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Article ; Online: New aspects of high-resolution ultrasound for tumor detection and treatments: M-Elite Program.

Michael, Jung Ernst / Xiaoyan, Xie / Xiaoer, Zhang

Clinical hemorheology and microcirculation

2023 Volume 86, Issue 1-2, Page(s) 3–7

MeSH term(s)	Humans ; Ultrasonography ; Running ; Neoplasms/diagnostic imaging ; Neoplasms/therapy
Language	English
Publishing date	2023-10-30
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	1381750-4
ISSN	1875-8622 ; 1386-0291
ISSN (online)	1875-8622
ISSN	1386-0291
DOI	10.3233/CH-238110
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Extracellular vesicle-loaded hydrogels for tissue repair and regeneration

Yikun Ju / Yue Hu / Pu Yang / Xiaoyan Xie / Bairong Fang

Materials Today Bio, Vol 18, Iss , Pp 100522- (2023)

2023

Abstract: Extracellular vesicles (EVs) are a collective term for nanoscale or microscale vesicles secreted by cells that play important biological roles. Mesenchymal stem cells are a class of cells with the potential for self-healing and multidirectional ... ...

Abstract	Extracellular vesicles (EVs) are a collective term for nanoscale or microscale vesicles secreted by cells that play important biological roles. Mesenchymal stem cells are a class of cells with the potential for self-healing and multidirectional differentiation. In recent years, numerous studies have shown that EVs, especially those secreted by mesenchymal stem cells, can promote the repair and regeneration of various tissues and, thus, have significant potential in regenerative medicine. However, due to the rapid clearance capacity of the circulatory system, EVs are barely able to act persistently at specific sites for repair of target tissues. Hydrogels have good biocompatibility and loose and porous structural properties that allow them to serve as EV carriers, thereby prolonging the retention in certain specific areas and slowing the release of EVs. When EVs are needed to function at specific sites, the EV-loaded hydrogels can stand as an excellent approach. In this review, we first introduce the sources, roles, and extraction and characterization methods of EVs and describe their current application status. We then review the different types of hydrogels and discuss factors influencing their abilities to carry and release EVs. We summarize several strategies for loading EVs into hydrogels and characterizing EV-loaded hydrogels. Furthermore, we discuss application strategies for EV-loaded hydrogels and review their specific applications in tissue regeneration and repair. This article concludes with a summary of the current state of research on EV-loaded hydrogels and an outlook on future research directions, which we hope will provide promising ideas for researchers.
Keywords	Extracellular vesicle ; Hydrogel ; Tissue repair ; Regeneration ; Exosome ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Application of 5-aminolevulinic acid-mediated Waterlase-assisted photodynamic therapy in the treatment of oral leukoplakia

Jiali Ou / Yijun Gao / Huan Li / Tianyou Ling / Xiaoyan Xie

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 9

Abstract: Abstract Photodynamic therapy (PDT) is an alternative microinvasive approach with satisfying results in the treatment of oral leukoplakia (OL). PDT combined with laser irradiation shows promise, safety and efficacy in treating OL. The efficacy of ... ...

Abstract	Abstract Photodynamic therapy (PDT) is an alternative microinvasive approach with satisfying results in the treatment of oral leukoplakia (OL). PDT combined with laser irradiation shows promise, safety and efficacy in treating OL. The efficacy of waterlase (YSGG) combined with PDT was studied by brush and tissue biopsy. Seventy-one patients with histologically diagnosed OL were enrolled, including patients with mild to moderate dysplasia, severe dysplasia and various dysplastic tissues. Patients were evaluated at baseline (t0), the end of treatment (t1) and 1 year later (t2). At t1, PDT showed a significant therapeutic effect on OL with mild to moderate dysplasia. Clinical and histological examinations revealed 60 cases (84.51%) of complete remission and 11 cases (15.49%) of partial remission. On brush biopsy, all PDT-treated patients showed reduced aneuploidy and normal histological findings. Unfortunately, at t2, 9 patients relapsed with OL, which may be related to continued smoking and betel nut chewing. At t2, 5 patients developed new severe epithelial dysplasia and even carcinoma in situ in other areas, mostly the tongue. ALA-mediated PDT combined with YSGG is effective in treating OL, particularly that with mild to moderate dysplasia. However, severe dysplasia may present undesirable effects, and the mechanism remains to be further investigated. ALA-mediated PDT combined with YSGG provides a new method for OL treatment.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Construction and Analysis of a Joint Diagnosis Model of Random Forest and Artificial Neural Network for Obesity

Jian Yu / Xiaoyan Xie / Yun Zhang / Feng Jiang / Chuyan Wu

Frontiers in Medicine, Vol

2022 Volume 9

Abstract: Obesity is a significant global health concern since it is connected to a higher risk of several chronic diseases. As a consequence, obesity may be described as a condition that reduces human life expectancy and significantly impacts life quality. ... ...

Abstract	Obesity is a significant global health concern since it is connected to a higher risk of several chronic diseases. As a consequence, obesity may be described as a condition that reduces human life expectancy and significantly impacts life quality. Because traditional obesity diagnosis procedures have several flaws, it is vital to design new diagnostic models to enhance current methods. More obesity-related markers have been discovered in recent years as a result of improvements and enhancements in gene sequencing technology. Using current gene expression profiles from the Gene Expression Omnibus (GEO) collection, we identified differentially expressed genes (DEGs) associated with obesity and found 12 important genes (CRLS1, ANG, ALPK3, ADSSL1, ABCC1, HLF, AZGP1, TSC22D3, F2R, FXN, PEMT, and SPTAN1) using a random forest classifier. ALPK3, HLF, FXN, and SPTAN1 are the only genes that have never been linked to obesity. We also used an artificial neural network to build a novel obesity diagnosis model and tested its diagnostic effectiveness using public datasets.
Keywords	obesity ; gene sequencing technology ; random forest classifier ; artificial neural network ; diagnosis model ; Medicine (General) ; R5-920
Subject code	006
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Therapeutic use of red blood cells and platelets derived from human cord blood stem cells

Xiaoyan Xie / Hailei Yao / Xiaoyan Han / Wen Yue / Xuetao Pei

Stem Cells Translational Medicine, Vol 10, Iss S2, Pp S48-S

2021 Volume 53

Abstract: Abstract Red blood cells (RBCs) and platelets derived from stem cells are possible solutions to the increasing demand for blood transfusion. Based on the availability of stem cells, their relatively defined differentiation mechanisms, and the massive ... ...

Abstract	Abstract Red blood cells (RBCs) and platelets derived from stem cells are possible solutions to the increasing demand for blood transfusion. Based on the availability of stem cells, their relatively defined differentiation mechanisms, and the massive exploration of induction systems, the generation of RBCs or platelets in vitro from cord blood hematopoietic stem/progenitor cells (CB‐HSPCs) has potential for clinical applications. However, information on the clinical translation of stem cell‐derived RBCs and platelets in the literature and at the ClinicalTrials.gov website is very limited. The only clinical trial on cultured RBCs, which aimed to assess the lifespan of RBCs cultured in vivo, was reported by Luc Douay and colleagues. Of note, the cultured RBCs they used were derived from autologous peripheral blood HSPCs, and no cultured platelets have been applied clinically to date. However, CB‐HSPC‐derived megakaryocytes, platelet precursors, have been used in the treatment of thrombocytopenia. A successful phase I trial was reported, followed by phase II and III clinical trials conducted in China. In this review, the gap between the many basic studies and limited clinical trials on stem cell‐derived RBCs and platelets is summarized. The possible reasons and solutions for this gap are discussed. Further technological improvements for blood cell expansion and maturation ex vivo and the establishment of biological standards for stem cell derivatives might help to facilitate the therapeutic applications of cultured RBCs and platelets derived from CB‐HSPCs in the near future.
Keywords	clinical translation ; cord blood hematopoietic stem/progenitor cells ; differentiation ; megakaryocytes ; platelets ; red blood cells ; Medicine (General) ; R5-920 ; Cytology ; QH573-671
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Oxford University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biomaterial‐based gene therapy

Yi Yu / Yijun Gao / Liming He / Bairong Fang / Wenhui Ge / Pu Yang / Yikun Ju / Xiaoyan Xie / Lanjie Lei

MedComm, Vol 4, Iss 3, Pp n/a-n/a (2023)

2023

Abstract: Abstract Gene therapy, a medical approach that involves the correction or replacement of defective and abnormal genes, plays an essential role in the treatment of complex and refractory diseases, such as hereditary diseases, cancer, and rheumatic immune ... ...

Abstract	Abstract Gene therapy, a medical approach that involves the correction or replacement of defective and abnormal genes, plays an essential role in the treatment of complex and refractory diseases, such as hereditary diseases, cancer, and rheumatic immune diseases. Nucleic acids alone do not easily enter the target cells due to their easy degradation in vivo and the structure of the target cell membranes. The introduction of genes into biological cells is often dependent on gene delivery vectors, such as adenoviral vectors, which are commonly used in gene therapy. However, traditional viral vectors have strong immunogenicity while also presenting a potential infection risk. Recently, biomaterials have attracted attention for use as efficient gene delivery vehicles, because they can avoid the drawbacks associated with viral vectors. Biomaterials can improve the biological stability of nucleic acids and the efficiency of intracellular gene delivery. This review is focused on biomaterial‐based delivery systems in gene therapy and disease treatment. Herein, we review the recent developments and modalities of gene therapy. Additionally, we discuss nucleic acid delivery strategies, with a focus on biomaterial‐based gene delivery systems. Furthermore, the current applications of biomaterial‐based gene therapy are summarized.
Keywords	biomaterial ; gene therapy ; nonviral vector ; viral vector ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Radiofrequency ablation induces tumor cell dissemination in a mouse model of hepatocellular carcinoma

Bowen Zhuang / Xi Zhu / Jinhua Lin / Fuli Zhang / Bin Qiao / Jihui Kang / Xiaohua Xie / Xunbin Wei / Xiaoyan Xie

European Radiology Experimental, Vol 7, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Background We tested the hypothesis that radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) promotes tumor cell release and explored a method for reducing these effects. Methods A green fluorescent protein-transfected orthotopic ... ...

Abstract	Abstract Background We tested the hypothesis that radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) promotes tumor cell release and explored a method for reducing these effects. Methods A green fluorescent protein-transfected orthotopic HCC model was established in 99 nude mice. In vivo flow cytometry was used to monitor circulating tumor cell (CTC) dynamics. Pulmonary fluorescence imaging and pathology were performed to investigate lung metastases. First, the kinetics of CTCs during the periablation period and the survival rate of CTCs released during RFA were investigated. Next, mice were allocated to controls, sham ablation, or RFA with/without hepatic vessel blocking (ligation of the portal triads) for evaluating the postablation CTC level, lung metastases, and survival over time. Moreover, the kinetics of CTCs, lung metastases, and mice survival were evaluated for RFA with/without ethanol injection. Pathological changes in tumors and surrounding parenchyma after ethanol injection were noted. Statistical analysis included t-test, ANOVA, and Kaplan-Meier survival curves. Results CTC counts were 12.3-fold increased during RFA, and 73.7% of RFA-induced CTCs were viable. Pre-RFA hepatic vessel blocking prevented the increase of peripheral CTCs, reduced the number of lung metastases, and prolonged survival (all p ≤ 0.05). Similarly, pre-RFA ethanol injection remarkably decreased CTC release during RFA and further decreased lung metastases with extended survival (all p ≤ 0.05). Histopathology revealed thrombus formation in blood vessels after ethanol injection, which may clog tumor cell dissemination during RFA. Conclusion RFA induces viable tumor cell dissemination, and pre-RFA ethanol injection may provide a prophylactic strategy to reduce this underestimated effect. Relevance statement RFA for HCC promotes viable tumor cell release during ablation, while ethanol injection can prevent RFA induced tumor cell release. Key points • RFA induced the release of viable tumor cells during the ablation ...
Keywords	Ethanol ; Hepatocellular carcinoma ; Lung neoplasms ; Neoplastic cells (circulating) ; Radiofrequency ablation ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Integrating Hybrid Pyramid Feature Fusion and Coordinate Attention for Effective Small Sample Hyperspectral Image Classification

Chen Ding / Youfa Chen / Runze Li / Dushi Wen / Xiaoyan Xie / Lei Zhang / Wei Wei / Yanning Zhang

Remote Sensing, Vol 14, Iss 2355, p

2022 Volume 2355

Abstract: In recent years, hyperspectral image (HSI) classification (HSIC) methods that use deep learning have proved to be effective. In particular, the utilization of convolutional neural networks (CNNs) has proved to be highly effective. However, some key ... ...

Abstract	In recent years, hyperspectral image (HSI) classification (HSIC) methods that use deep learning have proved to be effective. In particular, the utilization of convolutional neural networks (CNNs) has proved to be highly effective. However, some key issues need to be addressed when classifying hyperspectral images (HSIs), such as small samples, which can influence the generalization ability of the CNNs and the HSIC results. To address this problem, we present a new network that integrates hybrid pyramid feature fusion and coordinate attention for enhancing small sample HSI classification results. The innovative nature of this paper lies in three main areas. Firstly, a baseline network is designed. This is a simple hybrid 3D-2D CNN. Using this baseline network, more robust spectral-spatial feature information can be obtained from the HSI. Secondly, a hybrid pyramid feature fusion mechanism is used, meaning that the feature maps of different levels and scales can be effectively fused to enhance the feature extracted by the model. Finally, coordinate attention mechanisms are utilized in the network, which can not only adaptively capture the information of the spectral dimension, but also include the direction-aware and position sensitive information. By doing this, the proposed CNN structure can extract more useful HSI features and effectively be generalized to test samples. The proposed method was shown to obtain better results than several existing methods by experimenting on three public HSI datasets.
Keywords	hyperspectral image classification ; convolutional neural network ; small sample ; hybrid 3D-2D CNN ; pyramid feature fusion ; coordinate attention mechanism ; Science ; Q
Subject code	006
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of Two Kinds of Two-Dimensional Shear Wave Elastography Techniques in the Evaluation of Jaundiced Infants Suspected of Biliary Atresia

Wenying Zhou / Jinyu Liang / Quanyuan Shan / Huadong Chen / Pengfei Gao / Qinghua Cao / Guotao Wang / Xiaoyan Xie / Luyao Zhou

Diagnostics, Vol 12, Iss 1092, p

2022 Volume 1092

Abstract: Purpose: To compare the reliability and performance of Supersonic shear wave elastography (S-SWE) and Toshiba shear wave elastography (T-SWE) in the diagnosis of biliary atresia (BA) and assessment of liver fibrosis among jaundiced infants suspected of ... ...

Abstract	Purpose: To compare the reliability and performance of Supersonic shear wave elastography (S-SWE) and Toshiba shear wave elastography (T-SWE) in the diagnosis of biliary atresia (BA) and assessment of liver fibrosis among jaundiced infants suspected of BA. Material and Methods: A total of 35 patients with suspected BA who underwent both S-SWE and T-SWE examinations were prospectively included. Diagnostic performances of S-SWE and T-SWE in identifying BA were evaluated. The correlation between two types of SWE values and histological liver fibrosis stages by Metavir scores were investigated in 21 patients with pathology results. The intraclass correlation coefficients (ICCs) were calculated in 16 patients for inter- and intra-observer agreement. The area under the receiver operating characteristic curve (AUC) analysis was compared using a DeLong test. Results: There were 22 patients with BA and 13 patients without BA. The diagnostic performance of S-SWE was comparable to that of T-SWE (AUC 0.895 vs. 0.822, p = 0.071) in diagnosing BA. The AUCs of S-SWE in predicting liver fibrosis stages were from 0.676 to 1.000 and showed no statistical differences from that of T-SWE (from 0.704 to 1.000, all p > 0.05). T-SWE provided higher inter-operator agreement (ICC 0.990) and intra-operator agreement (ICCs 0.966–0.993), compared with that of S-SWE in a previous study (ICC 0.980 for inter-operator and 0.930–0.960 for intra-operator). Conclusions: For infants suspected of BA, T-SWE had good performances in the diagnosis of BA and the assessment of liver fibrosis compared with S-SWE. Furthermore, T-SWE showed higher measurement reproducibility than S-SWE.
Keywords	biliary atresia ; ultrasonography ; elasticity imaging techniques ; liver fibrosis ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Crystal structure of the histone heterodimer containing histone variant H2A.Bbd

Dai, Linchang / Xiaoyan Xie / Zheng Zhou

Biochemical and biophysical research communications. 2018 Sept. 10, v. 503, no. 3

2018

Abstract: H2A.Bbd, the most divergent histone variant among all known H2A type histones, is involved in gene transcription, spermiogenesis, DNA replication and RNA splicing. Incorporation of H2A.Bbd-H2B dimer, a fundamental unit of H2A.Bbd nucleosome, modulate ... ...

Abstract	H2A.Bbd, the most divergent histone variant among all known H2A type histones, is involved in gene transcription, spermiogenesis, DNA replication and RNA splicing. Incorporation of H2A.Bbd-H2B dimer, a fundamental unit of H2A.Bbd nucleosome, modulate structures of nucleosome or chromatin, but the underlying mechanism remains elusive. Here we determined a crystal structure of H2A.Bbd-H2B dimer at 2.6 Å resolution. Although the H2A.Bbd-H2B dimer structure largely resembles that of H2A-H2B, substitution of H2A αC helix residues by H2A.Bbd counterparts lead to the transition of a long αC-helix to the short 310-helix, likely owing to the rearrangement of the hydrogen-bond network. Moreover, structural comparison revealed a strikingly altered electrostatic potential surface for H2A.Bbd-H2B dimer displaying a diminished DNA binding capability. Our study provides the first high-resolution structure of histone variant H2A.Bbd and shed a light on biological function of H2A.Bbd.
Keywords	DNA ; DNA replication ; RNA splicing ; crystal structure ; histones ; hydrogen bonding ; nucleosomes ; spermiogenesis ; transcription (genetics)
Language	English
Dates of publication	2018-0910
Size	p. 1786-1791.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2018.07.114
Database	NAL-Catalogue (AGRICOLA)

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