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Article ; Online: Formononetin ameliorates cisplatin-induced hair cell death via activation of the PI3K/AKT-Nrf2 signaling pathway

Yimeng Li / Jingfang Wu / Huiqian Yu / Xiaoling Lu / Yusu Ni

Heliyon, Vol 10, Iss 1, Pp e23750- (2024)

1481

Abstract: Cisplatin (CDDP) stands as a highly effective chemotherapeutic agent; however, its ototoxicity remains a perplexing challenge in the field. Formononetin (FMNT), a potent flavonoid isolated from Astragalus membranaceus, displays a diverse range of ... ...

Abstract	Cisplatin (CDDP) stands as a highly effective chemotherapeutic agent; however, its ototoxicity remains a perplexing challenge in the field. Formononetin (FMNT), a potent flavonoid isolated from Astragalus membranaceus, displays a diverse range of promising pharmacological activities, encompassing antioxidant, anti-apoptotic, and anti-inflammatory effects. Nonetheless, the advantageous effects of FMNT on cisplatin-induced cochlear hair cell injury demand further investigation. This study aimed to assess the protective properties of FMNT against cisplatin-induced hair cell damage by conducting in vitro assays on explant-cultured cochlear hair cells. The findings revealed that FMNT exhibited a notable reduction in cisplatin-induced hair cell apoptosis. Also, FMNT effectively mitigated the accumulation of reactive oxygen species and mitochondrial damage in cochlear explants exposed to cisplatin, while also restoring the turnover of the reduced glutathione (GSH)/glutathione disulfide (GSSG) ratio. Furthermore, our study demonstrated that FMNT protects hair cells against CDDP injury through the activation of the PI3K/AKT-Nrf2 signaling pathway. Consequently, formononetin emerges as a potential therapeutic agent for the treatment of cisplatin-induced ototoxicity.
Keywords	Formononetin ; Reactive oxygen species (ROS) ; Ototoxicity ; Cisplatin ; Hair cell ; Phosphatidylinositol-3-kinase (PI3K)/ serine/threonine kinase 1 (AKT) ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	500
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development and validation of a risk prediction model for anxiety or depression among patients with chronic obstructive pulmonary disease between 2018 and 2020

Tingyu Tang / Zongju Li / Xiaoling Lu / Jianzong Du

Annals of Medicine, Vol 54, Iss 1, Pp 2181-

2022 Volume 2190

Abstract: Anxiety and depression are important risk factors for chronic obstructive pulmonary disease (COPD). The aim of this study was to develop a prediction model to predict anxiety or depression in COPD patients. The retrospective study was conducted in COPD ... ...

Abstract	Anxiety and depression are important risk factors for chronic obstructive pulmonary disease (COPD). The aim of this study was to develop a prediction model to predict anxiety or depression in COPD patients. The retrospective study was conducted in COPD patients receiving stable treatment between 2018 and 2020 to develop prediction model. The variables, were readily available in clinical practice, were analysed. After data preprocessing, model training and performance evaluation were performed. Validity of the prediction model was verified in 3 comparative model training. Between 2018 and 2020, 375 eligible patients were analysed. Thirteen variables were included into the final model: gender, age, marital status, education level, long-term residence, per capita annual household income, payment method of medical expenses, direct economic costs of treating COPD in the past year, smoking, COPD progression, number of acute exacerbation of COPD in the last year, regular treatment with inhalants and family oxygen therapy. Risk score threshold in each sample in the training set was 1.414. The area under the curve value was respectively 0.763 and 0.702 in the training set and test set, which were higher than three comparative models. The simple prediction model to predict anxiety or depression in patients with COPD has been developed. Based on 13 available data in clinical indicators, the model may serve as an instrument for clinical decision-making for COPD patients who may have anxiety or depression.Key messagesThirteen variables were included into the prediction model.The AUC value was, respectively, 0.763 and 0.702 in the training set and test set, which were higher than three comparative models.The simple prediction model to predict anxiety or depression in patients with COPD has been developed.
Keywords	Prediction model ; validation ; anxiety ; depression ; COPD ; Medicine ; R
Subject code	310
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Should more individuals be sampled when measuring functional traits of tree species in habitat-heterogeneous karst forests?

Chenling Wang / Xiaoling Lu / Tingting Yang / Yawen Zheng / Linhao Chen / Libin Liu / Jian Ni

Frontiers in Ecology and Evolution, Vol

2023 Volume 11

Abstract: When measuring plant functional traits across geomorphologies, 5–10 healthy individuals of a plant species are commonly sampled. However, whether more individuals should be sampled in habitat-heterogeneous karst vegetation remains unknown. In this study, ...

Abstract	When measuring plant functional traits across geomorphologies, 5–10 healthy individuals of a plant species are commonly sampled. However, whether more individuals should be sampled in habitat-heterogeneous karst vegetation remains unknown. In this study, two dominant tree species (Clausena dunniana and Platycarya strobilacea) in karst evergreen and broadleaved mixed forests in Southwestern China were selected. On the basis of a large quantity of individuals of the two species grown in different peak clumps and slope positions, variations of 10 morphological traits in the two species were statistically analyzed. The suggested sampling number of individuals, which could mostly represent the common trait characteristics, was further explored. All traits showed significant differences between the two species (p < 0.05). The traits of P. strobilacea displayed larger intraspecific variations than those of C. dunniana, except for twig dry matter content. The bark thickness (BT), leaf area (LA), and specific leaf area (SLA) of C. dunniana and the BT, SLA, LA, leaf tissue density, and bark tissue density of P. strobilacea presented large intraspecific variations. Most traits exhibited significant differences between peak clumps and/or among slope positions (p < 0.05). Random sampling analysis indicated that the suggested sampling numbers of individuals for the 10 traits are 6–23 in C. dunniana and 9–29 in P. strobilacea. The common accepted sample size in normal geomorphologies is not sufficiently large in most cases. Larger sample sizes are recommended for traits, such as SLA, BT, and LA, with larger intraspecific variations. Therefore, under sufficient labor, material, and time, more individuals should be sampled when measuring plant functional traits in habitat-heterogeneous karst vegetation.
Keywords	morphological traits ; interspecific and intraspecific variations ; sampling number ; habitat heterogeneity ; evergreen and deciduous broadleaved mixed forest ; karst geomorphology ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
Subject code	580 ; 590
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Universal protocol for the wafer-scale manufacturing of 2D carbon-based transducer layers for versatile biosensor applications

Xiaoling Lu / Walid-Madhat Munief / Pavel Damborský / Alice Kasjanow / Jaroslav Katrlík / Vivek Pachauri / Sven Ingebrandt

MethodsX, Vol 11, Iss , Pp 102402- (2023)

2023

Abstract: In this manuscript, we present a comprehensive fabrication protocol for high-performance graphene oxide (GO) sensor concepts. It is suitable for a variety of biosensing applications and contains the essential process steps, starting with vapor phase ... ...

Abstract	In this manuscript, we present a comprehensive fabrication protocol for high-performance graphene oxide (GO) sensor concepts. It is suitable for a variety of biosensing applications and contains the essential process steps, starting with vapor phase evaporation for siloxane monolayers, followed by spin-coating of GO as a nanometer-thin transducer with exceptional homogeneity and micromechanical surface methods which enable seamless transformation of GO transducers to be desired micro and nano dimensions.In addition to linking basic research and innovative sensor concepts with an outlook for commercial applications of point-of-care systems for early-stage diagnostics, the authors consider it necessary to take a closer look at the manufacturing processes to create more transparency and clarity, to manufacture such specific sensor concepts systematically. The detailed manufacturing approaches are intended to motivate practitioner to explore and improve this GO-based key technology.This process development is illustrated below using the manufacturing methods for three types of sensors, namely sensors based on i) surface plasmon resonance spectroscopy (SPR), ii) impedance spectroscopy and iii) bio-field effect transistors (ISFETs).The obtained results in this work prove successful GO sensor productions by achieving: • Uniform and stable immobilization of GO thin films, • High yield of sensor units on a wafer scale, here up to 96 %, • Promising integration potential for various biomedical sensor concepts to early-stage diagnostic.
Keywords	Wafer-scale processing of (reduced) GO thin-films (WSPgo) ; Science ; Q
Subject code	620
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Jiu-Wei-Yong-An Formula suppresses JAK1/STAT3 and MAPK signaling alleviates atopic dermatitis-like skin lesions

Qinwufeng, Gu / Jiacheng, Lin / Xiaoling, Lu / Tingru, Chen / Yunyang, Wu / Yanlong, Yang

Journal of ethnopharmacology. 2022 Sept. 15, v. 295

2022

Abstract: Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine (TCM) prescription used to treat atopic dermatitis (AD) in the clinic. JWYA is considered to have anti-inflammatory and antipruritic properties. However, the mechanism of JWYA remains ... ...

Abstract	Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine (TCM) prescription used to treat atopic dermatitis (AD) in the clinic. JWYA is considered to have anti-inflammatory and antipruritic properties. However, the mechanism of JWYA remains unclear. Aim of the study: This study aimed to investigate the effect of JWYA on an experimental mouse AD model. Mice were sensitized with 2,4-dinitrochlorobenzene (DNCB) and intragastrically administered with JWYA for 14 days. The therapeutic effect was assessed using a grade four dermatitis score, skin moisture, thickness measurements, and a mouse behavior tests. H&E and toluidine blue staining were used to observe epidermal inflammatory thickening and mast cells in mouse skin lesions. Serum IgE levels and skin TNF-α and IL-4 levels were determined using ELISAs. The TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ mRNA expression levels in skin lesions were detected using qPCR. Network pharmacology analysis based on serum active components was performed to elucidate the mechanism, and the results were verified by Western blotting. Finally, we tested the binding affinity between the active ingredients of JWYA and JAK1 via molecular docking. JWYA improved the skin lesions of AD mice, relieved itching and reduced skin thickening. Additionally, JWYA decreased the serum IgE level and the levels of TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ in skin. Moreover, JWYA inhibited the activation of JAK1/STAT3 and MAPK (p38, ERK, and JNK) signaling. Molecular docking showed that kaempferol, luteolin, and forsythin have high affinity for JAK1. JWYA alleviates AD-like skin lesions and inhibited inflammation and skin itch. The effect of JWYA is attributed to blocking the JAK1/STAT3 and MAPK signaling pathways. We suggest that JWYA may be an alternative therapy for the treatment of AD.
Keywords	Oriental traditional medicine ; atopic dermatitis ; blood serum ; gene expression ; inflammation ; interleukin-13 ; interleukin-4 ; kaempferol ; luteolin ; mice ; models ; pharmacology ; therapeutics ; toluidine blue
Language	English
Dates of publication	2022-0915
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115428
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Distributed forecasting and ant colony optimization for the bike-sharing rebalancing problem with unserved demands.

Yiwei Fan / Gang Wang / Xiaoling Lu / Gaobin Wang

PLoS ONE, Vol 14, Iss 12, p e

2019 Volume 0226204

Abstract: Bike-sharing systems (BSS) have widely spread over many cities in the world as an environmentally friendly means to reduce air pollution and traffic congestion. This paper focuses on the bike-sharing rebalancing problem (BRP), which consists of two ... ...

Abstract	Bike-sharing systems (BSS) have widely spread over many cities in the world as an environmentally friendly means to reduce air pollution and traffic congestion. This paper focuses on the bike-sharing rebalancing problem (BRP), which consists of two aspects: determining desired demands at each station and designing routes to redistribute bikes among stations. For the first task, we firstly apply the random forest, a very efficient machine learning algorithm, to forecast desired demands for each station, which can be easily implemented with distributed computing. For the second task, it belongs to the broad class of the vehicle routing problem with pickup and delivery (VRPPD). In most existing settings, all of the demands being strictly satisfied can lead to longer routes and add operational costs. In this paper, we propose a new model with unserved demands by relaxing demands satisfying constraints. Then, we design a distributed ant colony optimization (ACO) based algorithm with some specific modifications to increase its efficiency for the proposed model. We propose to use the percentage of average cost saving per bike as a metric to evaluate the performance of our method on cost-reducing and compare with existing methods and best-known values. Computational results on benchmarks show the advantage of our approach. Finally, we provide a real case study of BSS in Hangzhou, China, with insightful elaborations.
Keywords	Medicine ; R ; Science ; Q
Subject code	006
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Jiu-Wei-Yong-An Formula suppresses JAK1/STAT3 and MAPK signaling alleviates atopic dermatitis-like skin lesions.

Qinwufeng, Gu / Jiacheng, Lin / Xiaoling, Lu / Tingru, Chen / Yunyang, Wu / Yanlong, Yang

Journal of ethnopharmacology

2022 Volume 295, Page(s) 115428

Abstract: Ethnopharmacological relevance: Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine (TCM) prescription used to treat atopic dermatitis (AD) in the clinic. JWYA is considered to have anti-inflammatory and antipruritic properties. However, ... ...

Abstract	Ethnopharmacological relevance: Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine (TCM) prescription used to treat atopic dermatitis (AD) in the clinic. JWYA is considered to have anti-inflammatory and antipruritic properties. However, the mechanism of JWYA remains unclear. Aim of the study: This study aimed to investigate the effect of JWYA on an experimental mouse AD model. Materials and methods: Mice were sensitized with 2,4-dinitrochlorobenzene (DNCB) and intragastrically administered with JWYA for 14 days. The therapeutic effect was assessed using a grade four dermatitis score, skin moisture, thickness measurements, and a mouse behavior tests. H&E and toluidine blue staining were used to observe epidermal inflammatory thickening and mast cells in mouse skin lesions. Serum IgE levels and skin TNF-α and IL-4 levels were determined using ELISAs. The TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ mRNA expression levels in skin lesions were detected using qPCR. Network pharmacology analysis based on serum active components was performed to elucidate the mechanism, and the results were verified by Western blotting. Finally, we tested the binding affinity between the active ingredients of JWYA and JAK1 via molecular docking. Results: JWYA improved the skin lesions of AD mice, relieved itching and reduced skin thickening. Additionally, JWYA decreased the serum IgE level and the levels of TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ in skin. Moreover, JWYA inhibited the activation of JAK1/STAT3 and MAPK (p38, ERK, and JNK) signaling. Molecular docking showed that kaempferol, luteolin, and forsythin have high affinity for JAK1. Conclusions: JWYA alleviates AD-like skin lesions and inhibited inflammation and skin itch. The effect of JWYA is attributed to blocking the JAK1/STAT3 and MAPK signaling pathways. We suggest that JWYA may be an alternative therapy for the treatment of AD.
MeSH term(s)	Animals ; Cytokines/metabolism ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/metabolism ; Dinitrochlorobenzene ; Immunoglobulin E ; Interleukin-13/metabolism ; Interleukin-33/metabolism ; Interleukin-4/metabolism ; MAP Kinase Signaling System ; Mice ; Mice, Inbred BALB C ; Molecular Docking Simulation ; Plant Extracts/pharmacology ; Skin/pathology ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Cytokines ; Dinitrochlorobenzene ; Interleukin-13 ; Interleukin-33 ; Plant Extracts ; Tumor Necrosis Factor-alpha ; Interleukin-4 (207137-56-2) ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2022-05-31
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115428
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Article ; Online: Prediction of Potential Geographical Distribution Patterns of Actinidia arguta under Different Climate Scenarios

Yining Ma / Xiaoling Lu / Kaiwei Li / Chunyi Wang / Ari Guna / Jiquan Zhang

Sustainability, Vol 13, Iss 3526, p

2021 Volume 3526

Abstract: Actinidia arguta (Siebold and Zucc.) Planch.ex Miq, called “hardy kiwifruit”, “baby kiwi” or “kiwi berry”, has a unique taste, is rich in nutrients and has high economic value and broad market prospects. Active research on the potential geographic ... ...

Abstract	Actinidia arguta (Siebold and Zucc.) Planch.ex Miq, called “hardy kiwifruit”, “baby kiwi” or “kiwi berry”, has a unique taste, is rich in nutrients and has high economic value and broad market prospects. Active research on the potential geographic distribution of A. arguta in China aims to provide a reference basis for its resource investigation, conservation, development and utilization and introduction of cultivation. In this study, the Maxent model was used to combine climatic factors, soil factors and geographical factors (elevation, slope and aspect) to predict the current and future (2041–2060 and 2081–2100) potential distribution of A. arguta and to analyze the impact of climate change on it. The results showed that the suitable distribution range of A. arguta in China was 23–43 N and 100–125 E, with a total area of about 3.4451 × 10 6 km 2 . The highly suitable area of A. arguta was mainly concentrated in the middle and low mountain areas of the south of Shaanxi, the east of Sichuan, the middle and west of Guizhou and the west of Yunnan, presenting a circular distribution. The Jackknife test was used to calculate the main environmental factors affecting the distribution of A. arguta . The first four main factors were annual mean temperature (bio_1), precipitation of the warmest quarter (bio_18), elevation (ELE) and mean temperature of the warmest quarter (bio_10), which provided a contribution up to 81.7%. Under the scenarios of three representative concentrations (SSP1_2.6, SSP2_4.5 and SSP5_8.5) in the future, the area of low and moderate suitable habitat decreased, while the area of highly suitable habitat increased. The migration direction of the centroid in the highly suitable habitat moved to the southwest in the future scenario period.
Keywords	Actinidia arguta ; ENMeval ; MaxEnt ; climate change ; SSP scenarios ; suitable habitat ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Libertellenone H, a Natural Pimarane Diterpenoid, Inhibits Thioredoxin System and Induces ROS-Mediated Apoptosis in Human Pancreatic Cancer Cells

Weirui Zhang / Yuping Zhu / Haobing Yu / Xiaoyu Liu / Binghua Jiao / Xiaoling Lu

Molecules, Vol 26, Iss 2, p

2021 Volume 315

Abstract: Libertellenone H (LH), a marine-derived pimarane diterpenoid isolated from arctic fungus Eutypella sp. D-1, has shown effective cytotoxicity on a range of cancer cells. The present study is to explore the anticancer effect of LH on human pancreatic ... ...

Abstract	Libertellenone H (LH), a marine-derived pimarane diterpenoid isolated from arctic fungus Eutypella sp. D-1, has shown effective cytotoxicity on a range of cancer cells. The present study is to explore the anticancer effect of LH on human pancreatic cancer cells and to investigate the intracellular molecular target and underlying mechanism. As shown, LH exhibited anticancer activity in human pancreatic cancer cells by promoting cell apoptosis. Mechanistic studies suggested that LH-induced reactive oxygen species (ROS) accumulation was responsible for apoptosis as antioxidant N-acetylcysteine (NAC) and antioxidant enzyme superoxide dismutase (SOD) antagonized the inhibitory effect of LH. Zymologic testing demonstrated that LH inhibited Trx system but had little effect on the glutathione reductase and glutaredoxin. Mass spectrometry (MS) analysis revealed that the mechanism of action was based on the direct conjugation of LH to the Cys 32 /Cys 35 residue of Trx1 and Sec 498 of TrxR, leading to a decrease in the cellular level of glutathione (GSH) and activation of downstream ASK1/JNK signaling pathway. Taken together, our findings revealed LH was a marine derived inhibitor of Trx system and an anticancer candidate.
Keywords	Libertellenone H ; pancreatic cancer ; ROS ; Trx system ; apoptosis ; Organic chemistry ; QD241-441
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Statistical patterns of human mobility in emerging Bicycle Sharing Systems.

Xiangyu Chang / Jingzhou Shen / Xiaoling Lu / Shuai Huang

PLoS ONE, Vol 13, Iss 3, p e

2018 Volume 0193795

Abstract: The emerging Bicycle Sharing System (BSS) provides a new social microscope that allows us to "photograph" the main aspects of the society and to create a comprehensive picture of human mobility behavior in this new medium. BSS has been deployed in many ... ...

Abstract	The emerging Bicycle Sharing System (BSS) provides a new social microscope that allows us to "photograph" the main aspects of the society and to create a comprehensive picture of human mobility behavior in this new medium. BSS has been deployed in many major cities around the world as a short-distance trip supplement for public transportations and private vehicles. A unique value of the bike flow data generated by these BSSs is to understand the human mobility in a short-distance trip. This understanding of the population on short-distance trip is lacking, limiting our capacity in management and operation of BSSs. Many existing operations research and management methods for BSS impose assumptions that emphasize statistical simplicity and homogeneity. Therefore, a deep understanding of the statistical patterns embedded in the bike flow data is an urgent and overriding issue to inform decision-makings for a variety of problems including traffic prediction, station placement, bike reallocation, and anomaly detection. In this paper, we aim to conduct a comprehensive analysis of the bike flow data using two large datasets collected in Chicago and Hangzhou over months. Our analysis reveals intrinsic structures of the bike flow data and regularities in both spatial and temporal scales such as a community structure and a taxonomy of the eigen-bike-flows.
Keywords	Medicine ; R ; Science ; Q
Subject code	006
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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