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Article ; Online: A 3-miRNA Risk Scoring Signature in Early Diabetic Retinopathy

Jiali Wu / Ke Shi / Fang Zhang / Xiaodong Sun

Journal of Clinical Medicine, Vol 12, Iss 1777, p

2023 Volume 1777

Abstract: Purpose: The aim of our study was to investigate a comprehensive profile of streptozotocin (STZ)-induced early diabetic retinopathy (DR) mice to identify a risk scoring signature based on micorRNAs (miRNAs) for early DR diagnosis. Methods: RNA sequencing ...

Abstract	Purpose: The aim of our study was to investigate a comprehensive profile of streptozotocin (STZ)-induced early diabetic retinopathy (DR) mice to identify a risk scoring signature based on micorRNAs (miRNAs) for early DR diagnosis. Methods: RNA sequencing was performed to obtain the gene expression profile of retinal pigment epithelium (RPE) in early STZ-induced mice. Differentially expressed genes (DEGs) were determined with log2\|fold change (FC)\| > 1 and p value < 0.05. Functional analysis was carried out based on gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and the protein–protein interaction (PPI) network. We predicted the potential miRNAs via online tools and ROC curves were then conducted. Three potential miRNAs with AUC > 0.7 were explored via public datasets and a formula was further established to evaluate DR severity. Results: In total, 298 DEGs (200 up-regulating and 98 down-regulating) were obtained through RNA sequencing. Hsa-miR-26a-5p, hsa-miR-129-2-3p and hsa-miR-217 were three predicted miRNAs with AUC > 0.7, suggesting their potential to distinguish healthy controls from early DR. The formula of DR severity score = 19.257 − 0.004 × hsa-miR-217 + 5.09 × 10 −5 × hsa-miR-26a-5p − 0.003 × hsa-miR-129-2-3p was established based on regression analysis. Conclusions: In the present study, we investigated the candidate genes and molecular mechanisms based on RPE sequencing in early DR mice models. Hsa-miR-26a-5p, hsa-miR-129-2-3p and hsa-miR-217 could work as biomarkers for early DR diagnosis and DR severity prediction, which was beneficial for DR early intervention and treatment.
Keywords	diabetic retinopathy ; differentially expressed gene ; miRNA ; risk score signature ; Medicine ; R
Subject code	500
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: How Ski Tourism Involvement Promotes Tourists’ Low-Carbon Behavior?

Yang Yang / Xiaodong Sun / Lingli Hu / Yuzhu Ma / He Bu

Sustainability, Vol 15, Iss 10277, p

2023 Volume 10277

Abstract: China’s ski tourism industry has grown tremendously in the past few years, leading to an increasing amount of tourism-related carbon emissions with negative environmental impacts. Although the government and other market participants are trying to solve ... ...

Abstract	China’s ski tourism industry has grown tremendously in the past few years, leading to an increasing amount of tourism-related carbon emissions with negative environmental impacts. Although the government and other market participants are trying to solve the problem from both legislative and technological perspectives, encouraging tourists to engage in low-carbon behavior may play a more important role. This study aims to explore how tourism involvement influences ski tourists’ low-carbon behavior. A sampling survey was conducted to collect 422 valid responses from two ski resorts (indoor and outdoor). Findings from structural equation modeling revealed a significant positive impact of tourism involvement on both low-carbon tourism behavior and low-carbon daily behavior, and this impact can be serially mediated by place attachment and environmental responsibility. In addition, we confirmed that the impact of ski tourism involvement on place attachment is more significant for outdoor ski resorts compared with indoor ones. This study expands the categories of destinations for research on ski tourism and low-carbon behavior. It provides implications for encouraging visitor pro-environmental behavior while corroborating the social value of ski tourism in addressing environmental issues. It also offers insights for government low-carbon campaigns, business management practices, and individuals with actionable attitudes. However, it is worth noting that this study was conducted in a single latitude region and did not conduct a comparative analysis with different locations across latitudes. Future research could investigate skiers in cities of different latitudes to gain a more comprehensive understanding.
Keywords	ski tourism ; tourism involvement ; low-carbon tourism behavior ; daily low-carbon behavior ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research on Output Voltage Stability of Non-Contact Excitation Motor

Ke Li / Xuan Meng / Xiaodong Sun

Applied Sciences, Vol 12, Iss 3666, p

2022 Volume 3666

Abstract: In recent years, electric vehicles have developed rapidly. However, many electric cars are equipped with permanent magnet synchronous motors. Permanent magnet synchronous motors have several disadvantages: For example, permanent magnets tend to ... ...

Abstract	In recent years, electric vehicles have developed rapidly. However, many electric cars are equipped with permanent magnet synchronous motors. Permanent magnet synchronous motors have several disadvantages: For example, permanent magnets tend to demagnetize at high temperatures. Electrically excited synchronous motors have several excellent properties. First, they are cheaper because the stator and rotor of the motor only need to be wound, which is more affordable than permanent magnets for speed regulation. When the armature current reaches the maximum value, the excitation current can also be adjusted for speed regulation, which makes the speed regulation more flexible. In the case of a short circuit, the corresponding direct-axis current is smaller than the quadrature-axis current, so the fault tolerance is better. Since the traditional electric excitation motor has brushes and slips rings, sparks will be generated during commutation. Therefore, a new excitation method is adopted to make non-contact motor excitation, and the motor operation is safer and more environmentally friendly. At the same time, to ensure that the output power of the non-contact electric excitation motor remains stable, a step-down circuit and power-type fast discrete terminal sliding mode control are added after the full-bridge rectifier circuit to make the excitation current and voltage output of the motor more stable. That is, the output power reaches a steady production. In this paper, an improved sliding mode control algorithm is used to stabilize the output voltage of the non-contact excitation motor, which can still ensure the stable output of the voltage when the equivalent load changes. It is confirmed that the non-contact excitation motor can be applied to various complex situations, and the proposed algorithm is simulated and experimentally verified to verify the accuracy of the proposed algorithm.
Keywords	contactless excitation ; a resonant circuit ; buck transform ; power type fast discrete terminal sliding mode control ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	629
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study the Effect of eHMI Projection Distance and Contrast on People Acceptance in Blind-Spot Detection Scenario

Ali Hassan Shah / Xiaodong Sun / Yandan Lin

Applied Sciences, Vol 12, Iss 6730, p

2022 Volume 6730

Abstract: External human-machine interaction (eHMI) road projections are a new feature for automotive lighting to improve vehicle communication with other road users. These modalities are used to draw users’ attention and awareness to specific situations. However, ...

Abstract	External human-machine interaction (eHMI) road projections are a new feature for automotive lighting to improve vehicle communication with other road users. These modalities are used to draw users’ attention and awareness to specific situations. However, such advanced capabilities are still being debated to be used on the road in the context of whether or not such road projections can provide a clear and understandable message to road users in a specific scenario or lead to anticipation and change in the driving behavior. Therefore, it is necessary to investigate human factors aspects, such as the feeling of safety, useability, understanding, acceptability, and driver behavior. This study investigates the change in distance and luminance contrast and its effect on human driving behavior and acceptability in blind spot detection scenarios on the highway. A lab experiment with 12 participants is performed to analyze: understanding, satisfaction, usability, visibility, safety, workload, and driving behavior towards eHMI projection while varying projecting distance and luminance contrast. Video recordings and a designed questionnaire were used during the whole process. Results show that ego vehicle drivers prefer a projection distance between 5 to 10 m. However, a distance of 5 m is preferred by overtaking vehicle drivers in terms of visibility and safety. Luminance contrasts have no significant effect on the symbol’s visibility in 5 m and 10 m projection distances. In contrast, participants in overtaking vehicles feel difficult to understand the situation for 15 m condition, which increases their overall workload significantly ( p < 0.019). No significant effect is recorded in terms of change in driving behavior.
Keywords	eHMI projection system ; autonomous vehicles ; human factors ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	380
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An Overview of Position Sensorless Techniques for Switched Reluctance Machine Systems

Xingtao Tang / Xiaodong Sun / Ming Yao

Applied Sciences, Vol 12, Iss 3616, p

2022 Volume 3616

Abstract: Accurate real-time rotor position is indispensable for switched reluctance motors (SRM) speed and torque control. Traditional position sensors add complexity and potential failure risk to the system. Owing to the added advantages of high stability and ... ...

Abstract	Accurate real-time rotor position is indispensable for switched reluctance motors (SRM) speed and torque control. Traditional position sensors add complexity and potential failure risk to the system. Owing to the added advantages of high stability and low cost, the position sensorless method of SRMs has been extensively studied to advance its use in vehicles and construction machinery. This paper presents an overview of position sensorless control techniques from the perspective of whether the method requires the establishment of complex mathematical models. Various types of methods are compared for performance, such as speed regulation range, algorithm complexity, and requirement of the pre-stored parameter. A discussion is presented concerning current trends in technological development, which will facilitate the research addressing potentially effective methods for position estimation in SRM drive systems.
Keywords	additional components ; hybrid detection method ; position sensorless control ; magnetic-model-based ; switched reluctance machine (SRM) ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	629
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Optimization Design and Control of Six-Phase Switched Reluctance Motor with Decoupling Winding Connections

Wei Qiao / Shouyi Han / Kaikai Diao / Xiaodong Sun

Applied Sciences, Vol 12, Iss 8801, p

2022 Volume 8801

Abstract: In this paper, a design optimization method is proposed to reduce the current asymmetric and consequent torque ripple for a six-phase Switched Reluctance Motor (SRM). First, the inconsistent current phenomenon of the investigated SRM is introduced, and ... ...

Abstract	In this paper, a design optimization method is proposed to reduce the current asymmetric and consequent torque ripple for a six-phase Switched Reluctance Motor (SRM). First, the inconsistent current phenomenon of the investigated SRM is introduced, and the relationship between the magnetic distribution and the phase currents is investigated by magnetic circuit analysis. Then, for the reduction in computational cost, a surrogate model is utilized to establish the response surface model between the optimization objectives and variables. Furthermore, multiobjective optimization is performed based on structural design optimization and asymmetric control, and the best design solution is selected for the drive system. Compared with the traditional symmetric control, it can be found that the proposed asymmetric control can mitigate the inconsistent phase currents and reduce the torque ripple. Finally, a prototype motor is manufactured and tested. Both the simulation and experimental results verify the effectiveness and the reasonability of the analysis and the optimization.
Keywords	finite-element model (FEM) ; multiobjective optimization ; switched reluctance motor ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	510
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Secular trends of epidemiologic patterns of chronic kidney disease over three decades

Jing Liu / Xue Li / Yongping Liu / Xiaodong Sun / Xiaojin Feng / Ningning Hou / Zhenna Chen

BMJ Open, Vol 13, Iss

an updated analysis of the Global Burden of Disease Study 2019

2023 Volume 3

Abstract: Objectives To assess the characteristics of the global death burden imposed by chronic kidney disease (CKD) and the attributable risk factors from 1990 to 2019 to help inform a framework for policy discussions, resource allocation and research priorities. ...

Abstract	Objectives To assess the characteristics of the global death burden imposed by chronic kidney disease (CKD) and the attributable risk factors from 1990 to 2019 to help inform a framework for policy discussions, resource allocation and research priorities.Design A population-based observational study.Setting The death data and relative risk factors were obtained from the Global Burden of Disease (GBD) Study 2019 database.Main outcome measures Based on the GBD database, we estimated the death burden attributable to CKD stratified by sociodemographic index (SDI), geographic location, sex, age group, time period and risk factors from 1990 to 2019.Results Over three decade study period, the global number of CKD-related deaths increased from 0.60 million (95% uncertainty interval (UI): 0.57–0.63 million) in 1990 to 1.43 million (95% UI: 1.31–1.52 million) in 2019. The age-standardised death rate (ASDR) of CKD, among all causes, increased from 15th in 1990 to 10th in 2019. Globally, the ASDR in males was higher than that in females. CKD-related deaths mainly occurred in those aged over 50 years, especially in regions with higher SDIs. The ASDR was negatively related to SDI (ρ=−0.603, p<0.0001). Among risk factors, metabolic risk factors, especially systolic blood pressure, fasting plasma glucose and body mass index, were the main contributors to CKD-related deaths. Although the high-temperature-related death burden was low, the trend increased sharply in lower SDI regions.Conclusions CKD-related deaths continue to increase, with the majority occurring in elderly adults. The CKD-related death burden is higher in males than in females. Additionally, the increasing high-temperature-related death burdens in lower SDI regions should receive social attention.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Optical Coherence Tomography Angiography Characteristics Serve as Retinal Vein Occlusion Therapeutic Biomarkers for Dexamethasone Intravitreal Implant

Ke Shi / Xiaodong Sun / Jingfa Zhang

Disease Markers, Vol

2021 Volume 2021

Abstract: Background. Retinal vein occlusion (RVO) is the second most common vision-threatening retinal vascular disease. Intravitreal dexamethasone implant has been applied to treat macular edema secondary to RVO (RVO-ME). However, the alteration of morphologic ... ...

Abstract	Background. Retinal vein occlusion (RVO) is the second most common vision-threatening retinal vascular disease. Intravitreal dexamethasone implant has been applied to treat macular edema secondary to RVO (RVO-ME). However, the alteration of morphologic features detected with optical coherence tomography angiography (OCTA) has not been fully studied in RVO-ME patients before and after the treatment. Objective. This study is aimed at identifying potential therapeutic targets in RVO with integrative bioinformatic analysis and compares the OCTA characteristics alterations in patients with RVO-ME receiving injection of dexamethasone intravitreal implant. Methods. Bioinformatic analysis was analyzed in GSE101398 dataset from the Gene Expression Omnibus database. Multiple functional enrichment analyses were performed, and protein-protein interaction network was constructed to visualize the key node genes. Eleven eyes with RVO-ME were examined with OCTA before and after intravitreal dexamethasone implant. The OCTA parameters, including macular thickness, vessel density, foveal avascular zone parameters, the number of hyperreflective foci (HRF), area of cystoid edema, and subretinal fluid (SRF), were compared. The correlation was analyzed between best-corrected visual acuity (BCVA) and OCTA parameters. Results. A total of 79 differentially expressed genes were identified. Functional enrichment analyses revealed the enriched inflammatory events in RVO. In RVO-ME, Pearson correlation revealed that baseline BCVA was positively correlated with the area of SRF and central macular thickness, while no correlation was detected between baseline BCVA and HRF number or the area of cystoid edema. The visual acuity improved, and the central macular thickness was decreased after intravitreal dexamethasone implant injection. Besides, the number of HRF, the area of cystoid edema, and SRF were significantly alleviated after dexamethasone intravitreal injection. Conclusion. Retinal inflammation plays a crucial role in RVO pathogenesis. ...
Keywords	Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influence of lumbar support on tractor seat comfort based on body pressure distribution.

Qingyang Huang / Xiaoping Jin / Mengyu Gao / Mingyang Guo / Xiaodong Sun / Yuning Wei

PLoS ONE, Vol 18, Iss 3, p e

2023 Volume 0282682

Abstract: To solve the problem of lumbar spine injuries of tractor drivers, lumbar support devices were added to the tractor. The purpose of study is to design lumbar supports with different protrusion thicknesses to adjust the load on the operator's lumbar under ... ...

Abstract	To solve the problem of lumbar spine injuries of tractor drivers, lumbar support devices were added to the tractor. The purpose of study is to design lumbar supports with different protrusion thicknesses to adjust the load on the operator's lumbar under whole-body vibration. Integrating pressure distribution measurement with subjective assessment, pressure distribution on the contact surface between ten male tractor drivers and the seat under conditions of different lumbar supports and driving speeds and the influence of the presence of lumbar supports and their thickness on the subjects' comfort were analyzed. The results demonstrated that there existed a certain correlation between the pressure distribution indexes and the drivers' subjective evaluation, and the pressure distribution indexes could reflect ride comfort objectively. The 3 cm thick lumbar support did not improve ride comfort significantly, while the 9 cm thick support exerted too much stress on the waist, causing the lumbar spine to lean forward excessively and aggravating lumbar fatigue. Most subjects in the study would prefer to increase the thickness of the lumbar supports to approximately 6 cm. Based on the pressure distribution test, this study conducted an analysis of the influence of lumbar supports in tractors, which could provide a reference design for tractor seats.
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cysteine Substitution and Calcium-Binding Mutations in FBN1 cbEGF-Like Domains Are Associated With Severe Ocular Involvement in Patients With Congenital Ectopia Lentis

Min Zhang / Zexu Chen / Tianhui Chen / Xiaodong Sun / Yongxiang Jiang

Frontiers in Cell and Developmental Biology, Vol

2022 Volume 9

Abstract: Purpose: To investigate the clinical manifestations of congenital ectopia lentis (CEL) in patients with fibrillin (FBN1) calcium-binding epidermal growth factor (cbEGF)-like mutations.Design: Retrospective cohort study.Methods: Consecutive 68 CEL ... ...

Abstract	Purpose: To investigate the clinical manifestations of congenital ectopia lentis (CEL) in patients with fibrillin (FBN1) calcium-binding epidermal growth factor (cbEGF)-like mutations.Design: Retrospective cohort study.Methods: Consecutive 68 CEL probands with FBN1 cbEGF-like mutations were recruited, mostly comprising Marfan syndrome (MFS) patients. Patients were classified into the cysteine group (n = 43), calcium (Ca2+)-binding group (n = 13) or the others (n = 12) according to their genotypes. Ocular biometrics, morbidities and visual performance were compared among different mutation groups. Linear regression was used to evaluate the risk factors for axial length (AL) elongation.Results: With age-adjustment, cysteine substitution and Ca2+-binding mutations positively contributed to AL elongation (standardized coefficient: 0.410 and 0.367, p = 0.008 and 0.017, respectively). In addition, cataract formation was more frequently detected in patients with Ca2+-binding mutations (observed n = 3, expected n = 1.0; p = 0.036). Patients with cysteine substitutions had the poorest preoperative visual acuity among the three groups (p = 0.012) and did not recover as well as other patients. More MFS diagnoses were made in patients with cysteine substitutions (observed n = 16, expected n = 12.6), while ectopia lentis syndrome was detected more often in patients with cbEGF-like mutations out of the functional regions (observed n = 6, expected n = 2.5; p = 0.023).Conclusion: Compared with patients with cbEGF-like mutations out of functional regions, patients with cysteine substitutions or Ca2+-binding mutations had longer ALs with age adjustment, poorer ocular involvement, visual performance, and systematic manifestations.
Keywords	cbEGF-like ; FBN1 ; cysteine ; congenital ectopia lentis ; marfan syndrome ; Biology (General) ; QH301-705.5
Subject code	610 ; 616
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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