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  1. Article ; Online: Possible effects of Treponema pallidum infection on human vascular endothelial cells.

    Xie, Bibo / Zhao, Tie / Zhao, Sisi / Zhou, Jie / Zhao, Feijun

    Journal of clinical laboratory analysis

    2022  Volume 36, Issue 4, Page(s) e24318

    Abstract: Pathogens can affect host cells in various ways, and the same effect can be found in the Treponema pallidum acting on the endothelium of host vessels, and the mechanism is often complex and multiple. Based on the existing T. pallidum of a cognitive ... ...

    Abstract Pathogens can affect host cells in various ways, and the same effect can be found in the Treponema pallidum acting on the endothelium of host vessels, and the mechanism is often complex and multiple. Based on the existing T. pallidum of a cognitive framework, the first concerns involving T. pallidum or the bacteria protein directly acted on vascular endothelial cells of the host, the second concerns mainly involved in the process of T. pallidum infection in vivo blood lipid change, secretion of cytokines and the interactions between immune cells indirectly. Through both direct and indirect influence, this study explores the role of host by T. pallidum infect in the process of the vascular endothelium.
    MeSH term(s) Endothelial Cells ; Endothelium, Vascular ; Globus Pallidus ; Humans ; Syphilis ; Treponema ; Treponema pallidum
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.24318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2471: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Insight into the invasion process and immune-protective evaluation of Tp0971, a membrane lipoprotein from

    Zhang, Xiaohong / Duan, Junxia / Wang, Yali / Xie, Bibo / Zhou, Jie / Zhao, Sisi / Yin, Weiguo / Liu, Peng / Zhao, Feijun

    Microbiology spectrum

    2023  Volume 11, Issue 6, Page(s) e0004723

    Abstract: Importance: The past two decades have seen a worldwide resurgence in infections caused ... ...

    Abstract Importance: The past two decades have seen a worldwide resurgence in infections caused by
    MeSH term(s) Animals ; Humans ; Treponema pallidum/genetics ; Syphilis/prevention & control ; Spirochaetales ; Lipoproteins ; Vaccines
    Chemical Substances Lipoproteins ; Vaccines
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00047-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry.

    Sang, Xudong / Gan, Tian / Ge, Gai / Li, Dan / Mei, Youming / Pan, Chun / Long, Siyu / Xie, Bibo / Yu, Xiaobing / Chen, Zhiming / Wang, Hongsheng

    Journal of immunology research

    2024  Volume 2024, Page(s) 9927964

    Abstract: Background: Psoriasis, a systemic disorder mediated by the immune system, can appear on the skin, joints, or both. Individuals with cutaneous psoriasis (PsC) have an elevated risk of developing psoriatic arthritis (PsA) during their lifetime. Despite ... ...

    Abstract Background: Psoriasis, a systemic disorder mediated by the immune system, can appear on the skin, joints, or both. Individuals with cutaneous psoriasis (PsC) have an elevated risk of developing psoriatic arthritis (PsA) during their lifetime. Despite this known association, the cellular and molecular mechanisms underlying this progression remain unclear.
    Methods: We performed high-dimensional, in-depth immunophenotyping of peripheral blood mononuclear cells (PBMCs) in patients with PsA and psoriasis vulgaris (PsV) by mass cytometry. Blood samples were collected before and after therapy for a longitudinal study. Then three sets of comparisons were made here: active PsA
    Results: Marked differences were observed in multiple lymphocyte subsets of PsA related to PsV, with expansion of CD4
    Conclusion: In the circulation of PsA patients, the T
    MeSH term(s) Humans ; Arthritis, Psoriatic/diagnosis ; Longitudinal Studies ; Leukocytes, Mononuclear ; CD28 Antigens ; Psoriasis/diagnosis
    Chemical Substances CD28 Antigens
    Language English
    Publishing date 2024-04-01
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-7156
    ISSN (online) 2314-7156
    ISSN 2314-7156
    DOI 10.1155/2024/9927964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Research status and perspectives for pathogenic spirochete vaccines.

    Duan, Junxia / Zhao, Yue / Zhang, Xiaohong / Jiang, Han / Xie, Bibo / Zhao, Tie / Zhao, Feijun

    Clinica chimica acta; international journal of clinical chemistry

    2020  Volume 507, Page(s) 117–124

    Abstract: Leptospira interrogans, Borrelia burgdorferi, and Treponema pallidum are important pathogenic spirochetes. The incidence of human diseases caused by pathogenic spirochetes, e.g., leptospirosis, Lyme disease, and syphilis, has been recently increased, ... ...

    Abstract Leptospira interrogans, Borrelia burgdorferi, and Treponema pallidum are important pathogenic spirochetes. The incidence of human diseases caused by pathogenic spirochetes, e.g., leptospirosis, Lyme disease, and syphilis, has been recently increased, posing a threat to public health. Mechanisms of spirochete pathogenicity are not yet fully understood, and no safe and effective vaccine to prevent and control the infection by pathogenic spirochetes is currently available. In this article, we review the progress of research into the pathogenic spirochete vaccine, mainly in terms of vaccine types. The development of relevant vaccines against pathogenic spirochetes has generally proceeded via several stages, such as the whole-cell inactivated vaccine, live attenuated vaccine, and gene-engineered vaccine, and will likely enter a new stage with the application of gene editing technology. In this review, we mainly summarized the types of pathogenic spirochete vaccines and conducted a preliminary analysis on the protective effect of immunity, and proposed a further prospect for the development of pathogenic spirochete vaccines.
    MeSH term(s) Bacterial Vaccines/genetics ; Bacterial Vaccines/immunology ; Genetic Engineering ; Spirochaetaceae/immunology ; Vaccines, Attenuated/immunology
    Chemical Substances Bacterial Vaccines ; Vaccines, Attenuated
    Language English
    Publishing date 2020-04-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2020.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.173: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Mycobacterium marseillense Infection in Human Skin, China, 2018.

    Xie, Bibo / Chen, Yanqing / Wang, Jian / Gao, Wei / Jiang, Haiqing / Sun, Jiya / Jin, Xindong / Sang, Xudong / Yu, Xiaobing / Wang, Hongsheng

    Emerging infectious diseases

    2019  Volume 25, Issue 10, Page(s) 1991–1993

    Abstract: We describe a case of facial skin infection and sinusitis caused by Mycobacterium marseillense in an immunocompetent woman in China in 2018. The infection was cleared with clarithromycin, moxifloxacin, and amikacin. Antimicrobial drug treatments could ... ...

    Abstract We describe a case of facial skin infection and sinusitis caused by Mycobacterium marseillense in an immunocompetent woman in China in 2018. The infection was cleared with clarithromycin, moxifloxacin, and amikacin. Antimicrobial drug treatments could not be predicted by genetic analyses; further genetic characterization would be required to do so.
    MeSH term(s) China/epidemiology ; Face ; Female ; Humans ; Middle Aged ; Mycobacterium/genetics ; Mycobacterium Infections/diagnosis ; Mycobacterium Infections/epidemiology ; Mycobacterium Infections/microbiology ; Mycobacterium Infections/pathology ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Skin/microbiology ; Skin/pathology ; Skin Diseases, Bacterial/diagnosis ; Skin Diseases, Bacterial/epidemiology ; Skin Diseases, Bacterial/microbiology ; Skin Diseases, Bacterial/pathology
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2019-09-19
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2510.190695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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