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  1. Article: Structural Evolution of Polyaluminocarbosilane during the Polymer-Ceramic Conversion Process.

    Xie, Fucheng / Duan, Yangpeng / Mo, Gaoming / Huang, Qing / Huang, Zhengren

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 11

    Abstract: Polyaluminocarbosilane (PACS) is an important precursor for silicon carbide (SiC) fibers and ceramics. The structure of PACS and the oxidative curing, thermal pyrolysis, and sintering effect of Al have already been substantially studied. However, the ... ...

    Abstract Polyaluminocarbosilane (PACS) is an important precursor for silicon carbide (SiC) fibers and ceramics. The structure of PACS and the oxidative curing, thermal pyrolysis, and sintering effect of Al have already been substantially studied. However, the structural evolution of polyaluminocarbosilane itself during the polymer-ceramic conversion process, especially the changes in the structure forms of Al, are still pending questions. In this study, PACS with a higher Al content is synthesized and the above questions are elaborately investigated by FTIR, NMR, Raman, XPS, XRD, and TEM analyses. It is found that up to 800-900 °C the amorphous SiO
    Language English
    Publishing date 2023-06-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16114172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Metabolomics analysis of Xanthoceras sorbifolia husks protection of rats against Alzheimer's disease using liquid chromatography mass spectrometry

    Rong, Weiwei / Ding, Kewen / Guo, Sirui / Xie, Fucheng / Li, Qing / Bi, Kaishun

    Journal of chromatography. 2019 July 29,

    2019  

    Abstract: The promising effect of Xanthoceras sorbifolia Bunge husks against Alzheimer's disease has attracted more and more attention; however, its therapeutic mechanism has been unclear. A metabolomics study of the husks on rat serum and brain was carried out. ... ...

    Abstract The promising effect of Xanthoceras sorbifolia Bunge husks against Alzheimer's disease has attracted more and more attention; however, its therapeutic mechanism has been unclear. A metabolomics study of the husks on rat serum and brain was carried out. Cognitive impairment of rats was induced by D-galactose and amyloid β, and the result was evaluated by Morris water maze test and brain histological analysis. The metabolite profiling was performed through ultra-high-performance liquid chromatography time-of-flight mass spectrometry. Twelve potential biomarkers were identified in the rat serum and nineteen in the brain. All the biomarkers could be classified as amino acids, lipids, purines and bile acids. Both the husk extract and control drug, huperzine A, showed protective effect against the cognitive disorder induced by amyloid β, however, the husk extract exhibited significant effect on more targets, which included arachidonic acid, cholic acid, uric acid and citric acid etc., indicating the regulation of the husks of more pathways including neuroinflammation, energy metabolism and antioxidant ability. Triterpenoid saponins and polyphenols in the husks may contribute to the regulation of these pathways. This comprehensive study revealed the underlying therapeutic mechanism of the husks against Alzheimer's disease; some potential biomarkers for its clinical diagnosis were also provided.
    Keywords Alzheimer disease ; Xanthoceras sorbifolium ; amino acids ; amyloid ; antioxidant activity ; arachidonic acid ; biomarkers ; blood serum ; brain ; cholic acid ; citric acid ; cognitive disorders ; drugs ; energy metabolism ; galactose ; high performance liquid chromatography ; histology ; hulls ; mass spectrometry ; metabolites ; metabolomics ; polyphenols ; protective effect ; rats ; therapeutics ; triterpenoid saponins ; ultra-performance liquid chromatography ; uric acid
    Language English
    Dates of publication 2019-0729
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ISSN 1570-0232
    DOI 10.1016/j.jchromb.2019.121739
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Author Correction: pH-sensitive micelles for the intracellular co-delivery of curcumin and Pluronic L61 unimers for synergistic reversal effect of multidrug resistance.

    Hong, Wei / Shi, Hong / Qiao, Mingxi / Zhang, Zehui / Yang, Wenting / Dong, Lingying / Xie, Fucheng / Zhao, Chunpeng / Kang, Li

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 18061

    Language English
    Publishing date 2021-09-06
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-97676-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Metabolomics analysis of Xanthoceras sorbifolia husks protection of rats against Alzheimer's disease using liquid chromatography mass spectrometry.

    Rong, Weiwei / Ding, Kewen / Guo, Sirui / Xie, Fucheng / Li, Qing / Bi, Kaishun

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2019  Volume 1126-1127, Page(s) 121739

    Abstract: The promising effect of Xanthoceras sorbifolia Bunge husks against Alzheimer's disease has attracted more and more attention; however, its therapeutic mechanism has been unclear. A metabolomics study of the husks on rat serum and brain was carried out. ... ...

    Abstract The promising effect of Xanthoceras sorbifolia Bunge husks against Alzheimer's disease has attracted more and more attention; however, its therapeutic mechanism has been unclear. A metabolomics study of the husks on rat serum and brain was carried out. Cognitive impairment of rats was induced by D-galactose and amyloid β, and the result was evaluated by Morris water maze test and brain histological analysis. The metabolite profiling was performed through ultra-high-performance liquid chromatography time-of-flight mass spectrometry. Twelve potential biomarkers were identified in the rat serum and nineteen in the brain. All the biomarkers could be classified as amino acids, lipids, purines and bile acids. Both the husk extract and control drug, huperzine A, showed protective effect against the cognitive disorder induced by amyloid β, however, the husk extract exhibited significant effect on more targets, which included arachidonic acid, cholic acid, uric acid and citric acid etc., indicating the regulation of the husks of more pathways including neuroinflammation, energy metabolism and antioxidant ability. Triterpenoid saponins and polyphenols in the husks may contribute to the regulation of these pathways. This comprehensive study revealed the underlying therapeutic mechanism of the husks against Alzheimer's disease; some potential biomarkers for its clinical diagnosis were also provided.
    MeSH term(s) Alzheimer Disease/metabolism ; Animals ; Biomarkers/analysis ; Biomarkers/metabolism ; Brain/drug effects ; Brain/metabolism ; Chromatography, High Pressure Liquid ; Male ; Mass Spectrometry ; Maze Learning/drug effects ; Metabolome/drug effects ; Metabolome/physiology ; Metabolomics/methods ; Plant Extracts/pharmacology ; Rats ; Rats, Sprague-Dawley ; Sapindaceae
    Chemical Substances Biomarkers ; Plant Extracts
    Language English
    Publishing date 2019-07-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2019.121739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer's Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway.

    Guo, Sirui / Wang, Jiahong / Xu, Huarong / Rong, Weiwei / Gao, Cheng / Yuan, Ziyue / Xie, Fucheng / Bi, Kaishun / Zhang, Zhou / Li, Qing

    Oxidative medicine and cellular longevity

    2019  Volume 2019, Page(s) 9096409

    Abstract: Alzheimer's disease (AD) is a widespread neurodegenerative disease caused by complicated disease-causing factors. Unsatisfactorily, curative effects of approved anti-AD drugs were not good enough due to their actions on single-target, which led to ... ...

    Abstract Alzheimer's disease (AD) is a widespread neurodegenerative disease caused by complicated disease-causing factors. Unsatisfactorily, curative effects of approved anti-AD drugs were not good enough due to their actions on single-target, which led to desperate requirements for more effective drug therapies involved in multiple pathomechanisms of AD. The anti-AD effect with multiple action targets of Kai-Xin-San (KXS), a classic prescription initially recorded in
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Animals ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Male ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/pathology ; Rats
    Chemical Substances Drugs, Chinese Herbal ; Kai-Xin-San
    Language English
    Publishing date 2019-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2019/9096409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: pH-sensitive micelles for the intracellular co-delivery of curcumin and Pluronic L61 unimers for synergistic reversal effect of multidrug resistance.

    Hong, Wei / Shi, Hong / Qiao, Mingxi / Zhang, Zehui / Yang, Wenting / Dong, Lingying / Xie, Fucheng / Zhao, Chunpeng / Kang, Li

    Scientific reports

    2017  Volume 7, Page(s) 42465

    Abstract: Pluronic L61 unimers, which are biomacromolecular modulators, and curcumin, a small-molecule modulator, were co-formulated into pH-sensitive micelles to reveal the full synergistic potential of combination drug treatments to reverse multidrug resistance ( ...

    Abstract Pluronic L61 unimers, which are biomacromolecular modulators, and curcumin, a small-molecule modulator, were co-formulated into pH-sensitive micelles to reveal the full synergistic potential of combination drug treatments to reverse multidrug resistance (MDR). Compared to monotherapy, combined therapy significantly improved the cytotoxicity, cellular uptake and apoptotic effects of doxorubicin (DOX) against MCF-7/ADR cells. In mechanistic studies, both L61 and curcumin enhanced the cytotoxic effect by acting on mitochondrial signalling pathways. The compounds selectively accumulated in the mitochondria and disabled the mitochondria by dissipating the mitochondrial membrane potential, decreasing the ATP levels, and releasing cytochrome c, which initiated a cascade of caspase-9 and caspase-3 reactions. Furthermore, both curcumin and L61 down-regulated the expression and function of P-gp in response to drug efflux from the MCF-7/ADR cells. In the MCF-7/ADR tumour-bearing mouse model, intravenous administration of the combined therapy directly targeted the tumour, as revealed by the accumulation of DiR in the tumour site, which led to a significant inhibition of tumour growth without measurable side effects. In conclusion, co-formulation consisting of L61 and curcumin in pH-sensitive micelles induced significant synergistic effects on the reversal of MDR. Therefore, the intracellular co-delivery of various MDR modulators has great potential to reverse MDR in tumours.
    MeSH term(s) Adenosine Triphosphate/biosynthesis ; Animals ; Apoptosis ; Cell Survival ; Curcumin/administration & dosage ; Curcumin/chemistry ; Doxorubicin/administration & dosage ; Drug Compounding ; Drug Delivery Systems ; Drug Liberation ; Drug Resistance, Multiple/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Synergism ; Female ; Humans ; Hydrogen-Ion Concentration ; MCF-7 Cells ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Micelles ; Mitochondria/drug effects ; Mitochondria/metabolism ; Poloxamer/administration & dosage ; Poloxamer/chemistry ; Polyethylene Glycols/chemistry
    Chemical Substances Micelles ; pluronic L61 (09Y8E6164A) ; Poloxamer (106392-12-5) ; Polyethylene Glycols (3WJQ0SDW1A) ; Doxorubicin (80168379AG) ; Adenosine Triphosphate (8L70Q75FXE) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2017-02-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep42465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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