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Article ; Online: Total cholesterol mediates the association between history of gestational diabetes mellitus and bone mineral density in US women aged 20–49 years

Yan Zeng / Li Yin / Xiaoping Yin / Danqing Zhao

BMC Public Health, Vol 24, Iss 1, Pp 1-

2024 Volume 9

Abstract: Abstract Objective The aim of this study is to investigate the potential association between a history of gestational diabetes mellitus (GDM) and lumbar bone mineral density (BMD) among premenopausal women, with an additional examination of the mediating ...

Abstract	Abstract Objective The aim of this study is to investigate the potential association between a history of gestational diabetes mellitus (GDM) and lumbar bone mineral density (BMD) among premenopausal women, with an additional examination of the mediating role of serum total cholesterol (TC). Methods In this cross-sectional study, 1809 women aged 20–49 years with at least one live birth between 2011 and 2018, drawn from the NHANES dataset, were analyzed. GDM history was identified through questionnaires. Using weighted multiple linear regression, we assessed the relationship between GDM history and lumbar BMD. Additionally, mediation analysis was performed to investigate the potential mediating role of TC. Results The fully adjusted linear regression model revealed a negative association between a history of GDM and lumbar BMD, indicating a reduction in lumbar BMD (β = -0.023, 95% CI: -0.043, -0.003, P = 0.0275). Subgroup analysis highlighted a more pronounced trend in individuals aged ≥ 35 years and with a body mass index ≥ 30 kg/m². Furthermore, mediation analysis demonstrated a significant direct effect of a history of GDM on lumbar BMD (P < 0.0001), with serum TC playing a partial mediating role in this interaction (5.33%, P = 0.028). Conclusions In women aged 20–49 years within the United States, a history of GDM was associated with diminished lumbar BMD, potentially mediated through serum TC.
Keywords	History of gestational diabetes mellitus ; Bone mineral density ; Serum total cholesterol ; Mediation effect ; Premenopausal women ; Public aspects of medicine ; RA1-1270
Subject code	900
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mechanisms and therapeutic targets of mitophagy after intracerebral hemorrhage

Qinghua Huang / Xiaoqin Yu / Peijie Fu / Moxin Wu / Xiaoping Yin / Zhiying Chen / Manqing Zhang

Heliyon, Vol 10, Iss 1, Pp e23941- (2024)

1481

Abstract: Mitochondria are dynamic organelles responsible for cellular energy production. In addition to regulating energy homeostasis, mitochondria are responsible for calcium homeostasis, clearance of damaged organelles, signaling, and cell survival in the ... ...

Abstract	Mitochondria are dynamic organelles responsible for cellular energy production. In addition to regulating energy homeostasis, mitochondria are responsible for calcium homeostasis, clearance of damaged organelles, signaling, and cell survival in the context of injury and pathology. In stroke, the mechanisms underlying brain injury secondary to intracerebral hemorrhage are complex and involve cellular hypoxia, oxidative stress, inflammatory responses, and apoptosis. Recent studies have shown that mitochondrial damage and autophagy are essential for neuronal metabolism and functional recovery after intracerebral hemorrhage, and are closely related to inflammatory responses, oxidative stress, apoptosis, and other pathological processes. Because hypoxia and inflammatory responses can cause secondary damage after intracerebral hemorrhage, the restoration of mitochondrial function and timely clearance of damaged mitochondria have neuroprotective effects. Based on studies on mitochondrial autophagy (mitophagy), cellular inflammation, apoptosis, ferroptosis, the BNIP3 autophagy gene, pharmacological and other regulatory approaches, and normobaric oxygen (NBO) therapy, this article further explores the neuroprotective role of mitophagy after intracerebral hemorrhage.
Keywords	Autophagy ; Mitophagy ; Intracerebral hemorrhage ; BNIP3 ; Hypoxia ; Inflammation and oxidative stress ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gabor Dictionary of Sparse Image Patches Selected in Prior Boundaries for 3D Liver Segmentation in CT Images

Xuehu Wang / Zhiling Zhang / Kunlun Wu / Xiaoping Yin / Haifeng Guo

Journal of Healthcare Engineering, Vol

2021 Volume 2021

Abstract: The gray contrast between the liver and other soft tissues is low, and the boundary is not obvious. As a result, it is still a challenging task to accurately segment the liver from CT images. In recent years, methods of machine learning have become a ... ...

Abstract	The gray contrast between the liver and other soft tissues is low, and the boundary is not obvious. As a result, it is still a challenging task to accurately segment the liver from CT images. In recent years, methods of machine learning have become a research hotspot in the field of medical image segmentation because they can effectively use the “gold standard” personalized features of the liver from different data. However, machine learning usually requires a large number of data samples to train the model and improve the accuracy of medical image segmentation. This paper proposed a method for liver segmentation based on the Gabor dictionary of sparse image blocks with prior boundaries. This method reduced the number of samples by selecting the test sample set within the initial boundary area of the liver. The Gabor feature was extracted and the query dictionary was created, and the sparse coefficient was calculated to obtain the boundary information of the liver. By optimizing the reconstruction error and filling holes, a smooth liver boundary was obtained. The proposed method was tested on the MICCAI 2007 dataset and ISBI2017 dataset, and five measures were used to evaluate the results. The proposed method was compared with methods for liver segmentation proposed in recent years. The experimental results show that this method can improve the accuracy of liver segmentation and effectively repair the discontinuity and local overlap of segmentation results.
Keywords	Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
Subject code	006
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A mild type of childhood Covid-19 - A case report

Xiaoping Yin / Li Dong / Yu Zhang / Weilin Bian / Hongjun Li

Radiology of Infectious Diseases, Vol 7, Iss 2, Pp 78-

2020 Volume 80

Abstract: This case is about a 9-year-old child diagnosed with COVID-19, with a history of epidemiology; SARS-CoV-2 nucleic acids testing was positive, while chest CT examination was negative. The clinical classification was light. Nonetheless, isolation measures ... ...

Abstract	This case is about a 9-year-old child diagnosed with COVID-19, with a history of epidemiology; SARS-CoV-2 nucleic acids testing was positive, while chest CT examination was negative. The clinical classification was light. Nonetheless, isolation measures should still be taken to avoid infecting others.
Keywords	COVID-19 ; SARS-CoV-2 ; Child ; CT ; Mild ; Infectious and parasitic diseases ; RC109-216 ; covid19
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The metagenomic and metabolomic profile of the gut microbes in Chinese full-term and late preterm infants treated with Clostridium butyricum

Hong Li / Xingling Ma / Yongfu Li / Qin Liu / Qiuyan Tian / Xiaofeng Yang / Zhemin Zhou / Jing Ren / Bin Sun / Xing Feng / Hong Zhang / Xiaoping Yin / Heng Li / Xin Ding

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract The present study investigated the composition, abundance, and diversity of gut microbes in full-term and late-preterm infants from a medical center in eastern China. A total of 144 genomes of stool samples were captured for 16S rRNA metagenomic ...

Abstract	Abstract The present study investigated the composition, abundance, and diversity of gut microbes in full-term and late-preterm infants from a medical center in eastern China. A total of 144 genomes of stool samples were captured for 16S rRNA metagenomic analyses. A high abundance of commensal intestinal bacteria was detected in these samples such as Phocaeicola vulgatus, Escherichia coli, and Faecalibacterium prausnitzii, indicating a relatively consistent diversity of gut microbes in the present full-term infants aged 38–40 weeks. However, late preterm infants (n = 50) with mandatory antimicrobials feeding exhibited lower diversity but a higher composition of opportunistic pathogens such as Enterococcus species. Centralized on the situation, we explored the regulatory effect of Clostridium butyricum as probiotics on these late preterm infants. The consumption of C. butyricum did not restore the composition of gut microbes altered by antimicrobials to normal levels, although several opportunistic pathogens decreased significantly after probiotic therapy including Staphylococcus aureus, Sphingomonas echinoides, and Pseudomonas putida. We also compared the effects of day-fed versus night-fed probiotics. Intriguingly, the nighttime feeding showed a higher proportion of C. butyricum compared with probiotic day-feeding. Finally, fecal metabolome and metabolites were analyzed in late preterm infants with (n = 20) or without probiotic therapy (n = 20). The KEGG enrichment analysis demonstrated that vitamin digestion and absorption, synaptic vesicle cycle, and biotin metabolism were significantly increased in the probiotic-treated group, while MSEA indicated that a series of metabolism were significantly enriched in probiotic-treated infants including glycerolipid, biotin, and lysine, indicating the complex effects of probiotic therapy on glutathione metabolism and nutrients digestion and absorption in late preterm infants. Overall, this study provided metagenomic and metabolomic profile of the gut microbes in ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A cohort study of intrapartum group B streptococcus prophylaxis on atopic dermatitis in 2-year-old children.

Hong, Zhang / Jing, Ren / Hui, Li / Kang, Xu / Chunmei, Zhang / Yang, Wang / Baojian, Zhou / Xin, Ding / Xiaoping, Yin

BMC pediatrics

2022 Volume 22, Issue 1, Page(s) 693

Abstract: Objective: To understand the occurrence of atopic dermatitis (AD) in children aged 2 years on exposure to maternal group B streptococcus (GBS) antibiotic prophylaxis (IAP).: Design: Retrospective cohort study of 2909 mother-child pairs.: Setting: ... ...

Abstract	Objective: To understand the occurrence of atopic dermatitis (AD) in children aged 2 years on exposure to maternal group B streptococcus (GBS) antibiotic prophylaxis (IAP). Design: Retrospective cohort study of 2909 mother-child pairs. Setting: Taixing People's Hospital in Eastern China. Participants: Term infants born 2018-2019, followed longitudinally from birth to 2 years. Exposures: The GBS-IAP was defined as therapy with intravenous penicillin G or ampicillin or cefazolin ≥ 4 h prior to delivery to the mother. Reference infants were defined as born without or with other intrapartum antibiotic exposure. Outcomes: The logistic regression models were employed to analyze the effect of intrapartum GBS prophylaxis on AD in 2-year-old children during delivery. Analysis was a priori stratified according to the mode of delivery and adjusted for relevant covariates. Results: The cohorts showed that preventive GBS-IAP was potentially associated with increased incidence of AD in children delivered vaginally according to logistic regression models before and after covariate-adjusted treatment (OR: 6.719,95% CI: 4.730-9.544,P < 0.001;aOR: 6.562,95% CI: 4.302-10.008, P < 0.001). Conclusion: Prophylactic treatment of intrapartum GBS may raise the risk of AD in vaginally delivered children. These findings highlight the need to better understand the risk between childhood AD and current GBS-IAP intervention strategies.
MeSH term(s)	Infant ; Female ; Humans ; Child, Preschool ; Child ; Cohort Studies ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/prevention & control ; Retrospective Studies ; Streptococcus agalactiae ; Mothers
Language	English
Publishing date	2022-12-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-022-03758-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Safety and efficacy of normobaric oxygenation on rescuing acute intracerebral hemorrhage-mediated brain damage—a protocol of randomized controlled trial

Zhiying Chen / Jiayue Ding / Xiaoqin Wu / Bing Bao / Xianming Cao / Xiangbin Wu / Xiaoping Yin / Ran Meng

Trials, Vol 22, Iss 1, Pp 1-

2021 Volume 7

Abstract: Abstract Background All of the existing medication and surgical therapies currently cannot completely inhibit intracerebral hemorrhage (ICH)-mediated brain damage, resulting in disability in different degrees in the involved patients. Normobaric ... ...

Abstract	Abstract Background All of the existing medication and surgical therapies currently cannot completely inhibit intracerebral hemorrhage (ICH)-mediated brain damage, resulting in disability in different degrees in the involved patients. Normobaric oxygenation (NBO) was reported attenuating ischemic brain injury. Herein, we aimed to explore the safety and efficacy of NBO on rescuing the damaged brain tissues secondary to acute ICH, especially those in the perihematoma area being threatened by ischemia and hypoxia. Methods A total of 150 patients confirmed as acute spontaneous ICH by computed tomography (CT) within 6 h after symptoms onset, will enroll in this study after signing the informed consent, and enter into the NBO group or control group randomly according to a random number. In the NBO group, patients will inhale high-flow oxygen (8 L/min, 1 h each time for 6 cycles daily) and intake low-flow oxygen (2 L/min) in intermittent periods by mask for a total of 7 days. While in the control group, patients will breathe in only low-flow oxygen (2 L/min) by mask for 7 consecutive days. Computed tomography and perfusion (CT/CTP) will be used to evaluate cerebral perfusion status and brain edema. CT and CTP maps in the two groups at baseline and day 7 and 14 after NBO or low-flow oxygen control will be compared. The primary endpoint is mRS at both Day14 post-ICH and the end of the 3rd month follow-up. The secondary endpoints include NIHSS and plasma biomarkers at baseline and Day-1, 7, and 14 after treatment, as well as the NIHSS at the end of the 3rd month post-ICH and the incidence of bleeding recurrence and the mortalities within 3 months post-ICH. Discussion This study will provide preliminary clinical evidence about the safety and efficacy of NBO on correcting acute ICH and explore some mechanisms accordingly, to offer reference for larger clinical trials in the future. Trial registration ClinicalTrials.gov NCT04144868 . Retrospectively registered on October 29, 2019.
Keywords	Intracerebral hemorrhage ; Normobaric hyperoxia ; Cerebral perfusion ; Randomized controlled trial ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Flea surveillance on wild mammals in northern region of Xinjiang, northwestern China

Chang Shu / Mengmeng Jiang / Meihua Yang / Jun Xu / Shanshan Zhao / Xiaoping Yin / Baoju Wang / Jinliang Sheng / Yuanzhi Wang

International Journal for Parasitology: Parasites and Wildlife, Vol 11, Iss , Pp 12-

2020 Volume 16

Abstract: Flea distribution in northern region of Xinjiang Uygur Autonomous Region (XUAR) and fluctuations of the annual fleas index in Alataw Pass were investigated. During a 4-year (2015–2018) study, 5789 fleas were collected directly from 15 mammals at eight ... ...

Abstract	Flea distribution in northern region of Xinjiang Uygur Autonomous Region (XUAR) and fluctuations of the annual fleas index in Alataw Pass were investigated. During a 4-year (2015–2018) study, 5789 fleas were collected directly from 15 mammals at eight counties in northern XUAR of northwestern China. Nineteen flea species, belonging to sixteen genera and seven families, were further confirmed by four genetic markers (18S rDNA, 28S rDNA, COI and COII) after morphological observation. Pulex irritans and Paraceras crispum parasitizing Asian badgers (Meles leucurus) were recorded for the first time. In addition, the fluctuations of the annual fleas index in Alataw Pass were surveyed. Xenopsylla gerbilli minax, Xenopsylla conformis conformis and Nosopsyllus laeviceps laeviceps were highly detected in the warm season while Paradoxopsyllus repandus, Ctenophthalmus dolichus dolichus and Coptopsylla lamellifer ardua were only found in the cold season. These findings extend our knowledge of flea species, distribution and annual fluctuations especially in China-Kazakhstan border. Keywords: Flea distribution, XUAR, Fluctuations, The annual fleas index, Wild mammals
Keywords	Zoology ; QL1-991
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Interplay of Proximal Flow Confluence and Distal Flow Divergence in Patient-Specific Vertebrobasilar System.

Xiaoping Yin / Xu Huang / Yundi Feng / Wenchang Tan / Huaijun Liu / Yunlong Huo

PLoS ONE, Vol 11, Iss 7, p e

2016 Volume 0159836

Abstract: Approximately one-quarter of ischemic strokes involve the vertebrobasilar arterial system that includes the upstream flow confluence and downstream flow divergence. A patient-specific hemodynamic analysis is needed to understand the posterior circulation. ...

Abstract	Approximately one-quarter of ischemic strokes involve the vertebrobasilar arterial system that includes the upstream flow confluence and downstream flow divergence. A patient-specific hemodynamic analysis is needed to understand the posterior circulation. The objective of this study is to determine the distribution of hemodynamic parameters in the vertebrobasilar system, based on computer tomography angiography images. Here, the interplay of upstream flow confluence and downstream flow divergence was hypothesized to be a determinant factor for the hemodynamic distribution in the vertebrobasilar system. A computational fluid dynamics model was used to compute the flow fields in patient-specific vertebrobasilar models (n = 6). The inlet and outlet boundary conditions were the aortic pressure waveform and flow resistances, respectively. A 50% reduction of total outlet area was found to induce a ten-fold increase in surface area ratio of low time-averaged wall shear stress (i.e., TAWSS ≤ 4 dynes/cm2). This study enhances our understanding of the posterior circulation associated with the incidence of atherosclerotic plaques.
Keywords	Medicine ; R ; Science ; Q
Subject code	532
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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