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Article ; Online: Experimental Insights into the Interplay between Histone Modifiers and p53 in Regulating Gene Expression

Hyun-Min Kim / Xiaoyu Zheng / Ethan Lee

International Journal of Molecular Sciences, Vol 24, Iss 11032, p

2023 Volume 11032

Abstract: Chromatin structure plays a fundamental role in regulating gene expression, with histone modifiers shaping the structure of chromatin by adding or removing chemical changes to histone proteins. The p53 transcription factor controls gene expression, binds ...

Abstract	Chromatin structure plays a fundamental role in regulating gene expression, with histone modifiers shaping the structure of chromatin by adding or removing chemical changes to histone proteins. The p53 transcription factor controls gene expression, binds target genes, and regulates their activity. While p53 has been extensively studied in cancer research, specifically in relation to fundamental cellular processes, including gene transcription, apoptosis, and cell cycle progression, its association with histone modifiers has received limited attention. This review explores the interplay between histone modifiers and p53 in regulating gene expression. We discuss how histone modifications can influence how p53 binds to target genes and how this interplay can be disrupted in cancer cells. This review provides insights into the complex mechanisms underlying gene regulation and their implications for potential cancer therapy.
Keywords	histone modifications ; p53 ; cancer ; gene regulation ; chromatin structure ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In-sample stability and postsampling analysis of 21 illicit drugs, their metabolites and cotinine in wastewater

Xinfeng Che / Peipei Liu / Yan Ding / Wenjia Tao / Xiaoyu Zheng / Bin Di / Hongwei Qiao

Ecotoxicology and Environmental Safety, Vol 270, Iss , Pp 115900- (2024)

2024

Abstract: A thorough understanding of the degradation of chemical biomarkers in wastewater after the sampling is critical in the surveillance of illicit drug use based on the back-calculation technique. Herein, three temperatures, eight groups of matrices, and ... ...

Abstract	A thorough understanding of the degradation of chemical biomarkers in wastewater after the sampling is critical in the surveillance of illicit drug use based on the back-calculation technique. Herein, three temperatures, eight groups of matrices, and acidification were applied to simulate the preservation condition of 21 illicit drugs, their metabolites, and cotinine for a 240-day stability study. It was proved that the temperature, matrices, and acidification play vital roles in their stability in wastewater. Most of them demonstrated high stability (transformation rates < 20%) during room temperature for 45 days, and the transformation rates decreased while the storage temperature reduced. The stability of the target compounds such as cocaine (COC), 6-monoacetylmorphine (6-MAM), and amphetamine (AM) is influenced by matrices. Acidification prevented the majority of analytes from transforming, making it a feasible solution for preservation after sampling. A model that combined the effects of temperature and matrix was developed to back-calculate the concentration of target compounds during the postsampling process. The feasibility of this model was validated by correcting the loss of COC and 6-MAM from 24.2% and 16.2% to 2.98% and 2.77%. This study simulated a typical large-scale sampling and storage scenario. The effect of the temperature, pH, and matrix on in-sample stability and the postsampling analysis of selected target compounds was investigated for the first time in this study.
Keywords	Wastewater ; Matrix ; Postsampling Analysis ; Stability ; Illicit Drugs ; Online-SPE-UPLC3MS/MS ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	500
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring the Spatiotemporal Impacts of the Built Environment on Taxi Ridership Using Multisource Data

Chen Xie / Dexin Yu / Ciyun Lin / Xiaoyu Zheng / Bo Peng

Sustainability, Vol 14, Iss 6045, p

2022 Volume 6045

Abstract: Taxis are an important component of the urban public transportation system, with wide geographical coverage and on-demand services characteristics. Thorough understanding of the built environment affecting taxi ridership can enable transportation ... ...

Abstract	Taxis are an important component of the urban public transportation system, with wide geographical coverage and on-demand services characteristics. Thorough understanding of the built environment affecting taxi ridership can enable transportation authorities to develop targeted policies for transportation planning. Previous studies in this field had few data sources and did not consider the spatiotemporal variability. This study aims to develop an analytical framework for understanding the spatiotemporal correlation between the urban built environment and taxi ridership, which is empirically analyzed in New York City. The built environment is defined through multisource data in terms of density, design, diversity, and destination accessibility. Besides the exploration of travel patterns, the spatiotemporal heterogeneity of taxi ridership is modeled using geographically and temporally weighted regression (GTWR). The result shows that GTWR outperforms ordinary least squares (OLS), geographically weighted regression (GWR), and temporally weighted regression (TWR) in both goodness of fit and explanatory accuracy. More importantly, our study found that land use diversity is negatively correlated with taxi ridership, while transportation diversity is positively correlated with it. A highly accessible road network improves the people’s demand for taxis in the morning rush hours. Moreover, the density of railway stations is positively correlated with taxi ridership on weekdays but adversely on weekends. These findings provide practical insights for urban transportation policy development and taxicab regulation.
Keywords	taxi ridership ; built environment ; travel behavior ; spatiotemporal heterogeneity ; geographically and temporally weighted regression (GTWR) ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Chinese version of the Maltreatment and Abuse Chronology of Exposure (MACE) scale

Yuanyuan Chen / Zhen Wang / Xiaoyu Zheng / Zhiyin Wu / Jianjun Zhu

PLoS ONE, Vol 17, Iss 6, p e

Psychometric properties in a sample of young adults.

2022 Volume 0270709

Abstract: There are several effective self-report instruments used by Chinese researchers to retrospectively assess exposure to childhood maltreatment. However, these measures do not assess the timing of exposure, restricting efforts to identify periods of ... ...

Abstract	There are several effective self-report instruments used by Chinese researchers to retrospectively assess exposure to childhood maltreatment. However, these measures do not assess the timing of exposure, restricting efforts to identify periods of development when childhood maltreatment maximally increases vulnerability to psychopathology and health outcomes. In the current study we created a Chinese version of the Maltreatment and Abuse Chronology of Exposure (MACE) scale, which assesses multiplicity (number of types of maltreatment experienced) and severity of maltreatment as well as when it occurred during childhood and adolescence. Rasch modeling was used for scale development in a sample of 812 undergraduate students. Item reduction analysis of the original 75 items produced a 58-item Chinese version with ten subdimensions. The new scale showed good three-week test-retest reliability, and good convergent validity with the Childhood Trauma Questionnaire (CTQ) and the revised Adverse Childhood Experiences Questionnaire (ACEQ-R). Variance decomposition analyses found that compared to the CTQ and ACE, the MACE Severity and Multiplicity scores explained higher variance in self-reported depression and anxiety symptom ratings on the Depression Anxiety Stress Scales (DASS). The results of the present study confirmed that the Chinese version of the MACE has sound psychometric properties in the Chinese cultural context. This new instrument will be a valuable tool for Chinese researchers, psychiatrists and psychologists to ascertain the type and timing of exposure to maltreatment.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Regimes in the Response of Photomechanical Materials

Tianyi Guo / Anastasiia Svanidze / Xiaoyu Zheng / Peter Palffy-Muhoray

Applied Sciences, Vol 12, Iss 15, p

2022 Volume 7723

Abstract: Photomechanical materials perform mechanical work in response to illumination. Photoisomerization-based photomechanical materials may operate in different regimes depending on the intensity of the illuminating light. We examine the photoresponse of ... ...

Abstract	Photomechanical materials perform mechanical work in response to illumination. Photoisomerization-based photomechanical materials may operate in different regimes depending on the intensity of the illuminating light. We examine the photoresponse of liquid crystalline azo-acrylate networks and show that a material property, the characteristic intensity of the material, defines the boundaries between different regimes. Asymptotic analysis indicates that whereas at low relative light levels, photostress is proportional to intensity, at high levels, it is proportional to fluence. Model predictions are in good agreement with the experimental results.
Keywords	photomechanical materials ; photoisomerization ; characteristic intensity ; lifetime ; azo ; liquid crystal elastomer ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: HOMA-IR is positively correlated with biological age and advanced aging in the US adult population

Haifang Yang / Rongpeng Gong / Moli Liu / Ying Deng / Xiaoyu Zheng / Tianyang Hu

European Journal of Medical Research, Vol 28, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract Background Insulin resistance (IR) had been reported to be associated with age; however, few studies have explored the association between IR and biological age (BA). The HOMA-IR value is a useful indicator of the extent of IR. This cross- ... ...

Abstract	Abstract Background Insulin resistance (IR) had been reported to be associated with age; however, few studies have explored the association between IR and biological age (BA). The HOMA-IR value is a useful indicator of the extent of IR. This cross-sectional study is to explore the relationship between HOMA-IR and BA/advanced aging in the US population. Methods This study is a cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) data. The survey comprised 12,266 people from the NHANES, and their full HOMA-IR data as well as BA data were extracted. Four multiple linear regressions were performed to analyze the association between HOMA-IR and BA, and four multiple logistic regression models were performed to analyze the association between HOMA-IR and advanced aging. In addition, trend tests and stratified analysis were performed and smoothed fitted curves were plotted to test the robustness of the results. Results HOMA-IR was positively correlated with BA [β: 0.51 (0.39, 0.63)], and it was the same to advanced aging [OR: 1.05 (1.02, 1.07)], and both showed a monotonically increasing trend. The trend tests showed that the results were stable (all P for trend < 0.0001). The smoothed fitted curves showed that there were non-linear relationships between HOMA-IR and BA/advanced aging. And the stratified analysis indicated that the relationship between HOMA-IR and BA/advanced aging remained robust in all subgroups. Conclusion The study suggested that HOMA-IR is positively correlated with BA and advanced aging in the US adult population, with a monotonic upward trend. This is a new finding to reveal the relationship between HOMA-IR and age from new standpoint of BA rather than chronological age (CA). And it may contribute to a better understanding of human health aging and may aid future research in this field.
Keywords	HOMA-IR ; Biological age ; Advanced aging ; Cross-sectional study ; NHANES ; Medicine ; R
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multi-material Additive Manufacturing of Metamaterials with Giant, Tailorable Negative Poisson’s Ratios

Da Chen / Xiaoyu Zheng

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 8

Abstract: Abstract Nature has evolved with a recurring strategy to achieve unusual mechanical properties through coupling variable elastic moduli from a few GPa to below KPa within a single tissue. The ability to produce multi-material, three-dimensional (3D) ... ...

Abstract	Abstract Nature has evolved with a recurring strategy to achieve unusual mechanical properties through coupling variable elastic moduli from a few GPa to below KPa within a single tissue. The ability to produce multi-material, three-dimensional (3D) micro-architectures with high fidelity incorporating dissimilar components has been a major challenge in man-made materials. Here we show multi-modulus metamaterials whose architectural element is comprised of encoded elasticity ranging from rigid to soft. We found that, in contrast to ordinary architected materials whose negative Poisson’s ratio is dictated by their geometry, these type of metamaterials are capable of displaying Poisson’s ratios from extreme negative to zero, independent of their 3D micro-architecture. The resulting low density metamaterials is capable of achieving functionally graded, distributed strain amplification capabilities within the metamaterial with uniform micro-architectures. Simultaneous tuning of Poisson’s ratio and moduli within the 3D multi-materials could open up a broad array of material by design applications ranging from flexible armor, artificial muscles, to actuators and bio-mimetic materials.
Keywords	Medicine ; R ; Science ; Q
Subject code	621
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Acquiring momentum

Xiaoyu Zheng / Peter Palffy-Muhoray

New Journal of Physics, Vol 20, Iss 8, p

simple strategies by simple objects

2018 Volume 081001

Keywords	momentum ; transfer ; gain ; chains ; fountain ; Science ; Q ; Physics ; QC1-999
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	IOP Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Coal Resource Security Assessment in China

Yuexiang Yang / Xiaoyu Zheng / Zhen Sun

Sustainability, Vol 12, Iss 6, p

A Study Using Entropy-Weight-Based TOPSIS and BP Neural Network

2020 Volume 2294

Abstract: Energy security has become a worldwide issue in recent years. Coal resources security (CRS), an important part of energy security, has been an emerging concern in many countries, due to the diminishing fossil energy reserve and unbalanced energy ... ...

Abstract	Energy security has become a worldwide issue in recent years. Coal resources security (CRS), an important part of energy security, has been an emerging concern in many countries, due to the diminishing fossil energy reserve and unbalanced energy structure. However, there is no universally agreed method of constructing indicator system for CRS assessment. Subjectivity in the process of evaluation also affects the results of assessment. Moreover, CRS is a complex system that should be evaluated scientifically under diverse methods. Therefore, we constructed an indicator system and evaluation model of CRS and used a case study of China and 31 provinces in its mainland to evaluate CRS at both national and provincial levels. The indicator system included two subsystems—long-term CRS and short-term CRS. We also chose a few elements and factors that are consistent with China’s reality. Different research methods were used: the entropy-weight-based TOPSIS (Technique for Order Preference by Similarity to an Ideal Solution) method is applied to evaluate the degree of CRS, which avoids the subjectivity of weight determination and reflects the relative merit of each indicator; the BP (Back-Propagation) Neural Network method is used to analyze the sensitivity of CRS to each index. The results show that the national level of CRS dropped in the early years but slowly picked up with the help of government intervention. Investment in coal industry development resulted in the immediate effect of improving CRS. The positive impact of maintaining environmental sustainability is stable over either the short, medium, or long term. The degrees of CRS vary significantly across provinces, even between those with similar coal stock levels. Extra attention should be paid to the transportation of coal resources among provinces and intervention to balance supply and demand within the regions.
Keywords	entropy-weight-based topsis ; bp neural network ; coal resources security ; indicator system of evaluation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	120
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Revealing spatiotemporal travel demand and community structure characteristics with taxi trip data

Chen Xie / Dexin Yu / Xiaoyu Zheng / Zhuorui Wang / Zhongtai Jiang

PLoS ONE, Vol 16, Iss

A case study of New York City

2021 Volume 11

Abstract: Urban traffic demand distribution is dynamic in both space and time. A thorough analysis of individuals’ travel patterns can effectively reflect the dynamics of a city. This study aims to develop an analytical framework to explore the spatiotemporal ... ...

Abstract	Urban traffic demand distribution is dynamic in both space and time. A thorough analysis of individuals’ travel patterns can effectively reflect the dynamics of a city. This study aims to develop an analytical framework to explore the spatiotemporal traffic demand and the characteristics of the community structure shaped by travel, which is analyzed empirically in New York City. It uses spatial statistics and graph-based approaches to quantify travel behaviors and generate previously unobtainable insights. Specifically, people primarily travel for commuting on weekdays and entertainment on weekends. On weekdays, people tend to arrive in the financial and commercial areas in the morning, and the functions of zones arrived in the evening are more diversified. While on weekends, people are more likely to arrive at parks and department stores during the daytime and theaters at night. These hotspots show positive spatial autocorrelation at a significance level of p = 0.001. In addition, the travel flow at different peak times form relatively stable community structures, we find interesting phenomena through the complex network theory: 1) Every community has a very small number of taxi zones (TZs) with a large number of passengers, and the weighted degree of TZs in the community follows power-law distribution; 2) As the importance of TZs increases, their interaction intensity within the community gradually increases, or increases and then decreases. In other words, the formation of a community is determined by the key TZs with numerous traffic demands, but these TZs may have limited connection with the community in which they are located. The proposed analytical framework and results provide practical insights for urban and transportation planning.
Keywords	Medicine ; R ; Science ; Q
Subject code	380
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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