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Article ; Online: Macrophage-derived exosomes rescue the TNF-ɑ-suppressed osteo-/cementogenic differentiation of hPDLCs.

Deng, Yifei / Xiao, Junhong / Huang, Xin / Cao, Zhengguo

2024

Abstract: Objective: Inflammatory stimuli compromise the differentiation potency of human periodontal ligament cells (hPDLCs). Macrophage-derived exosomes (M-Exo) play a role in several aspects of cellular activity. This study investigated how M-Exo contributes ... ...

Abstract	Objective: Inflammatory stimuli compromise the differentiation potency of human periodontal ligament cells (hPDLCs). Macrophage-derived exosomes (M-Exo) play a role in several aspects of cellular activity. This study investigated how M-Exo contributes to the osteo-/cementogenic differentiation of hPDLCs under inflammation and the mechanism involved. Methods: M-Exo was identified by transmission electron microscopy, western blotting (WB), and dynamic light scattering. The internalization of M-Exo by hPDLCs was observed. After M-Exo treatment, the osteo-/cementogenic markers were detected by RT-qPCR and WB, and alkaline phosphatase (ALP) activity by ALP staining. Tumor necrosis factor alpha (TNF-ɑ) was applied to simulate inflammation. The rescue effect of M-Exo on TNF-ɑ-suppressed differentiation was validated. The p38 MAPK pathway activity was tested and a specific inhibitor was applied to explore the mechanism. Results: M-Exo was successfully isolated, identified and internalized by hPDLCs. M-Exo enhanced the osteo-/cementogenic differentiation of hPDLCs, as indicated by upregulated osteo-/cementogenic markers and elevated ALP activity. Moreover, TNF-ɑ inhibited the differentiation capabilities of hPDLCs, on which M-Exo showed a rescue effect. M-Exo activated the p38 MAPK pathway and SB203580 attenuated its promotion effect. Conclusion: This study showed that M-Exo ameliorated the TNF-ɑ-suppressed osteo-/cementogenic differentiation of hPDLCs partly through the p38 MAPK pathway.
Language	English
Publishing date	2024-04-02
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.14947
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Article ; Online: Mitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies.

Deng, Yifei / Xiao, Junhong / Ma, Li / Wang, Chuan / Wang, Xiaoxuan / Huang, Xin / Cao, Zhengguo

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Periodontitis is a chronic infectious disorder damaging periodontal tissues, including the gingiva, periodontal ligament, cementum, and alveolar bone. It arises from the complex interplay between pathogenic oral bacteria and host immune response. ... ...

Abstract	Periodontitis is a chronic infectious disorder damaging periodontal tissues, including the gingiva, periodontal ligament, cementum, and alveolar bone. It arises from the complex interplay between pathogenic oral bacteria and host immune response. Contrary to the previous view of "energy factories", mitochondria have recently been recognized as semi-autonomous organelles that fine-tune cell survival, death, metabolism, and other functions. Under physiological conditions, periodontal tissue cells participate in dynamic processes, including differentiation, mineralization, and regeneration. These fundamental activities depend on properly functioning mitochondria, which play a crucial role through bioenergetics, dynamics, mitophagy, and quality control. However, during the initiation and progression of periodontitis, mitochondrial quality control is compromised due to a range of challenges, such as bacterial-host interactions, inflammation, and oxidative stress. Currently, mounting evidence suggests that mitochondria dysfunction serves as a common pathological mechanism linking periodontitis with systemic conditions like type II diabetes, obesity, and cardiovascular diseases. Therefore, targeting mitochondria to intervene in periodontitis and multiple associated systemic diseases holds great therapeutic potential. This review provides advanced insights into the interplay between mitochondria, periodontitis, and associated systemic diseases. Moreover, we emphasize the significance of diverse therapeutic modulators and signaling pathways that regulate mitochondrial function in periodontal and systemic cells.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2 ; Periodontitis/complications ; Inflammation ; Periodontium ; Mitochondrial Diseases
Language	English
Publishing date	2024-01-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021024
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Article ; Online: Irisin attenuates P. gingivalis-suppressed osteogenic/cementogenic differentiation of periodontal ligament cells via p38 signaling pathway.

Huang, Xin / Xiao, Junhong / Wang, Xiaoxuan / Cao, Zhengguo

Biochemical and biophysical research communications

2022 Volume 618, Page(s) 100–106

Abstract: Regeneration of periodontal hard tissues damaged by Porphyromonas gingivalis (P. gingivalis) is essential for tooth stability and dental health. Irisin, a myokine secreted by skeletal muscle, is involved in different biological processes, such as ... ...

Abstract	Regeneration of periodontal hard tissues damaged by Porphyromonas gingivalis (P. gingivalis) is essential for tooth stability and dental health. Irisin, a myokine secreted by skeletal muscle, is involved in different biological processes, such as myogenesis, adipogenesis, neurogenesis and osteogenesis. However, whether irisin regulates the osteogenic/cementogenic differentiation of human periodontal ligament cell (hPDLCs), especially under P. gingivalis-triggered inflammation, remains unknown. In this study, we verified the suppression role of P. gingivalis in the osteogenic/cementogenic differentiation of hPDLCs. Also, compared with the control cells, hPDLCs with irisin stimulation showed higher expression of osteogenic-/cementogenic-related markers, ALP activity and mineralization ability, as measured by RT-qPCR, western blotting, ALP staining and Alizarin red staining, respectively. Moreover, the osteogenic/cementogenic differentiation-facilitating role of irisin was also demonstrated under P. gingivalis-elicited inflammation, which implied a rescue function of irisin in P. gingivalis-suppressed hPDLC differentiation. Finally, the underlying mechanism involved in the process was explored. We observed that the p38 signaling pathway was activated during irisin-accelerated hPDLC differentiation. Furthermore, hPDLC differentiation was weakened after the p38 inhibitor was applied. In summary, we found that irisin can facilitate the osteogenic/cementogenic differentiation of hPDLCs partially through the p38 signaling pathway, which may provide evidence for the regeneration of P. gingivalis-destroyed periodontal hard tissues.
MeSH term(s)	Alkaline Phosphatase/metabolism ; Cell Differentiation/physiology ; Cells, Cultured ; Fibronectins/metabolism ; Humans ; Inflammation/metabolism ; MAP Kinase Signaling System ; Osteogenesis/physiology ; Periodontal Ligament/metabolism ; Signal Transduction ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	FNDC5 protein, human ; Fibronectins ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Alkaline Phosphatase (EC 3.1.3.1)
Language	English
Publishing date	2022-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.06.001
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Article: Irisin attenuates P. gingivalis-suppressed osteogenic/cementogenic differentiation of periodontal ligament cells via p38 signaling pathway

Huang, Xin / Xiao, Junhong / Wang, Xiaoxuan / Cao, Zhengguo

Biochemical and biophysical research communications. 2022 Aug. 27, v. 618

2022

Abstract	Regeneration of periodontal hard tissues damaged by Porphyromonas gingivalis (P. gingivalis) is essential for tooth stability and dental health. Irisin, a myokine secreted by skeletal muscle, is involved in different biological processes, such as myogenesis, adipogenesis, neurogenesis and osteogenesis. However, whether irisin regulates the osteogenic/cementogenic differentiation of human periodontal ligament cell (hPDLCs), especially under P. gingivalis-triggered inflammation, remains unknown. In this study, we verified the suppression role of P. gingivalis in the osteogenic/cementogenic differentiation of hPDLCs. Also, compared with the control cells, hPDLCs with irisin stimulation showed higher expression of osteogenic-/cementogenic-related markers, ALP activity and mineralization ability, as measured by RT-qPCR, western blotting, ALP staining and Alizarin red staining, respectively. Moreover, the osteogenic/cementogenic differentiation-facilitating role of irisin was also demonstrated under P. gingivalis-elicited inflammation, which implied a rescue function of irisin in P. gingivalis-suppressed hPDLC differentiation. Finally, the underlying mechanism involved in the process was explored. We observed that the p38 signaling pathway was activated during irisin-accelerated hPDLC differentiation. Furthermore, hPDLC differentiation was weakened after the p38 inhibitor was applied. In summary, we found that irisin can facilitate the osteogenic/cementogenic differentiation of hPDLCs partially through the p38 signaling pathway, which may provide evidence for the regeneration of P. gingivalis-destroyed periodontal hard tissues.
Keywords	Porphyromonas gingivalis ; adipogenesis ; alizarin ; bone formation ; dental health ; humans ; inflammation ; ligaments ; mineralization ; muscle development ; neurogenesis ; research ; skeletal muscle
Language	English
Dates of publication	2022-0827
Size	p. 100-106.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.06.001
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Article ; Online: Using 3D Medical Modeling to Evaluate the Accuracy of Single-Photon Emission Computed Tomography (SPECT) Bone Scintigraphy in Diagnosing Condylar Hyperplasia.

Xiao, Junhong / Wu, Zhongxing / Ye, Wengwanyue

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

2021 Volume 80, Issue 2, Page(s) 285.e1–285.e9

Abstract: Purpose: To evaluate the accuracy of single-photon emission computed tomography (SPECT) in diagnosing unilateral condylar hyperplasia (UCH) and to describe the condylar growth of patients with UCH.: Materials and methods: Using a retrospective study ... ...

Abstract	Purpose: To evaluate the accuracy of single-photon emission computed tomography (SPECT) in diagnosing unilateral condylar hyperplasia (UCH) and to describe the condylar growth of patients with UCH. Materials and methods: Using a retrospective study design, patients with UCH who had undergone SPECT and cone-beam computed tomography (CBCT) examinations at the same time were included in the study. We used 3D medical models based on CBCT data as the gold standard. The SPECT results were compared with the model data, and the sensitivity and specificity were calculated. To further describe the condylar growth activity, statistical analysis was performed, and the P value was set at 0.05. Results: The sample was composed of 75 patients. The sensitivity of SPECT was 55.3%, the specificity was 48.6%, and the area under the receiver operating characteristic curve was 0.53. There was no significant difference in sex between patients with and without active growth. Conclusion: The sensitivity and specificity of SPECT are poor, and SPECT alone is not suitable for evaluating the active stage of condylar growth. 3D medical modeling has good prospects for application in the diagnosis of condylar hyperplasia.
MeSH term(s)	Humans ; Hyperplasia/diagnostic imaging ; Mandibular Condyle/diagnostic imaging ; Mandibular Condyle/pathology ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, Emission-Computed, Single-Photon
Language	English
Publishing date	2021-09-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	392404-x
ISSN	1531-5053 ; 0278-2391
ISSN (online)	1531-5053
ISSN	0278-2391
DOI	10.1016/j.joms.2021.09.005
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Article ; Online: Genetically engineered M2-like macrophage-derived exosomes for

Huang, Xin / Deng, Yifei / Xiao, Junhong / Wang, Huiyi / Yang, Qiudong / Cao, Zhengguo

Bioactive materials

2023 Volume 32, Page(s) 473–487

Abstract: Cementum, a thin layer of mineralized tissue covering tooth root surface, is recognized as the golden standard in periodontal regeneration. However, current efforts mainly focus on alveolar bone regeneration rather than cementum regeneration, and rarely ... ...

Abstract	Cementum, a thin layer of mineralized tissue covering tooth root surface, is recognized as the golden standard in periodontal regeneration. However, current efforts mainly focus on alveolar bone regeneration rather than cementum regeneration, and rarely take
Language	English
Publishing date	2023-10-27
Publishing country	China
Document type	Journal Article
ISSN	2452-199X
ISSN (online)	2452-199X
DOI	10.1016/j.bioactmat.2023.10.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Study on water purification with warm and cold season aquatic plants

Sun Jiajun / Zhang Yajie / Ma Guangyu / Xiao Junhong / Cai Yajing / Wang Zhi / Cao Hongbin

E3S Web of Conferences, Vol 260, p

2021 Volume 01016

Abstract: As a national key protection and restoration project, ecological restoration of Baiyangdian Wetland has an important significance for environmental management. As the research area in Zaozhadian wetland, the purification effect of warm season and cold ... ...

Abstract	As a national key protection and restoration project, ecological restoration of Baiyangdian Wetland has an important significance for environmental management. As the research area in Zaozhadian wetland, the purification effect of warm season and cold season aquatic plants was studied under different overflying water qualities. It provides a theoretical and experimental basis for the ecological environment restoration and management of wetlands. The results showed that the warm season and cold season aquatic plants all played important roles on the nitrogen and phosphorus removal and maintained the stable water environmental from the nutrient release from soil. The warm season plant-mixed Myriophyllum spicatum and Ceratophyllum demersum and the cold season plant-Potamogeton crispus L. can be reasonably configurated for the wetland restoration.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: CKIP-1 mediates

Huang, Xin / Xiao, Junhong / Wang, Huiyi / Peng, Yan / Liu, Heyu / Ma, Li / Wang, Xiaoxuan / Cao, Zhengguo

Journal of oral microbiology

2023 Volume 15, Issue 1, Page(s) 2236427

Abstract: Objectives: Casein kinase 2 interacting protein-1 (CKIP-1) is a versatile player involved in various biological processes. However, whether CKIP-1 mediates the osteogenic/cementogenic differentiation of periodontal ligament cells (PDLCs) under : ... ...

Abstract	Objectives: Casein kinase 2 interacting protein-1 (CKIP-1) is a versatile player involved in various biological processes. However, whether CKIP-1 mediates the osteogenic/cementogenic differentiation of periodontal ligament cells (PDLCs) under Material and methods: The effect of Pg on PDLC differentiation was first verified. CKIP-1 expression in Pg-infected PDLCs or in PDL of apical periodontitis (AP) mice was detected. The changes of CKIP-1 during PDLC differentiation was also determined. PDLC differentiation capacity in Results: The suppression effect of Pg on PDLC differentiation was demonstrated. CKIP-1 increased in the PDL of AP mice and Pg-induced PDLCs, and decreased gradually during PDLC differentiation. Increased OSX and RUNX2 expression in PDL were observed in Conclusions: CKIP-1 mediated the osteogenic/cementogenic differentiation of PDLCs partially through p38 signaling pathway, which may provide evidence for the regeneration of periodontal hard tissues damaged by Pg.
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2523919-3
ISSN	2000-2297
ISSN	2000-2297
DOI	10.1080/20002297.2023.2236427
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Article ; Online: CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy.

Xiao, Junhong / Huang, Xin / Wang, Huiyi / Peng, Yan / Liu, Heyu / Huang, Hantao / Ma, Li / Wang, Chuan / Wang, Xiaoxuan / Cao, Zhengguo

Inflammation

2023 Volume 46, Issue 5, Page(s) 1997–2010

Abstract: As a chronic inflammatory disease, periodontitis involves many biological processes including autophagy. At the same time, casein kinase 2 interacting protein-1 (CKIP-1) was reported to play a role in regulation of inflammation. But whether CKIP-1 and ... ...

Abstract	As a chronic inflammatory disease, periodontitis involves many biological processes including autophagy. At the same time, casein kinase 2 interacting protein-1 (CKIP-1) was reported to play a role in regulation of inflammation. But whether CKIP-1 and autophagy interact in periodontitis remains unclear. In this paper, our research team verified the levels of CKIP-1 expression and autophagy increase in the periodontal tissues of a ligature-induced periodontitis mouse model. And this result was also confirmed in Porphyromonas gingivalis (Pg)-induced human gingival fibroblasts (HGF) and human periodontal ligament cells (PDLC). We also showed the autophagy level in periodontal tissues is higher in Ckip-1 knockout (KO) mice than wild type (WT). At the same time, CKIP-1 knockdown lentivirus was used in PDLC and HGF, and it was found that silencing CKIP-1 significantly activated autophagy. Unfortunately, the regulatory role of autophagy in periodontitis is still unclear. Then, the autophagy agonist Rapamycin and inhibitor 3-MA were used in a periodontitis mouse model to investigate periodontal tissue destruction. We found the inflammation in periodontal tissue was reduced when autophagy activated. All these conclusions have been verified both in vivo and in vitro experiments. Finally, our research proved that silencing CKIP-1 reduces the expression of inflammatory cytokines in Pg-induced PDLC and HGF by regulating autophagy. Overall, a new role for CKIP-1 in regulating periodontal tissue inflammation was demonstrated in our study, and it is possible to treat periodontitis by targeting the CKIP-1 gene.
MeSH term(s)	Mice ; Animals ; Humans ; Inflammation/metabolism ; Periodontitis/metabolism ; Gingiva/metabolism ; Cytokines/metabolism ; Porphyromonas gingivalis/metabolism ; Autophagy ; Carrier Proteins/metabolism
Chemical Substances	Cytokines ; Carrier Proteins
Language	English
Publishing date	2023-06-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	434408-x
ISSN	1573-2576 ; 0360-3997
ISSN (online)	1573-2576
ISSN	0360-3997
DOI	10.1007/s10753-023-01856-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tet methylcytosine dioxygenase 1 modulates Porphyromonas gingivalis-triggered pyroptosis by regulating glycolysis in cementoblasts.

Peng, Yan / Wang, Huiyi / Huang, Xin / Liu, Heyu / Xiao, Junhong / Wang, Chuan / Ma, Li / Wang, Xiaoxuan / Cao, Zhengguo

Annals of the New York Academy of Sciences

2023 Volume 1523, Issue 1, Page(s) 119–134

Abstract: Porphyromonas gingivalis is involved in the pathogenesis of multiple polymicrobial biofilm-induced inflammatory diseases, including apical periodontitis, and it triggers pyroptosis accompanied by robust inflammatory responses. Tet methylcytosine ... ...

Abstract	Porphyromonas gingivalis is involved in the pathogenesis of multiple polymicrobial biofilm-induced inflammatory diseases, including apical periodontitis, and it triggers pyroptosis accompanied by robust inflammatory responses. Tet methylcytosine dioxygenase 1 (TET1), an epigenetic modifier enzyme, has been is correlated with inflammation, though an association of TET1 and P. gingivalis-related pyroptosis in cementoblasts and the molecular mechanisms has not been shown. Our study here demonstrated that P. gingivalis downregulated Tet1 expression and elicited CASP11- and GSDMD-dependent pyroptosis. Additionally, Tet1 mRNA silencing in cementoblasts appeared to result in a more severe pyroptotic phenotype, where levels of CASP11 and GSDMD cleavage, lactate dehydrogenase release, and IL-1β and IL-18 production were significantly increased. Moreover, Tet1 overexpression resulted in blockade of pyroptosis activation accompanied by inflammation moderation. Further analyses revealed that TET1 modulated glycolysis, confirmed by the application of the specific inhibitor 2-deoxy-d-glucose (2-DG). The pyroptosis phenotype enhanced by Tet1 silencing was moderated by 2-DG upon P. gingivalis invasion. Taken together, these data show the effects and underlying mechanisms of TET1 on pyroptosis and inflammatory phenotype induced by P. gingivalis in cementoblasts, and provides insight into the involvement of P. gingivalis in apical periodontitis and, possibly, other inflammatory diseases.
MeSH term(s)	Humans ; Pyroptosis ; Porphyromonas gingivalis/metabolism ; Dental Cementum/metabolism ; Inflammation/metabolism ; Periapical Periodontitis ; Glycolysis ; Dioxygenases/metabolism ; Mixed Function Oxygenases/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism
Chemical Substances	Dioxygenases (EC 1.13.11.-) ; TET1 protein, human (EC 1.-) ; Mixed Function Oxygenases (EC 1.-) ; Proto-Oncogene Proteins
Language	English
Publishing date	2023-03-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	211003-9
ISSN	1749-6632 ; 0077-8923
ISSN (online)	1749-6632
ISSN	0077-8923
DOI	10.1111/nyas.14979
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