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Article: [Development of traditional Chinese medicine:New Era and new strategy].

Xiao, Xiao-He

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2019 Volume 44, Issue 18, Page(s) 3837–3841

Abstract: As China's social development enters the New Era and the pursuit of healthcare is on the rise,people put forward the new requirements to traditional Chinese medicine( TCM) service capability. It is a great mission entrusted to practitioners to give full ... ...

Abstract	As China's social development enters the New Era and the pursuit of healthcare is on the rise,people put forward the new requirements to traditional Chinese medicine( TCM) service capability. It is a great mission entrusted to practitioners to give full play to the unique characteristics and strengths of TCM. The development of TCM is currently confronted with important chances and challenges,and has entered a period of adjustment. In order to promote the healthy and sustainable development of TCM and enlarge people's sense of gaining in particular,it is vital to improve the contribution of TCM in China's medical and health services. My suggestions are as follows: ①The development of TCM should stay true to the vision of people's health-oriented development,accelerate shift of " three work emphasis",and scientifically construct five " should do" and five " should do even more" development path suited to features of TCM. ②The development of TCM should focus on the study of its " new four natures"( safety,effectiveness,controllability,accessibility) further,and pursue innovation-driven high quality development of TCM.
MeSH term(s)	China ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional/trends
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2019-12-24
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20190823.301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Study and thought on the safety of traditional Chinese medicines under Healthy China strategy].

Xiao, Xiao-He

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2018 Volume 43, Issue 5, Page(s) 857–860

Abstract: As the Healthy China planning has been implemented, traditional Chinese medicine (TCM) has witnessed unprecedented developmental opportunities. However, the safety of TCM has always been like The Sword of Damocles in TCM area, endangering the healthy and ...

Abstract	As the Healthy China planning has been implemented, traditional Chinese medicine (TCM) has witnessed unprecedented developmental opportunities. However, the safety of TCM has always been like The Sword of Damocles in TCM area, endangering the healthy and sustainable development of TCM. In order to solve the problem of TCM safety in China as soon as possible, the author puts forward that the situation and issues of TCM safety should be considered with the change of the times. At the same time, it is suggested that the research on TCM safety should be listed as the most important project in TCM science and technology field. The safety evaluation and risk control system in line with China national situation and TCM characteristics should be established as soon as possible. The research strategy of TCM safety should be innovated from "five changes". The transition of adverse drug reactions of TCM from "still not clear" to "basically clear" should be tried to realize, which allow TCM inherited from our ancestors to make a greater contribution to human's health.
MeSH term(s)	China ; Drug-Related Side Effects and Adverse Reactions ; Drugs, Chinese Herbal/standards ; Humans ; Medicine, Chinese Traditional ; Research Design
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2018-04-19
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20180117.009
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Article: [On indirect actions of Chinese medicines and innovation of indirect-acting Chinese medicines].

Wang, Jia-Bo / Xiao, Xiao-He

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2021 Volume 46, Issue 21, Page(s) 5443–5449

Abstract: The output of high level innovative Chinese medicines(CM) is very rare for a few years, which is in sharp contrast to the reality that antibody drugs, small molecular targeted therapy, antibody-drug conjugate and other innovative drugs have heavy ... ...

Abstract	The output of high level innovative Chinese medicines(CM) is very rare for a few years, which is in sharp contrast to the reality that antibody drugs, small molecular targeted therapy, antibody-drug conjugate and other innovative drugs have heavy investment and high yield. Acceleration for the research and development of innovative CM drugs obviously relies on breakthrough of the modes of thinking and methodology. Deeply influenced by the thinking of allopathic medicine in Western science system, the mainstream of current basic researches on CM is to find the components and their molecular mechanisms that can directly inhibit or antagonize the target in disease focal. However, it is difficult to explain the mechanism of the reported " active" components in many CMs, since their steady-state concentrations in disease focal are usually significantly lower than the effective concentrations of those components. Therefore, based on the original methodology of CM-systemism and harmonizing medicine, this paper proposed that the mechanism of action of CMs may not be limited to the direct antagonistic effect on the target in disease focal. Instead, it may involve indirect action through the intermediate substances across different organs or systems with a long-distance action pattern.A fundamentally break may be achieved when exploring the mechanism of action of CM active components from the perspective of indirect action. It may also change the thinking of allopathic medicine in the researches of CM and start a new innovative road for the development of indirect-acting CMs.
MeSH term(s)	China ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2021-12-23
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20210978.601
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Article: Integrative medicine in the era of cancer immunotherapy: Challenges and opportunities.

Zhang, Ning / Xiao, Xiao-He

Journal of integrative medicine

2021 Volume 19, Issue 4, Page(s) 291–294

Abstract: Cancer immunotherapy has led to a new era of cancer treatment strategies, and transforming healthcare for cancer patients. Meanwhile, reports of immune-related adverse events have been increasing, greatly hindering the use of cancer immunotherapy. ... ...

Abstract	Cancer immunotherapy has led to a new era of cancer treatment strategies, and transforming healthcare for cancer patients. Meanwhile, reports of immune-related adverse events have been increasing, greatly hindering the use of cancer immunotherapy. Traditional Chinese medicine (TCM), which has been widely used in Asian countries for thousands of years, is known to play a complementary role in the treatment of cancer. Taken in combined with conventional modern therapies, such as resection, ablation and radiotherapy, TCM exerts its main anti-cancer effects in two ways: health-strengthening (Fu-Zheng) and pathogen-eliminating (Qu-Xie). Theoretically, pathogen-eliminating TCM can promote the release of tumor-related antigens and should be able to increase the effect of immunotherapy, while health-strengthening TCM may have immune-enhancing mechanisms that overlap with immunotherapy. In the era of cancer immunotherapy, it is important to balance the use of TCM and immunotherapy, with the goal of enhancing immune efficacy and antagonizing immune toxicity. In this article, we discuss this issue by considering the mechanism of tumor immunotherapy, alongside the theoretical basis of TCM treatment of tumors, with the aim of bringing new insights to future research in this field.
MeSH term(s)	Drugs, Chinese Herbal ; Humans ; Immunotherapy ; Integrative Medicine ; Medicine, Chinese Traditional ; Neoplasms/therapy
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2021-03-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2705612-0
ISSN	2095-4964
ISSN	2095-4964
DOI	10.1016/j.joim.2021.03.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Herb induced liver injury by Xianling Gubao Tablets: A case assessed for causality using updated RUCAM and integrated evidence chain.

Li, Chunyu / Li, Yingying / Bai, Zhaofang / Wang, Jiabo / Li, Guohui / Xiao, Xiaohe

Chinese herbal medicines

2024 Volume 16, Issue 2, Page(s) 301–309

Abstract: Objective: A typical case of Xianling Gubao (XLGB) Tablets-induced liver injury was systematically studied in the clinic and the laboratory.: Methods: A patient with herb-induced liver injury (HILI) and a history of taking XLGB Tablets before disease ...

Abstract	Objective: A typical case of Xianling Gubao (XLGB) Tablets-induced liver injury was systematically studied in the clinic and the laboratory. Methods: A patient with herb-induced liver injury (HILI) and a history of taking XLGB Tablets before disease onset was engaged as the study subject, and the case was diagnosed according to the updated Roussel Uclaf Causality Assessment Method (RUCAM) and the integrated evidence chain (iEC) method recommended by the Results: Clinical history, biochemical indexes and imaging tests were used to exclude the influence of fundamental diseases and confusing liver diseases such as viral, alcoholic and autoimmune liver diseases on the diagnosis. Based on an investigation of the patient's medication history, she was suspected to have HILI caused by XLGB Tablets, as the patient was only taking an oral preparation of XLGB Tablets, and the influence of other drugs on the diagnosis was excluded. This patient with alanine aminotransferase (ALT) ≥ 3 × upper limit of normal (ULN) and a calculated R of 6 was diagnosed with possible acute drug-induced hepatocellular injury. The relationship was considered "highly probable" (score of 9) using the updated RUCAM of 2016. Moreover, the fingerprint similarity between the preparation taken by the patient and a commercially available preparation was 0.99, suggesting that the patient was consuming XLGB Tablets rather than another drug. LC-MS technology and the Agilent Fake TCM-Drugs database were used to investigate the drug, and no chemical additions were found. Examination of the drug for pesticide residues, heavy metals, aflatoxins and other exogenous substances indicated compliance with the content limits of the Conclusion: In summary, the final diagnosis of XLGB-induced liver injury reached the clinical diagnosis of HILI and was acute severe hepatocellular injury type by the updated RUCAM and iEC. Therefore, this study provides scientific evidence regarding the causality evaluation of compound preparations of traditional Chinese medicines-induced liver injury.
Language	English
Publishing date	2024-02-21
Publishing country	Singapore
Document type	Journal Article
ISSN	2589-3610
ISSN (online)	2589-3610
DOI	10.1016/j.chmed.2023.10.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors.

Zhan, Xiaoyan / Li, Qiang / Xu, Guang / Xiao, Xiaohe / Bai, Zhaofang

Frontiers in immunology

2023 Volume 13, Page(s) 1109938

Abstract: NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Once activated, NLRP3 ... ...

Abstract	NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Once activated, NLRP3 initiates the inflammasome assembly together with the adaptor ASC and the effector caspase-1, leading to caspase-1 activation and subsequent cleavage of IL-1β and IL-18. Aberrant NLRP3 inflammasome activation is linked with the pathogenesis of multiple inflammatory diseases, such as cryopyrin-associated periodic syndromes, type 2 diabetes, non-alcoholic steatohepatitis, gout, and neurodegenerative diseases. Thus, NLRP3 is an important therapeutic target, and researchers are putting a lot of effort into developing its inhibitors. The review summarizes the latest advances in the mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors.
MeSH term(s)	Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Diabetes Mellitus, Type 2 ; Cryopyrin-Associated Periodic Syndromes ; Caspase 1/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2023-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1109938
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: New Insights into Herb-Induced Liver Injury.

Ma, Zhi-Tao / Shi, Zhuo / Xiao, Xiao-He / Wang, Jia-Bo

Antioxidants & redox signaling

2023 Volume 38, Issue 16-18, Page(s) 1138–1149

Abstract: Significance: ...

Abstract	Significance:
MeSH term(s)	Humans ; Chemical and Drug Induced Liver Injury, Chronic ; Chemical and Drug Induced Liver Injury/etiology ; Risk Factors ; Liver
Language	English
Publishing date	2023-03-02
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2022.0134
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Cognition innovation of toxicity of Chinese medicine and safe and precise medication].

Bai, Zhao-Fang / Wang, Jia-Bo / Xiao, Xiao-He

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 47, Issue 10, Page(s) 2557–2564

Abstract: Traditional Chinese medicine(TCM) has made outstanding contributions to disease prevention and treatment, survival, and reproduction of the Chinese nation. Currently, the inheritance and innovative development of TCM have become a national strategy. ... ...

Abstract	Traditional Chinese medicine(TCM) has made outstanding contributions to disease prevention and treatment, survival, and reproduction of the Chinese nation. Currently, the inheritance and innovative development of TCM have become a national strategy. However, in recent years, adverse reactions/events of Chinese medicine frequently occurred. In particular, in terms of the safety problem of newly discovered "toxic" Chinese medicine, it is often difficult to answer the question scientifically and develop effective solutions. When facing international public opinions and public questioning, they are often "passively criticized". To solve the difficult problem about the safety of Chinese medicine, we urgently need to make breakthroughs in the cognition of toxicity of Chinese medicine and prevention and control of risks. This research team has been committed to the research on the safety of Chinese medicine for the long term. In particular, in terms of safety evaluation and risk prevention and control of newly discovered "toxic" Chinese medicine, they have made a series of original discoveries. On the basis of the discoveries, they innovated the cognition theory and methods of the toxicity of Chinese medicine, opened up a new field of research on the idiosyncratic toxicity and indirect toxicity of Chinese medicine, and proposed and established the disease-syndrome-based toxicology(DSBT), the model and method of safety evaluation of Chinese medicine related to diseases and syndromes. In light of the theory and methods of DSBT which have been applied to the objective eva-luation and analysis of the mechanism of the hepatotoxicity of Chinese medicine such as Polygoni Multiflori Radix, the mechanism hypothesis of "toxicity due to three causes" of idiosyncratic hepatotoxicity of Chinese medicine was proposed and confirmed. The findings revealed that the substances that induced idiosyncratic or indirect toxicity in Chinese medicine often did not possess definite direct toxi-city. Therefore, this research team proposed the concept of toxicity-related substances(TRS) in Chinese medicine. Based on the mo-dern scientific cognition of toxicity of Chinese medicine, the team proposed the strategy and method of Chinese medicine compatibility to reduce the toxicity based on the component-effect-target interaction to underpin the demonstration of the scientific connotation of toxicity and side effects of "toxic" Chinese medicine and establishment of scientific and effective risk prevention and control strategies. In light of the innovative development of toxicity cognition of Chinese medicine, this study is expected to provide important theoretical guidance and methodological support for scientific evaluation and precise prevention and control of the safety risk of "toxic" Chinese medicine.
MeSH term(s)	Chemical and Drug Induced Liver Injury ; Cognition ; Drug-Related Side Effects and Adverse Reactions/prevention & control ; Drugs, Chinese Herbal/toxicity ; Humans ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2022-02-26
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20220211.601
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [New outlook on safety of traditional Chinese medicine: concept and practice].

Xiao, Xiao-He / Zhao, Xu / Bai, Zhao-Fang / Wang, Jia-Bo / Song, Hai-Bo

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2023 Volume 48, Issue 10, Page(s) 2557–2564

Abstract: Profound changes have taken place in human disease spectrum, constitution spectrum, and drug use behavior, and the safety of traditional Chinese medicine(TCM) faces new trends and problems. In particular, serious adverse reactions/events such as liver ... ...

Abstract	Profound changes have taken place in human disease spectrum, constitution spectrum, and drug use behavior, and the safety of traditional Chinese medicine(TCM) faces new trends and problems. In particular, serious adverse reactions/events such as liver injury and kidney injury caused by non-toxic TCM have been frequently reported, overturning people's understanding of TCM safety, and even shaking the public's confidence in the development of TCM. In the new era of globalization, correctly understanding the situation and problems of TCM safety and addressing the dilemmas in safety evaluation and risk prevention of TCM are the key missions to be undertaken by TCM practitioners. This paper suggests that the situation and problems of TCM safety should be viewed objectively and dialectically, and the use standard of TCM should be advanced with the times. Furthermore, this paper puts forward the new conception and methodology of TCM safety(including one innovative understanding, two types of evaluation modes, tri-elements injury hypothesis; four-quadrant risk decision processes, and five-grade safety evidence body) for the first time, hoping to provide new theories, new strategies, new methods and successful examples for solving the safety problems of TCM.
MeSH term(s)	Humans ; Medicine, Chinese Traditional/adverse effects ; Internationality ; Drugs, Chinese Herbal/adverse effects
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2023-06-01
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20230309.601
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Article ; Online: Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development.

Xu, Mengwei / Bai, Zhaofang / Xie, Baocheng / Peng, Rui / Du, Ziwei / Liu, Yan / Zhang, Guangshuai / Yan, Si / Xiao, Xiaohe / Qin, Shuanglin

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 5

Abstract: Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than ...

Abstract	Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than that of other natural derivatives. Currently, there are 20 marine-derived drugs used in clinical practice, with 11 of them demonstrating anti-tumor effects. This article provides a thorough review of recent advancements in anti-tumor exploration involving 167 natural marine bisindole products and their derivatives. Not only has enzastaurin entered clinical practice, but there is also a successfully marketed marine-derived bisindole compound called midostaurin that is used for the treatment of acute myeloid leukemia. In summary, investigations into the biological activity and clinical progress of marine-derived bisindoles have revealed their remarkable selectivity, minimal toxicity, and efficacy against various cancer cells. Consequently, they exhibit immense potential in the field of anti-tumor drug development, especially in the field of anti-tumor drug resistance. In the future, these compounds may serve as promising leads in the discovery and development of novel cancer therapeutics.
MeSH term(s)	Humans ; Antineoplastic Agents/chemistry ; Biological Products/chemistry ; Leukemia, Myeloid, Acute/drug therapy ; Drug Discovery ; Aquatic Organisms/chemistry
Chemical Substances	Antineoplastic Agents ; Biological Products
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29050933
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