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Article ; Online: Study on Preparation and Performance of Amino Acid/Urea-Formaldehyde Slow-Release Fertilizer

Xiaohua DUAN / Yaqing LIU

Guangdong nongye kexue, Vol 50, Iss 4, Pp 93-

2023 Volume 99

Abstract: Objective】The study was conducted to develop a slow-release fertilizer with multiple nutrients, excellent nitrogen slow-release performance, simple process, and semi-interpenetrating network structure.【Method】By using solution polymerization with in ... ...

Abstract	【Objective】The study was conducted to develop a slow-release fertilizer with multiple nutrients, excellent nitrogen slow-release performance, simple process, and semi-interpenetrating network structure.【Method】By using solution polymerization with in situ extrusion technology, the polymerization and processing processes were combined. With amino acid powder (AARP) and ferrous sulfate (FeSO4) as raw materials, AARP and AARPFe were compounded with urea-formaldehyde (UF) macromolecular chains to form slow-release fertilizers with semi-interpenetrating network structures (AARP-UF and AARPFe-UF). The structures of the slow-release fertilizers were characterized and analyzed by infrared spectroscopy, X-ray diffraction and thermogravimetry, and the surface morphology was observed by scanning electron microscopy (SEM). The compression strength and nitrogen nutrient release rate in still water and soil were measured to investigate the effects of adding AARP and AARPFe on the slow-release performance and to analyze the reasons for their performance improvement.【Result】The crystallinity of the three slow-release fertilizers UF, AARP-UF, and AARPFe-UF were 67.9%, 59.2%, and 57.4%, respectively, and the compression strengths were 1.64, 3.01 and 4.06 MPa. The initial nitrogen release rates in still water were 24.8%, 18.6%, and 15.1% respectively, and the cumulative release rates in soil after 90-day-treatment were 55.9%, 51.4%, and 46.3%, respectively. The addition of AARP and AARPFe disrupted the crystal structure of UF molecular chains and formed hydrogen bonding interactions, which reduced the crystallinity of the slow-release fertilizer, increased the compression strength, and significantly improved the nitrogen slow-release performance. Combining all the results, the effect of slow-release fertilizer AARPFe-UF was optimal.【Conclusion】The prepared new slow-release fertilizer solves the problem of the high initial nitrogen release rate of urea-formaldehyde fertilizer and avoids the waste of resources. The fertilizer ...
Keywords	slow-release performance ; urea-formaldehyde ; hydrogen bonding ; trace element ; crystallinity ; semi-interpenetrating network structure ; Agriculture ; S
Subject code	500
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Guangdong Academy of Agricultural Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Ameliorative effects of a Chinese herbal formula, fufang meidengmu on uterine leiomyoma in a mice model.

Liping Yang, - / Guangyun Zhang, - / Deqiang Feng, - / Maomao Zhang, - / Xiaohua Duan, -

Pakistan journal of pharmaceutical sciences

2023 Volume 36, Issue 3, Page(s) 863–871

Abstract: Fufang Meidengmu (FFMDM) is an ethnic herbal medicine form Yunnan province of China, which is often used for the treatment of uterine leiomyoma (UL). Combined Gancao (Glycyrrhiza uralensis Fisch.) and Haizao (Sargassum pallidum (Turn.) C.Ag) in FFMDM ... ...

Abstract	Fufang Meidengmu (FFMDM) is an ethnic herbal medicine form Yunnan province of China, which is often used for the treatment of uterine leiomyoma (UL). Combined Gancao (Glycyrrhiza uralensis Fisch.) and Haizao (Sargassum pallidum (Turn.) C.Ag) in FFMDM represent an herbal pair in the so-called "eighteen antagonistic medicaments" according to traditional Chinese medicine. In this study, we explored the prevention and treatment effects of FFMDM component compatibility on UL in mice. Female Kunming mice were injected for different periods of time with different concentrations of estradiol benzoate (EB) to investigate a feasible method to establish a mice model of UL. Treatment with 0.3mg/kg EB for 15 days was found to be the optimal condition for UL mice models. We then investigate the role of Gancao and Haizao in FFMDM, and explored the underlying mechanism of action of UL mice. Our findings suggested that Gancao and Haizao exerted the favorable effects. In addition, FFMDM is effective in the treatment of UL, and its mechanism was associated with the estrogen (ER) and progesterone receptors (PR).
MeSH term(s)	Mice ; Female ; Animals ; Humans ; China ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Leiomyoma/drug therapy ; Medicine, Chinese Traditional ; Receptors, Progesterone ; Uterine Neoplasms/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Receptors, Progesterone
Language	English
Publishing date	2023-08-15
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article ; Online: Palmatine treats urticaria by reducing inflammation and increasing autophagy

Tian Xiao / Xingzhi Yu / Liping Yang / Xiaohua Duan

Frontiers in Immunology, Vol

2023 Volume 14

Abstract: IntroductionChronic spontaneous urticaria (CSU) is mainly manifested as wheals and erythema on the skin accompanied by itching, which will cause emotional anxiety and seriously affect the quality of life in patients. Palmatine (PAL) is a main chemical ... ...

Abstract	IntroductionChronic spontaneous urticaria (CSU) is mainly manifested as wheals and erythema on the skin accompanied by itching, which will cause emotional anxiety and seriously affect the quality of life in patients. Palmatine (PAL) is a main chemical component of Yajieshaba, which has been found to effectively alleviate the symptoms of food allergy. However, its role and mechanism in CSU remain unclear. The present study aimed to investigate the protective effect of PAL on CSU rats.MethodsWe replicated the CSU rat model by intraperitoneal injection of ovalbumin (OVA) in rats on days 0, 2, 4, and 14, with a double dose given on the last challenge. PAL, loratadine and saline were given by gavage from day 5 to day 14. We observed the skin pathologic changes, mast cell degranulation, immune factor levels, inflammatory response and autophagy-related protein expression in CSU rats.ResultsWe found PAL treatment to be effective in alleviating CSU-like skin lesions and reducing itching and mast cell degranulation in rats. Compared with the OVA group, the levels of immune and inflammatory factors were significantly reduced, neutrophil recruitment was alleviated, suggesting a reduced inflammatory response. The autophagy results showed that PAL further increased the expression of LC3, Beclin-1 and p-LKB1, p-AMPK, Atg5, Atg12 and Atg5-Atg12, while P62 and p-p70S6K1 expression decreased. They collectively suggested that autophagic flux was activated after PAL treatment. However, there was an increase in the expression of LC3I, probably due to the fact that PAL induced its accumulation in order to provide substrate for the generation of more LC3II.DiscussionOverall, PAL had a protective effect on CSU in normal rats, activated the expression of autophagy and improved the inflammatory response.
Keywords	chronic spontaneous urticaria ; palmatine ; inflammation ; autophagy ; ethnic medicine ; Immunologic diseases. Allergy ; RC581-607
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Yajieshaba prevents lipopolysaccharide-induced intestinal barrier injuryanti-inflammatory and anti-apoptosis.

Liping, Yang / Xinglin, Y U / Chao, Zhang / Pu, Chen / Xiaohua, Duan

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2022 Volume 42, Issue 5, Page(s) 707–714

Abstract: Objective: To investigate the protective effect of Yajieshaba (YJSB) on the intestinal barrier dysfunction induced by lipopolysaccharide (LPS).: Methods: C57BL/6 mice and rat intestinal epithelial cells were treated with LPS. Thiazolyl Blue ... ...

Abstract	Objective: To investigate the protective effect of Yajieshaba (YJSB) on the intestinal barrier dysfunction induced by lipopolysaccharide (LPS). Methods: C57BL/6 mice and rat intestinal epithelial cells were treated with LPS. Thiazolyl Blue Tetrazolium Bromide assay were used to detect cell viability. D-Lactate, diamine oxidase and myeloperoxidase and cytokines were determined by enzyme-linked immunosorbent assay. Western blot was used to detect apoptosis-related proteins and tight junction (TJ) proteins. Real-time quantitative polymerase chain reaction was used to quantify the levels of mRNA expression of cytokines. Histological analysis was performed by hematoxylin and eosin staining. An immunofluorescence staining assay was performed to determine the expression level of TJ protein. Results: YJSB increased cell viability and decreased apoptosis, maintained intestinal permeability after LPS-induced. YJSB inhibited LPS-induced decrease of TJ protein expression, pro-inflammatory cytokine levels and neutrophil infiltration. Conclusion: YJSB protect against LPS-induced intestinal barrier dysfunction anti-inflammatory and anti-apoptosis, suggesting its therapeutic potential against intestinal barrier injury-related diseases.
MeSH term(s)	Animals ; Cytokines/genetics ; Cytokines/metabolism ; Intestinal Mucosa ; Lipopolysaccharides/adverse effects ; Mice ; Mice, Inbred C57BL ; Permeability ; Rats
Chemical Substances	Cytokines ; Lipopolysaccharides
Language	English
Publishing date	2022-10-31
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603186-9
ISSN	2589-451X ; 0254-6272 ; 0255-2922
ISSN (online)	2589-451X ; 0254-6272
ISSN	0255-2922
DOI	10.19852/j.cnki.jtcm.2022.05.005
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Article ; Online: Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women

Chenguang Li / Peizhan Chen / Xiaohua Duan / Jing Wang / Bing Shu / Xiaoguang Li / Qian Ba / Jingquan Li / Yongjun Wang / Hui Wang

EBioMedicine, Vol 15, Iss C, Pp 184-

2017 Volume 192

Abstract: Total 25(OH)D levels were determined to assess bone health in elderly populations; however, the bioavailability of 25(OH)D is regulated by the albumin and vitamin D binding protein (DBP) levels and DBP variations. Whether bioavailable 25(OH)D level is a ... ...

Abstract	Total 25(OH)D levels were determined to assess bone health in elderly populations; however, the bioavailability of 25(OH)D is regulated by the albumin and vitamin D binding protein (DBP) levels and DBP variations. Whether bioavailable 25(OH)D level is a superior biomarker for vitamin D than total 25(OH)D level regarding the BMD and the bone metabolism were not yet fully understood. With a community based cross-sectional study of 967 postmenopausal women, we found that the variant rs7041, but not rs4588, of DBP was significantly associated with the blood DBP level, which was positively correlated with the total 25(OH)D level but negatively associated with bioavailable 25(OH)D levels. Both total and bioavailable 25(OH)D levels were significantly correlated with the BMD value in postmenopausal women; however, only the bioavailable 25(OH)D level was an independent determinant of the BMD values when adjusted for age, body mass index and bone turnover biomarkers (OST and β-CTX). The bioavailable and total 25(OH)D were negatively correlated with bone formation biomarkers (OST, PINP and ALP) and PTH levels, while they were positively correlated with osteoprotegerin (OPG) level; however, the bone resorption biomarker (β-CTX) was not correlated with the 25(OH)D levels. An increment of PTH level, along with reduced bioavailable 25(OH)D levels, was evident when the bioavailable 25(OH)D level was <5 ng/mL, which may be the optimal cutpoint for sufficient vitamin D in Chinese elderly women. The blood calcium, magnesium, ALP, TSH, FGF23, and phosphorus levels were not correlated with the total or the bioavailable 25(OH)D levels. These results suggested that high bioavailable 25(OH)D levels were correlated with reduced bone turnover processes and were a biomarker superior to total 25(OH)D for vitamin D in assessing the risks of bone-related diseases. The results indicate that the bioavailable 25(OH)D level should be determined in assessing the bone health.
Keywords	Total 25(OH)D ; Bioavailable 25(OH)D ; Bone mineral density ; Bone turnover biomarkers ; Postmenopausal women ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2017-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Profiles of expression pattern and tissue distribution of host defense peptides genes in different chicken (Gallus gallus) breeds related to body weight.

Zhengtian Li / Irfan Ahmed / Zhiqiang Xu / Shuai Sun / Tao Li / Dahai Gu / Yong Liu / Xia Zhang / Shixiong Yan / Wenyuan Hu / Ziqing Jiang / Xiaohua Duan / Qihua Li / Lixian Liu / Hua Rong / Kun Wang / Alsoufi Mohammed Abdulwahid / Tengfei Dou / Shanrong Wang /

Zhengchang Su / Changrong Ge / Marinus F W Te Pas / Junjing Jia / Ying Huang

PLoS ONE, Vol 15, Iss 12, p e

2020 Volume 0238675

Abstract: Host defense peptides (HDPs) are an important first line of defense with antimicrobial and immunomodulatory properties. Selection for increased body weight is hypothesized to be related to reduced immune response. We studied the relationships among body ... ...

Abstract	Host defense peptides (HDPs) are an important first line of defense with antimicrobial and immunomodulatory properties. Selection for increased body weight is hypothesized to be related to reduced immune response. We studied the relationships among body weight, age, and the HDP expression patterns in intestine and immune organs. We used chickens with marked differences of body sizes. The non-selected Daweishan mini chickens showed the highest indexes of immune organs and the lowest concentrations of the plasma immune parameters C3, C4, IgA, and IgY, while the commercial Avian broiler showed the opposite results. The Daweishan mini chickens showed the highest mRNA expressions of HDP genes in small intestine followed by the semi-selected Wuding chickens. Compared with local breeds, broiler chickens showed higher mRNA expression of HDP genes in spleen, thymus, and bursa. Body weight and HDP expression levels were negatively correlated in the intestine and positively in the immune organs. Our results indicated that the HDP immune regulatory roles in small intestine acted as first line of defense in innate immunity in local breeds, and as an adaptive immunity in broiler chickens. Selection was associated with different expression expressions of HDP genes in breed-, age-, and organ-specific manners.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Natural CCR2 Antagonist Relieves Tumor-associated Macrophage-mediated Immunosuppression to Produce a Therapeutic Effect for Liver Cancer

Wenbo Yao / Qian Ba / Xiaoguang Li / Huiliang Li / Shoude Zhang / Ya Yuan / Feng Wang / Xiaohua Duan / Jingquan Li / Weidong Zhang / Hui Wang

EBioMedicine, Vol 22, Iss C, Pp 58-

2017 Volume 67

Abstract: Hepatocellular carcinoma (HCC) is a common malignant tumor in the digestive tract with limited therapeutic choices. Although sorafenib, an orally administered multikinase inhibitor, has produced survival benefits for patients with advanced HCC, favorable ...

Abstract	Hepatocellular carcinoma (HCC) is a common malignant tumor in the digestive tract with limited therapeutic choices. Although sorafenib, an orally administered multikinase inhibitor, has produced survival benefits for patients with advanced HCC, favorable clinical outcomes are limited due to individual differences and resistance. The application of immunotherapy, a promising approach for HCC is urgently needed. Macrophage infiltration, mediated by the CCL2/CCR2 axis, is a potential immunotherapeutic target. Here, we report that a natural product from Abies georgei, named 747 and related in structure to kaempferol, exhibits sensitivity and selectivity as a CCR2 antagonist. The specificity of 747 on CCR2 was demonstrated via calcium flux, the binding domain of CCR2 was identified in an extracellular loop by chimera binding assay, and in vivo antagonistic activity of 747 was confirmed through a thioglycollate-induced peritonitis model. In animals, 747 elevated the number of CD8+ T cells in tumors via blocking tumor-infiltrating macrophage-mediated immunosuppression and inhibited orthotopic and subcutaneous tumor growth in a CD8+ T cell-dependent manner. Further, 747 enhanced the therapeutic efficacy of low-dose sorafenib without obvious toxicity, through elevating the numbers of intra-tumoral CD8+ T cells and increasing death of tumor cells. Thus, we have discovered a natural CCR2 antagonist and have provided a new perspective on development of this antagonist for treatment of HCC. In mouse models of HCC, 747 enhanced the tumor immunosuppressive microenvironment and potentiated the therapeutic effect of sorafenib, indicating that the combination of an immunomodulator with a chemotherapeutic drug could be a new approach for treating HCC.
Keywords	Preclinical models ; Combination therapy ; Experimental therapeutics ; Kaempferol ; Immunotherapy ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2017-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of Yajieshaba, a preparation of Dai indigenous medicine, on enhanced liver detoxification.

Xiaohua, Duan / Jin, Zheng / Hui, Wang / Haifeng, Cheng / Chao, Zhang / Zepu, Yu

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2011 Volume 35, Issue 2, Page(s) 197–205

Abstract: Objective: To explore the mechanistic effects of Yajieshaba (YJSB) on enhanced liver detoxification.: Methods: The effects of YJSB on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assayed in five acute chemical liver injury ...

Abstract	Objective: To explore the mechanistic effects of Yajieshaba (YJSB) on enhanced liver detoxification. Methods: The effects of YJSB on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assayed in five acute chemical liver injury models [carbon tetrachloride (CCl4), D-galactosamine (D-Glan), 4-acetamidophenol (AAP), thioacetamide (TAA) and 1-naphthyl isothiocyanate (ANIT)]. Sleep latency and sleep time of pentobarbital sodium were tested in control mice and CCl4 model miceafter oral YJSB administration. The effects of YJSB on drug metabolism enzymes of liver microsomes were tested in control rats and CCl4 model rats. The levels of cytochrome P450 (CYP450) and Cyt b5 in liver microsomes were assayed using the method by Omura and Sato, and activities of erythromycin N-demethylase (ERD) and aminopyrine N-demethyl (ADM) were evaluated by Nash colorimetry. Probe substrate-based high performance liquid chromatography (HPLC) methods were established for CYP3A4 and CYP1A2. Results: The level of serum ALT was reduced by YJSB at 3.51 g/kg in the five models as follows: CCl4 > D-Glan, AAP, ANIT > TAA. YJSB treatment did not reduce the level of serum AST. YJSB at 3.51 g/kg prolonged the sleep latency in control mice and shortened the sleep time of control mice and CCl4 model mice. For control rats, YJSB at 2.43 g/kg increased the levels of CYP450 and Cyt b5 and induced the activities of ERD and ADM; for liver injuries induced by CCl4 in rats, YJSB at 2.43 g/kg increased the levels of CYP450 and Cyt b5. These results suggest that YJSB at 2.43 g/kg induces CYP3A4 and CYP1A2. Conclusion: These results suggest that YJSB enhanced liver detoxification and the mechanisms may be partially related to CYP3A4 and CYP1A2 induction.
MeSH term(s)	Alanine Transaminase/genetics ; Alanine Transaminase/metabolism ; Animals ; Aspartate Aminotransferases/genetics ; Aspartate Aminotransferases/metabolism ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Drugs, Chinese Herbal/administration & dosage ; Humans ; Inactivation, Metabolic ; Liver/drug effects ; Liver/enzymology ; Liver Diseases/drug therapy ; Liver Diseases/enzymology ; Liver Diseases/genetics ; Male ; Medicine, Chinese Traditional ; Mice ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Drugs, Chinese Herbal ; Cytochrome P-450 Enzyme System (9035-51-2) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2011-05-24
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603186-9
ISSN	0254-6272 ; 0255-2922
ISSN (online)	0254-6272
ISSN	0255-2922
DOI	10.1016/s0254-6272(15)30028-5
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