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  1. Book ; Online: Chapter Botanical design

    Zhang, Linli / Xiao, Liang / Tsekleves, Emmanuel / Pollastri, Serena / Tian, Bingqing

    Exploring the application of parametric plants in furniture

    2023  

    Keywords Interior design, decor & style guides ; Sustainability ; Plant arts ; biophilic design ; parametrical design ; sustainability ; furniture design
    Language English
    Size 1 electronic resource (5 pages)
    Publisher Academia Press
    Publishing place Ghent
    Document type Book ; Online
    Note English
    HBZ-ID HT030645211
    ISBN 9789401496476 ; 9401496471
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Interplay of mitochondria and diabetes: Unveiling novel therapeutic strategies.

    Xiao Liang, Kristina

    Mitochondrion

    2024  Volume 75, Page(s) 101850

    Abstract: The interplay between mitochondrial function and diabetes has gained significant attention due to its crucial role in the pathogenesis and progression of the disease. Mitochondria, known as the cellular powerhouses, are essential for glucose metabolism. ... ...

    Abstract The interplay between mitochondrial function and diabetes has gained significant attention due to its crucial role in the pathogenesis and progression of the disease. Mitochondria, known as the cellular powerhouses, are essential for glucose metabolism. Dysfunction of these organelles has been implicated in the development of insulin resistance and beta-cell failure, both prominent features of diabetes. This comprehensive review explores the intricate mechanisms involved, including the generation of reactive oxygen species and the impact of mitochondrial DNA (mtDNA) mutations. Moreover, the review delves into emerging therapeutic strategies that specifically target mitochondria, such as mitochondria-targeted antioxidants, agents promoting mitochondrial biogenesis, and compounds modulating mitochondrial dynamics. The potential of these novel approaches is critically evaluated, taking into account their benefits and limitations, to provide a well-rounded perspective. Ultimately, this review emphasizes the importance of advancing our understanding of mitochondrial biology to revolutionize the treatment of diabetes.
    MeSH term(s) Humans ; Mitochondria/metabolism ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/metabolism ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Reactive Oxygen Species/metabolism ; Insulin Resistance ; Oxidative Stress
    Chemical Substances DNA, Mitochondrial ; Reactive Oxygen Species
    Language English
    Publishing date 2024-02-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2056923-3
    ISSN 1872-8278 ; 1567-7249
    ISSN (online) 1872-8278
    ISSN 1567-7249
    DOI 10.1016/j.mito.2024.101850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dexmedetomidine promotes ferroptotic cell death in gastric cancer via hsa_circ_0008035/miR‐302a/E2F7 axis

    Xiang Gao / Xiao‐Liang Wang

    Kaohsiung Journal of Medical Sciences, Vol 39, Iss 4, Pp 390-

    2023  Volume 403

    Abstract: Abstract Dexmedetomidine (DEX), a common anesthetic, has significant effects on the biological features of cancer cells. Although numerous studies have been published on the impact of DEX on the biological characteristics of GC cells, the mechanism ... ...

    Abstract Abstract Dexmedetomidine (DEX), a common anesthetic, has significant effects on the biological features of cancer cells. Although numerous studies have been published on the impact of DEX on the biological characteristics of GC cells, the mechanism remains unknown. This study aimed to explore the effect of DEX on the biological properties of GC cells. DEX suppressed the viability and increased the apoptosis of GC cells in vitro and inhibited tumor growth in vivo. Besides, DEX raised the levels of reactive oxygen species (ROS) and iron, but decreased the levels of glutathione (GSH), glutathione peroxidase 4 (GPX4), and solute carrier family 7 member 11 (SLC7A11) in GC cells, which were abolished by Ferrostatin‐1 (the inhibitor of ferroptosis) treatment. In addition, the level of circ0008035 and E2F7 were downregulated, but miR‐302a level was upregulated in DEX‐treated GC cells. Circ0008035 increased the expression of E2F2 by acting as a sponge for miR‐302a. Circ0008035 inhibited DEX‐induced ferroptotic cell death in GC cells, which was reversed by miR‐302a overexpression or E2F7 reduction. Taken together, DEX mediated ferroptotic cell death in GC through regulating the circ0008035/miR‐302a/E2F7 axis, suggesting a feasible therapy option for GC.
    Keywords circular RNA ; dexmedetomidine ; ferroptosis ; gastric cancer ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Experimental study on performance of high purity nitrogen supply system in liquefaction unit of low concentration coalbed methane

    Jia Xiao-liang

    E3S Web of Conferences, Vol 267, p

    2021  Volume 02076

    Abstract: Aiming at the problems such as low CBM utilization rate caused by low concentration CBM with methane content less than 8% extracted from a small coal mine in Hancheng mining area, Shaanxi Province, and serious environmental pollution caused by coal-fired ...

    Abstract Aiming at the problems such as low CBM utilization rate caused by low concentration CBM with methane content less than 8% extracted from a small coal mine in Hancheng mining area, Shaanxi Province, and serious environmental pollution caused by coal-fired hot blast stove for heating, the heat storage and oxidation heating technology of ultra-low concentration gas in small coal mine was studied by combining field investigation and heat balance calculation. This technology replaces the coal-fired hot blast stove, realizes “coal and CBM mining and sharing” in the coal mine, and constructs a virtuous cycle development of “promoting drainage by using and promoting safety by drainage”. The research shows that: the scheme improves the utilization rate of CBM in the mining area, cancels the consumption of coal combustion, and can use 2.59 million Nm3 of pure CBM every year, generating 1.95 million yuan of economic benefits. And the emissions reduction of CO2 equivalent is 36000 tons. The benefits of safety, economy and environmental protection are remarkable. This technology is especially suitable for the utilization of ultra-low concentration CBM whose concentration is less than 8%, which has practical significance to improve the CBM utilization rate and promote the realization of the goal of “zero emission”.
    Keywords Environmental sciences ; GE1-350
    Subject code 620
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Integrated Economic and Financial Analysis of China’s Sponge City Program for Water-resilient Urban Development

    Xiao Liang

    Sustainability, Vol 10, Iss 3, p

    2018  Volume 669

    Abstract: To improve Chinese cities’ resilience to climate change, the Sponge City Program, which was designed to tackle water pollution, storm water management, and flooding, was initiated in 2014. Being a major policy initiative, the Sponge City Program raises ... ...

    Abstract To improve Chinese cities’ resilience to climate change, the Sponge City Program, which was designed to tackle water pollution, storm water management, and flooding, was initiated in 2014. Being a major policy initiative, the Sponge City Program raises heated discussions among Chinese academics; however, no relevant extensive economic or financial analysis has been conducted. The research carries out an integrated economic and financial analysis on the Sponge City Program from the perspectives of two stakeholders: the government and the project manager. Different stakeholders have unique perspectives on the management of water projects. This study has two parts: economic analysis and financial analysis. The economic analysis is from the government perspective, and considers all the economic, environmental, and social effects. The financial analysis is from the project manager’s perspective, and judges the financial feasibility of projects. Changde city, one of the demo cities of Sponge City Program, is chosen for the research. The results show that from the perspective of the government, the Sponge City Program should be promoted, because most water projects are economically feasible. From the perspective of the project manager, the program should not be invested in, because the water projects are financially infeasible. A more comprehensive and integrated plan for developing and managing the water projects of the Sponge City Program is required. Otherwise, the private sector may not be interested in investing in the water projects, and the water projects may not be operational in the long term.
    Keywords China ; economic analysis ; financial analysis ; Sponge City Program ; urban water management ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 710
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Toward a Value-Based Therapy Recommendation Model.

    Liu, Zhang / Xiao, Liang

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 16

    Abstract: Patient value is an important factor in clinical decision making, but conventionally, it is not incorporated in the decision processes. Clinical decision making has some clinical guidelines as a reference. There are very few value-based clinical ... ...

    Abstract Patient value is an important factor in clinical decision making, but conventionally, it is not incorporated in the decision processes. Clinical decision making has some clinical guidelines as a reference. There are very few value-based clinical guidelines, but knowledge about how values affect decision making is mentioned in some scattered studies in the literature. We use a literature review method to extract evidence and integrate it as part of the decision-making model. In this paper, a value-based therapy recommendation comprehensive model is proposed. A literature analysis is conducted to collect value-based evidence. The patients' values are defined and classified with fine granularity. Categorized values and candidate therapies are used in combination as filtering keywords to build this literature database. The literature analysis method generates a literature database used as a source of arguments for influencing decision making based on values. Then, a formalism model is put forward to integrate the value-based evidence with clinical evidence, and the literature databases and clinical guidelines are collected and analyzed to populate the evidence repository. During the decision-making processes, the evidence repository is utilized to match patients' clinical information and values. Decision-makers can dynamically adjust the relative importance of the two pieces of evidence to obtain a treatment plan that is more suitable for the patient. A prototype system was implemented using a case study for breast cancer and validated for feasibility and effectiveness through controlled experiments.
    Language English
    Publishing date 2023-08-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11162362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Linked Argumentation Graphs for Multidisciplinary Decision Support.

    Xiao, Liang / Greer, Des

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 4

    Abstract: Multidisciplinary clinical decision-making has become increasingly important for complex diseases, such as cancers, as medicine has become very specialized. Multiagent systems (MASs) provide a suitable framework to support multidisciplinary decisions. In ...

    Abstract Multidisciplinary clinical decision-making has become increasingly important for complex diseases, such as cancers, as medicine has become very specialized. Multiagent systems (MASs) provide a suitable framework to support multidisciplinary decisions. In the past years, a number of agent-oriented approaches have been developed on the basis of argumentation models. However, very limited work has focused, thus far, on systematic support for argumentation in communication among multiple agents spanning various decision sites and holding varying beliefs. There is a need for an appropriate argumentation scheme and identification of recurring styles or patterns of multiagent argument linking to enable versatile multidisciplinary decision applications. We propose, in this paper, a method of linked argumentation graphs and three types of patterns corresponding to scenarios of agents changing the minds of others (argumentation) and their own (belief revision): the collaboration pattern, the negotiation pattern, and the persuasion pattern. This approach is demonstrated using a case study of breast cancer and lifelong recommendations, as the survival rates of diagnosed cancer patients are rising and comorbidity is the norm.
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11040585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dexmedetomidine promotes ferroptotic cell death in gastric cancer via hsa_circ_0008035/miR-302a/E2F7 axis.

    Gao, Xiang / Wang, Xiao-Liang

    The Kaohsiung journal of medical sciences

    2023  Volume 39, Issue 4, Page(s) 390–403

    Abstract: Dexmedetomidine (DEX), a common anesthetic, has significant effects on the biological features of cancer cells. Although numerous studies have been published on the impact of DEX on the biological characteristics of GC cells, the mechanism remains ... ...

    Abstract Dexmedetomidine (DEX), a common anesthetic, has significant effects on the biological features of cancer cells. Although numerous studies have been published on the impact of DEX on the biological characteristics of GC cells, the mechanism remains unknown. This study aimed to explore the effect of DEX on the biological properties of GC cells. DEX suppressed the viability and increased the apoptosis of GC cells in vitro and inhibited tumor growth in vivo. Besides, DEX raised the levels of reactive oxygen species (ROS) and iron, but decreased the levels of glutathione (GSH), glutathione peroxidase 4 (GPX4), and solute carrier family 7 member 11 (SLC7A11) in GC cells, which were abolished by Ferrostatin-1 (the inhibitor of ferroptosis) treatment. In addition, the level of circ0008035 and E2F7 were downregulated, but miR-302a level was upregulated in DEX-treated GC cells. Circ0008035 increased the expression of E2F2 by acting as a sponge for miR-302a. Circ0008035 inhibited DEX-induced ferroptotic cell death in GC cells, which was reversed by miR-302a overexpression or E2F7 reduction. Taken together, DEX mediated ferroptotic cell death in GC through regulating the circ0008035/miR-302a/E2F7 axis, suggesting a feasible therapy option for GC.
    MeSH term(s) Humans ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics ; Dexmedetomidine/pharmacology ; Cell Death ; Apoptosis/genetics ; Glutathione ; MicroRNAs/genetics ; Cell Proliferation ; Cell Line, Tumor ; E2F7 Transcription Factor
    Chemical Substances Dexmedetomidine (67VB76HONO) ; Glutathione (GAN16C9B8O) ; MicroRNAs ; E2F7 protein, human ; E2F7 Transcription Factor
    Language English
    Publishing date 2023-01-31
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Trident

    Seyedomid Sajedi / Xiao Liang

    Applied Sciences, Vol 12, Iss 10999, p

    A Deep Learning Framework for High-Resolution Bridge Vibration Monitoring

    2022  Volume 10999

    Abstract: Bridges are the essential components in lifeline transportation systems, and their safe operation is of great importance. Information on structural damage could assist in timely repairs and reduce downtime. With the latest advancements in sensing ... ...

    Abstract Bridges are the essential components in lifeline transportation systems, and their safe operation is of great importance. Information on structural damage could assist in timely repairs and reduce downtime. With the latest advancements in sensing technology, collecting vibration data from bridges has become more accessible. However, effective vibration processing is still a challenge, given the high dimensionality and massive size of vibration data. Existing studies have shown that machine/deep learning techniques can be valuable tools for this task. However, the learning and computational capacities of these models are challenged in the presence of large sensor arrays. We propose Trident as a novel deep learning framework that enables automatic damage feature extraction by simultaneously learning from temporal and three-dimensional (3D) spatial variations of 6D input data in instrumented bridges. Trident is equipped with 3 ConvLSTM3D branches to achieve this goal. A 3D steel truss bridge subject to dynamic traffic loads is monitored for its vibrations to evaluate Trident’s robustness in finding damaged elements. A damage dataset of 52,800 vehicle passing simulations is generated leveraging a database of 528 passenger vehicles in the United States, obtained from the National Highway and Traffic Safety Administration. Bayesian optimization is utilized to tune the model’s hyperparameters, achieving a test Node Average Geometric Mean Accuracy of 86%. This level of performance is promising given the high dimensionality and complexities of the output space in vibration-based monitoring. Trident’s concept can be extended to other vibration monitoring tasks with different time series data and damage labeling strategies.
    Keywords deep learning ; signal processing ; structural health monitoring ; traffic simulations ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 621
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Hexafluoro-2-propanol (HFIP) decreased LPS-induced inflammatory response of Human microvascular endothelial cells.

    Liang, Lei / Xiao, Liang / Yu, Ze / Liu, Jia

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-04-22
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.04.079
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