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Article: Value of procalcitonin and presepsin in the diagnosis and severity stratification of sepsis and septic shock.

Ren, Enfeng / Xiao, Hongli / Wang, Guoxing / Zhao, Yongzhen / Yu, Han / Li, Chunsheng

2024 Volume 15, Issue 2, Page(s) 135–138

Language	English
Publishing date	2024-02-22
Publishing country	China
Document type	Journal Article
ZDB-ID	2753264-1
ISSN	1920-8642
ISSN	1920-8642
DOI	10.5847/wjem.j.1920-8642.2024.028
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Article ; Online: Vitamin D Attenuates Airway Inflammation in Asthmatic Guinea Pigs Using Mammalian Target of Rapamycin-Mediated Autophagy.

Zha, Lin / Wu, Guangji / Xiao, Hongli / Xiao, Yanmin

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2022 Volume 42, Issue 4, Page(s) 170–179

Abstract: The purpose of this experiment is to find out the function of Vitamin D (VD) in airway inflammation in asthmatic guinea pigs by regulating mammalian target of rapamycin (mTOR)-mediated autophagy. A total of 40 male guinea pigs were randomly assigned into ...

Abstract	The purpose of this experiment is to find out the function of Vitamin D (VD) in airway inflammation in asthmatic guinea pigs by regulating mammalian target of rapamycin (mTOR)-mediated autophagy. A total of 40 male guinea pigs were randomly assigned into the Con group, the ovalbumin (OVA)-sensitized group, the VD group, the VD + dimethyl sulfoxide group, and the VD + rapamycin (mTOR inhibitor) group. Then, serum from all groups was harvested for the measurement of immunoglobulin E (IgE), interleukin (IL)-4, and IL-5 levels. Next, bronchoalveolar lavage fluid was collected for cell counting. Moreover, lung tissues were extracted to assess levels of p-mTOR and autophagy factors (LC3B, Beclin1, Atg5, and P62). Compared with the Con group, the OVA group showed elevated levels of IgE, IL-4, and IL-5, increased contents of eosinophils, neutrophil, and lymphocytes, and declined monocytes. And the VD group improved inflammatory reactions in the guinea pigs. Besides, the OVA group showed lower levels of p-mTOR and P62 and higher autophagy levels than the Con group, while the VD group had opposite results. Rapamycin annulled the suppressive role of VD to airway inflammation in asthmatic guinea pigs. VD might inhibit OVA-induced airway inflammation by inducing mTOR activation and downregulating autophagy in asthmatic guinea pigs.
MeSH term(s)	Animals ; Asthma/drug therapy ; Autophagy ; Disease Models, Animal ; Female ; Guinea Pigs ; Immunoglobulin E ; Inflammation/drug therapy ; Interleukin-5 ; Lung ; Male ; Mammals ; Ovalbumin ; Sirolimus ; TOR Serine-Threonine Kinases ; Vitamin D/therapeutic use
Chemical Substances	Interleukin-5 ; Vitamin D (1406-16-2) ; Immunoglobulin E (37341-29-0) ; Ovalbumin (9006-59-1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2022-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2021.0189
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Article: Alternative splicing analysis showed the splicing factor polypyrimidine tract-binding protein 1 as a potential target in acute myeloid leukemia therapy.

Zhang, Qiao-Xia / Pan, Yu-Ming / Xiao, Hong-Li / An, Na / Deng, Si-Si / Du, Xin

Neoplasma

2022 Volume 69, Issue 5, Page(s) 1198–1208

Abstract: Alternative splicing (AS) is a universal post-transcriptional regulation process in cells, and increasing evidences have validated its crucial role in tumors. We collected AS event, gene expression, and clinical data of 178 AML patients from The Cancer ... ...

Abstract	Alternative splicing (AS) is a universal post-transcriptional regulation process in cells, and increasing evidences have validated its crucial role in tumors. We collected AS event, gene expression, and clinical data of 178 AML patients from The Cancer Genome Atlas (TCGA) project. More than 1,000 AS events were found associated with overall survival (OS), and alternate promoter (AP) events were the most significant. The expression of the KIAA0930 transcript was the most significantly different AS event selected from AP events and significantly correlated with the expression of the splicing factor (SF) polypyrimidine tract-binding protein 1 (PTBP1). Then, the roles of PTBP1 on AS of the KIAA0930 and the proliferation of AML cells were confirmed. KIAA0930 variant 1 (KIAA0930-1) was upregulated and variant 2 (KIAA0930-2) downregulated with knockdown PTBP1 expression of AML cells by specific shRNA. A low level of PTBP1 can decrease the proliferation ability of AML cells. In conclusion, the results showed that PTBP1 might be a potential target for AML therapy.
MeSH term(s)	Alternative Splicing ; Exons ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Polypyrimidine Tract-Binding Protein/genetics ; Polypyrimidine Tract-Binding Protein/metabolism ; RNA Splicing Factors/genetics ; RNA Splicing Factors/metabolism ; RNA, Small Interfering
Chemical Substances	Heterogeneous-Nuclear Ribonucleoproteins ; PTBP1 protein, human ; RNA Splicing Factors ; RNA, Small Interfering ; Polypyrimidine Tract-Binding Protein (139076-35-0)
Language	English
Publishing date	2022-09-22
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	415445-9
ISSN	0028-2685
ISSN	0028-2685
DOI	10.4149/neo_2022_220314N279
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Article: Acupuncture Relieves Cervical Spondylosis Radiculopathy by Regulating Spinal Microglia Activation Through MAPK Signaling Pathway in Rats.

Shi, Tianyu / Liu, Yitian / Ji, Bo / Wang, Jiajia / Ge, Yunpeng / Fang, Yang / Xie, Yana / Xiao, Hongli / Wu, Le / Wang, Yifei

Journal of pain research

2023 Volume 16, Page(s) 3945–3960

Abstract: Purpose: Local acupuncture has been found to have a good analgesic effect in rats with cervical spondylosis radiculopathy (CSR), but it lacks a regulatory effect on traditional Chinese medicine syndrome types of CSR. We proposed "Invigorating Qi and ... ...

Abstract	Purpose: Local acupuncture has been found to have a good analgesic effect in rats with cervical spondylosis radiculopathy (CSR), but it lacks a regulatory effect on traditional Chinese medicine syndrome types of CSR. We proposed "Invigorating Qi and activating Blood" (IQAB) acupuncture, compared with Fenbid, and local electroacupuncture (LEA), to observe whether it has advantages in the protection of the CSR rat model and to elucidate its mechanism through the MAPK (mitogen-activated protein kinase) signaling pathway. Materials and methods: Male Sprague-Dawley rats were randomly divided into six groups: control, sham, model, Fenbid, LEA, and IQAB. The CSR model was induced by inserting nylon sutures to compress the C Results: Mechanical allodynia, gait disorder, edema, reduced Nissl-positive cell numbers, and increased IL-6 and TNF-α levels in the spinal cord were observed in CSR rats. IQAB significantly alleviated these changes, and the effects were generally comparable to those of Fenbid. Meanwhile, the phosphorylation ratios of p38 and extracellular regulated protein kinase (ERK), co-expression of p-p38 with neuron/microglia, and MCP-1 levels in the spinal cord were markedly down-regulated by IQAB compared with those in CSR model rats. Conclusion: IQAB reduced p38-activation-related microglia activation and MCP-1 levels, thus alleviating pathological changes, inflammation levels in the local spinal cord, and pain behavior of CSR.
Language	English
Publishing date	2023-11-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S419927
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Article ; Online: Simultaneous Improvement in the Thermostability and Catalytic Activity of Epoxidase Lsd18 for the Synthesis of Lasalocid A.

Liu, Ning / Xiao, Hongli / Zang, Yongjian / Zhou, Longji / Mencius, Jun / Yang, Zhiwei / Quan, Shu / Chen, Xi

International journal of molecular sciences

2023 Volume 24, Issue 23

Abstract: Enzymes used in the synthesis of natural products are potent catalysts, capable of efficient and stereoselective chemical transformations. Lsd18 catalyzes two sequential epoxidations during the biosynthesis of lasalocid A, a polyether polyketide natural ... ...

Abstract	Enzymes used in the synthesis of natural products are potent catalysts, capable of efficient and stereoselective chemical transformations. Lsd18 catalyzes two sequential epoxidations during the biosynthesis of lasalocid A, a polyether polyketide natural product. We performed protein engineering on Lsd18 to improve its thermostability and catalytic activity. Utilizing structure-guided methods of FoldX and Rosetta-ddG, we designed 15 mutants of Lsd18. Screening of these mutants using thermal shift assay identified stabilized variants Lsd18-T189M, Lsd18-S195M, and the double mutant Lsd18-T189M-S195M. Trypsin digestion, molecular dynamic simulation, circular dichroism (CD) spectroscopy, and X-ray crystallography provided insights into the molecular basis for the improved enzyme properties. Notably, enhanced hydrophobic interaction within the enzyme core and interaction of the protein with the FAD cofactor appear to be responsible for its better thermostability.
MeSH term(s)	Lasalocid/chemistry ; Lasalocid/metabolism ; Proteins ; Molecular Dynamics Simulation ; Enzyme Stability ; Temperature
Chemical Substances	Lasalocid (W7V2ZZ2FWB) ; epoxidase (EC 1.-) ; Proteins
Language	English
Publishing date	2023-11-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242316795
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Article ; Online: Predictive value of presepsin and acylcarnitines for severity and biliary drainage in acute cholangitis.

Zhang, Han-Yu / Xiao, Hong-Li / Wang, Guo-Xing / Lu, Zhao-Qing / Xie, Miao-Rong / Li, Chun-Sheng

World journal of gastroenterology

2023 Volume 29, Issue 16, Page(s) 2502–2514

Abstract: Background: Bacteremia, which is a major cause of mortality in patients with acute cholangitis, induces hyperactive immune response and mitochondrial dysfunction. Presepsin is responsible for pathogen recognition by innate immunity. Acylcarnitines are ... ...

Abstract	Background: Bacteremia, which is a major cause of mortality in patients with acute cholangitis, induces hyperactive immune response and mitochondrial dysfunction. Presepsin is responsible for pathogen recognition by innate immunity. Acylcarnitines are established mitochondrial biomarkers. Aim: To clarify the early predictive value of presepsin and acylcarnitines as biomarkers of severity of acute cholangitis and the need for biliary drainage. Methods: Of 280 patients with acute cholangitis were included and the severity was stratified according to the Tokyo Guidelines 2018. Blood presepsin and plasma acylcarnitines were tested at enrollment by chemiluminescent enzyme immunoassay and ultra-high-performance liquid chromatography-mass spectrometry, respectively. Results: The concentrations of presepsin, procalcitonin, short- and medium-chain acylcarnitines increased, while long-chain acylcarnitines decreased with the severity of acute cholangitis. The areas under the receiver operating characteristic curves (AUC) of presepsin for diagnosing moderate/severe and severe cholangitis (0.823 and 0.801, respectively) were greater than those of conventional markers. The combination of presepsin, direct bilirubin, alanine aminotransferase, temperature, and butyryl-L-carnitine showed good predictive ability for biliary drainage (AUC: 0.723). Presepsin, procalcitonin, acetyl-L-carnitine, hydroxydodecenoyl-L-carnitine, and temperature were independent predictors of bloodstream infection. After adjusting for severity classification, acetyl-L-carnitine was the only acylcarnitine independently associated with 28-d mortality (hazard ratio 14.396; Conclusion: Presepsin could serve as a specific biomarker to predict the severity of acute cholangitis and need for biliary drainage. Acetyl-L-carnitine is a potential prognostic factor for patients with acute cholangitis. Innate immune response was associated with mitochondrial metabolic dysfunction in acute cholangitis.
MeSH term(s)	Humans ; Procalcitonin ; Acetylcarnitine ; Biomarkers ; Sepsis/diagnosis ; Carnitine ; Cholangitis/diagnosis ; Cholangitis/complications ; Lipopolysaccharide Receptors ; Peptide Fragments ; Drainage ; C-Reactive Protein/analysis
Chemical Substances	Procalcitonin ; acylcarnitine ; Acetylcarnitine (6DH1W9VH8Q) ; Biomarkers ; Carnitine (S7UI8SM58A) ; Lipopolysaccharide Receptors ; Peptide Fragments ; C-Reactive Protein (9007-41-4) ; presepsin protein, human
Language	English
Publishing date	2023-05-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v29.i16.2502
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Article ; Online: Vitamin D has an effect on airway inflammation and Th17/Treg balance in asthmatic mice.

Ma, Jing-Guo / Wu, Guang-Ji / Xiao, Hong-Li / Xiao, Yan-Min / Zha, Lin

The Kaohsiung journal of medical sciences

2021 Volume 37, Issue 12, Page(s) 1113–1121

Abstract: Asthma is regarded as a chronic inflammation of the airway. Research has highlighted the significance of Vitamin D in asthma. This study explored the mechanism of vitamin D on asthma. The asthma mouse model was established by ovalbumin (OVA) ... ...

Abstract	Asthma is regarded as a chronic inflammation of the airway. Research has highlighted the significance of Vitamin D in asthma. This study explored the mechanism of vitamin D on asthma. The asthma mouse model was established by ovalbumin (OVA) sensitization and treated with vitamin D (50 or 100 ng/ml). The morphological changes of the airway were observed by HE staining. The serum IgE contents and MDA, ROS, and SOD expressions in the bronchoalveolar lavage fluid (BALF) were detected by ELISA. The Th17 and Treg cells were detected using flow cytometry. The RORγt and Foxp 3 expressions were detected by Reverse transcription quantitative polymerase chain reaction (RT-qPCR). IL-17, IL-10, and TGF-β1 expressions were detected using ELISA. The NF-κB pathway was blocked using the NF-κB pathway inhibitor, Andrographolide sulfonate. The NF-κB pathway-related indexes were detected by western blotting. After blockade of the NF-κB pathway, the IL-17, IL-10, and TGF-G1 expressions were detected. OVA-sensitized asthma induced airway remodeling and elevated IgE content in mice, which was downregulated after vitamin D treatment. MDA and ROS were upregulated and SOD was downregulated in asthmatic mice, while vitamin D inverted the changes. Th17/Treg ratio was imbalanced, RORγt and IL-17 were upregulated, and Foxp 3, IL-10, and TGF-β1 were downregulated after OVA sensitization, while vitamin D treatment inverted these changes and inhibited the NF-κB-p65 phosphorylation level. After blockade of the NF-κB pathway, IL-17 was downregulated and IL-10 and TGF-β1 were upregulated. In conclusion, vitamin D rectified the Th17/Treg balance and alleviated airway inflammation by inhibiting the NF-κB pathway in asthmatic mice.
MeSH term(s)	Animals ; Asthma/drug therapy ; Asthma/immunology ; Asthma/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; NF-kappa B/physiology ; Reactive Oxygen Species/metabolism ; Signal Transduction/physiology ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/drug effects ; Th17 Cells/immunology ; Vitamin D/pharmacology ; Vitamin D/therapeutic use
Chemical Substances	NF-kappa B ; Reactive Oxygen Species ; Vitamin D (1406-16-2)
Language	English
Publishing date	2021-08-30
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12441
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Article ; Online: Acute pancreatitis in pregnancy: a 10-year, multi-center, retrospective study in Beijing.

Zhang, Tingting / Wang, Guoxing / Cao, Zheng / Huang, Wenyang / Xiao, Hongli / Wei, Hongtao / Lu, Junli / Liu, Ruixia / Yin, Chenghong

BMC pregnancy and childbirth

2022 Volume 22, Issue 1, Page(s) 414

Abstract: Objective: Acute pancreatitis in pregnancy (APIP) is a rare and serious complication during pregnancy. It has acute onset and is difficult to diagnose and treat. The aim of the present study was to describe the etiology, clinical manifestations, and ... ...

Abstract	Objective: Acute pancreatitis in pregnancy (APIP) is a rare and serious complication during pregnancy. It has acute onset and is difficult to diagnose and treat. The aim of the present study was to describe the etiology, clinical manifestations, and maternofetal outcomes of APIP. Methods: We retrospectively reviewed 32 pregnant women who were treated at three tertiary care hospitals in Beijing, China. The correlation between the causes of APIP, severity, laboratory indices, and outcomes was analyzed. Results: The most common causes of APIP were hypertriglyceridemia (56.2%,18/32) and gallstones (28.1%, 9/32). Hypertriglyceridemia-induced APIP was associated with a higher rate of severe acute pancreatitis (P = 0.025). Serum level of triglycerides showed a positive correlation with the severity of APIP (P = 0.039). The most frequent presentation of APIP was abdominal pain (93.7%, 30/32). There were no maternal or fetal deaths in our study. Apgar scores at 1 min, 5 min, and 10 min of the premature neonates was correlated with the severity of APIP of the mother (P = 0.022; 0.002; 0.002). Conclusion: High level of triglycerides may serve as a useful marker of the severity of APIP. The severity of APIP was associated with higher risk of neonate asphyxia. Appropriate timing of termination of pregnancy is a key imperative for APIP patients.
MeSH term(s)	Acute Disease ; Female ; Humans ; Hypertriglyceridemia/complications ; Infant, Newborn ; Pancreatitis/complications ; Pancreatitis/etiology ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Complications/etiology ; Retrospective Studies ; Triglycerides
Chemical Substances	Triglycerides
Language	English
Publishing date	2022-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-022-04742-8
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Article ; Online: Identification of gut microbes associated with feed efficiency by daily-phase feeding strategy in growing-finishing pigs.

Jiang, Qin / Xie, Chunlin / Chen, Lingli / Xiao, Hongli / Xie, Zhilian / Zhu, Xiaoyan / Ma, Libao / Yan, Xianghua

Animal nutrition (Zhongguo xu mu shou yi xue hui)

2022 Volume 12, Page(s) 42–53

Abstract: Feed efficiency is one of the most important issues for sustainable pig production. Daily-phase feeding (DPF) is a form of precision feeding that could improve feed efficiency in pigs. Gut microbiota can regulate host nutrient digestion, absorption, and ... ...

Abstract	Feed efficiency is one of the most important issues for sustainable pig production. Daily-phase feeding (DPF) is a form of precision feeding that could improve feed efficiency in pigs. Gut microbiota can regulate host nutrient digestion, absorption, and metabolism. However, which key microbes may play a vital role in improving the feed efficiency during DPF remains unclear. In the present study, we used a DPF program compared to a three-phase feeding (TPF) program in growing-finishing pigs to investigate the effects of gut microbiota on feed efficiency. A total of 204 Landrace × Yorkshire pigs (75 d) were randomly assigned into 2 treatments. Each treatment was replicated 8 times with 13 to 15 pigs per replicate pen. Pigs in the TPF group were fed with a commercial feeding program that supplied fixed feed for phases I, II, and III, starting at 81, 101, and 132 d of age, respectively, and pigs in the DPF group were fed a blend of adjacent phase feed from 81 to 155 d at a gradual daily ratio and phase III feed from 155 to 180 d of age. Daily feed intake and body weight were recorded by a computerized device in the feeders. Feces and blood samples were collected from 1 pig per replicate at 155 and 180 d of age. The results showed that the DPF program remarkably improved the feed efficiency at 155 d (
Language	English
Publishing date	2022-09-29
Publishing country	China
Document type	Journal Article
ISSN	2405-6383
ISSN (online)	2405-6383
DOI	10.1016/j.aninu.2022.09.005
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Article ; Online: Dynamic blood presepsin levels are associated with severity and outcome of acute pancreatitis: A prospective cohort study.

Xiao, Hong-Li / Wang, Guo-Xing / Wang, Yan / Tan, Zhi-Min / Zhou, Jie / Yu, Han / Xie, Miao-Rong / Li, Chun-Sheng

World journal of gastroenterology

2022 Volume 28, Issue 35, Page(s) 5203–5216

Abstract: Background: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas with an unpredictable course of illness. A major challenge of AP is the early identification of patients at high-risk for organ failure and death. However, scoring systems ... ...

Abstract	Background: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas with an unpredictable course of illness. A major challenge of AP is the early identification of patients at high-risk for organ failure and death. However, scoring systems are complicated and time consuming, and the predictive values for the clinical course are vague. Aim: To determine whether the dynamic changes in presepsin levels can be used to evaluate the severity of disease and outcome of AP. Methods: In this multicentric cohort study, 133 patients with AP were included. Clinical severity was dynamically evaluated using the 2012 revised Atlanta Classification. Blood presepsin levels were measured at days 1, 3, 5 and 7 after admission by chemiluminescent enzyme immunoassay. Results: The median concentration of presepsin increased and the clearance rate of presepsin decreased with disease severity and organ failure in AP patients. The presepsin levels on days 3, 5 and 7 were independent predictors of moderately severe and severe AP with time-specific area under the curve (AUC) values of 0.827, 0.848 and 0.867, respectively. The presepsin levels positively correlated with bedside index of severity in AP, Ranson, acute physiology and chronic health evaluation II, computed tomography severity index and Marshall scores. Presepsin levels on days 3, 5 and 7 were independent predictors of 28-d mortality of AP patients with AUC values of 0.781, 0.846 and 0.843, respectively. Conclusion: Blood presepsin levels within 7 d of admission were associated with and may be useful to dynamically predict the severity of disease course and 28-d mortality in AP patients.
MeSH term(s)	Acute Disease ; Cohort Studies ; Humans ; Lipopolysaccharide Receptors ; Pancreatitis ; Peptide Fragments ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Retrospective Studies ; Severity of Illness Index
Chemical Substances	Lipopolysaccharide Receptors ; Peptide Fragments ; presepsin protein, human
Language	English
Publishing date	2022-07-11
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v28.i35.5203
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