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  1. Article ; Online: Spatially Confined Nanoreactors Designed for Biological Applications.

    Wang, Yating / Xie, Fengjuan / Zhao, Liang

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2310331

    Abstract: The applications of nanoreactors in biology are becoming increasingly significant and prominent. Specifically, nanoreactors with spatially confined, due to their exquisite design that effectively limits the spatial range of biomolecules, attracted ... ...

    Abstract The applications of nanoreactors in biology are becoming increasingly significant and prominent. Specifically, nanoreactors with spatially confined, due to their exquisite design that effectively limits the spatial range of biomolecules, attracted widespread attention. The main advantage of this structure is designed to improve reaction selectivity and efficiency by accumulating reactants and catalysts within the chambers, thus increasing the frequency of collisions between reactants. Herein, the recent progress in the synthesis of spatially confined nanoreactors and their biological applications is summarized, covering various kinds of nanoreactors, including porous inorganic materials, porous crystalline materials with organic components and self-assembled polymers to construct nanoreactors. These design principles underscore how precise reaction control could be achieved by adjusting the structure and composition of the nanoreactors to create spatial confined. Furthermore, various applications of spatially confined nanoreactors are demonstrated in the biological fields, such as biocatalysis, molecular detection, drug delivery, and cancer therapy. These applications showcase the potential prospects of spatially confined nanoreactors, offering robust guidance for future research and innovation.
    Language English
    Publishing date 2024-01-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202310331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Self-assembly of Peptide dendrimers and their bio-applications in theranostics.

    Xie, Fengjuan / Li, Rongxin / Shu, Weikang / Zhao, Liang / Wan, Jingjing

    Materials today. Bio

    2022  Volume 14, Page(s) 100239

    Abstract: Nanotechnology has brought revolutionized advances in disease diagnosis and therapy. Self-assembled peptide dendrimers own novel physicochemical properties through the synergistic effects of the polypeptide chain, dendrimer and nano-structure, exhibiting ...

    Abstract Nanotechnology has brought revolutionized advances in disease diagnosis and therapy. Self-assembled peptide dendrimers own novel physicochemical properties through the synergistic effects of the polypeptide chain, dendrimer and nano-structure, exhibiting great potential in theranostic. This review provides comprehensive insights into various peptide dendrimers for self-assembly. Their nanosize, morphology and composition are presented to understand self-assembly behaviors precisely. We further introduce the emerging theranostic applications based on specific imaging and efficient delivery recently.
    Language English
    Publishing date 2022-03-08
    Publishing country England
    Document type Journal Article
    ISSN 2590-0064
    ISSN (online) 2590-0064
    DOI 10.1016/j.mtbio.2022.100239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity.

    Xie, Fengjuan / Lin, Yingying / Andersson, Åsa / Vetter, Irina / Zhao, Liang / Wan, JingJing

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 93, Page(s) 13855–13858

    Abstract: Herein, we designed alkylated lysine-dendron oxytocin amphiphiles (ALOAs) 1G-OTK and 2G-OTK, which were self-assembled into spherical nanoparticles and nanostrips, respectively, and showed superior stability compared to native oxytocin. We found similar ... ...

    Abstract Herein, we designed alkylated lysine-dendron oxytocin amphiphiles (ALOAs) 1G-OTK and 2G-OTK, which were self-assembled into spherical nanoparticles and nanostrips, respectively, and showed superior stability compared to native oxytocin. We found similar trends in the functional activity of ALOAs and native OT for human oxytocin receptor. This work may inspire the development of peptide drugs for clinical applications.
    MeSH term(s) Humans ; Oxytocin/pharmacology ; Dendrimers/pharmacology ; Lysine ; Receptors, Oxytocin ; Nanoparticles
    Chemical Substances Oxytocin (50-56-6) ; Dendrimers ; Lysine (K3Z4F929H6) ; Receptors, Oxytocin
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc03801g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Designing Peptide-Based Nanoinhibitors of Programmed Cell Death Ligand 1 (PD-L1) for Enhanced Chemo-immunotherapy.

    Xie, Fengjuan / Tang, Shasha / Zhang, Ye / Zhao, Yinbing / Lin, Yingying / Yao, Yining / Wang, Meiyan / Gu, Zhengying / Wan, Jingjing

    ACS nano

    2024  Volume 18, Issue 2, Page(s) 1690–1701

    Abstract: The combination of immune checkpoint blockade (ICB) and chemotherapy has shown significant potential in the clinical treatment of various cancers. However, circulating regeneration of PD-L1 within tumor cells greatly limits the efficiency of chemo- ... ...

    Abstract The combination of immune checkpoint blockade (ICB) and chemotherapy has shown significant potential in the clinical treatment of various cancers. However, circulating regeneration of PD-L1 within tumor cells greatly limits the efficiency of chemo-immunotherapy and consequent patient response rates. Herein, we report the synthesis of a nanoparticle-based PD-L1 inhibitor (FRS) with a rational design for effective endogenous PD-L1 suppression. The nanoinhibitor is achieved through self-assembly of fluoroalkylated competitive peptides that target PD-L1 palmitoylation. The FRS nanoparticles provide efficient protection and delivery of functional peptides to the cytoplasm of tumors, showing greater inhibition of PD-L1 than nonfluorinated peptidic inhibitors. Moreover, we demonstrate that FRS synergizes with chemotherapeutic doxorubicin (DOX) to boost the antitumor activities via simultaneous reduction of PD-L1 abundance and induction of immunogenic cell death in murine colon tumor models. The nano strategy of PD-L1 regulation present in this study is expected to advance the development of ICB inhibitors and overcome the limitations of conventional ICB-assisted chemo-immunotherapy.
    MeSH term(s) Humans ; Animals ; Mice ; B7-H1 Antigen ; Ligands ; Immunotherapy ; Apoptosis ; Peptides/pharmacology ; Cell Line, Tumor
    Chemical Substances B7-H1 Antigen ; Ligands ; Peptides
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c09968
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  5. Article ; Online: Dendrimer-Modified Silica Nanoparticles for Efficient Enrichment of Low-Concentration Peptides.

    Qu, Chengxue / Shu, Weikang / Xie, Fengjuan / Liu, Yang / Li, Rongxin / Pei, Congcong / Wan, Jingjing

    Applied biochemistry and biotechnology

    2022  Volume 194, Issue 8, Page(s) 3419–3434

    Abstract: Peptide profiling based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is of particular interest as it can provide physiologically and pathologically related information of the bio-samples. Due to the ... ...

    Abstract Peptide profiling based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is of particular interest as it can provide physiologically and pathologically related information of the bio-samples. Due to the complexity of real biological samples, MALDI-TOF MS-based peptide mapping methods rely strongly on particular enrichment methods to improve the signal intensity. This paper introduces third-generation dendrimer-modified SBA-15 with the surface functionalization of amino and carboxyl group, respectively (denoted as SBA-15/G3-NH
    MeSH term(s) Dendrimers ; Nanoparticles ; Peptides/chemistry ; Silicon Dioxide/chemistry ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
    Chemical Substances Dendrimers ; Peptides ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2022-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-022-03892-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3053: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Dendrimer-Modified Silica Nanoparticles for Efficient Enrichment of Low-Concentration Peptides

    Qu, Chengxue / Shu, Weikang / Xie, Fengjuan / Liu, Yang / Li, Jung-hsin / Pei, Congcong / Wan, Jingjing

    Appl Biochem Biotechnol. 2022 Aug., v. 194, no. 8 p.3419-3434

    2022  

    Abstract: Peptide profiling based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is of particular interest as it can provide physiologically and pathologically related information of the bio-samples. Due to the ... ...

    Abstract Peptide profiling based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is of particular interest as it can provide physiologically and pathologically related information of the bio-samples. Due to the complexity of real biological samples, MALDI-TOF MS-based peptide mapping methods rely strongly on particular enrichment methods to improve the signal intensity. This paper introduces third-generation dendrimer-modified SBA-15 with the surface functionalization of amino and carboxyl group, respectively (denoted as SBA-15/G3-NH₂ and SBA-15/G3-COOH), for the efficient capture of low-abundance peptides. The enrichment ability of the nanocomposites was evaluated by standard peptides digests and real biological samples. The synthesized nanocomposites incorporated the benefit of dendrimers and mesoporous silica nanomaterial SBA-15, showing enhanced peptide enrichment ability. Therefore, this work may provide a new class of nanomaterials for peptide mapping from biological samples.
    Keywords dendrimers ; desorption ; mass spectrometry ; nanocomposites ; nanoparticles ; peptides ; porous media ; silica
    Language English
    Dates of publication 2022-08
    Size p. 3419-3434.
    Publishing place Springer US
    Document type Article ; Online
    ZDB-ID 392344-7
    ISSN 0273-2289
    ISSN 0273-2289
    DOI 10.1007/s12010-022-03892-x
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    In stock of ZB MED Bonn / Germany

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