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Article ; Online: Identifying Organic Matter (OM) Types and Characterizing OM Pores in the Wufeng-Longmaxi Shales.

Xie, Guoliang / Hao, Weiduo

ACS omega

2022 Volume 7, Issue 43, Page(s) 38811–38824

Abstract: Organic matter (OM) pores are considered to be an important pore type in the Ordovician Wufeng-Silurian Longmaxi Formation shales in the Sichuan Basin, China, because they have a high capacity to store natural gas. However, to the best of our knowledge, ... ...

Abstract	Organic matter (OM) pores are considered to be an important pore type in the Ordovician Wufeng-Silurian Longmaxi Formation shales in the Sichuan Basin, China, because they have a high capacity to store natural gas. However, to the best of our knowledge, research on the characterization and quantitation of different OM pore characteristics is insufficient. In this study, detailed optical microscope and scanning electron microscope (SEM) observations and the pores/particles and cracks analysis system (PCAS) were applied to identify the OM pores and obtain quantitative information on pores such as pore size, surface porosity, form factor, and probability entropy. Moreover, CO
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c04497
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Precipitation Behavior of a Cu-Ni-Si Alloy with Cr Addition Prepared by Heating-Cooling Combined Mold (HCCM) Continuous Casting.

Meng, Xianghao / Xie, Guoliang / Xue, Wenli / Fu, Yilei / Wang, Rui / Liu, Xinhua

Materials (Basel, Switzerland)

2022 Volume 15, Issue 13

Abstract: A Cu-Ni-Si alloy containing (Ni + Si) ≥ 5 wt.%, with the addition of Cr, is fabricated by HCCM continuous casting and two steps of aging treatment. The evolution of the microstructures and precipitations, as well as the effect of Cr atoms, is studied in ... ...

Abstract	A Cu-Ni-Si alloy containing (Ni + Si) ≥ 5 wt.%, with the addition of Cr, is fabricated by HCCM continuous casting and two steps of aging treatment. The evolution of the microstructures and precipitations, as well as the effect of Cr atoms, is studied in this paper. An excellent combination of mechanical property (hardness HV 250-270) and electrical conductivity (46-47 %IACS) is obtained by the first step aging at 500 °C for 0.25 h and the second step aging at 450 °C for 1 h. The cold rolling and aging process are directly conducted on the solution treated specimens fabricated by HCCM continuous casting process without hot deformation, since the excellent homogeneity of matrix is obtained by solution treatment with δ-Ni
Language	English
Publishing date	2022-06-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15134521
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Article: An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties

Chen, Weizhen / Xie, Guoliang / Lu, Yang / Wang, Jiayuan / Feng, Baihuan / Wang, Qi / Xu, Kui / Bao, Jiaqi

Biomaterials. 2022 Jan., v. 280

2022

Abstract: An increasing number of works have highlighted the importance of metal implants surface modification in enhancing bone defect healing through the synergistic osteogenesis-angiogenesis regulation. Studies have shown that pitavastatin has the effect of ... ...

Abstract	An increasing number of works have highlighted the importance of metal implants surface modification in enhancing bone defect healing through the synergistic osteogenesis-angiogenesis regulation. Studies have shown that pitavastatin has the effect of promoting osteogenesis and angiogenesis. However, how to prepare pitavastatin functionalized implants and how pitavastatin regulates the synergies of osteogenesis and angiogenesis around implants as well as the related mechanisms remain unclear. In the present study, multilayer films with osteogenic and angiogenic properties were constructed on pure titanium substrates via the layer-by-layer assembly of pitavastatin-loaded β-cyclodextrin grafted chitosan and gelatin. In vitro experiments demonstrated that locally applied pitavastatin could dramatically enhance osteogenic potential of mesenchymal stem cells (MSCs) and angiogenic potential of endothelial cells (ECs). Moreover, pitavastatin loaded multilayer films could regulate the paracrine signaling mediated crosstalk between MSCs and ECs, and indirectly increase the angiogenic potential of MSCs and osteogenic potential of ECs via multiple paracrine signaling. The results of subcutaneous and femur implantation confirmed that locally released pitavastatin had potentially triggered a chain of biological events: mobilizing endogenous stem cells and ECs to the implant-bone interface, in turn facilitating coupled osteogenesis and angiogenesis, and eventually enhancing peri-implant osseointegration. This study enlarges the application scope of pitavastatin and provides an optional choice for developing a multifunctional bioactive coating on the surfaces of mental implants.
Keywords	angiogenesis ; biocompatible materials ; bone formation ; chitosan ; femur ; gelatin ; titanium
Language	English
Dates of publication	2022-01
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	603079-8
ISSN	0142-9612
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2021.121260
Database	NAL-Catalogue (AGRICOLA)

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Article: Combustion Behavior and Mechanism of Ti14 Titanium Alloy.

Shao, Lei / Xie, Guoliang / Li, Hongying / Lu, Wanran / Liu, Xiao / Yu, Jiabin / Huang, Jinfeng

Materials (Basel, Switzerland)

2020 Volume 13, Issue 3

Abstract: The combustion behavior and mechanism of Ti14 titanium alloy are studied by promoted ignition combustion tests at different oxygen pressures in this paper. The burning velocity increases at higher oxygen pressures and also increases with longer burning ... ...

Abstract	The combustion behavior and mechanism of Ti14 titanium alloy are studied by promoted ignition combustion tests at different oxygen pressures in this paper. The burning velocity increases at higher oxygen pressures and also increases with longer burning times instead of a constant at the same pressure. The Cu atoms are found enriched in two zones-i.e., the heat affected zone and melting zone during the combustion process-which can prevent the diffusion process of oxygen atoms. The different combustion behavior of Ti14 and Ti-Cr-V alloys is basically controlled by the characteristics of phase structures and chemical reactions.
Language	English
Publishing date	2020-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13030682
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Article ; Online: The Epidemiological and Clinical Characteristics of Hand, Foot, and Mouth Disease in Hangzhou, China, 2016 to 2018.

Wang, Jie / Zhou, Jun / Xie, Guoliang / Zheng, Shufa / Lou, Bin / Chen, Yu / Wu, Yidong

Clinical pediatrics

2020 Volume 59, Issue 7, Page(s) 656–662

Abstract: Hand, foot, and mouth disease (HFMD) is most frequently caused by several serotypes of human enterovirus (EV) including Enterovirus 71 (EV-A71), coxsackievirus A16 (CV-A16), or other types of EV. The aim of this study was to determine the epidemiological ...

Abstract	Hand, foot, and mouth disease (HFMD) is most frequently caused by several serotypes of human enterovirus (EV) including Enterovirus 71 (EV-A71), coxsackievirus A16 (CV-A16), or other types of EV. The aim of this study was to determine the epidemiological characteristics of HFMD and to describe the epidemiologic characteristics of HFMD among severe and mild cases. We collected 4760 HFMD cases in Hangzhou from 2016 to 2018. Specimens from these cases were collected and tested for EV-A71, CV-A16, CV-A6, CV-A10, CV-A2, and CV-A5 by reverse transcriptase polymerase chain reaction. From 2016 to 2018, the prevalence of HFMD was seasonal each year. Among the 4760 probable HFMD cases, 3559 cases were confirmed (74.8%), including 426 cases of EV-A71 infections (8.9%), 249 cases of CV-A16 infections (5.2%), and 2884 cases of other EV infections (60.6%). The percentage of other EV infections was more than 80%, which increased year by year. Random selection of samples for detection of other EV infections in 2017 and 2018, among the 1297 cases, showed there were 835 (64.4%) cases of CV-A6 infections, 177 (13.6%) cases of CV-A10 infections, 100 (7.7%) cases of CV-A2 infections, 40 (3.1%) cases of CV-A5 infections, 3 (0.02 %) cases of mixed infections, and 11.0% untyped EV infections. Preschool children were still the primary population susceptible to HFMD. In severe cases, EV-A71 infection was the main cause. Characterizing the epidemiology and the relationship between severe and common cases of HFMD would provide relevant evidences for the prevention and treatment of HFMD.
MeSH term(s)	Age Factors ; Child, Preschool ; China/epidemiology ; Female ; Hand, Foot and Mouth Disease/epidemiology ; Hand, Foot and Mouth Disease/pathology ; Hand, Foot and Mouth Disease/physiopathology ; Humans ; Infant ; Male ; Real-Time Polymerase Chain Reaction
Language	English
Publishing date	2020-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/0009922820910822
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Article ; Online: An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties.

Chen, Weizhen / Xie, Guoliang / Lu, Yang / Wang, Jiayuan / Feng, Baihuan / Wang, Qi / Xu, Kui / Bao, Jiaqi

Biomaterials

2021 Volume 280, Page(s) 121260

Abstract	An increasing number of works have highlighted the importance of metal implants surface modification in enhancing bone defect healing through the synergistic osteogenesis-angiogenesis regulation. Studies have shown that pitavastatin has the effect of promoting osteogenesis and angiogenesis. However, how to prepare pitavastatin functionalized implants and how pitavastatin regulates the synergies of osteogenesis and angiogenesis around implants as well as the related mechanisms remain unclear. In the present study, multilayer films with osteogenic and angiogenic properties were constructed on pure titanium substrates via the layer-by-layer assembly of pitavastatin-loaded β-cyclodextrin grafted chitosan and gelatin. In vitro experiments demonstrated that locally applied pitavastatin could dramatically enhance osteogenic potential of mesenchymal stem cells (MSCs) and angiogenic potential of endothelial cells (ECs). Moreover, pitavastatin loaded multilayer films could regulate the paracrine signaling mediated crosstalk between MSCs and ECs, and indirectly increase the angiogenic potential of MSCs and osteogenic potential of ECs via multiple paracrine signaling. The results of subcutaneous and femur implantation confirmed that locally released pitavastatin had potentially triggered a chain of biological events: mobilizing endogenous stem cells and ECs to the implant-bone interface, in turn facilitating coupled osteogenesis and angiogenesis, and eventually enhancing peri-implant osseointegration. This study enlarges the application scope of pitavastatin and provides an optional choice for developing a multifunctional bioactive coating on the surfaces of mental implants.
MeSH term(s)	Cell Differentiation ; Endothelial Cells ; Osseointegration ; Osteogenesis ; Quinolines ; Surface Properties ; Titanium/chemistry ; Titanium/pharmacology
Chemical Substances	Quinolines ; Titanium (D1JT611TNE) ; pitavastatin (M5681Q5F9P)
Language	English
Publishing date	2021-11-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2021.121260
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Article: Scaling up an electrochemical signal with a catalytic hairpin assembly coupling nanocatalyst label for DNA detection

Hun, Xu / Xie, Guoliang / Luo, Xiliang

Chemical communications. 2015 Apr. 9, v. 51, no. 33

2015

Abstract: A strategy for the electrochemical detection of DNA based on catalytic hairpin assembly combined with nanocatalyst label-based redox cycling reaction signal amplification. A superior detection limit of 0.3 aM toward DNA can be achieved. ...

Abstract	A strategy for the electrochemical detection of DNA based on catalytic hairpin assembly combined with nanocatalyst label-based redox cycling reaction signal amplification. A superior detection limit of 0.3 aM toward DNA can be achieved.
Keywords	DNA ; catalysts ; catalytic activity ; chemical compounds ; chemical reactions ; detection limit ; electrochemistry ; nanomaterials
Language	English
Dates of publication	2015-0409
Size	p. 7100-7103.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c5cc00680e
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Scaling up an electrochemical signal with a catalytic hairpin assembly coupling nanocatalyst label for DNA detection.

Hun, Xu / Xie, Guoliang / Luo, Xiliang

Chemical communications (Cambridge, England)

2015 Volume 51, Issue 33, Page(s) 7100–7103

Abstract	A strategy for the electrochemical detection of DNA based on catalytic hairpin assembly combined with nanocatalyst label-based redox cycling reaction signal amplification. A superior detection limit of 0.3 aM toward DNA can be achieved.
MeSH term(s)	Catalysis ; DNA/analysis ; DNA/chemistry ; Electrochemistry/methods ; Inverted Repeat Sequences ; Limit of Detection ; Nanostructures/chemistry
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2015-04-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c5cc00680e
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of short-term ambient air pollution exposure on the risk of severe COVID-19.

Feng, Baihuan / Lian, Jiangshan / Yu, Fei / Zhang, Dan / Chen, Weizhen / Wang, Qi / Shen, Yifei / Xie, Guoliang / Wang, Ruonan / Teng, Yun / Lou, Bin / Zheng, Shufa / Yang, Yida / Chen, Yu

Journal of environmental sciences (China)

2022 Volume 135, Page(s) 610–618

Abstract: Ecological studies suggested a link between air pollution and severe COVID-19 outcomes, while studies accounting for individual-level characteristics are limited. In the present study, we aimed to investigate the impact of short-term ambient air ... ...

Abstract	Ecological studies suggested a link between air pollution and severe COVID-19 outcomes, while studies accounting for individual-level characteristics are limited. In the present study, we aimed to investigate the impact of short-term ambient air pollution exposure on disease severity among a cohort of 569 laboratory confirmed COVID-19 patients admitted to designated hospitals in Zhejiang province, China, from January 17 to March 3, 2020, and elucidate the possible biological processes involved using transcriptomics. Compared with mild cases, severe cases had higher proportion of medical conditions as well as unfavorable results in most of the laboratory tests, and manifested higher air pollution exposure levels. Higher exposure to air pollutants was associated with increased risk of severe COVID-19 with odds ratio (OR) of 1.89 (95% confidence interval (CI): 1.01, 3.53), 2.35 (95% CI: 1.20, 4.61), 2.87 (95% CI: 1.68, 4.91), and 2.01 (95% CI: 1.10, 3.69) for PM
MeSH term(s)	Humans ; Nitrogen Dioxide/analysis ; Particulate Matter/analysis ; COVID-19/epidemiology ; Air Pollution/adverse effects ; Air Pollution/analysis ; Air Pollutants/toxicity ; Air Pollutants/analysis ; China/epidemiology ; Environmental Exposure/analysis
Chemical Substances	Nitrogen Dioxide (S7G510RUBH) ; Particulate Matter ; Air Pollutants
Language	English
Publishing date	2022-10-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1092300-7
ISSN	1878-7320 ; 1001-0742
ISSN (online)	1878-7320
ISSN	1001-0742
DOI	10.1016/j.jes.2022.09.040
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Article ; Online: Assessment of the Diagnostic Ability of Four Detection Methods Using Three Sample Types of COVID-19 Patients.

Yu, Fei / Xie, Guoliang / Zheng, Shufa / Han, Dongsheng / Bao, Jiaqi / Zhang, Dan / Feng, Baihuan / Wang, Qi / Zou, Qianda / Wang, Ruonan / Yang, Xianzhi / Chen, Weizhen / Lou, Bin / Chen, Yu

Frontiers in cellular and infection microbiology

2021 Volume 11, Page(s) 685640

Abstract: Background: Viral nucleic acid detection is considered the gold standard for the diagnosis of coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2 infection. However, unsuitable sample types and laboratory detection kits/methods lead to ... ...

Abstract	Background: Viral nucleic acid detection is considered the gold standard for the diagnosis of coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2 infection. However, unsuitable sample types and laboratory detection kits/methods lead to misdiagnosis, which delays the prevention and control of the pandemic. Methods: We compared four nucleic acid detection methods [two kinds of reverse transcription polymerase chain reactions (RT-PCR A: ORF1ab and N testing; RT-PCRB: only ORF1ab testing), reverse transcription recombinase aided amplification (RT-RAA) and droplet digital RT-PCR (dd-RT-PCR)] using 404 samples of 72 hospitalized COVID-19 patients, including oropharyngeal swab (OPS), nasopharyngeal swabs (NPS) and saliva after deep cough, to evaluate the best sample type and method for SARS-CoV-2 detection. Results: Among the four methods, dd-RT-PCR exhibited the highest positivity rate (93.0%), followed by RT-PCR B (91.2%) and RT-RAA (91.2%), while the positivity rate of RT-PCR A was only 71.9%. The viral load in OPS [24.90 copies/test (IQR 15.58-129.85)] was significantly lower than that in saliva [292.30 copies/test (IQR 20.20-8628.55)] and NPS [274.40 copies/test (IQR 33.10-2836.45)]. In addition, if OPS samples were tested alone by RT-PCR A, only 21.4% of the COVID-19 patients would be considered positive. The accuracy of all methods reached nearly 100% when saliva and NPS samples from the same patient were tested simultaneously. Conclusions: SARS-CoV-2 nucleic acid detection methods should be fully evaluated before use. High-positivity rate methods such as RT-RAA and dd-RT-PCR should be considered when possible. Furthermore, saliva after deep cough and NPS can greatly improve the accuracy of the diagnosis, and testing OPS alone is not recommended.
MeSH term(s)	COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; COVID-19 Testing/methods ; Humans ; Nasopharynx ; Pandemics ; RNA, Viral/genetics ; SARS-CoV-2 ; Saliva ; Specimen Handling
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-06-07
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.685640
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