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Article ; Online: Human Resource Data Integration System Based on Artificial Intelligence Environment.

Xie, Fei

Journal of environmental and public health

2022 Volume 2022, Page(s) 1650583

Abstract: In an AI environment, this article suggests an HR data integration system based on a hidden semantic model to address the low integration of HR raw data. It provides a decision-making framework for enterprise personnel recruitment and employee training ... ...

Abstract	In an AI environment, this article suggests an HR data integration system based on a hidden semantic model to address the low integration of HR raw data. It provides a decision-making framework for enterprise personnel recruitment and employee training by making predictions and analyses based on HR information. The basis for the HR data integration model base is established in this article, along with its construction principle, process, and model types. Based on this, a method for creating an HR data integration system that has a straightforward modeling process, an easy solution, high prediction accuracy, verifiability, and correction is chosen. An HR recommendation algorithm combining a hidden semantic model and a deep forest model is proposed. At the same time, preprocess HR data and create a data warehouse. According to experiments, this system's stability can reach a maximum of 95.84 percent and its efficiency in integrating HR data can reach 96.37 percent. The system operates with ease and consistently delivers superior performance. It can more effectively realize the fusion and mining of HR data and offer practical services for related work.
MeSH term(s)	Artificial Intelligence ; Humans ; Workforce
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9813
ISSN (online)	1687-9813
ISSN	1687-9813
DOI	10.1155/2022/1650583
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: In vitro evaluation of PET radiotracers reflecting multidimensionality of Alzheimer's disease: building more roadmaps for clinical translation.

He, Yingfang / Xie, Fang

American journal of nuclear medicine and molecular imaging

2024 Volume 14, Issue 1, Page(s) 78–81

Abstract: In the current issue of American Journal of Nuclear Medicine and Molecular Imaging, Vasdev et al. presented a work entitled "In Vitro Evaluation of PET Radiotracers for Imaging Synaptic Density, the Acetylcholine Transporter, AMPA-tarp-γ8 and Muscarinic ... ...

Abstract	In the current issue of American Journal of Nuclear Medicine and Molecular Imaging, Vasdev et al. presented a work entitled "In Vitro Evaluation of PET Radiotracers for Imaging Synaptic Density, the Acetylcholine Transporter, AMPA-tarp-γ8 and Muscarinic M4 receptors in Alzheimer's disease". In which, in vitro autoradiography studies using radioligands were employed as a valuable tool to gain more insights for potential clinical translation. In this invited perspective, we would like to briefly introduce the current state of AD diagnosis, especially PET imaging on synapse, and highlight the advances of PET imaging in pre-clinic and clinic that might assist on precise therapy in the future.
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Editorial
ZDB-ID	2623515-8
ISSN	2160-8407
ISSN	2160-8407
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Article ; Online: SOX4 silencing alleviates renal injury in rats with acute renal failure by inhibiting the NF-κB signaling pathway and reducing apoptosis and oxidative stress.

Xie, Fengyan / Xu, Min

Journal of biochemical and molecular toxicology

2024 Volume 38, Issue 4, Page(s) e23703

Abstract: Acute renal failure (ARF) is a huge threat to the lives of most patients in intensive care units, and there is currently no satisfactory treatment strategy. SRY-box transcription factor 4 (SOX4) plays a key role in the development of various diseases, ... ...

Abstract	Acute renal failure (ARF) is a huge threat to the lives of most patients in intensive care units, and there is currently no satisfactory treatment strategy. SRY-box transcription factor 4 (SOX4) plays a key role in the development of various diseases, but its effect on ARF is unknown. Therefore, this study aimed to explore the relationship between SOX4 and ARF. Blood samples were collected from 20 ARF patients and 20 healthy volunteers. We also established an ARF rat model by excising the right kidney and ligating the left renal artery, and SOX4 knockdown in ARF rats was achieved down by means of lentiviral infection. Subsequently, we used quantitative polymerase chain reaction and western bolt assays to detect the expression levels of SOX4 and nuclear factor-κB (NF-κB) signaling pathway-related proteins in human blood or rat renal tissue and hematoxylin and eosin and terminal deoxynucleotidyl transferase (TdT) 2'-deoxyuridine 5'-triphosphate (dUTP) nick-end labeling staining to observe the pathological changes and apoptosis of renal tissue. Enzyme-linked immunosorbent assay and biochemical kits were used to measure the levels of renal function-related indicators (blood urea nitrogen, creatinine, and neutrophil gelatinase-associated lipocalin) and inflammatory factors (interleukin [IL]-1β, IL-6, and tumor necrosis factor-alpha), as well as changes in oxidative stress-related indicators (malondialdehyde [MDA], superoxide dismutase [SOD], and reactive oxygen species [ROS]) in rat serum. SOX4 expression levels in blood samples from ARF patients and renal tissue from ARF rats were significantly higher compared with those in healthy volunteers and control rats, respectively. ARF model rats displayed the typical ARF phenotype, while SOX4 silencing significantly improved pathological injury and apoptosis of renal tissue in ARF rats. Moreover, SOX4 silencing significantly inhibited increased levels of renal function-related indicators and inflammatory factors and reduced the level of excessive oxidative stress (MDA and ROS were upregulated, and SOD was downregulated) in ARF rats. SOX4 also reduced the activity of the NF-κB signaling pathway in ARF samples. Thus, SOX4 knockdown may reduce oxidative stress, the inflammatory response, and apoptosis by reducing the activity of the NF-κB signaling pathway, thereby improving renal injury in ARF rats.
MeSH term(s)	Animals ; Humans ; Rats ; Acute Kidney Injury/metabolism ; Apoptosis ; Kidney ; NF-kappa B/metabolism ; Oxidative Stress ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Signal Transduction ; SOXC Transcription Factors/genetics ; SOXC Transcription Factors/metabolism ; Superoxide Dismutase/metabolism
Chemical Substances	NF-kappa B ; Reactive Oxygen Species ; SOX4 protein, human ; SOXC Transcription Factors ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1410020-4
ISSN	1099-0461 ; 1095-6670
ISSN (online)	1099-0461
ISSN	1095-6670
DOI	10.1002/jbt.23703
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Article: A Study on Chinese EFL Teachers' Work Engagement: The Predictability Power of Emotion Regulation and Teacher Resilience.

Xie, Fei

Frontiers in psychology

2021 Volume 12, Page(s) 735969

Abstract: Employing a sequential mixed-methods design, the current study examined the role of Chinese EFL teachers' emotion regulation and resilience in predicting their work engagement. To this end, 314 Chinese EFL teachers with various academic degrees and ... ...

Abstract	Employing a sequential mixed-methods design, the current study examined the role of Chinese EFL teachers' emotion regulation and resilience in predicting their work engagement. To this end, 314 Chinese EFL teachers with various academic degrees and teaching experiences were opted from different schools, institutes, and universities of China. To obtain the quantitative data, Utrecht Work Engagement Scale (UWES), Connor-Davidson Resilience Scale (CD-RISC), and Emotion Regulation Questionnaire (ERQ) were electronically distributed among participants. Performing correlational analyses, a strong association was found between teacher resilience and work engagement. The inspection of the correlations also revealed a moderate correlation between cognitive reappraisal and resilience as well as cognitive reappraisal and work engagement. To probe the predictability power of teacher resilience and emotion regulation (cognitive reappraisal), structural equation modeling (SEM) was performed. The results of the SEM analysis demonstrated that Chinese EFL teachers' work engagement was predicted significantly and favorably by their resilience. Using semi-structured interviews, some qualitative data were also collected to fully understand Chinese EFL teachers' perceptions of work engagement. The thematic analysis (TA) of Chinese EFL teachers' responses to interview questions resulted in two main themes and 14 sub-themes, revealing extrinsic and intrinsic factors contributing to teaching engagement. The findings of TA illuminated that both personal resources and job resources can predict teaching engagement. The pedagogical implications for administrators and teacher trainers are further discussed.
Language	English
Publishing date	2021-08-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.735969
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Article ; Online: ASH2L, Core Subunit of H3K4 Methylation Complex, Regulates Amelogenesis.

Zhu, X / Ma, Z / Xie, F / Wang, J

Journal of dental research

2023 Volume 103, Issue 1, Page(s) 81–90

Abstract: Histone methylation assumes a crucial role in the intricate process of enamel development. Our study has illuminated the substantial prevalence of H3K4me3 distribution, spanning from the cap stage to the late bell stage of dental germs. In order to delve ...

Abstract	Histone methylation assumes a crucial role in the intricate process of enamel development. Our study has illuminated the substantial prevalence of H3K4me3 distribution, spanning from the cap stage to the late bell stage of dental germs. In order to delve into the role of H3K4me3 modification in amelogenesis and unravel the underlying mechanisms, we performed a conditional knockout of
MeSH term(s)	Animals ; Mice ; Ameloblasts/metabolism ; Amelogenesis/genetics ; Dental Enamel/metabolism ; Dental Enamel Proteins/genetics ; Dental Enamel Proteins/metabolism ; Methylation ; Mice, Knockout
Chemical Substances	Dental Enamel Proteins ; Ash2l protein, mouse
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/00220345231207309
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Ul III Zs.75: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Sponsorship bias in oncology cost effectiveness analysis.

Zhou, Ting / Xie, Feng

Journal of clinical epidemiology

2023 Volume 156, Page(s) 22–29

Abstract: Objectives: Cost effectiveness analysis (CEA) has been increasingly used to inform cancer treatment coverage policy making worldwide. The primary objective of this study was to assess the association between industry sponsorship and CEA results in ... ...

Abstract	Objectives: Cost effectiveness analysis (CEA) has been increasingly used to inform cancer treatment coverage policy making worldwide. The primary objective of this study was to assess the association between industry sponsorship and CEA results in oncology. Study design and setting: All CEAs in oncology used incremental cost per quality-adjusted life year (QALY) as health effect identified from the Tufts CEA Registry since 1976 was analyzed. Descriptive analyses were performed to present and compare the characteristics of CEA funded by industry and non-industry. Robust logistic regression was performed to assess the relationship between the industry sponsorship and cost effective conclusion over a wide range of threshold values. Results: A total of 1537 CEAs in oncology published from 1976 to 2021 were included. There were 387 (25.2%) with the industry sponsorship. CEAs sponsored by the industry were more likely to report ICERs below $50,000/QALY (adjusted odds ratio (OR), 1.91, 95% confidence interval (CI), 1.45-2.51, P < 0.001), $100,000/QALY (2.74, 1.98-3.79, P < 0.001), and $150,000/QALY (3.53, 2.37-5.27, P < 0.001) than studies without industry sponsorship. Conclusions: Our study suggests that there has been a significant sponsorship bias in CEAs in oncology. This bias could have a profound implication on drug pricing and coverage policy making.
MeSH term(s)	Humans ; Cost-Effectiveness Analysis ; Bias ; Quality-Adjusted Life Years ; Industry ; Research Report ; Cost-Benefit Analysis
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2023.02.011
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Article ; Online: Collection on molecular imaging in neurodegeneration.

Xie, Fang / Ni, Ruiqing

European journal of nuclear medicine and molecular imaging

2023 Volume 50, Issue 11, Page(s) 3166–3167

Language	English
Publishing date	2023-07-21
Publishing country	Germany
Document type	Editorial
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-023-06347-5
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Article ; Online: Spatially Confined Nanoreactors Designed for Biological Applications.

Wang, Yating / Xie, Fengjuan / Zhao, Liang

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2310331

Abstract: The applications of nanoreactors in biology are becoming increasingly significant and prominent. Specifically, nanoreactors with spatially confined, due to their exquisite design that effectively limits the spatial range of biomolecules, attracted ... ...

Abstract	The applications of nanoreactors in biology are becoming increasingly significant and prominent. Specifically, nanoreactors with spatially confined, due to their exquisite design that effectively limits the spatial range of biomolecules, attracted widespread attention. The main advantage of this structure is designed to improve reaction selectivity and efficiency by accumulating reactants and catalysts within the chambers, thus increasing the frequency of collisions between reactants. Herein, the recent progress in the synthesis of spatially confined nanoreactors and their biological applications is summarized, covering various kinds of nanoreactors, including porous inorganic materials, porous crystalline materials with organic components and self-assembled polymers to construct nanoreactors. These design principles underscore how precise reaction control could be achieved by adjusting the structure and composition of the nanoreactors to create spatial confined. Furthermore, various applications of spatially confined nanoreactors are demonstrated in the biological fields, such as biocatalysis, molecular detection, drug delivery, and cancer therapy. These applications showcase the potential prospects of spatially confined nanoreactors, offering robust guidance for future research and innovation.
Language	English
Publishing date	2024-01-06
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202310331
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Article: A Meta-analysis of the Effect of Noninvasive Brain Stimulation on Dysphagia in Patients with Cerebral Stroke.

Guo, Jie / Chen, Chunying / Xie, Fei

Alternative therapies in health and medicine

2024

Abstract: The objective of this study is to assess the efficacy of non-invasive brain stimulation (NIBS) in preventing and treating dysphagia in patients who have experienced a cerebral stroke (CS). Both Chinese and international guidelines for the management of ... ...

Abstract	The objective of this study is to assess the efficacy of non-invasive brain stimulation (NIBS) in preventing and treating dysphagia in patients who have experienced a cerebral stroke (CS). Both Chinese and international guidelines for the management of dysphagia resulting from CS mention various non-pharmacological treatments, such as acupuncture, mechanical myoelectric stimulation, and NIBS. However, due to limited evidence, these treatments are often suggested as measures rather than interventions. Therefore, this study assesses the impact of NIBS on the severity and improvement of dysphagia in CS patients. The researchers provide evidence-based recommendations for clinical practice by conducting a comprehensive literature review and meta-analysis. The researchers analyze the impact of NIBS on the severity of dysphagia and its overall improvement in CS patients. Employing a systematic computer-based search, the researchers retrieved randomized controlled trials and cohort studies published between the inception of relevant databases and December 1, 2022, about the utilization of NIBS in managing dysphagia in CS patients. This effort included nine articles for meta-analysis, with sample sizes ranging from 14 to 59, allowing an assessment of the effectiveness of NIBS in CS patients. The analysis revealed a mean difference (MD) score of 1.05 in the NIBS studies for the prevention and treatment of dysphagia severity in stroke patients, indicating a notable alleviation of dysphagia severity in CS patients through NIBS. The MD for the dysphagia score was also 1.05, and the MD for the functional dysphagia score was 1.78, suggesting that NIBS provided relief from dysphagia in CS patients. In summary, this meta-analysis thoroughly evaluated NIBS efficacy in CS patients and provided evidence-based recommendations for clinical practice. Future research needs to collect additional indicators to elucidate the nuances of various interventions, contributing to a more robust theoretical foundation for clinical therapy.
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: CDKN2B-AS1 may act as miR-92a-3p sponge in coronary artery disease.

Xie, Fei / Wang, Dan / Cheng, Ming

Minerva cardiology and angiology

2024 Volume 72, Issue 2, Page(s) 125–133

Abstract: Background: LncRNAs, miRNAs, and the sponge effect between them exert diverse biological influences on the pathogenesis and progression of coronary artery disease (CAD), thus necessitating an exploration of the lncRNA-miRNA-gene regulatory network in ... ...

Abstract	Background: LncRNAs, miRNAs, and the sponge effect between them exert diverse biological influences on the pathogenesis and progression of coronary artery disease (CAD), thus necessitating an exploration of the lncRNA-miRNA-gene regulatory network in CAD. Methods: Expression profile GSE98583 was obtained from NCBI, containing the data of 12 CAD patients and 6 controls. Limma package was utilized to determine the differentially expressed genes (DEGs). Functional enrichment analysis was performed by DAVID. The CAD-related miRNA-DEG associations were retrieved via HMDD and miRTarBase, and the CAD-related lncRNA-miRNA associations were retrieved via LncRNADisease and starBase. The CAD-related lncRNA-miRNA-DEG regulatory network was constructed by combining these associations. The dual luciferase test was carried out to validate the connections among lncRNA, miRNA, and gene. Results: Overall, 534 DEGs were identified between CAD samples and controls, including 243 up-regulated and 291 down-regulated, and were enriched in various gene ontology biological processes and KEGG pathways. The CAD-related miRNAs targeting DEGs included hsa-miR-206, has-miR-320b, has-miR-4513, has-miR-765, and has-miR-92a-3p, and hsa-miR-92a-3p regulated the most DEGs. In the lncRNA-miRNA associations, only CDKN2B-AS1 regulated the CAD-related miRNA, hsa-miR-92a-3p, which was validated using the dual luciferase test. Conclusions: CDKN2B-AS1 may act as an hsa-miR-92a-3p sponge to regulate the downstream DEGs in CAD. CDKN2B-AS1/ hsa-miR-92a-3p/GATA2 might be a novel mechanism for CAD.
MeSH term(s)	Humans ; Coronary Artery Disease/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; MicroRNAs/genetics ; Gene Regulatory Networks ; Luciferases/genetics
Chemical Substances	RNA, Long Noncoding ; MicroRNAs ; Luciferases (EC 1.13.12.-) ; MIRN206 microRNA, human ; MIRN-4513 microRNA, human ; MIRN765 microRNA, human
Language	English
Publishing date	2024-01-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3059238-0
ISSN	2724-5772
ISSN (online)	2724-5772
DOI	10.23736/S2724-5683.23.06441-4
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