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Article ; Online: Novel genotypes of Coxiella burnetii circulating in rats in Yunnan Province, China

Mengjiao Fu / Peisheng He / Xuan OuYang / Yonghui Yu / Bohai Wen / Dongsheng Zhou / Xiaolu Xiong / Qinghong Yuan / Jun Jiao

BMC Veterinary Research, Vol 18, Iss 1, Pp 1-

2022 Volume 9

Abstract: Abstract Background Coxiella burnetii (Cb) is the causative agent of the zoonotic disease Q fever which is distributed worldwide. Molecular typing of Cb strains is essential to find out the infectious source and prevent Q fever outbreaks, but there has ... ...

Abstract	Abstract Background Coxiella burnetii (Cb) is the causative agent of the zoonotic disease Q fever which is distributed worldwide. Molecular typing of Cb strains is essential to find out the infectious source and prevent Q fever outbreaks, but there has been a lack of typing data for Cb strains in China. The aim of this study was to investigate the genotypes of Cb strains in wild rats in Yunnan Province, China. Results Eighty-six wild rats (Rattus flavipectus) were collected in Yunnan Province and 8 of the 86 liver samples from the wild rats were positive in Cb-specific quantitative PCR (qPCR). The Cb strains from the 8 rats were then typed into 3 genotypes using 10-spacer multispacer sequence typing (MST), and 2 of the 3 genotypes were recognized as novel ones. Moreover, the Cb strains in the wild rats were all identified as genotype 1 using 6-loci multilocus variable number of tandem repeat analysis (MLVA). Conclusions This is the first report of genotypic diversity of Cb strains from wild rats in China. Further studies are needed to explore the presence of more genotypes and to associate the genotypes circulating in the wildlife-livestock interaction with those causing human disease to further expand on the epidemiological aspects of the pathogen.
Keywords	Rattus flavipectus ; Coxiella burnetii ; Genotype ; MST ; MLVA ; China ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ultrasmall Fe-doped carbon dots nanozymes for photoenhanced antibacterial therapy and wound healing

Yunhang Liu / Bolong Xu / Mingzhu Lu / Shanshan Li / Juan Guo / Fangzhou Chen / Xiaolu Xiong / Zhe Yin / Huiyu Liu / Dongsheng Zhou

Bioactive Materials, Vol 12, Iss , Pp 246-

2022 Volume 256

Abstract: Pathogenic bacteria pose a devastating threat to public health. However, because of the growing bacterial antibiotic resistance, there is an urgent need to develop alternative antibacterial strategies to the established antibiotics. Herein, iron-doped ... ...

Abstract	Pathogenic bacteria pose a devastating threat to public health. However, because of the growing bacterial antibiotic resistance, there is an urgent need to develop alternative antibacterial strategies to the established antibiotics. Herein, iron-doped carbon dots (Fe-CDs, ∼3 nm) nanozymes with excellent photothermal conversion and photoenhanced enzyme-like properties are developed through a facile one-pot pyrolysis approach for synergistic efficient antibacterial therapy and wound healing. In particular, Fe doping endows CDs with photoenhanced peroxidase (POD)-like activity, which lead to the generation of heat and reactive oxygen species (ROS) for Gram-positive and Gram-negative bacteria killing. This study demonstrates Fe-CDs have significant wound healing efficiency of Fe-CDs by preventing infection, promoting fibroblast proliferation, angiogenesis, and collagen deposition. Furthermore, the ultrasmall size of Fe-CDs possesses good biocompatibility favoring clinical translation. We believe that the nanozyme-mediated therapeutic platform presented here is expected to show promising applications in antibacterial.
Keywords	Carbon dots ; Nanozymes ; Photothermal effect ; Antibacterial therapy ; Wound healing ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: First detection of Rickettsia aeschlimannii in Hyalomma marginatum in Tibet, China

Jun Jiao / Yonghui Yu / Peisheng He / Weiqiang Wan / Xuan OuYang / Bohai Wen / Yi Sun / Xiaolu Xiong

Zoonoses, Vol 2, Iss 1, p

2022 Volume 976

Abstract: Hyalomma marginatum is an important arthropod vector in the transmission of various zoonoses. The aim of this study was to identify the tick-borne pathogens (TBPs) maintained in Hy. marginatum in Tibet and to estimate the risk of human tick-borne ... ...

Abstract	Hyalomma marginatum is an important arthropod vector in the transmission of various zoonoses. The aim of this study was to identify the tick-borne pathogens (TBPs) maintained in Hy. marginatum in Tibet and to estimate the risk of human tick-borne diseases. Adult Hy. marginatum ticks (n = 14) feeding on yaks were collected. The individual DNA samples of these ticks were sequenced with metagenomic next-generation sequencing to survey the presence of TBPs. TBPs in individual ticks were identified with nested polymerase chain reaction (PCR) combined with DNA sequencing. The presence of Rickettsia , Anaplasma , and Ehrlichia in individual ticks was indicated by the taxonomic profiles at the genus level, but only Rickettsia aeschlimannii (100%, 13/13) was further detected in the ticks by nested PCR. This study provides information on the microbial communities of Hy. marginatum in Tibet, China, and provides the first report of R. aeschlimannii found in Hy. marginatum in Tibet. The results of this study indicated that yaks in Tibet are exposed to R. aeschlimannii .
Keywords	Infectious and parasitic diseases ; RC109-216 ; Veterinary medicine ; SF600-1100
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Compuscript Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molten salt electrosynthesis of Cr2GeC nanoparticles as anode materials for lithium-ion batteries

Zhongya Pang / Feng Tian / Xiaolu Xiong / Jinjian Li / Xueqiang Zhang / Shun Chen / Fei Wang / Guangshi Li / Shujuan Wang / Xing Yu / Qian Xu / Xionggang Lu / Xingli Zou

Frontiers in Chemistry, Vol

2023 Volume 11

Abstract: The two-dimensional MAX phases with compositional diversity are promising functional materials for electrochemical energy storage. Herein, we report the facile preparation of the Cr2GeC MAX phase from oxides/C precursors by the molten salt electrolysis ... ...

Abstract	The two-dimensional MAX phases with compositional diversity are promising functional materials for electrochemical energy storage. Herein, we report the facile preparation of the Cr2GeC MAX phase from oxides/C precursors by the molten salt electrolysis method at a moderate temperature of 700°C. The electrosynthesis mechanism has been systematically investigated, and the results show that the synthesis of the Cr2GeC MAX phase involves electro-separation and in situ alloying processes. The as-prepared Cr2GeC MAX phase with a typical layered structure shows the uniform morphology of nanoparticles. As a proof of concept, Cr2GeC nanoparticles are investigated as anode materials for lithium-ion batteries, which deliver a good capacity of 177.4 mAh g−1 at 0.2 C and excellent cycling performance. The lithium-storage mechanism of the Cr2GeC MAX phase has been discussed based on density functional theory (DFT) calculations. This study may provide important support and complement to the tailored electrosynthesis of MAX phases toward high-performance energy storage applications.
Keywords	MAX phase ; Cr2GeC ; molten salt electrosynthesis ; lithium-ion batteries ; energy storage ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sintering-induced cation displacement in protonic ceramics and way for its suppression

Ze Liu / Yufei Song / Xiaolu Xiong / Yuxuan Zhang / Jingzeng Cui / Jianqiu Zhu / Lili Li / Jing Zhou / Chuan Zhou / Zhiwei Hu / Guntae Kim / Francesco Ciucci / Zongping Shao / Jian-Qiang Wang / Linjuan Zhang

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 10

Abstract: Abstract Protonic ceramic fuel cells with high efficiency and low emissions exhibit high potential as next-generation sustainable energy systems. However, the practical proton conductivity of protonic ceramic electrolytes is still not satisfied due to ... ...

Abstract	Abstract Protonic ceramic fuel cells with high efficiency and low emissions exhibit high potential as next-generation sustainable energy systems. However, the practical proton conductivity of protonic ceramic electrolytes is still not satisfied due to poor membrane sintering. Here, we show that the dynamic displacement of Y3+ adversely affects the high-temperature membrane sintering of the benchmark protonic electrolyte BaZr0.1Ce0.7Y0.1Yb0.1O3−δ, reducing its conductivity and stability. By introducing a molten salt approach, pre-doping of Y3+ into A-site is realized at reduced synthesis temperature, thus suppressing its further displacement during high-temperature sintering, consequently enhancing the membrane densification and improving the conductivity and stability. The anode-supported single cell exhibits a power density of 663 mW cm−2 at 600 °C and long-term stability for over 2000 h with negligible performance degradation. This study sheds light on protonic membrane sintering while offering an alternative strategy for protonic ceramic fuel cells development.
Keywords	Science ; Q
Subject code	620
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Degradable Pseudo Conjugated Polymer Nanoparticles with NIR‐II Photothermal Effect and Cationic Quaternary Phosphonium Structural Bacteriostasis for Anti‐Infection Therapy

Huiling Zhou / Dongsheng Tang / Xiaoxu Kang / Haitao Yuan / Yingjie Yu / Xiaolu Xiong / Nier Wu / Fangzhou Chen / Xing Wang / Haihua Xiao / Dongsheng Zhou

Advanced Science, Vol 9, Iss 16, Pp n/a-n/a (2022)

2022

Abstract: Abstract Photothermal therapy based on conjugated polymers represents a promising antibacterial strategy but still possesses notable limitations. Herein, degradable pseudo conjugated polymers (PCPs) containing photothermal molecular backbones and ... ...

Abstract	Abstract Photothermal therapy based on conjugated polymers represents a promising antibacterial strategy but still possesses notable limitations. Herein, degradable pseudo conjugated polymers (PCPs) containing photothermal molecular backbones and reactive oxygen species (ROS)‐sensitive thioketal bonds are designed. Triphenylphosphine (PPh3) is introduced into PCPs to generate phosphonium‐based PCPs (pPCPs), which further assembled with hyaluronic acid into pPCP nanoparticles (pPCP‐NPs). pPCP‐NPs with quaternary phosphonium cations selectively anchor on and destroy bacterial cell membranes through electrostatic action. Under 1064 nm laser irradiation, pPCP‐NPs (pPCP‐NPs/+L) produce near‐infrared‐II (NIR‐II) photothermal antibacterial effect, thereby killing bacteria in a sustained manner. pPCP‐NPs are readily degraded upon ROS abundant at infection sites, therefore exhibiting enough biosafety. pPCP‐NPs/+L display an almost 100% bacterial inhibition rate in vitro and resultin a nearly complete recovery of bacteria‐induced mouse wounds. A further metabolomics analysis denotes that pPCP‐NPs/+L work in a concerted way to induce bacterial DNA damage, inhibit bacterial carbon/nitrogen utilization and amino acid/nucleotide synthesis. Taken together, degradable pPCP‐NPs with both NIR‐II photothermal effect and cationic phosphonium structural bacteriostasis provide a new avenue for antibiotics‐alternative anti‐infection therapy.
Keywords	anti‐infectieon therapy ; cationic quaternary phosphonium structural bacteriostasis ; nanoparticle ; photothermal antibacterial effect ; pseudo conjugated polymer ; Science ; Q
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Electronic Structure and Oxidation Mechanism of Nickel–Copper Converter Matte from First-Principles Calculations

Wen Tao / Chuncheng Zhu / Qian Xu / Shenggang Li / Xiaolu Xiong / Hongwei Cheng / Xingli Zou / Xionggang Lu

ACS Omega, Vol 5, Iss 32, Pp 20090-

2020 Volume 20099

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An updated meta-analysis of the association between tumor necrosis factor-α -308G/A polymorphism and obstructive sleep apnea-hypopnea syndrome.

Anyuan Zhong / Xiaolu Xiong / Huajun Xu / Minhua Shi

PLoS ONE, Vol 9, Iss 9, p e

2014 Volume 106270

Abstract: Background Several studies have reported that the tumor necrosis factor-α (TNF-α) -308G/A polymorphism is associated with susceptibility to obstructive sleep apnea-hypopnea syndrome (OSAHS). However, these results are controversial and conflicting. ... ...

Abstract	Background Several studies have reported that the tumor necrosis factor-α (TNF-α) -308G/A polymorphism is associated with susceptibility to obstructive sleep apnea-hypopnea syndrome (OSAHS). However, these results are controversial and conflicting. Objective To evaluate the association between TNF-α-308G/A and OSAHS risk by meta-analysis. Methods Electronic databases, including PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, and Weipu, were searched to identify relevant studies. Data were extracted from the included studies. A model-free approach using odds ratio (OR), generalized odds ratio (ORG) and 95% confidence interval (CI) of the allele contrast to assess the association between the -308G/A polymorphism and OSAHS risk. Cumulative and recursive cumulative meta-analyses (CMA) were also carried out to investigate the trend and stability of effect sizes as evidence accumulated. Results Seven studies including 1369 OSAHS patients and 1064 controls were identified in this meta-analysis. Significant associations were derived from the variants of the allele contrast [(OR, 1.78; 95% CI, 1.45-2.18) or (ORG, 2.01; 95% CI, 1.27-3.19). CMA showed a trend of an association. Recursive CMA indicated that more evidence is needed to conclude on the status of significance. No significant publication bias was found. Conclusions Our meta-analysis suggested that the TNF-α-308G/A polymorphism contribute to the risk of OSAHS. Further studies with larger sample should be performed to confirm our findings.
Keywords	Medicine ; R ; Science ; Q
Subject code	306
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of cyanotoxins on the hypothalamic-pituitary-gonadal axis in male adult mouse.

Xiaolu Xiong / Anyuan Zhong / Huajun Xu

PLoS ONE, Vol 9, Iss 11, p e

2014 Volume 106585

Abstract: Microcystins LR (MC-LR) are hepatotoxic cyanotoxins that have been shown to induce reproductive toxicity, and Hypothalamic-Pituitary-Gonadal Axis (HPG) is responsible for the control of reproductive functions. However, few studies have been performed to ... ...

Abstract	Microcystins LR (MC-LR) are hepatotoxic cyanotoxins that have been shown to induce reproductive toxicity, and Hypothalamic-Pituitary-Gonadal Axis (HPG) is responsible for the control of reproductive functions. However, few studies have been performed to evaluate the effects of MC-LR on HPG axis. This study aimed to investigate the MC-LR-induced toxicity in the reproductive system of mouse and focus on the HPG axis.Adult male C57BL/6 mice were exposed to various concentrations of MC-LR (0, 3.75, 7.50, 15.00 and 30.00 µg/kg body weight per day) for 1 to 14 days, and it was found that exposure to different concentrations of MC-LR significantly disturbed sperm production in the mice testes in a dose- and time-dependent manner. To elucidate the associated possible mechanisms, the serum levels of testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were assessed. Meanwhile, PCR assays were employed to detect alterations in a series of genes involved in HPG axis, such as FSH, LH, gonadotropin-releasing hormone (GnRH) and their complement receptors. Furthermore, the effect of MC-LR on the viability and testosterone production of Leydig cells were tested in vitro.MC-LR significantly impaired the spermatogenesis of mice possibly through the direct or indirect inhibition of GnRH synthesis at the hypothalamic level, which resulted in reduction of serum levels of LH that lead to suppression of testosterone production in the testis of mice.MC-LR may be a GnRH toxin that would disrupt the reproductive system of mice.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Th1 epitope peptides induce protective immunity against Rickettsia rickettsii infection in C3H/HeN mice

Wang, Pengcheng / Xiaolu Xiong / Jun Jiao / Xiaomei Yang / Yongqiang Jiang / Bohai Wen / Wenping Gong

Vaccine. 2017 Dec. 18, v. 35, no. 51

2017

Abstract: Rickettsia rickettsii is the causative pathogen of Rocky Mountain spotted fever (RMSF). Adr2, YbgF and OmpB are protective antigens of R. rickettsii. In this study, 90 candidate peptides were selected from these antigens based on their high-affinity ... ...

Abstract	Rickettsia rickettsii is the causative pathogen of Rocky Mountain spotted fever (RMSF). Adr2, YbgF and OmpB are protective antigens of R. rickettsii. In this study, 90 candidate peptides were selected from these antigens based on their high-affinity binding capacity for the MHC class II molecule H2 I-A or H2 I-E using bioinformatic methods. Six peptides were determined using ELISPOT assay to be immunodominant based on the IFN-γ recall responses of CD4+ T cells from mice immunized with R. rickettsii. Six nucleotide sequences encoding the immunodominant peptides were linked in series and inserted into a plasmid for expression in Escherichia coli cells, resulting in a new, recombinant polypeptide termed GWP. After immunization and challenge, the rickettsial load or histopathological lesions in the organs of mice immunized with GWP or pooled peptides was significantly lower than that in organs of mice immunized with PBS or the individual peptide OmpB399. An in vitro neutralization test revealed that sera from mice immunized with GWP, OmpB399, or pooled peptides reduced R. rickettsii adherence to, and invasion of, vascular endothelial cells. Furthermore, significantly higher levels of IgG, IgG1, or IgG2a were detected in sera from mice immunized with GWP or pooled peptides, and significantly higher levels of IFN-γ or TNF-α secreted by CD4+ T cells from R. rickettsii-infected mice were detected after immunization with GWP. Altogether, our results indicated that polypeptides, especially GWP, could induce a Th1-type immune response against R. rickettsii infection, which might contribute to the rational design of peptide-based vaccines for RMSF.
Keywords	CD4-positive T-lymphocytes ; Escherichia coli ; Rickettsia rickettsii ; Rocky Mountain spotted fever ; binding capacity ; bioinformatics ; endothelial cells ; epitopes ; histopathology ; immune response ; immunization ; immunoglobulin G ; interferon-gamma ; mice ; neutralization tests ; nucleotide sequences ; pathogens ; plasmids ; polypeptides ; tumor necrosis factor-alpha ; vaccines
Language	English
Dates of publication	2017-1218
Size	p. 7204-7212.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2017.09.068
Database	NAL-Catalogue (AGRICOLA)

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