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  1. Article ; Online: Usability and feasibility of a cognitive-behavioral mobile app for ADHD in adults.

    Laura E Knouse / Xiaodi Hu / George Sachs / Sebastian Isaacs

    PLOS Digital Health, Vol 1, Iss 8, p e

    2022  Volume 0000083

    Abstract: Objective Cognitive-behavioral therapy (CBT) has growing evidence of efficacy for Attention-Deficit/Hyperactivity Disorder (ADHD) in adults. Mobile health apps are promising tools for delivering scalable CBT. In a 7-week open study of Inflow, a CBT-based ...

    Abstract Objective Cognitive-behavioral therapy (CBT) has growing evidence of efficacy for Attention-Deficit/Hyperactivity Disorder (ADHD) in adults. Mobile health apps are promising tools for delivering scalable CBT. In a 7-week open study of Inflow, a CBT-based mobile app, we assessed usability and feasibility to prepare for a randomized controlled trial (RCT). Method 240 adults recruited online completed baseline and usability assessments at 2 (n = 114), 4 (n = 97) and after 7 weeks (n = 95) of Inflow use. 93 participants self-reported ADHD symptoms and impairment at baseline and 7 weeks. Results Participants rated Inflow's usability favorably, used the app a median of 3.86 times per week, and a majority of those using the app for 7 weeks self-reported decreases in ADHD symptoms and impairment. Conclusion Inflow demonstrated usability and feasibility among users. An RCT will determine whether Inflow is associated with improvement among more rigorously assessed users and beyond non-specific factors.
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7
    Subject code 005 ; 150
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Spatial Distribution of Soil Heavy Metal Concentrations in Road-Neighboring Areas Using UAV-Based Hyperspectral Remote Sensing and GIS Technology

    Wenxia Gan / Yuxuan Zhang / Jinying Xu / Ruqin Yang / Anna Xiao / Xiaodi Hu

    Sustainability, Vol 15, Iss 10043, p

    2023  Volume 10043

    Abstract: Monitoring and restoring soil quality in areas neighboring roads affected by traffic activities require a thorough investigation of heavy metal concentrations. This study examines the spatial heterogeneity of copper (Cu) and chromium (Cr) concentrations ... ...

    Abstract Monitoring and restoring soil quality in areas neighboring roads affected by traffic activities require a thorough investigation of heavy metal concentrations. This study examines the spatial heterogeneity of copper (Cu) and chromium (Cr) concentrations in a 0.113 km² area adjacent to Jin-Long Avenue in Wuhan, China, using Unmanned Aerial Vehicle (UAV)-based hyperspectral remote sensing technology. Through this UAV-based remote sensing technology, we innovatively achieve a small-scale and fine-grained analysis of soil heavy metal pollution related with traffic activities, which represents a major contribution of this research study. In our approach, we generated 4375 spectral variates by transforming the original spectrum. To enhance result accuracy, we applied the Boruta algorithm and correlation analysis to select optimal spectral variates. We developed the retrieval model using the Gradient Boosting Decision Tree (GBDT) regression method, selected from a set of four regression methods using the LOOCV method. The resulting model yielded R-square values of 0.325 and 0.351 for Cu and Cr, respectively, providing valuable insights into the heavy metal concentrations. Based on the retrieved heavy metal concentrations from bare soil pixels (17,420 points), we analyzed the relationship between heavy metal concentrations and the perpendicular distance from the road. Additionally, we employed the universal kriging interpolation method to map heavy metal concentrations across the entire area. Our findings reveal that the concentration of heavy metals in this area exceeds background values and decreases as the distance from the road increases. This research significantly contributes to the understanding of spatial distribution characteristics and pollution caused by heavy metal concentrations resulting from traffic activities.
    Keywords soil heavy metal ; traffic activities ; UAV ; hyperspectral ; remote sensing ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 910
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Hepatocyte-Specific Deficiency of BAP31 Amplified Acetaminophen-Induced Hepatotoxicity via Attenuating Nrf2 Signaling Activation in Mice

    Jie Zhao / Xiaotong Lv / Yan Huo / Xiaodi Hu / Xiaochen Li / Shizhuo Sun / Xin Zhao / Xuewei Kong / Jialin Xu

    International Journal of Molecular Sciences, Vol 22, Iss 10788, p

    2021  Volume 10788

    Abstract: Liver-specific deficiency of B-cell receptor-associated protein 31 knockout mice (BAP31-LKO) and the littermates were injected with acetaminophen (APAP), markers of liver injury, and the potential molecular mechanisms were determined. In response to APAP ...

    Abstract Liver-specific deficiency of B-cell receptor-associated protein 31 knockout mice (BAP31-LKO) and the littermates were injected with acetaminophen (APAP), markers of liver injury, and the potential molecular mechanisms were determined. In response to APAP overdose, serum aspartate aminotransferase and alanine aminotransferase levels were increased in BAP31-LKO mice than in wild-type controls, accompanied by enhanced liver necrosis. APAP-induced apoptosis and mortality were increased. Hepatic glutathione was decreased (1.60 ± 0.31 μmol/g tissue in WT mice vs. 0.85 ± 0.14 μmol/g tissue in BAP31-LKO mice at 6 h, p < 0.05), along with reduced glutathione reductase activity and superoxide dismutase; while malondialdehyde was significantly induced (0.41 ± 0.03 nmol/mg tissue in WT mice vs. 0.50 ± 0.05 nmol/mg tissue in BAP31-LKO mice for 6 h, p < 0.05). JNK signaling activation and APAP-induced hepatic inflammation were increased in BAP31-LKO mice. The mechanism research revealed that BAP31-deficiency decreased Nrf2 mRNA stability (half-life of Nrf2 mRNA decreased from ~1.3 h to ~40 min) and miR-223 expression, led to reduced nuclear factor erythroid 2-related factor 2 (Nrf2) signaling activation and antioxidant genes induction. BAP31-deficiency decreased mitochondrial membrane potentials, reduced mitochondria-related genes expression, and resulted in mitochondrial dysfunction in the liver. Conclusions: BAP31-deficiency reduced the antioxidant response and Nrf2 signaling activation via reducing Nrf2 mRNA stabilization, enhanced JNK signaling activation, hepatic inflammation, and apoptosis, amplified APAP-induced hepatotoxicity in mice.
    Keywords BAP31 ; acetaminophen ; oxidative stress ; Nrf2 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Author Correction

    Xi Yu / Xiaodi Hu / Maria Pop / Nicole Wernet / Frank Kirschhöfer / Gerald Brenner-Weiß / Julia Keller / Mirko Bunzel / Reinhard Fischer

    Nature Communications, Vol 12, Iss 1, Pp 1-

    Fatal attraction of Caenorhabditis elegans to predatory fungi through 6-methyl-salicylic acid

    2021  Volume 1

    Keywords Science ; Q
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Fatal attraction of Caenorhabditis elegans to predatory fungi through 6-methyl-salicylic acid

    Xi Yu / Xiaodi Hu / Maria Pop / Nicole Wernet / Frank Kirschhöfer / Gerald Brenner-Weiß / Julia Keller / Mirko Bunzel / Reinhard Fischer

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 10

    Abstract: Methyl salicylate ester is a plant metabolite involved in plant-insect and plant-plant interactions. Here, Yu et al. show that a nematode-trapping fungus has potential to produce a related compound, 6-methyl salicylate, which attracts its prey (nematodes) ...

    Abstract Methyl salicylate ester is a plant metabolite involved in plant-insect and plant-plant interactions. Here, Yu et al. show that a nematode-trapping fungus has potential to produce a related compound, 6-methyl salicylate, which attracts its prey (nematodes) and modulates spore germination and trap formation in the fungus.
    Keywords Science ; Q
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The Sapria himalayana genome provides new insights into the lifestyle of endoparasitic plants

    Xuelian Guo / Xiaodi Hu / Jianwu Li / Bingyi Shao / Yajun Wang / Long Wang / Kui Li / Dongliang Lin / Hanchen Wang / Zhiyuan Gao / Yuannian Jiao / Yingying Wen / Hongyu Ji / Chongbo Ma / Song Ge / Wenkai Jiang / Xiaohua Jin

    BMC Biology, Vol 21, Iss 1, Pp 1-

    2023  Volume 22

    Abstract: Abstract Background Sapria himalayana (Rafflesiaceae) is an endoparasitic plant characterized by a greatly reduced vegetative body and giant flowers; however, the mechanisms underlying its special lifestyle and greatly altered plant form remain unknown. ... ...

    Abstract Abstract Background Sapria himalayana (Rafflesiaceae) is an endoparasitic plant characterized by a greatly reduced vegetative body and giant flowers; however, the mechanisms underlying its special lifestyle and greatly altered plant form remain unknown. To illustrate the evolution and adaptation of S. himalayasna, we report its de novo assembled genome and key insights into the molecular basis of its floral development, flowering time, fatty acid biosynthesis, and defense responses. Results The genome of S. himalayana is ~ 1.92 Gb with 13,670 protein-coding genes, indicating remarkable gene loss (~ 54%), especially genes involved in photosynthesis, plant body, nutrients, and defense response. Genes specifying floral organ identity and controlling organ size were identified in S. himalayana and Rafflesia cantleyi, and showed analogous spatiotemporal expression patterns in both plant species. Although the plastid genome had been lost, plastids likely biosynthesize essential fatty acids and amino acids (aromatic amino acids and lysine). A set of credible and functional horizontal gene transfer (HGT) events (involving genes and mRNAs) were identified in the nuclear and mitochondrial genomes of S. himalayana, most of which were under purifying selection. Convergent HGTs in Cuscuta, Orobanchaceae, and S. himalayana were mainly expressed at the parasite–host interface. Together, these results suggest that HGTs act as a bridge between the parasite and host, assisting the parasite in acquiring nutrients from the host. Conclusions Our results provide new insights into the flower development process and endoparasitic lifestyle of Rafflesiaceae plants. The amount of gene loss in S. himalayana is consistent with the degree of reduction in its body plan. HGT events are common among endoparasites and play an important role in their lifestyle adaptation.
    Keywords Sapria himalayana ; Endophyte ; Genome ; Horizontal gene transfer ; Flower development ; fatty acid biosynthesis ; Biology (General) ; QH301-705.5
    Subject code 580 ; 572
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning

    Xiaodi Hu / Mingwei Sun / Qian Chen / Yixia Zhao / Na Liang / Siyuan Wang / Pengbin Yin / Yuanping Yang / Sin Man Lam / Qianying Zhang / Alimujiang Tudiyusufu / Yingying Gu / Xin Wan / Meihong Chen / Hu Li / Xiaofei Zhang / Guanghou Shui / Suneng Fu / Licheng Zhang /
    Peifu Tang / Catherine C. L. Wong / Yong Zhang / Dahai Zhu

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 18

    Abstract: Abstract MyoD is a skeletal muscle-specifically expressed transcription factor and plays a critical role in regulating myogenesis during muscle development and regeneration. However, whether myofibers-expressed MyoD exerts its metabolic function in ... ...

    Abstract Abstract MyoD is a skeletal muscle-specifically expressed transcription factor and plays a critical role in regulating myogenesis during muscle development and regeneration. However, whether myofibers-expressed MyoD exerts its metabolic function in regulating whole body energy homeostasis in vivo remains largely unknown. Here, we report that genetic deletion of Myod in male mice enhances the oxidative metabolism of muscle and, intriguingly, renders the male mice resistant to high fat diet-induced obesity. By performing lipidomic analysis in muscle-conditioned medium and serum, we identify 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) as a muscle-released lipid that is responsible for MyoD-orchestrated body energy homeostasis in male Myod KO mice. Functionally, the administration of DLPC significantly ameliorates HFD-induced obesity in male mice. Mechanistically, DLPC is found to induce white adipose browning via lipid peroxidation-mediated p38 signaling in male mice. Collectively, our findings not only uncover a novel function of MyoD in controlling systemic energy homeostasis through the muscle-derived lipokine DLPC but also suggest that the DLPC might have clinical potential for treating obesity in humans.
    Keywords Science ; Q
    Subject code 572
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Prospective of Societal and Environmental Benefits of Piezoelectric Technology in Road Energy Harvesting

    Lubinda F. Walubita / Dagbegnon Clement Sohoulande Djebou / Abu N. M. Faruk / Sang Ick Lee / Samer Dessouky / Xiaodi Hu

    Sustainability, Vol 10, Iss 2, p

    2018  Volume 383

    Abstract: Road energy harvesting is an ingenious horizon for clean and renewable energy production. The concept is very compatible with current traffic trends and the ongoing depletion of natural resources. Yet, the idea of harvesting roadway energy is still in ... ...

    Abstract Road energy harvesting is an ingenious horizon for clean and renewable energy production. The concept is very compatible with current traffic trends and the ongoing depletion of natural resources. Yet, the idea of harvesting roadway energy is still in its genesis, and only a few real-time implementation projects have been reported in the literature. This review article summarizes the current state of the art in road energy harvesting technology, with a focus on piezoelectric systems, including an analysis of the impact of the technology from social and environmental standpoints. Based on an extensive desktop review study, this article provides a comprehensive insight into roadway energy harvesting technologies. Specifically, the article discusses the societal and environmental benefits of road energy harvesting technologies, as well as the challenges. The study outlined the meaningful benefits that positively align with the concept of sustainability. Overall, the literature findings indicate that the expansion of the roadway energy harvesting technology to a large practical scale is feasible, but such an undertaking should be wisely weighed from broader perspectives. Ultimately, the article provides a positive outlook of the potential contributions of road energy harvesting technologies to the ongoing energy and environmental challenges of human society.
    Keywords transportation ; piezoelectric sensors ; society ; environment ; sustainability ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 690
    Language English
    Publishing date 2018-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Chromosome-level genome assembly of bunching onion illuminates genome evolution and flavor formation in Allium crops

    Nanqiao Liao / Zhongyuan Hu / Jinshan Miao / Xiaodi Hu / Xiaolong Lyu / Haitian Fang / Yi-Mei Zhou / Ahmed Mahmoud / Guancong Deng / Yi-Qing Meng / Kejia Zhang / Yu-Yuan Ma / Yuelin Xia / Meng Zhao / Haiyang Yang / Yong Zhao / Ling Kang / Yiming Wang / Jing-Hua Yang /
    Yan-Hong Zhou / Ming-Fang Zhang / Jing-Quan Yu

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 15

    Abstract: Genome evolution of Allium genus and genomic basis underlying the pungency flavor formation remain poorly understood. Here, the authors assemble the genome of bunching onion and conduct population genetics analyses to reveal Allium genome evolution, ... ...

    Abstract Genome evolution of Allium genus and genomic basis underlying the pungency flavor formation remain poorly understood. Here, the authors assemble the genome of bunching onion and conduct population genetics analyses to reveal Allium genome evolution, flavor formation and domestication history.
    Keywords Science ; Q
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease

    Emmanouela Tsagkaraki / Sarah M. Nicoloro / Tiffany DeSouza / Javier Solivan-Rivera / Anand Desai / Lawrence M. Lifshitz / Yuefei Shen / Mark Kelly / Adilson Guilherme / Felipe Henriques / Nadia Amrani / Raed Ibraheim / Tomas C. Rodriguez / Kevin Luk / Stacy Maitland / Randall H. Friedline / Lauren Tauer / Xiaodi Hu / Jason K. Kim /
    Scot A. Wolfe / Erik J. Sontheimer / Silvia Corvera / Michael P. Czech

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 17

    Abstract: Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mice. ...

    Abstract Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mice.
    Keywords Science ; Q
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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