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Article ; Online: The host–guest inclusion driven by host-stabilized charge transfer for construction of sequentially red-shifted mechanochromic system

Dongdong Sun / Yong Wu / Xie Han / Simin Liu

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract Developing more extensive methods to understand the underlying structure-property relationship of mechanochromic luminescent molecules is demanding but remains challenging. Herein, the effect of host-guest interaction on the mechanochromic ... ...

Abstract	Abstract Developing more extensive methods to understand the underlying structure-property relationship of mechanochromic luminescent molecules is demanding but remains challenging. Herein, the effect of host-guest interaction on the mechanochromic properties of organic molecules is illustrated. A series of pyridinium-functionalized triphenylamine derivatives show bathochromic-shifted emission upon mechanical stimulation. These derivatives bind to cucurbit[8]uril to form homoternary host-guest inclusion complexes through host-stabilized intermolecular charge transfer interactions. Remarkably, the homoternary complexes exhibit longer emission than that of free guests in the solid state (even longer than ground guests), and a further bathochromic-shifted emission is observed upon grinding. Additionally, a heteroternary complex constructed through the encapsulation of pyrene (donor) and pyridinium (acceptor) guest pair in cucurbit[8]uril also displays the mechanochromic luminescent property. This work not only discloses the effect of host-guest inclusion on the mechanochromic property of organic molecules, but also provides a principle and a facile way to design the sequentially red-shifted mechanochromic materials.
Keywords	Science ; Q
Subject code	540
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Editorial: Advance in translational research of preterm birth and related pregnancy.

Xie, Han / Ying, Hao

Frontiers in pharmacology

2022 Volume 13, Page(s) 1047649

Language	English
Publishing date	2022-11-03
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1047649
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Peer victimization, environmental and psychological distress, and academic performance among children in China: A serial mediation model moderated by migrant status.

Xie, Han / Cui, Kunjie

Child abuse & neglect

2022 Volume 133, Page(s) 105850

Abstract: Background: Despite robust evidence indicating the adverse academic, psychological, and school-related impacts of being victimized, the ways in which peer victimization indirectly affects children's academic performance by psychological and ... ...

Abstract	Background: Despite robust evidence indicating the adverse academic, psychological, and school-related impacts of being victimized, the ways in which peer victimization indirectly affects children's academic performance by psychological and environmental distress remain poorly understood, especially in China. Objective: We sought to investigate how peer victimization negatively impacts academic performance via the serial mediation effects of environmental and psychological distress among migrant versus non-migrant children in China. Participants and setting: Participants were selected by multistage stratified cluster sampling, and data were collected with a cross-sectional survey administered in Nanjing and Guangzhou, China. The sample included 1747 students in Grades 4 to 9 (boys = 54.7 %, mean age = 11.7 years). Methods: Structural equation modeling and group comparison analysis were conducted to examine the hypothesized model. Results: Children's experiences with peer victimization significantly affected their academic performance and in relationships partially mediated by environmental distress (i.e., perception of school safety), followed by psychological distress (i.e., anxiety) (95 % CI: [-0.010, -0.001], B = -0.005, p < .01). The serial mediation model applied to non-migrant children only (95 % CI: [-0.026, -0.001], B = -0.008, p < .05), however, whereas environmental distress exerted a single mediating effect on the association between peer victimization and academic performance among migrant children only (95 % CI: [-0.125, -0.044], B = -0.076, p < .001). Conclusion: Environmental and psychological distress exerted serial mediating effect on the association between peer victimization and academic performance. School-based comprehensive intervention programs designed for migrant versus non-migrant children are recommended.
MeSH term(s)	Academic Performance ; Bullying/psychology ; Child ; China/epidemiology ; Crime Victims/psychology ; Cross-Sectional Studies ; Humans ; Male ; Peer Group ; Psychological Distress
Language	English
Publishing date	2022-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	799143-5
ISSN	1873-7757 ; 0145-2134
ISSN (online)	1873-7757
ISSN	0145-2134
DOI	10.1016/j.chiabu.2022.105850
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Article ; Online: FedBrain: Federated Training of Graph Neural Networks for Connectome-based Brain Imaging Analysis.

Yang, Yi / Xie, Han / Cui, Hejie / Yang, Carl

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

2023 Volume 29, Page(s) 214–225

Abstract: Recent advancements in neuroimaging techniques have sparked a growing interest in understanding the complex interactions between anatomical regions of interest (ROIs), forming into brain networks that play a crucial role in various clinical tasks, such ... ...

Abstract	Recent advancements in neuroimaging techniques have sparked a growing interest in understanding the complex interactions between anatomical regions of interest (ROIs), forming into brain networks that play a crucial role in various clinical tasks, such as neural pattern discovery and disorder diagnosis. In recent years, graph neural networks (GNNs) have emerged as powerful tools for analyzing network data. However, due to the complexity of data acquisition and regulatory restrictions, brain network studies remain limited in scale and are often confined to local institutions. These limitations greatly challenge GNN models to capture useful neural circuitry patterns and deliver robust downstream performance. As a distributed machine learning paradigm, federated learning (FL) provides a promising solution in addressing resource limitation and privacy concerns, by enabling collaborative learning across local institutions (i.e., clients) without data sharing. While the data heterogeneity issues have been extensively studied in recent FL literature, cross-institutional brain network analysis presents unique data heterogeneity challenges, that is, the inconsistent ROI parcellation systems and varying predictive neural circuitry patterns across local neuroimaging studies. To this end, we propose FedBrain, a GNN-based personalized FL framework that takes into account the unique properties of brain network data. Specifically, we present a federated atlas mapping mechanism to overcome the feature and structure heterogeneity of brain networks arising from different ROI atlas systems, and a clustering approach guided by clinical prior knowledge to address varying predictive neural circuitry patterns regarding different patient groups, neuroimaging modalities and clinical outcomes. Compared to existing FL strategies, our approach demonstrates superior and more consistent performance, showcasing its strong potential and generalizability in cross-institutional connectome-based brain imaging analysis. The implementation is available here.
MeSH term(s)	Humans ; Connectome ; Computational Biology ; Brain/diagnostic imaging ; Neural Networks, Computer ; Neuroimaging
Language	English
Publishing date	2023-12-31
Publishing country	United States
Document type	Journal Article
ISSN	2335-6936
ISSN (online)	2335-6936
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Article ; Online: Research on Compressed Sensing Spectrometry Based on Electro-Optical Transmittance Coding

Shuang Wang / Kewu Li / Xie Han / Zhibin Wang

Applied Sciences, Vol 12, Iss 12097, p

2022 Volume 12097

Abstract: To develop fast and integrated spectrometry, we present a new method of compressed sensing spectrometry based on electro-optical transmittance coding. A LiNbO 3 electro-optic modulator was applied to a directly compressed measurement code in the spectral ...

Abstract	To develop fast and integrated spectrometry, we present a new method of compressed sensing spectrometry based on electro-optical transmittance coding. A LiNbO 3 electro-optic modulator was applied to a directly compressed measurement code in the spectral dimension. Subsequently, a sequential forward floating selection algorithm was employed to select the coding measurement matrix, and sparsity adaptive matching pursuit was used as a solver algorithm. The principle was analyzed, and the measurement system was built for verification experiments. The experimental results reveal that the spectral reconstruction relative error is in the order of 10 −2 , and the full width at half maximum of the spectral measurement is as high as 1.2 nm. The spectral resolution can reach approximately 0.4 nm in the visible light band range (0.38–0.78 μm) with 1024 spectral channels. The compressed ratio of the compressed sensing spectrometry is up to 1:29. Furthermore, the spectral signal measurement time is only 0.25 ms. The study demonstrates a novel method, which exhibits high precision, speed, high compressed ratio and hyperspectral resolution.
Keywords	compressed sensing ; spectrometry ; electro-optical modulation ; transmittance coding ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	530
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Generation of cylindrical vector vortex beams using a biconical glass rod.

Lin, Jiun-You / Xie, Han-Sheng

Optics letters

2021 Volume 46, Issue 4, Page(s) 701–704

Abstract: This Letter proposes a biconical glass rod for generating a cylindrical vector vortex (CVV) beam. Based on the principle of total internal reflection and the cylindrical symmetry structure of the glass rod, a circularly polarized incident beam with a ... ...

Abstract	This Letter proposes a biconical glass rod for generating a cylindrical vector vortex (CVV) beam. Based on the principle of total internal reflection and the cylindrical symmetry structure of the glass rod, a circularly polarized incident beam with a constant phase distribution can be converted into a CVV beam, which possesses both a spatially inhomogeneous polarization and a helical phase distribution. The polarization azimuth of the CVV beam can be tuned with the aid of a polarization rotator composed of two cascade half-wave plates. The design theory is presented, and the feasibility of the design is demonstrated experimentally.
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.413947
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Article: Plasma Proteomic Analysis Based on 4D-DIA Evaluates the Clinical Response to Imrecoxib in the Early Treatment of Osteoarthritis.

Xie, Han / Zhang, Yuan / Zhu, Zunyi / Wei, Jingxuan / Ainiwaer, Gulinigeer / Ge, Weihong

Rheumatology and therapy

2024 Volume 11, Issue 2, Page(s) 269–283

Abstract: Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the primary treatment for osteoarthritis (OA), but prolonged use has adverse effects and varying efficacy. Among NSAIDs, imrecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, reduces ... ...

Abstract	Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the primary treatment for osteoarthritis (OA), but prolonged use has adverse effects and varying efficacy. Among NSAIDs, imrecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, reduces side effects yet remains ineffective for half of the patient population. This study aims to identify biomarkers for early evaluation of imrecoxib efficacy in OA for personalized therapy optimization. Methods: From September 2021 to January 2022, imrecoxib was administered to patients with OA at Nanjing Drum Tower Hospital. Plasma samples from these patients underwent proteomic analysis through the four-dimensional data-independent acquisition (4D-DIA) method, followed by bioinformatics analysis. Potential differentially expressed proteins (DEPs) were validated using enzyme-linked immunosorbent assays (ELISA). Results: Sixty-six patients with knee OA were included and divided into responders (n = 35) and non-responders (n = 31). Proteomic analysis was conducted on 15 patients from each group, with ELISA validation for every patient. We found 140 DEPs between the two groups after imrecoxib treatment, characterized by 29 proteins showing upregulation and 111 displaying downregulation (P < 0.05, fold change > ± 1.2). Galectin-1 (LGALS1), galectin-3 (LGALS3), and cluster of differentiation 44 (CD44) were identified as potential markers for evaluating clinical response to imrecoxib in OA following ELISA validation. Conclusion: This study successfully identified biomarkers for evaluating imrecoxib's clinical response in patients with OA using 4D-DIA technology. These biomarkers may play a vital role in future personalized OA treatment strategies, pending further confirmation.
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2783278-8
ISSN	2198-6584 ; 2198-6576
ISSN (online)	2198-6584
ISSN	2198-6576
DOI	10.1007/s40744-023-00636-z
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Article ; Online: Fabrication of Au nanoclusters confined on hydroxy double salt-based intelligent biosensor for on-site monitoring of urease and its inhibitors.

Han, Yaqing / Wang, Mengke / Xie, Han / Zhou, Yitong / Wang, Shun / Wang, Guannan

Talanta

2024 Volume 271, Page(s) 125725

Abstract: Sensitive and convenient sensing of urease and its inhibitors is exceptionally urgent in clinical diagnosis and new drug development. In this study, the gold nanoclusters (AuNCs) and hydroxyl double salt (HDS) were composited by a simple confinement ... ...

Abstract	Sensitive and convenient sensing of urease and its inhibitors is exceptionally urgent in clinical diagnosis and new drug development. In this study, the gold nanoclusters (AuNCs) and hydroxyl double salt (HDS) were composited by a simple confinement effect to prepare highly fluorescent AuNCs@HDS composites to monitor urease and its drug inhibitors. HDS was used as a matrix to confine AuNCs (AuNCs@HDS), facilitating the emission intensity of AuNCs. However, acidic conditions (low pH) can disrupt the structure of HDS to break the confinement effect, and quench the fluorescence of AuNCs. Therefore, a sensing platform for pH-related enzyme urease detection was constructed based on the sensitive response of AuNCs@HDS to pH. This sensing platform had a linear response range of 0.5-22.5 U/L and a low limit of detection (LOD) of 0.19 U/L for urease. Moreover, this sensing platform was also applied to monitor urease inhibitors and urease in human saliva samples. Additionally, a portable hydrogel kit combined with a smartphone was developed for urease detection to achieve portable, low-cost, instrument-free, and on-site monitoring of urease.
MeSH term(s)	Humans ; Urease ; Sodium Chloride ; Biosensing Techniques ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Spectrometry, Fluorescence
Chemical Substances	Urease (EC 3.5.1.5) ; Sodium Chloride (451W47IQ8X) ; Gold (7440-57-5)
Language	English
Publishing date	2024-01-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2024.125725
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Article: Subchorionic Hematoma Association with Pregnancy Complications and Outcomes in the Third Trimester.

Huang, Haixia / Han, Huan / Xie, Han / Ying, Hao / Bao, Yirong

Journal of personalized medicine

2023 Volume 13, Issue 3

Abstract: Introduction: Our objective was to explore the clinical features, pregnancy complications, and outcomes of subchorionic hematomas (SCHs) in the third trimester.: Material and methods: This was a retrospective analysis and evaluation of 1112 cases ... ...

Abstract	Introduction: Our objective was to explore the clinical features, pregnancy complications, and outcomes of subchorionic hematomas (SCHs) in the third trimester. Material and methods: This was a retrospective analysis and evaluation of 1112 cases diagnosed with SCHs from January 2014 to December 2020. Comparisons were performed according to the clinical features (e.g., number of pregnancies, parity, gestational weeks, and age), pregnancy complications, and outcomes associated with SCHs. Results: In total, 71.85% (799/1112) of the patients were diagnosed with different pregnancy complications. The overall rates of gestational diabetes mellitus (GDM), hypertensive disorder complicating pregnancy (HDCP), premature rupture of membranes (PROM), and IVF were 12.14%, 7.55%, 17.27%, and 10.34%, respectively. The positive rates for newborn outcomes such as premature birth and low birth weight (LBW) were 9.35% and 6.47%, respectively. There was a significant relationship between repeated pregnancies and the incidence of GDM ( Conclusions: The coexistence of SCHs with HDCP, IVF, or PROM lacked an effective predictive value for premature birth, but increased the rate of a cesarean section.
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13030479
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Article ; Online: Catalpol Inhibits Autophagy to Ameliorate Doxorubicin-Induced Cardiotoxicity via the AKT-mTOR Pathway.

Liu, Bo / Xie, Han / Du, Xiongbing / Zhou, Yuyang / Huang, Jiashun

International heart journal

2023 Volume 64, Issue 5, Page(s) 910–917

Abstract: As a kind of anthracycline, doxorubicin (DOX) is commonly used as an antitumor drug, but its clinical application has been greatly hindered due to its severe cardiotoxicity. Hence, in this study, we investigated the role of catalpol (CTP) and its effect ... ...

Abstract	As a kind of anthracycline, doxorubicin (DOX) is commonly used as an antitumor drug, but its clinical application has been greatly hindered due to its severe cardiotoxicity. Hence, in this study, we investigated the role of catalpol (CTP) and its effect on DOX-induced cardiotoxicity.The cardiac function of mice was evaluated by assessing lactate dehydrogenase, creatine kinase isoenzyme, heart weight to body weight, and heart weight/tibia length levels. Histopathological changes were observed using hematoxylin and eosin staining, and the terminal deoxynucleotidyl transferase dUTP nick end labeling assay was used to examine myocardial apoptosis. Superoxide dismutase (SOD) activity, glutathione (GSH), and malondialdehyde (MDA) levels were measured to confirm the changes in oxidative stress. Western blotting showed the levels of autophagy- and pathway-related proteins. Expression of autophagy marker LC3 was examined using immunofluorescence staining.CTP alleviated DOX-induced cardiac damage in mice. We further observed upregulated SOD and GSH levels, and downregulated MDA level after the CTP treatment in DOX-treated mice, indicating the protective role of CTP against oxidative injury. DOX-induced myocardial apoptosis was also inhibited by CTP treatment in mice. In addition, CTP decreased the levels of Beclin1 and LC3II/LC3I, increased the levels of P62, and activated the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in DOX-treated mice.CTP ameliorated DOX-induced cardiotoxicity by inhibiting oxidative stress, myocardial apoptosis, and autophagy via the AKT-mTOR pathway.
MeSH term(s)	Mice ; Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Cardiotoxicity/etiology ; Doxorubicin/toxicity ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/pharmacology ; TOR Serine-Threonine Kinases/therapeutic use ; Myocardium/pathology ; Oxidative Stress ; Autophagy ; Superoxide Dismutase/metabolism ; Apoptosis/physiology ; Myocytes, Cardiac/metabolism ; Mammals/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; catalpol (2415-24-9) ; Doxorubicin (80168379AG) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2023-09-29
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2187806-7
ISSN	1349-3299 ; 1349-2365
ISSN (online)	1349-3299
ISSN	1349-2365
DOI	10.1536/ihj.23-062
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