu

    Marine Drugs, Vol 12, Iss 10, Pp 5124-

    2014  Volume 5131

    Abstract: Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were ... ...

    Abstract Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. Apochalasin V showed moderate activity at IC50 values of 30.4 and 39.2 μM, respectively.
    Keywords gut fungi ; Aspergillus sp ; aspochalasin ; methylthiol ; cytotoxicity ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2014-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: A new taurine derivative from South China Sea marine sponge Axinella sp

    Huang, Riming / Yan Peng / Xuefeng Zhou / Xianwen Yang / Yonghong Liu

    Natural product research. 2013 Sept. 1, v. 27, no. 17

    2013  

    Abstract: A new (1) and two known (2 and 3) acylated taurine derivatives were isolated from the South China Sea marine sponge Axinella sp. The structures of the compounds were determined on the basis of spectral analysis. Compounds 1–3 did not inhibit the growth ... ...

    Abstract A new (1) and two known (2 and 3) acylated taurine derivatives were isolated from the South China Sea marine sponge Axinella sp. The structures of the compounds were determined on the basis of spectral analysis. Compounds 1–3 did not inhibit the growth of hepatoma carcinoma cell (HepG2), lung carcinoma cell (A549), human breast carcinoma (MCF-7), no-small cell lung cancer (NCI-H460) and human nasopharyngeal carcinoma cell lines.
    Keywords Porifera ; breast neoplasms ; carcinoma ; hepatoma ; humans ; lung neoplasms ; spectral analysis ; taurine ; South China Sea
    Language English
    Dates of publication 2013-0901
    Size p. 1537-1541.
    Publishing place Taylor & Francis Group
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2012.733389
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: System Design of a Trusted SoC and Detailed Analysis of its Secure State Transitions

    Xianwen Yang / Luguo Zhang / Zheng Li / Shixiong Zhu / Wenzheng Zhang / Yongqi Lv

    International Journal of Computer Network and Information Security , Vol 2, Iss 1, Pp 52-

    2010  Volume 59

    Abstract: According to the relevant criterion and principle for designing and evaluating various trusted computing chips, we have proposed a new trusted SoC chip, and have given the implementation of its basic functional modules. In detail, we have discussed the ... ...

    Abstract According to the relevant criterion and principle for designing and evaluating various trusted computing chips, we have proposed a new trusted SoC chip, and have given the implementation of its basic functional modules. In detail, we have discussed the design of the trusted SoC security architecture and the main module functional modules such as microprocessor, cryptographic function module, security management module, input/output interface, along with the most important memory management unit. Moreover, we have discussed reliability of relevant parameters and transfer strategy for trusted root in chip development and application, together with the simulation and validation of corresponding functions. At last, we point out that one of the most important further research directions is the trusted measurement of dynamic data and software running in security environment.
    Keywords SoC ; COS ; security system design ; trusted measurement ; trusted transfer strategy ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
    Subject code 005
    Language English
    Publishing date 2010-11-01T00:00:00Z
    Publisher MECS Publisher
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.

    Bin Yang / Shengrong Liao / Xiuping Lin / Junfeng Wang / Juan Liu / Xuefeng Zhou / Xianwen Yang / Yonghong Liu

    Marine Drugs, Vol 11, Iss 12, Pp 4741-

    2013  Volume 4750

    Abstract: Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based ... ...

    Abstract Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.
    Keywords soft coral ; Sinularia sp ; sesquiterpenes ; sinularianins ; NF-κB ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2013-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce

    Wang, Junfeng / Bin Yang / Hao Chen / Juan Liu / Shengrong Liao / Tianyu Zhang / Xianwen Yang / Xiaochu Qin / Xiaoyi Wei / Xiuping Lin / Xuefeng Zhou / Yonghong Liu / Zhengchao Tu

    Phytochemical Society of Europe Phytochemistry letters. 2015 June, v. 12

    2015  

    Abstract: Two new prenylated phenols vaccinol H (1) and vaccinol I (2), together with three known phenols derivatives 3–5, one glyceride derivative 6, and ergosterol 7 were isolated from endogenous Pestalotiopsis vaccinii (cgmcc3.9199) of mangrove plant Kandelia ... ...

    Abstract Two new prenylated phenols vaccinol H (1) and vaccinol I (2), together with three known phenols derivatives 3–5, one glyceride derivative 6, and ergosterol 7 were isolated from endogenous Pestalotiopsis vaccinii (cgmcc3.9199) of mangrove plant Kandelia candel (L.) Druce (Rhizophoraceae). The new structures of 1 and 2 were determined by spectroscopic analyses and circular dichroism (CD) spectra. Most of the isolated compounds (2–6) were tested for their antiviral (EV71), cytotoxic, anti-tuberculosis, and anti-inflammatory effects. Among these compounds, compound 2 exhibited potent COX-2 inhibitory activity with an IC50 value of 16.8μM.
    Keywords anti-inflammatory activity ; circular dichroism spectroscopy ; cytotoxicity ; ergosterol ; fungi ; inhibitory concentration 50 ; Kandelia candel ; Pestalotiopsis ; phenols
    Language English
    Dates of publication 2015-06
    Size p. 59-62.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2015.02.013
    Database NAL-Catalogue (AGRICOLA)

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