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Article ; Online: Key Technologies of Lightweight Materials for New Energy Vehicles Based on Ant Colony Algorithm.

Mei, Lin / Xiaoke, Li

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 1617814

Abstract: From the perspective of the new energy vehicle, application of lightweight technology can effectively improve the endurance level of new energy vehicles and promote the steady improvement and rapid development of China's new energy vehicle industry. By ... ...

Abstract	From the perspective of the new energy vehicle, application of lightweight technology can effectively improve the endurance level of new energy vehicles and promote the steady improvement and rapid development of China's new energy vehicle industry. By keeping in view the importance of lightweight effect of new energy vehicles, in this paper, we have carried out an in-depth analysis of key contents such as new materials, battery weight, carbon fiber technology, and structural design technology in the process of lightweight development of new energy vehicles. Furthermore, this paper introduces the pseudorandom proportional rule to improve the selection method of the seed solution, makes appropriate random disturbance to the center of the pheromone distribution, and reforms the standard deviation of the pheromone distribution. Taking the lightweight of new energy vehicle doors as an example, this paper verifies the new energy vehicle lightweight algorithm based on ant colony algorithm. It is found that the improved continuous domain basic ant colony algorithm is superior to the other two algorithms and it has the capacity to solve optimization problems and has the advantages of high reliability.
MeSH term(s)	Algorithms ; Electric Power Supplies ; Pheromones ; Reproducibility of Results ; Technology
Chemical Substances	Pheromones
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/1617814
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Low-temperature and anhydrous preparation of NixFey-LDHs as an efficient electrocatalyst for water and urea electrolysis

Xiaoke Li / Xuejing Cui / Luhua Jiang

Catalysis Communications, Vol 162, Iss , Pp 106390- (2022)

2022

Abstract: Oxygen evolution reaction (OER) and urea oxidation reaction (UOR) limit the efficiency of electrolytic water and urea oxidation to hydrogen formation processes, respectively. Here, a facile low-temperature anhydrous method was used to synthesize NixFey- ... ...

Abstract	Oxygen evolution reaction (OER) and urea oxidation reaction (UOR) limit the efficiency of electrolytic water and urea oxidation to hydrogen formation processes, respectively. Here, a facile low-temperature anhydrous method was used to synthesize NixFey-LDHs catalysts with good eletrocatalytic activity for OER and UOR. With urea oxidation as an alternative anodic reaction, the anodic oxidation potential decreased significantly to 1.37 V@20 mA cm−2. The electrolyzer voltage decreased to only 1.41 V@10 mA cm−2 with the Ni9Fe1-LDHs anode. It was demonstrated that Fe induced the formation of Ni(III) on the surface and promoted the reversible Ni(II)/Ni(III) transition.
Keywords	Urea oxidation reaction ; Oxygen evolution reaction ; Layered double hydroxide ; Hydrogen production ; Chemistry ; QD1-999
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Machine Learning in Computational Surface Science and Catalysis

Xiaoke Li / Wolfgang Paier / Joachim Paier

Frontiers in Chemistry, Vol

Case Studies on Water and Metal–Oxide Interfaces

2020 Volume 8

Abstract: The goal of many computational physicists and chemists is the ability to bridge the gap between atomistic length scales of about a few multiples of an Ångström (Å), i. e., 10−10 m, and meso- or macroscopic length scales by virtue of simulations. The same ...

Abstract	The goal of many computational physicists and chemists is the ability to bridge the gap between atomistic length scales of about a few multiples of an Ångström (Å), i. e., 10−10 m, and meso- or macroscopic length scales by virtue of simulations. The same applies to timescales. Machine learning techniques appear to bring this goal into reach. This work applies the recently published on-the-fly machine-learned force field techniques using a variant of the Gaussian approximation potentials combined with Bayesian regression and molecular dynamics as efficiently implemented in the Vienna ab initio simulation package, VASP. The generation of these force fields follows active-learning schemes. We apply these force fields to simple oxides such as MgO and more complex reducible oxides such as iron oxide, examine their generalizability, and further increase complexity by studying water adsorption on these metal oxide surfaces. We successfully examined surface properties of pristine and reconstructed MgO and Fe3O4 surfaces. However, the accurate description of water–oxide interfaces by machine-learned force fields, especially for iron oxides, remains a field offering plenty of research opportunities.
Keywords	MgO ; magnetite ; density functional theory ; machine learning ; force fields ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Baduanjin exercise for patients with breast cancer

Xiaogang Gong / Guang Rong / Zhiyong Wang / Ayuan Zhang / Xiaoke Li / Lepeng Wang

Complementary Therapies in Medicine, Vol 71, Iss , Pp 102886- (2022)

A systematic review and meta-analysis

2022

Abstract: Objective: Baduanjin exercise is a traditional Chinese mind-body exercise routine characterized by slow, coordinated, and sequential movements. We have performed the first meta-analysis on the main effect of Baduanjin exercise in patients with breast ... ...

Abstract	Objective: Baduanjin exercise is a traditional Chinese mind-body exercise routine characterized by slow, coordinated, and sequential movements. We have performed the first meta-analysis on the main effect of Baduanjin exercise in patients with breast cancer. Methods: This study followed the 2020 PRISMA guideline. We searched for randomized controlled trials in PubMed, Embase, Cochrane Library, Web of Science, Clinical Trials.gov, Chinese National Knowledge Infrastructure, Wanfang Data Information Site, Chinese Biomedical Database, and Chinese Science and Technique Journals Database through 31 August 2022. Data were analyzed for the outcomes of quality of life, anxiety, and depression. Review Manager 5.4 software was used for data analysis. Results: Seven randomized controlled trials with a total of 537 patients with breast cancer were examined. Compared with the control therapies, Baduanjin exercise significantly improved the total quality of life score (SMD = 0.83; 95 % CI, 0.58–1.08; P < 0.00001) and in two associated domains: emotional well-being (SMD = 0.67; 95 % CI, 0.26–1.07; P = 0.001), functional well-being (SMD = 0.55; 95 % CI, 0.30–0.79; P < 0.00001) and breast cancer subscale (SMD = 0.39; 95 % CI, 0.02–0.77; P = 0.04). Meanwhile, it significantly reduced anxiety score (SMD = − 0.60; 95 % CI, − 1.15 to − 0.05; P = 0.03) and in depression score (SMD = − 0.70 95 % CI, − 0.97 to − 0.42; P < 0.00001). None adverse event was reported. Conclusion: The meta-analysis suggests that Baduanjin exercise is an effective and safe exercise for improving quality of life and alleviating depression and anxiety in patients with breast cancer. Significant methodological concerns of the included studies limit the interpretation of the results. For future trials of Baduanjin exercise on BC, we highlight the importance of adopting more rigorous study design in terms of assessor blinding, hypothesis/purpose blinding, allocation concealment, objective outcome selection and consistent reporting of adverse events.
Keywords	Baduanjin exercise ; Breast cancer ; Systematic review ; Other systems of medicine ; RZ201-999
Subject code	796
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: A Particle Swarm Optimization Algorithm with Sigmoid Increasing Inertia Weight for Structural Damage Identification

Zhen Chen / Yaru Wang / Tommy H. T. Chan / Xiaoke Li / Shunbo Zhao

Applied Sciences, Vol 12, Iss 3429, p

2022 Volume 3429

Abstract: In this study, a particle swarm optimization with a sigmoid increasing inertia weight (SIPSO) algorithm is proposed for structural damage identification based on the optimization of structural vibration response constraints. In view of the existing ... ...

Abstract	In this study, a particle swarm optimization with a sigmoid increasing inertia weight (SIPSO) algorithm is proposed for structural damage identification based on the optimization of structural vibration response constraints. In view of the existing problems for particle swarm optimization algorithms used for structural damage identification, such as low accuracy of damage identification and easy misjudgment of damage location, the sigmoid increasing inertia weight is introduced to improve the global and local search ability of the algorithm. Simulation results show that the parameters of the sigmoid increasing inertia weight have a significant effect on the performance of the SIPSO algorithm for structural damage identification. Compared with similar improved particle swarm optimization algorithms, the SIPSO algorithm has some advantages of fast convergence speed, high identification accuracy, and strong robustness ability in structural damage identification.
Keywords	structural damage identification ; particle swarm optimization ; inertia weight ; identification accuracy ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of pseudo-immune tolerance for chronic hepatitis B patients

Shuo Li / Zhiguo Li / Hongbo Du / Xiaobin Zao / Da’nan Gan / Xianzhao Yang / Xiaoke Li / Yufeng Xing / Yong’an Ye

Frontiers in Public Health, Vol

Development and validation of a non-invasive prediction model

2023 Volume 11

Abstract: Background and aimsPatients with chronic hepatitis B (CHB) in the immune tolerant (IT) phase were previously thought to have no or slight inflammation or fibrosis in the liver. In fact, some CHB patients with normal ALT levels still experience liver ... ...

Abstract	Background and aimsPatients with chronic hepatitis B (CHB) in the immune tolerant (IT) phase were previously thought to have no or slight inflammation or fibrosis in the liver. In fact, some CHB patients with normal ALT levels still experience liver fibrosis. This study aimed to develop and validate a non-invasive model for identifying pseudo-immune tolerance (pseudo-IT) of CHB by predicting significant liver fibrosis.MethodsThis multi-center study enrolled a total of 445 IT-phase patients who had undergone liver biopsy for the training cohort (n = 289) and validation cohort (n = 156) during different time periods. A risk model (IT-3) for predicting significant liver fibrosis (Ishak score ≥ 3) was developed using high-risk factors which were identified using multivariate stepwise logistic regression. Next, an online dynamic nomogram was created for the clinical usage. The receiver operating characteristic (ROC) curve, net reclassification improvement and integrated discrimination improvement were used to assess the discrimination of the IT-3 model. Calibration curves were used to evaluate the models’ calibration. The clinical practicability of the model was evaluated using decision curve analysis and clinical impact curves.Results8.8% (39 of 445) patients presented with significant liver fibrosis in this study. Aspartate aminotransferase (AST), hepatitis B e-antigen (HBeAg), and platelet (PLT) were included in the prediction model (IT-3). The IT-3 model showed good calibration and discrimination both in the training and validation cohorts (AUC = 0.888 and 0.833, respectively). The continuous NRI and IDI showed that the IT-3 model had better predictive accuracy than GPR, APRI, and FIB-4 (p < 0.001). Decision curve analysis and clinical impact curves were used to demonstrate the clinical usefulness. At a cut-off value of 106 points, the sensitivity and specificity were 91.7 and 70.2%, respectively.ConclusionThe IT-3 model proved an accurate non-invasive method in identifying pseudo-IT of CHB, which can help to ...
Keywords	chronic hepatitis B ; liver fibrosis ; immune tolerant ; liver biopsy ; nomogram ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between leptin and NAFLD

Ziwei Guo / Hongbo Du / Yi Guo / Qian Jin / Ruijia Liu / Zhangjun Yun / Jiaxin Zhang / Xiaoke Li / Yong’an Ye

European Journal of Medical Research, Vol 28, Iss 1, Pp 1-

a two-sample Mendelian randomization study

2023 Volume 11

Abstract: Abstract Background The etiology of nonalcoholic fatty liver disease (NAFLD) involves a complex interaction of genetic and environmental factors. Previous observational studies have revealed that higher leptin levels are related to a lower risk of ... ...

Abstract	Abstract Background The etiology of nonalcoholic fatty liver disease (NAFLD) involves a complex interaction of genetic and environmental factors. Previous observational studies have revealed that higher leptin levels are related to a lower risk of developing NAFLD, but the causative association remains unknown. We intended to study the causal effect between leptin and NAFLD using the Mendelian randomization (MR) study. Methods We performed a two-sample Mendelian randomization (TSMR) analysis using summary GWAS data from leptin (up to 50,321 individuals) and NAFLD (8,434 cases and 770,180 controls) in a European population. Instrumental variables (IVs) that satisfied the three core assumptions of Mendelian randomization were selected. The TSMR analysis was conducted using the inverse variance weighted (IVW) method, MR-Egger regression method, and weighted median (WM) method. To ensure the accuracy and stability of the study results, heterogeneity tests, multiple validity tests, and sensitivity analyses were conducted. Results The findings of the TSMR correlation analysis between NAFLD and leptin were as follows: IVW method (odds ratio (OR) 0.6729; 95% confidence interval (95% CI) 0.4907–0.9235; P = 0.0142), WM method (OR 0.6549; 95% CI 0.4373–0.9806; P = 0.0399), and MR-Egger regression method (P = 0.6920). Additionally, the findings of the TSMR correlation analysis between NAFLD and circulating leptin levels adjusted for body mass index (BMI) were as follows: IVW method (OR 0.5876; 95% CI 0.3781–0.9134; P = 0.0181), WM method (OR 0.6074; 95% CI 0.4231–0.8721; P = 0.0069), and MR-Egger regression method (P = 0.8870). It has also been shown that higher levels of leptin are causally linked to a lower risk of developing NAFLD, suggesting that leptin may serve as a protective factor for NAFLD. Conclusions Using TSMR analysis and the GWAS database, we investigated the genetic relationship between elevated leptin levels and lowered risk of NAFLD in this study. However, further research is required to understand the ...
Keywords	Nonalcoholic fatty liver disease ; Leptin ; Causal effect ; Two-sample Mendelian randomization ; Medicine ; R
Subject code	630
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Stability Analysis and Clinic Phenomenon Simulation of a Fractional-Order HBV Infection Model

Yongmei Su / Sinuo Liu / Shurui Song / Xiaoke Li / Yongan Ye

Complexity, Vol

2020 Volume 2020

Abstract: In this paper, a fractional-order HBV model was set up based on standard mass action incidences and quasisteady assumption. The basic reproductive number R0 and the cytotoxic T lymphocytes’ immune-response reproductive number R1 were derived. There were ... ...

Abstract	In this paper, a fractional-order HBV model was set up based on standard mass action incidences and quasisteady assumption. The basic reproductive number R0 and the cytotoxic T lymphocytes’ immune-response reproductive number R1 were derived. There were three equilibrium points of the model, and stable analysis of each equilibrium point was given with corresponding hypothesis about R0 or R1. Some numerical simulations were also given based on HBeAg clinical data, and the simulation showed that there existed positive logarithmic correlation between the number of infected cells and HBeAg, which was consistent with the clinical facts. The simulation also showed that the clinical individual differences should be reflected by the fractional-order model.
Keywords	Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Systematic review

Yuhao Yao / Jiaxin Zhang / Xiaoke Li / Xiaobin Zao / Xu Cao / Guang Chen / Yong'an Ye

Frontiers in Public Health, Vol

Clinical outcomes of discontinuation of oral antivirals in hepatitis B-related liver cirrhosis

2022 Volume 10

Abstract: BackgroundDiscontinuation of Nucleos(t)ide analogs (NAs) remains one of the most controversial topics in the management of hepatitis B-related liver cirrhosis. However, clinical outcomes after NAs discontinuation have not been studied.AimThe aim of this ... ...

Abstract	BackgroundDiscontinuation of Nucleos(t)ide analogs (NAs) remains one of the most controversial topics in the management of hepatitis B-related liver cirrhosis. However, clinical outcomes after NAs discontinuation have not been studied.AimThe aim of this systematic review is to evaluate existing data on clinical outcomes of NAs withdrawal in chronic hepatitis B (CHB) patients with cirrhosis.MethodsA literature search (until May 2022) was performed in order to identify all published studies including hepatitis B-related cirrhotic patients who discontinued NAs in virological remission with off-therapy follow-up >12 months.ResultsNineteen studies with 1,287 hepatitis B-related cirrhotic patients were included. Most cirrhotic patients were compensated and achieved complete virological suppression when they stopped the antiviral therapy. The pooled proportions of virological relapse and clinical relapse after NAs discontinuation in cirrhotic patients were 55.23 (95% CI: 40.33–69.67) and 43.56% (95% CI: 26.13–61.85), respectively. HBsAg loss was observed in 56 of 500 (pooled proportion = 13.68%, 95% CI: 5.82–24.18) cirrhotic patients. And the pooled proportions of HCC development, hepatic decompensation and overall mortality were 8.76 (95% CI: 2.25–18.95), 3.63 (95% CI: 1.31–7.03), and 0.85% (95% CI: 0.35–1.57), respectively, after NAs discontinuation in cirrhotic patients.ConclusionIn hepatitis B-related compensated cirrhosis, who have achieved complete virological suppression, discontinuation of oral antivirals still carries a high relapse rate, but the incidence of adverse events is generally low and controlled during follow-up of at least 12 months. Of attention is that discontinuation of NAs can achieve a high rate of HBsAg seroclearance. This study may be helpful in the management of NAs in cirrhotic patients.Systematic review registrationhttp://www.crd.york.ac.uk/PROSPERO, identifier: CRD42020170103.
Keywords	chronic hepatitis B ; discontinuation ; nucleos(t)ide analog ; cirrhosis ; review—systematic ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units

Zhen Yang / Bin Wang / Wei Liu / Xiaoke Li / Kaini Liang / Zejun Fan / Jiao Jiao Li / Yudi Niu / Zihao He / Hui Li / Du Wang / Jianjing Lin / Yanan Du / Jianhao Lin / Dan Xing

Bioactive Materials, Vol 27, Iss , Pp 200-

2023 Volume 215

Abstract: The regeneration of hierarchical osteochondral units is challenging due to difficulties in inducing spatial, directional and controllable differentiation of mesenchymal stem cells (MSCs) into cartilage and bone compartments. Emerging organoid technology ... ...

Abstract	The regeneration of hierarchical osteochondral units is challenging due to difficulties in inducing spatial, directional and controllable differentiation of mesenchymal stem cells (MSCs) into cartilage and bone compartments. Emerging organoid technology offers new opportunities for osteochondral regeneration. In this study, we developed gelatin-based microcryogels customized using hyaluronic acid (HA) and hydroxyapatite (HYP), respectively for inducing cartilage and bone regeneration (denoted as CH-Microcryogels and OS-Microcryogels) through in vivo self-assembly into osteochondral organoids. The customized microcryogels showed good cytocompatibility and induced chondrogenic and osteogenic differentiation of MSCs, while also demonstrating the ability to self-assemble into osteochondral organoids with no delamination in the biphasic cartilage-bone structure. Analysis by mRNA-seq showed that CH-Microcryogels promoted chondrogenic differentiation and inhibited inflammation, while OS-Microcryogels facilitated osteogenic differentiation and suppressed the immune response, by regulating specific signaling pathways. Finally, the in vivo engraftment of pre-differentiated customized microcryogels into canine osteochondral defects resulted in the spontaneous assembly of an osteochondral unit, inducing simultaneous regeneration of both articular cartilage and subchondral bone. In conclusion, this novel approach for generating self-assembling osteochondral organoids utilizing tailor-made microcryogels presents a highly promising avenue for advancing the field of tissue engineering.
Keywords	Mesenchymal stem cells ; Self-assembly ; Microcryogels ; Osteochondral regeneration ; Organoid ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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