Article ; Online: Microstructural brain abnormalities and associated neurocognitive dysfunction in obstructive sleep apnea: a pilot study with diffusion kurtosis imaging.
2024
Abstract: Study objectives: To assess the possible brain abnormalities in adult patients with moderate and severe obstructive sleep apnea (OSA) using the mean kurtosis (MK) from diffusion kurtosis imaging (DKI) and analyze the correlation between MK and cognitive ...
| Abstract | Study objectives: To assess the possible brain abnormalities in adult patients with moderate and severe obstructive sleep apnea (OSA) using the mean kurtosis (MK) from diffusion kurtosis imaging (DKI) and analyze the correlation between MK and cognitive function. Methods: A total of 30 patients with moderate and severe OSA and 30 healthy controls (HCs) evaluated by the Montreal Cognitive Assessment (MoCA) scale were enrolled. All subjects underwent DKI and 3D T1-weighted imaging (T1WI) on a 3.0T MR scanner. The MK values of gray and white matter brain regions were compared. Partial correlation analysis was used to analyze the correlation between respiratory sleep parameters/cognitive score and MK values in different brain regions. Results: Compared with the HCs, the MK of 20 brain regions (13 after false discovery rate (FDR) correction) and cognitive scores in the OSA group were significantly lower. In the OSA group, the apnea-hypopnea index (AHI) was negatively correlated with the MK in the white matter of the right occipital lobe; the LSpO Conclusions: MK values of DKI imaging may provide valuable information in assessing the neurological impacts of obstructive sleep apnea. |
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| Language | English | |||||
| Publishing date | 2024-04-24 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2397213-0 | |||||
| ISSN | 1550-9397 ; 1550-9389 | |||||
| ISSN (online) | 1550-9397 | |||||
| ISSN | 1550-9389 | |||||
| DOI | 10.5664/jcsm.11184 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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