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Article ; Online: Matrix Metalloproteinase-10 in Kidney Injury Repair and Disease

Xiaoli Sun / Youhua Liu

International Journal of Molecular Sciences, Vol 23, Iss 2131, p

2022 Volume 2131

Abstract: Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase with the ability to degrade a broad spectrum of extracellular matrices and other protein substrates. The expression of MMP-10 is induced in acute kidney injury (AKI) and chronic ... ...

Abstract	Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase with the ability to degrade a broad spectrum of extracellular matrices and other protein substrates. The expression of MMP-10 is induced in acute kidney injury (AKI) and chronic kidney disease (CKD), as well as in renal cell carcinoma (RCC). During the different stages of kidney injury, MMP-10 may exert distinct functions by cleaving various bioactive substrates including heparin-binding epidermal growth factor (HB-EGF), zonula occludens-1 (ZO-1), and pro-MMP-1, -7, -8, -9, -10, -13. Functionally, MMP-10 is reno-protective in AKI by promoting HB-EGF-mediated tubular repair and regeneration, whereas it aggravates podocyte dysfunction and proteinuria by disrupting glomerular filtration integrity via degrading ZO-1. MMP-10 is also involved in cancerous invasion and emerges as a promising therapeutic target in patients with RCC. As a secreted protein, MMP-10 could be detected in the circulation and presents an inverse correlation with renal function. Due to the structural similarities between MMP-10 and the other MMPs, development of specific inhibitors targeting MMP-10 is challenging. In this review, we summarize our current understanding of the role of MMP-10 in kidney diseases and discuss the potential mechanisms of its actions.
Keywords	MMP-10 ; acute kidney injury ; chronic kidney disease ; renal fibrosis ; proteinuria ; HB-EGF ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Communication Anti-Jamming Scheme Assisted by RIS with Angular Response

Jinpeng Wang / Wenyu Jiang / Kaizhi Huang / Xiaoli Sun

Entropy, Vol 25, Iss 12, p

2023 Volume 1638

Abstract: By optimizing the reconfigurable intelligent surface (RIS) reflection coefficients, the channel capacity of legitimate users can be increased, thereby enhancing the anti-jamming performance of communication systems. However, existing studies on RIS- ... ...

Abstract	By optimizing the reconfigurable intelligent surface (RIS) reflection coefficients, the channel capacity of legitimate users can be increased, thereby enhancing the anti-jamming performance of communication systems. However, existing studies on RIS-assisted anti-jamming assume that there is no coupling between the RIS reflection coefficients and the incident angle of electromagnetic (EM) waves, which is quite unreasonable. Therefore, we consider the effect of the incident angle of EM waves on the reflection coefficients of the RIS and propose a communication anti-jamming scheme assisted by an RIS with angular response. Specifically, a problem is formulated to optimize the RIS reflection coefficients so that the legitimate signal is amplified, but the jamming signal is attenuated, thus enhancing the legitimate channel capacity. However, the coupling of the EM incident angle and the RIS reflection coefficients causes the problem to be non-convex. To tackle this problem, we equivalently transform the RIS reflection coefficients optimization problem into a quadratically constrained quadratic programming (QCQP) problem using the complex Taylor expansion and the multidimensional complex quadratic transform (MCQT) and solve it utilizing the alternating direction method of the multipliers (ADMM) algorithm. The simulation results reveal that, compared to other schemes supported by RIS without angular response, the proposed scheme is able to achieve a significant improvement in the anti-jamming performance.
Keywords	channel capacity ; reconfigurable intelligent surface ; anti-jamming ; angular response ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
Subject code	535
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cholesterol Metabolism

Fangli Zhou / Xiaoli Sun

Frontiers in Cell and Developmental Biology, Vol

A Double-Edged Sword in Hepatocellular Carcinoma

2021 Volume 9

Abstract: Hepatocellular carcinoma (HCC) represents a leading cause of cancer-related deaths globally. The rising incidence of metabolic syndrome and its hepatic manifestation, nonalcoholic fatty liver disease (NAFLD), have emerged as the fastest-growing cause of ... ...

Abstract	Hepatocellular carcinoma (HCC) represents a leading cause of cancer-related deaths globally. The rising incidence of metabolic syndrome and its hepatic manifestation, nonalcoholic fatty liver disease (NAFLD), have emerged as the fastest-growing cause of HCC in recent years. Cholesterol, a major lipid component of the cell membrane and lipoprotein particles, is primarily produced and metabolized by the liver. Numerous studies have revealed an increased cholesterol biosynthesis and uptake, reduced cholesterol exportation and excretion in HCC, which all contribute to lipotoxicity, inflammation, and fibrosis, known HCC risk factors. In contrast, some clinical studies have shown that higher cholesterol is associated with a reduced risk of HCC. These contradictory observations imply that the relationship between cholesterol and HCC is far more complex than initially anticipated. Understanding the role of cholesterol and deciphering the underlying molecular events in HCC development is highly relevant to developing new therapies. Here, we discuss the current understanding of cholesterol metabolism in the pathogenesis of NAFLD-associated HCC, and the underlying mechanisms, including the roles of cholesterol in the disruption of normal function of specific cell types and signaling transduction. We also review the clinical progression in evaluating the association of cholesterol with HCC. The therapeutic effects of lowering cholesterol will also be summarized. We also interpret reasons for the contradictory observations from different preclinical and human studies of the roles of cholesterol in HCC, aiming to provide a critical assessment of the potential of cholesterol as a therapeutic target.
Keywords	hepatocellular carcinoma ; nonalcoholic fatty liver disease ; nonalcoholic steatohepatitis ; cholesterol metabolism ; tumor microenvironment ; lipotoxicity ; Biology (General) ; QH301-705.5
Subject code	616 ; 610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Human health-risk assessment of heavy metal-contaminated soil based on Monte Carlo simulation.

Panqing, Ye / Abliz, Abdugheni / Xiaoli, Sun / Aisaiduli, Halidan

Scientific reports

2023 Volume 13, Issue 1, Page(s) 7033

Abstract: Soil contamination soils of by heavy metals (HMs) poses serious threats to the soil environment and enters the human body through exposure pathways such as ingestion and skin contact, posing a threat to human health. The purpose of this study was to ... ...

Abstract	Soil contamination soils of by heavy metals (HMs) poses serious threats to the soil environment and enters the human body through exposure pathways such as ingestion and skin contact, posing a threat to human health. The purpose of this study was to analyze the sources and contributions of soil HMs, and to quantitatively assess the human health risks of soil HMs to different populations (i.e. children, adult females and adult males), and to analyze the human health risks caused by various sources of sensitive populations. 170 topsoil (0-20 cm) were collected from Fukang, Jimsar and Qitai on the northern slope of Tianshan Mountains in Xinjiang, China, and the contents of Zn, Cu, Cr, Pb and Hg were determined. This study used the Unmix model and a health-risk assessment (HRA) model to assess the human health risks of five HMs. The results showed that: (1) The mean values of Zn and Cr were lower than the background values of Xinjiang, the mean values of Cu and Pb were slightly higher than the background values of Xinjiang but lower than the national standard, and the mean value of Hg and Pb was higher than the background value of Xinjiang and the national standard. (2) The sources of soil HMs in the region were mainly traffic, natural, coal, and industrial sources. Moreover, the HRA model combined with Monte Carlo simulation showed similar trends in the health-risk status of all population groups in the region. Probabilistic HRA revealed that noncarcinogenic risks were acceptable for all populations (HI < 1) while carcinogenic risks were high (children: 77.52%; female: 69.09%; male: 65.63%). For children, carcinogenic risk from industrial and coal sources exceeded the acceptable threshold by 2.35 and 1.20 times, respectively, and Cr was the main element contributing to human carcinogenic risk. These findings suggest that carcinogenic risks from coal-based Cr emissions cannot be ignored, and the study area should aim to control Cr emissions from industrial sources. The results of this study provide support for the prevention of human health risks and the control of soil HMs pollution across different age groups.
MeSH term(s)	Adult ; Child ; Humans ; Female ; Male ; Environmental Monitoring ; Lead ; Monte Carlo Method ; Soil Pollutants/analysis ; Risk Assessment ; China ; Metals, Heavy/analysis ; Mercury ; Carcinogens ; Soil ; Coal
Chemical Substances	Lead (2P299V784P) ; Soil Pollutants ; Metals, Heavy ; Mercury (FXS1BY2PGL) ; Carcinogens ; Soil ; Coal
Language	English
Publishing date	2023-04-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-33986-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessment of Soil Heavy Metal Pollution and Health Risks in Different Functional Areas on the Northern Slope of the Eastern Tianshan Mountains in Xinjiang, NW China

Halidan Asaiduli / Abdugheni Abliz / Abudukeyimu Abulizi / Xiaoli Sun / Panqing Ye

International Journal of Environmental Research and Public Health, Vol 20, Iss 4843, p

2023 Volume 4843

Abstract: In typical semi-arid areas, the timely and effective monitoring and evaluation of soil heavy metal pollution are of critical importance to prevent soil deterioration and achieve the sustainable use of soil resources. To further understand the degree of ... ...

Abstract	In typical semi-arid areas, the timely and effective monitoring and evaluation of soil heavy metal pollution are of critical importance to prevent soil deterioration and achieve the sustainable use of soil resources. To further understand the degree of soil heavy metal pollution in different functional areas, we studied the soil heavy metal pollution on the northern slope of the eastern Tianshan Mountains in Xinjiang. We collected 104 surface soil samples from typical commercial (A), industrial (B), and agricultural (C) areas with different land-use patterns. The contents of Zn, Cu, Cr, Pb, As, and Hg in the soil of different functional areas were evaluated using the geo-accumulation index, the single-factor pollution index, and potential ecological risk. The results showed that the contents of Pb, As, and Hg in soils of different functional areas exceeded 4.47, 8.03, and 1.5 times the background values of Xinjiang soil, respectively. The average contents of Zn, Cu, and Cr were lower than the background values of Xinjiang soil. Except for As in different functional areas, the contents of the other elements in the different functional areas reached the level of soil environmental quality standards in China (GB15618-2018). The geo-accumulation index of heavy metals in different functional areas was in the order of Area C > Area A > Area B, indicating that Area C was the most polluted. The results of the single-factor pollution index showed that the pollution levels of Pb, As, and Hg were higher, and the pollution levels of Cr, Cu, and Zn were lower. The results of the potential ecological risk index showed that the northwest of Area A was higher, the southeast of Area B was more polluted, and the central and eastern parts of Area C were more polluted. From the perspective of spatial distribution, the spatial distribution characteristics of Zn and Cr elements in different functional areas are consistent, but the spatial distribution characteristics of Cu, Pb, As, and Hg in different functional areas are quite ...
Keywords	different functional areas ; soil heavy metal ; spatial distribution ; pollution assessment ; source analysis ; Medicine ; R
Subject code	910
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effect of Oxytocin plus Carboprost Methylate in Preventing Postpartum Hemorrhage in High-Risk Pregnancy and Its Effect on Blood Pressure

Lin Wei / Haiping Yang / Xiaoli Sun

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Objective. This study aimed to explore and analyze the effectiveness of oxytocin plus carboprost methylate in preventing postpartum hemorrhage in high-risk pregnancies and its effect on blood pressure. A total of 60 women with high-risk pregnancies who ... ...

Abstract	Objective. This study aimed to explore and analyze the effectiveness of oxytocin plus carboprost methylate in preventing postpartum hemorrhage in high-risk pregnancies and its effect on blood pressure. A total of 60 women with high-risk pregnancies who gave birth in our hospital from January 2020 to May 2021 were recruited and assigned via random number table method (1 : 1) to receive either oxytocin (control group) or oxytocin plus carboprost methylate (observation group). Outcome measures included hemorrhage and blood pressure. The bleeding volume of the women in the observation group (210.55 ± 45.98, 45.21 ± 9.27, and 73.74 ± 12.18) was significantly less than that in the control group during delivery and 2h and 24h after the delivery (276.91 ± 49.21, 72.98 ± 19.68, and 92.61 ± 15.67) (all P<0.05). The observation group showed a significantly lower bleeding rate (6.67%) than the control group (16.67%) (P<0.05). The two groups showed similar diastolic and systolic blood pressures (P>0.05). Oxytocin plus carboprost methylate suppository effectively prevents postpartum hemorrhage in high-risk pregnancies, significantly reduces the amount of postpartum hemorrhage in high-risk pregnancies, and has little effect on the blood pressure of patients. Given its favorable treatment efficiency and high safety profile, this treatment protocol shows great potential for clinical application.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intelligent Reflecting Surface–Assisted Wireless Secret Key Generation against Multiple Eavesdroppers

Ya Liu / Kaizhi Huang / Xiaoli Sun / Shaochuan Yang / Liang Wang

Entropy, Vol 24, Iss 446, p

2022 Volume 446

Abstract: In this paper, we propose an improved physical layer key generation scheme that can maximize the secret key capacity by deploying intelligent reflecting surface (IRS) near the legitimate user aiming at improving its signal-to-noise ratio (SNR). We ... ...

Abstract	In this paper, we propose an improved physical layer key generation scheme that can maximize the secret key capacity by deploying intelligent reflecting surface (IRS) near the legitimate user aiming at improving its signal-to-noise ratio (SNR). We consider the scenario of multiple input single output (MISO) against multiple relevant eavesdroppers. We elaborately design and optimize the reflection coefficient matrix of IRS elements that can improve the legitimate user’s SNR through IRS passive beamforming and deteriorate the channel quality of eavesdroppers at the same time. We first derive the lower bound expression of the achievable key capacity, then solve the optimization problem based on semi-definite relaxation (SDR) and the convex–concave procedure (CCP) to maximize the secret key capacity. Simulation results show that our proposed scheme can significantly improve the secret key capacity and reduce hardware costs compared with other benchmark schemes.
Keywords	Intelligent reflecting surface ; physical layer secret key generation ; semi-definite relaxation ; convex–concave procedure ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
Subject code	003
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epitaxy‐Directed Self‐Assembly of Copolymers and Polymer Blends

Chunyue Hou / Junjie Wang / Peng Wang / Jiahui Cui / Shaojuan Wang / Rui Xin / Huihui Li / Xiaoli Sun / Zhongjie Ren / Shouke Yan

Advanced Science, Vol 11, Iss 2, Pp n/a-n/a (2024)

2024

Abstract: Abstract Directed self‐assembly of materials into patterned structures is of great importance since the performance of them depends remarkably on their multiscale hierarchical structures. Therefore, purposeful structural regulation at different length ... ...

Abstract	Abstract Directed self‐assembly of materials into patterned structures is of great importance since the performance of them depends remarkably on their multiscale hierarchical structures. Therefore, purposeful structural regulation at different length scales through crystallization engineering provides an opportunity to modify the properties of polymeric materials. Here, an epitaxy‐directed self‐assembly strategy for regulating the pattern structures including phase structure as well as crystal modification and orientation of each component for both copolymers and polymer blends is reported. Owing to the specific crystallography registration between the depositing crystalline polymers and the underlying crystalline substrate, not only order phase structure with controlled size at nanometer scale but also the crystal structure and chain orientation of each component within the separated phases for both copolymers and polymer blend systems can be precisely regulated.
Keywords	copolymers ; epitaxy ; patterned structure ; polymer blends ; self‐assembly ; Science ; Q
Subject code	540
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of predictors of the ovarian response to clomiphene citrate in infertile women with polycystic ovary syndrome

Hexia Xia / Xiaoli Sun / Haiyun Guan / Ruixiu Zhang / Wei Zhang

Journal of International Medical Research, Vol

a prospective cohort study

2021 Volume 49

Abstract: Objective To identify predictors of the ovarian response to clomiphene citrate (CC) in infertile patients with polycystic ovary syndrome (PCOS). Methods We performed a prospective cohort study of infertile patients with PCOS. The participants underwent ... ...

Abstract	Objective To identify predictors of the ovarian response to clomiphene citrate (CC) in infertile patients with polycystic ovary syndrome (PCOS). Methods We performed a prospective cohort study of infertile patients with PCOS. The participants underwent assessments of their physical, endocrine, and metabolic characteristics, and treatment with CC at an initial dose of 50 mg/day and a maximum of 100 mg/day between days 3 and 7 of their menstrual cycles. Participants who ovulated were identified as responders and those who did not as non-responders. Results Of the 72 participants, 48 (66.7%) were identified as responders and 24 as non-responders. Sex hormone-binding globulin (SHBG) (odds ratio 1.022, 95% confidence interval: 1.000–1.045) was found to be associated with the ovarian response to CC using logistic multivariate regression analysis. Receiver operating characteristic analysis also showed that SHBG was a significant predictor of the response to CC (area under the curve 0.799). Conclusion We have shown that SHBG is the best prognostic indicator of an ovulatory response to CC. However, larger prospective studies, in which more variables are assessed, are required to confirm this finding and to identify appropriate cut-off values.
Keywords	Medicine (General) ; R5-920
Subject code	310
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mapping quantitative trait loci related to nodule number in soybean (Glycine max (L.) Merr.) in response to the Sinorhizobium (Ensifer) fredii HH103 NopT type III effector

Yanru Liu / Mingzhe Sun / Qingshan Chen / Dawei Xin / Xiaoli Sun

Journal of Plant Interactions, Vol 16, Iss 1, Pp 126-

2021 Volume 135

Abstract: Type III effectors play a vital role in the establishment of symbiosis. In this study, positive and negative effects of NopT on nodulation were detected in 30 soybean germplasms. The quantitative trait loci (QTL) related to nodule number were identified ... ...

Abstract	Type III effectors play a vital role in the establishment of symbiosis. In this study, positive and negative effects of NopT on nodulation were detected in 30 soybean germplasms. The quantitative trait loci (QTL) related to nodule number were identified and their responses to NopT in recombinant inbred lines and chromosome segment substitution lines were evaluated. Ten QTL were identified on chromosomes 02, 05, 06, 10, and 13. One overlapping region on chromosome 02 was responsive to the wild-type rhizobium and the NopT mutant. The expression patterns of the genes in this overlapping region were determined and single nucleotide polymorphisms and haplotypes were analyzed to identify the candidate genes. Four candidate genes were identified as significantly responsive to NopT. Glyma.02G135100 and Glyma.02G100800 expression levels were directly affected by NopT. These results form the basis of future efforts to identify the plant host genes affected by type III effectors.
Keywords	quantitative trait loci ; rhizobia ; symbiosis ; recombinant inbred line ; nopt ; Plant culture ; SB1-1110 ; Plant ecology ; QK900-989
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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