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Article ; Online: Socioeconomic status and quality of life among older adults with hypertension in rural Shandong, China

Yingjie Fu / Shuo Zhang / Xiaolei Guo / Zilong Lu / Xiaojie Sun

Frontiers in Public Health, Vol

a mediating effect of social capital

2023 Volume 11

Abstract: BackgroundImproving the quality of life (QoL) of older adults is becoming an important global issue. However, very few studies have been focused on the relationship between socioeconomic status (SES) and QoL in older adults with hypertension. The purpose ...

Abstract	BackgroundImproving the quality of life (QoL) of older adults is becoming an important global issue. However, very few studies have been focused on the relationship between socioeconomic status (SES) and QoL in older adults with hypertension. The purpose of this study is to investigate (a) the status of QoL and (b) the mediating effect of social capital in the relationship between SES and QoL, among rural older adults with hypertension in China.MethodsUsing multistage stratified random sampling, a face-to-face questionnaire survey was conducted among rural older adults with hypertension in Shandong province of China from June to July 2021. Three typical measures representing SES were used, namely, annual household income, educational level, and employment status. Individual social capital and QoL were assessed by the Resource Generator-China Scale (RG—China) and a 34-item simplified Patient Report Outcome (PRO)-specific scale for older adults with hypertension, respectively. A total of 950 rural older adults with hypertension were included in the analysis. The mediation model based on bootstrap analyses was employed to explore the relationship between SES and QoL and the mediating role of social capital in the SES-QoL nexus.ResultsThe sampled rural older adults with hypertension had an upper-middle level of QoL, and the average score was 132.57 ± 19.40. SES was positively correlated with both QoL and individual social capital; individual social capital was significantly positively correlated with QoL. Controlling for sociodemographic variables, SES was still significantly associated with individual social capital (β = 0.140, P < 0.001), and the higher the individual social capital, the better QoL (β = 0.153, P < 0.001). Individual social capital played a partially mediating role in the association between SES and QoL (indirect effect = 0.021, 95% CI: 0.010–0.038), which accounted for 9.38% of the total effect.ConclusionThis study provides evidence that the effect of SES on QoL was partially mediated by ...
Keywords	socioeconomic status ; quality of life ; social capital ; older adults with hypertension ; rural ; China ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Evaluation of Postharvest Senescence of Broccoli via Hyperspectral Imaging

Xiaolei Guo / Yogesh K. Ahlawat / Tie Liu / Alina Zare

Plant phenomics. 2022, v. 2022

2022

Abstract: Fresh fruit and vegetables are invaluable for human health; however, their quality often deteriorates before reaching consumers due to ongoing biochemical processes and compositional changes. We currently lack any objective indices which indicate the ... ...

Abstract	Fresh fruit and vegetables are invaluable for human health; however, their quality often deteriorates before reaching consumers due to ongoing biochemical processes and compositional changes. We currently lack any objective indices which indicate the freshness of fruit or vegetables resulting in limited capacity to improve product quality eventually leading to food loss and waste. In this conducted study, we hypothesized that certain proteins and compounds, such as glucosinolates, could be used as one potential indicator to monitor the freshness of broccoli following harvest. To support our study, glucosinolate contents in broccoli based on HPLC measurement and transcript expression of glucosinolate biosynthetic genes in response to postharvest stresses were evaluated. We found that the glucosinolate biosynthetic pathway coincided with the progression of senescence in postharvest broccoli during storage. Additionally, we applied machine learning-based hyperspectral image (HSI) analysis, unmixing, and subpixel target detection approaches to evaluate glucosinolate level to detect postharvest senescence in broccoli. This study provides an accessible approach to precisely estimate freshness in broccoli through machine learning-based hyperspectral image analysis. Such a tool would further allow significant advancement in postharvest logistics and bolster the availability of high-quality, nutritious fresh produce.
Keywords	biochemical pathways ; biosynthesis ; broccoli ; food loss ; freshness ; fruits ; glucosinolates ; human health ; hyperspectral imagery ; image analysis ; phenomics ; raw fruit ; wastes
Language	English
Publishing place	American Association for the Advancement of Science (AAAS)
Document type	Article
ISSN	2643-6515
DOI	10.34133/2022/9761095
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Cancer survival analysis and spatial distribution during 2014–2016 in Shandong Province, China

Fan Jiang / Zhentao Fu / Zilong Lu / Jie Chu / Aiqiang Xu / Xiaolei Guo / Jixiang Ma

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 10

Abstract: Abstract We aimed to analyse cancer survival and its spatial distribution in Shandong Province. A total of 609,861 cancer cases from 2014 to 2016 were included in the analysis. Survival analysis was performed using strs in Stata. Spatial analysis was ... ...

Abstract	Abstract We aimed to analyse cancer survival and its spatial distribution in Shandong Province. A total of 609,861 cancer cases from 2014 to 2016 were included in the analysis. Survival analysis was performed using strs in Stata. Spatial analysis was performed with GeoDa to determine measures of global and local spatial autocorrelation. Hotspot analysis was used to identify spatial clusters of high values (hotspots) and low values (cold spots) through ArcGIS. The 5-year relative survival rates were 37.85% for all cancers combined, 29.29% for males and 48.88% for females. After age standardisation, the survival rates were 34.47% for all cancers, 28.43% for males and 41.56% for females. Cancers with higher survival rates included thyroid (78.80%), breast (69.52%), uterus (64.51%) and bladder (62.54%) cancers. However, cancers with lower survival rates included pancreatic (11.34%), liver (13.19%), lung (18.39%), bone (19.71%), gallbladder (19.78%), oesophagus (24.52%), and stomach (28.85%) cancers and leukaemia (26.30%). Cancer survival rates in urban areas (37.53%) were higher than those in rural areas (32.83%). From the geographic distribution of cancer survival, we observed that the survival rate displayed a downward trend from east to west and from north to south. The hotspot analysis revealed that some counties of Qingdao, Jinan, Zibo, Dongying and Yantai cities were hotspots, whereas almost all counties of Linyi city and some counties of Weifang, Heze, Rizhao, and Dezhou cities were cold spots. In conclusion, the cancer survival rate in Shandong is still lower than that in China overall. The early diagnosis and treatment of lung and digestive tract cancers need to be further strengthened. Nevertheless, our results reflect a critical first step in obtaining and reporting accurate and reliable estimates of survival in Shandong.
Keywords	Medicine ; R ; Science ; Q
Subject code	910
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficient Synthesis of cis -4-Propylcyclohexanol Using a Mutant Alcohol Dehydrogenase Coupled with Glucose Dehydrogenase

Licheng Wu / Zhiwei Wang / Xiaolei Guo / Pengfu Liu / Ziduo Liu / Gaobing Wu

Catalysts, Vol 12, Iss 406, p

2022 Volume 406

Abstract: cis -4-Propylcyclohexanol is an important intermediate for synthesizing trans -2-(4-propylcyclohexyl)-1,3-propanediol, which is widely used in the manufacture of liquid crystal displays. In this study, cis -4-propylcyclohexanol was prepared using a ... ...

Abstract	cis -4-Propylcyclohexanol is an important intermediate for synthesizing trans -2-(4-propylcyclohexyl)-1,3-propanediol, which is widely used in the manufacture of liquid crystal displays. In this study, cis -4-propylcyclohexanol was prepared using a mutant alcohol dehydrogenase from Lactobacillus kefir (LK-TADH, A94T/F147L/L199H/A202L) coupled with glucose dehydrogenase. Using the optimal catalytic conditions, 125 g/L (250 g) of 4-propylcyclohexanone was completely transformed after 5 h, and 225.8 g of cis -4-propylcyclohexanol ( cis / trans ratio of 99.5:0.5) was obtained through extraction and rotary evaporation at a yield of 90.32%. This study reports a potential method for the green production of cis -4-propylcyclohexanol as the key intermediate of trans -2-(4-propylcyclohexyl)-1,3-propanediol at an industrial level.
Keywords	alcohol dehydrogenase ; liquid crystal display ; 4-propylcyclohexanone ; cis -4-propylcyclohexanol ; biotransformation ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Progress and prospect of technical and regulatory challenges on tissue-engineered cartilage as therapeutic combination product

Xiaolei Guo / Yuan Ma / Yue Min / Jiayi Sun / Xinli Shi / Guobiao Gao / Lei Sun / Jiadao Wang

Bioactive Materials, Vol 20, Iss , Pp 501-

2023 Volume 518

Abstract: Hyaline cartilage plays a critical role in maintaining joint function and pain. However, the lack of blood supply, nerves, and lymphatic vessels greatly limited the self-repair and regeneration of damaged cartilage, giving rise to various tricky issues ... ...

Abstract	Hyaline cartilage plays a critical role in maintaining joint function and pain. However, the lack of blood supply, nerves, and lymphatic vessels greatly limited the self-repair and regeneration of damaged cartilage, giving rise to various tricky issues in medicine. In the past 30 years, numerous treatment techniques and commercial products have been developed and practiced in the clinic for promoting defected cartilage repair and regeneration. Here, the current therapies and their relevant advantages and disadvantages will be summarized, particularly the tissue engineering strategies. Furthermore, the fabrication of tissue-engineered cartilage under research or in the clinic was discussed based on the traid of tissue engineering, that is the materials, seed cells, and bioactive factors. Finally, the commercialized cartilage repair products were listed and the regulatory issues and challenges of tissue-engineered cartilage repair products and clinical application would be reviewed.
Keywords	Tissue engineering cartilage ; Regulatory challenge ; Stem cell ; Scaffolds ; Bioactive factor ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Estimating future PM2.5-attributed acute myocardial infarction incident cases under climate mitigation and population change scenarios in Shandong Province, China

Xiaoyun Ma / Bingyin Zhang / Haiping Duan / Han Wu / Jing Dong / Xiaolei Guo / Zilong Lu / Jixiang Ma / Bo Xi

Ecotoxicology and Environmental Safety, Vol 256, Iss , Pp 114893- (2023)

2023

Abstract: Background: The effects of fine particulate matter (PM2.5) on acute myocardial infarction (AMI) have been widely recognized. However, no studies have comprehensively evaluated future PM2.5-attributed AMI burdens under different climate mitigation and ... ...

Abstract	Background: The effects of fine particulate matter (PM2.5) on acute myocardial infarction (AMI) have been widely recognized. However, no studies have comprehensively evaluated future PM2.5-attributed AMI burdens under different climate mitigation and population change scenarios. We aimed to quantify the PM2.5-AMI association and estimate the future change in PM2.5-attributed AMI incident cases under six integrated scenarios in 2030 and 2060 in Shandong Province, China. Methods: Daily AMI incident cases and air pollutant data were collected from 136 districts/counties in Shandong Province from 2017 − 2019. A two-stage analysis with a distributed lag nonlinear model was conducted to quantify the baseline PM2.5-AMI association. The future change in PM2.5-attributed AMI incident cases was estimated by combining the fitted PM2.5-AMI association with the projected daily PM2.5 concentrations under six integrated scenarios. We further analyzed the factors driving changes in PM2.5-related AMI incidence using a decomposition method. Results: Each 10 μg/m3 increase in PM2.5 exposure at lag05 was related to an excess risk of 1.3 % (95 % confidence intervals: 0.9 %, 1.7 %) for AMI incidence from 2017 − 2019 in Shandong Province. The estimated total PM2.5-attributed AMI incident cases would increase by 10.9−125.9 % and 6.4–244.6 % under Scenarios 1 − 3 in 2030 and 2060, whereas they would decrease by 0.9–5.2 % and 33.0–46.2 % under Scenarios 5 – 6 in 2030 and 2060, respectively. Furthermore, the percentage increases in PM2.5-attributed female cases (2030: −0.3 % to 135.1 %; 2060: −33.2 % to 321.5 %) and aging cases (2030: 15.2–171.8 %; 2060: −21.5 % to 394.2 %) would wholly exceed those in male cases (2030: −1.8 % to 133.2 %; 2060: −41.1 % to 264.3 %) and non-aging cases (2030: −41.0 % to 45.7 %; 2060: −89.5 % to −17.0 %) under six scenarios in 2030 and 2060. Population aging is the main driver of increased PM2.5-related AMI incidence under Scenarios 1 − 3 in 2030 and 2060, while improved air quality can offset these negative ...
Keywords	Fine particulate matter ; Short-term exposure ; Acute myocardial infarction ; Incidence ; Climate mitigation ; Population change ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The relationship between oral health status, loneliness, and sleep quality among the migrant elderly following children in Weifang, Shandong Province, China

Xiaoxu Jiang / Guangwen Liu / Jing Xu / Hexian Li / Jieru Wang / Mingli Pang / Shixue Li / Lingzhong Xu / Xiaolei Guo / Fanlei Kong

Frontiers in Public Health, Vol

A comparative analysis on different migration types

2023 Volume 10

Abstract: BackgroundThe migrant elderly following children (MEFC) are a vulnerable group that emerged during fast urbanization in China. The MEFC faced physical and psychological discomfort upon their arrival in the inflow city, particularly those who came from ... ...

Abstract	BackgroundThe migrant elderly following children (MEFC) are a vulnerable group that emerged during fast urbanization in China. The MEFC faced physical and psychological discomfort upon their arrival in the inflow city, particularly those who came from rural areas.ObjectiveThis study aimed to explore the relationship between oral health status, loneliness, and sleep quality among the MEFC in China and to clarify the disparities in the above mentioned relationship by migration type.MethodsIn 2021, a cross-sectional survey was conducted in Weifang, Shandong Province, using multistage cluster random sampling to collect data from the MEFC aged 60 years and over. In total, 613 respondents [525 rural-to-urban (RTU) and 88 urban-to-urban (UTU)] were included in the final database. The chi-square test, t-test, and structural equation modeling (SEM) were used to investigate the relationship between oral health status, loneliness, and sleep quality among the RTU and UTU MEFC.ResultsTotal scores [mean ± standard deviation (SD)] for oral health status, loneliness, and sleep quality were 54.95 ± 6.47, 8.58 ± 3.03, and 4.47 ± 3.60, respectively. SEM revealed that, among the RTU and UTU MEFC, oral health status was positively and significantly related to sleep quality; however, the correlation was slightly stronger in the UTU MEFC. In both groups, there was a significant negative correlation between oral health status and loneliness, which was stronger in the UTU MEFC. In the RTU MEFC, a significant negative correlation between loneliness and sleep quality was observed, and in the UTU MEFC, no significant association between loneliness and sleep quality was observed.ConclusionThe sleep quality among the MEFC in this study was higher compared to previous studies. Oral health status was negatively correlated with loneliness and positively associated with sleep quality, whereas loneliness was negatively correlated with sleep quality. These three associations differed significantly between the UTU and RTU MEFC. The government, ...
Keywords	oral health status ; loneliness ; sleep quality ; migrant elderly following children ; migration type disparity ; structural equation modeling ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between availability of glucose-lowering drugs in primary health institutions and diabetes patients’ medication adherence

Jiansen Yao / Haipeng Wang / Di Shao / Jia Yin / Xiaolei Guo / Xiao Yin / Qiang Sun

Global Health Journal, Vol 5, Iss 2, Pp 83-

a cross-sectional study in Shandong Province, China

2021 Volume 89

Abstract: Background: Primary health care system is a critical component of diabetes care and management. This article aimed to analyze the availability of glucose-lowering drugs in primary health institutions (PHIs) in China, and to explore the relationship ... ...

Abstract	Background: Primary health care system is a critical component of diabetes care and management. This article aimed to analyze the availability of glucose-lowering drugs in primary health institutions (PHIs) in China, and to explore the relationship between availability of glucose-lowering drugs and medication adherence among type 2 diabetes mellitus (T2DM) patients. Methods: This cross-sectional study conducted in Shandong Province, eastern China (hereafter referred to as Shandong), between August and December 2017. In total, 2 520 community-managed T2DM patients were selected from 68 PHIs in Shandong, including 62 village-level and 6 township-level PHIs. The self-developed questionnaire was used to survey the availability of glucose-lowering drugs in PHIs. Patients’ medication adherence was assessed by four self-reported questions, and was classified as either adherent or non-adherent. Descriptive statistics was used to analyze the availability of glucose-lowering drugs in PHIs and the medication adherence among the T2DM patients. Multilevel logistic regression models were used to explore the relationship between the availability of glucose-lowering drugs in PHIs and patients’ medication adherence. Results: A total of 1 866 T2DM patients prescribed with at least one glucose-lowering drug were included in analysis. Among them, 58.5% patients followed their antidiabetic treatment well. In village-level PHIs, the patient's adherence rate was lower than in township-level PHIs (55.9% vs. 61.1%, P < 0.05). Among the 68 PHIs, average (2.53±0.97) glucose-lowering products (generic names) were available, which in village-level PHIs were less than in township-level PHIs (2.47 vs. 3.17, P < 0.05). And the number of available glucose-lowering products in PHIs was associated with the adherence of T2DM patients. Conclusion: Poor availability of glucose-lowering products was found in PHIs in Shandong. The availability of glucose-lowering products in PHIs was positively associated with patients’ medication adherence, and ...
Keywords	Diabetes mellitus ; Primary health institutions ; Medication adherence ; Shandong ; China ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rational Design of Better Hydrogen Evolution Electrocatalysts for Water Splitting

Fan Liu / Chengxiang Shi / Xiaolei Guo / Zexing He / Lun Pan / Zhen‐Feng Huang / Xiangwen Zhang / Ji‐Jun Zou

Advanced Science, Vol 9, Iss 18, Pp n/a-n/a (2022)

A Review

2022

Abstract: Abstract The excessive dependence on fossil fuels contributes to the majority of CO2 emissions, influencing on the climate change. One promising alternative to fossil fuels is green hydrogen, which can be produced through water electrolysis from ... ...

Abstract	Abstract The excessive dependence on fossil fuels contributes to the majority of CO2 emissions, influencing on the climate change. One promising alternative to fossil fuels is green hydrogen, which can be produced through water electrolysis from renewable electricity. However, the variety and complexity of hydrogen evolution electrocatalysts currently studied increases the difficulty in the integration of catalytic theory, catalyst design and preparation, and characterization methods. Herein, this review first highlights design principles for hydrogen evolution reaction (HER) electrocatalysts, presenting the thermodynamics, kinetics, and related electronic and structural descriptors for HER. Second, the reasonable design, preparation, mechanistic understanding, and performance enhancement of electrocatalysts are deeply discussed based on intrinsic and extrinsic effects. Third, recent advancements in the electrocatalytic water splitting technology are further discussed briefly. Finally, the challenges and perspectives of the development of highly efficient hydrogen evolution electrocatalysts for water splitting are proposed.
Keywords	catalyst design ; extrinsic effects ; hydrogen evolution reaction ; intrinsic effects ; water‐splitting technology ; Science ; Q
Subject code	660
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of the COVID-19 Lockdown on Air Pollutant Levels and Associated Reductions in Ischemic Stroke Incidence in Shandong Province, China

Han Wu / Zilong Lu / Jing Wei / Bingyin Zhang / Xue Liu / Min Zhao / Wenhui Liu / Xiaolei Guo / Bo Xi

Frontiers in Public Health, Vol

2022 Volume 10

Abstract: BackgroundLocal governments in China took restrictive measures after the outbreak of COVID-19 to control its spread, which unintentionally resulted in reduced anthropogenic emission sources of air pollutants. In this study, we intended to examine the ... ...

Abstract	BackgroundLocal governments in China took restrictive measures after the outbreak of COVID-19 to control its spread, which unintentionally resulted in reduced anthropogenic emission sources of air pollutants. In this study, we intended to examine the effects of the COVID-19 lockdown policy on the concentration levels of particulate matter with aerodynamic diameters of ≤1 μm (PM1), ≤2.5 μm (PM2.5), and ≤10 μm (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and carbon monoxide (CO) and the potential subsequent reductions in the incidence of ischemic and hemorrhagic stroke in Shandong Province, China.MethodsA difference-in-difference model combining the daily incidence data for ischemic and hemorrhagic stroke and air pollutant data in 126 counties was used to estimate the effect of the COVID-19 lockdown on the air pollutant levels and ischemic and hemorrhagic stroke incident counts. The avoided ischemic stroke cases related to the changes in air pollutant exposure levels were further estimated using concentration-response functions from previous studies.ResultsThe PM1, PM2.5, PM10, NO2, and CO levels significantly decreased by −30.2, −20.9, −13.5, −46.3, and −13.1%, respectively. The O3 level increased by 11.5% during the lockdown compared with that in the counterfactual lockdown phase of the past 2 years. There was a significant reduction in population-weighted ischemic stroke cases (−15,315, 95% confidence interval [CI]: −27,689, −2,942), representing a reduction of 27.6% (95% CI: −49.9%, −5.3%). The change in the number of hemorrhagic stroke cases was not statistically significant. The total avoided PM1-, PM2.5-, PM10-, NO2-, and CO–related ischemic stroke cases were 739 (95% CI: 641, 833), 509 (95% CI: 440, 575), 355 (95% CI: 304, 405), 1,132 (95% CI: 1,024, 1,240), and 289 (95% CI: 236, 340), respectively.ConclusionThe COVID-19 lockdown indirectly reduced the concentration levels of PM1, PM2.5, PM10, NO2, and CO and subsequently reduced the associated ischemic stroke incidence. The health ...
Keywords	lockdown ; air pollution ; ischemic stroke ; COVID-19 ; incidence ; Public aspects of medicine ; RA1-1270
Subject code	333
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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