Article ; Online: Development and Structural Analysis of Antibody Therapeutics for Filoviruses
Pathogens, Vol 11, Iss 374, p
2022 Volume 374
Abstract: The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts. ...
Abstract | The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts. With recent technological developments, potent antibodies have been identified from immunized animals and human survivors of virus infections and have been characterized functionally and structurally. Structural insight into how the most successful antibodies target GP further guides vaccine development. Here we review the recent developments in the identification and characterization of neutralizing antibodies and cocktail immunotherapies. |
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Keywords | antibody therapeutic ; cryo-EM ; ebolavirus ; filovirus ; marburgvirus ; structural biology ; Medicine ; R |
Language | English |
Publishing date | 2022-03-01T00:00:00Z |
Publisher | MDPI AG |
Document type | Article ; Online |
Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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