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  1. Article ; Online: Coupling metal organic frameworks nanozyme with carbon nanotubes on the gradient porous hollow fiber membrane for nonenzymatic electrochemical H

    Ma, Shuyan / Xiao, Shenghao / Hong, Yinhui / Bao, Yuheng / Xu, Zhikang / Chen, Dajing / Huang, Xiaojun

    Analytica chimica acta

    2024  Volume 1293, Page(s) 342285

    Abstract: In this paper, we present a gradient porous hollow fiber structure integrated the signal transduction within a microspace, serving as a platform for cellular metabolism monitoring. We developed a nonenzymatic electrochemical electrode by coupling carbon ... ...

    Abstract In this paper, we present a gradient porous hollow fiber structure integrated the signal transduction within a microspace, serving as a platform for cellular metabolism monitoring. We developed a nonenzymatic electrochemical electrode by coupling carbon nanotubes (CNT) and metal organic frameworks (MOF) nanozyme on three-dimensional (3D) gradient porous hollow fiber membrane (GPF) for in-situ detection of cell released hydrogen peroxide (H
    MeSH term(s) Metal-Organic Frameworks/chemistry ; Nanotubes, Carbon/chemistry ; Hydrogen Peroxide/chemistry ; Porosity ; Peroxidase ; Electrochemical Techniques/methods
    Chemical Substances Metal-Organic Frameworks ; Nanotubes, Carbon ; Hydrogen Peroxide (BBX060AN9V) ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2024-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2024.342285
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  2. Article ; Online: Revolutionizing Precision Medicine: Exploring Wearable Sensors for Therapeutic Drug Monitoring and Personalized Therapy.

    Liu, Yuqiao / Li, Junmin / Xiao, Shenghao / Liu, Yanhui / Bai, Mingxia / Gong, Lixiu / Zhao, Jiaqian / Chen, Dajing

    Biosensors

    2023  Volume 13, Issue 7

    Abstract: Precision medicine, particularly therapeutic drug monitoring (TDM), is essential for optimizing drug dosage and minimizing toxicity. However, current TDM methods have limitations, including the need for skilled operators, patient discomfort, and the ... ...

    Abstract Precision medicine, particularly therapeutic drug monitoring (TDM), is essential for optimizing drug dosage and minimizing toxicity. However, current TDM methods have limitations, including the need for skilled operators, patient discomfort, and the inability to monitor dynamic drug level changes. In recent years, wearable sensors have emerged as a promising solution for drug monitoring. These sensors offer real-time and continuous measurement of drug concentrations in biofluids, enabling personalized medicine and reducing the risk of toxicity. This review provides an overview of drugs detectable by wearable sensors and explores biosensing technologies that can enable drug monitoring in the future. It presents a comparative analysis of multiple biosensing technologies and evaluates their strengths and limitations for integration into wearable detection systems. The promising capabilities of wearable sensors for real-time and continuous drug monitoring offer revolutionary advancements in diagnostic tools, supporting personalized medicine and optimal therapeutic effects. Wearable sensors are poised to become essential components of healthcare systems, catering to the diverse needs of patients and reducing healthcare costs.
    MeSH term(s) Humans ; Drug Monitoring/methods ; Wearable Electronic Devices ; Precision Medicine/methods ; Delivery of Health Care ; Monitoring, Physiologic/methods
    Language English
    Publishing date 2023-07-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13070726
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  3. Article ; Online: Bi-enzyme competition based on ZIF-67 co-immobilization for real-time monitoring of exocellular ATP.

    Lu, Yan / Li, Junmin / Liu, Yuqiao / Zhu, Ling / Xiao, Shenghao / Bai, Mingxia / Chen, Dajing / Xie, Tian

    Mikrochimica acta

    2023  Volume 190, Issue 2, Page(s) 71

    Abstract: Monitoring exocellular adenosine-5'-triphosphate (ATP) is a demanding task but the biosensor development is limited by the low concentration and rapid degradation of ATP. Herein, we developed a simple yet effective biosensor based on ZIF-67 loaded with ... ...

    Abstract Monitoring exocellular adenosine-5'-triphosphate (ATP) is a demanding task but the biosensor development is limited by the low concentration and rapid degradation of ATP. Herein, we developed a simple yet effective biosensor based on ZIF-67 loaded with bi-enzymes of glucose (GOx) and hexokinase (HEX) for effective detection of ATP. In the confined space of the porous matrix, the bi-enzymes competed for the glucose substrate in the presence of ATP, facilitating the biosensor to detect low ATP concentrations down to the micromole level (3.75 μM) at working potential of 0.55 V (vs. Ag/AgCl). Furthermore, ZIF-67 with cobalt served as a porous matrix to specifically adsorb ATP molecules, allowing it to differentiate isomers with sensitivity of 0.53 nA/μM, RSD of 5.4%, and recovery rate of 93.3%. We successfully applied the fabricated biosensor to measure ATP secreted from rat PC12 cells in the pericellular space thus realizing time-resolving measurement. This work paved the path for real-time monitoring of ATP released by cells, which will aid in understanding tumor cell glycolysis and immune responses.
    MeSH term(s) Animals ; Rats ; Enzymes, Immobilized/chemistry ; Glucose Oxidase/chemistry ; Hexokinase/chemistry ; Hexokinase/metabolism ; Adenosine Triphosphate/chemistry ; Glucose
    Chemical Substances Enzymes, Immobilized ; Glucose Oxidase (EC 1.1.3.4) ; Hexokinase (EC 2.7.1.1) ; Adenosine Triphosphate (8L70Q75FXE) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-01-25
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-023-05652-y
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