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  1. AU="Xie, Hongming"
  2. AU="Attila Toth"
  3. AU="Rocío Martínez dePablos"
  4. AU="Hou, Ting-Jun"
  5. AU="María Gracia de Garnica García"
  6. AU="Zirbes, Christian"

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  1. Artikel: Exploring the processes and mechanisms by which nonprofit organizations orchestrate global innovation networks: A case study of the COVAX program.

    Xie, Hongming / Guo, Manman / Yang, Yingnan

    Heliyon

    2024  Band 10, Heft 5, Seite(n) e27098

    Abstract: In cocreating value with other organizations, nonprofit organizations may face multiple management challenges, posed by multistakeholder global innovation networks. Since these have not yet been systematically studied by academics, this study explores ... ...

    Abstract In cocreating value with other organizations, nonprofit organizations may face multiple management challenges, posed by multistakeholder global innovation networks. Since these have not yet been systematically studied by academics, this study explores how nonprofit organizations can promote the cocreation of value in multistakeholder global innovation networks. Adopting a longitudinal single-case study approach from the perspective of network orchestration theory, this work deeply analyzes how nonprofit organizations can promote the evolution of the global innovation network of the COVID-19 vaccine under the COVAX program. The results show that nonprofits need to successively address the dilemmas of legitimacy, direction, and heterogeneity in constructing global innovation networks and that to solve these stage dilemmas, orchestrators must successively function as network architects, liaisons, and leaders to direct the implementation of network actions using trusted, leveraged, and adapted orchestration logics. This paper further proposes a model of the orchestration process and mechanisms by which nonprofit organizations facilitate multistakeholder global innovation networks. Theoretically, this study therefore extends network orchestration theory by summarizing the mechanisms and orchestration logics by which NPOs construct and develop networks when they act as orchestrators. From a practical perspective, this study also provides guidance for future unexpected global public health crises, improving the global community's ability to combat them.
    Sprache Englisch
    Erscheinungsdatum 2024-03-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27098
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Does Firm Life Cycle Impact Corporate Investment Efficiency?

    Bilal Ahmed / Minhas Akbar / Tanaza Sabahat / Saqib Ali / Ammar Hussain / Ahsan Akbar / Xie Hongming

    Sustainability, Vol 13, Iss 197, p

    2021  Band 197

    Abstract: Corporate investment efficiency (CIE) is an imperative factor influencing the smooth functioning and financial sustainability of an enterprise. The role of a firm life cycle on risk and performance fundamentals has been extensively explored in the ... ...

    Abstract Corporate investment efficiency (CIE) is an imperative factor influencing the smooth functioning and financial sustainability of an enterprise. The role of a firm life cycle on risk and performance fundamentals has been extensively explored in the literature. However, it remains unclear as to whether the life cycle stages of a firm have any impact on corporate investment efficiency. This paper investigates the role of firm life cycle stages (FLCS) in determining the investment efficiency of 351 Pakistani non-financial listed firms over the course of 12 years (2005–2016). It used panel data fixed effects and ordinary least squares (OLS) techniques to empirically examine the proposed relationship. By employing Dickinson’s FLCS measure, we found that CIE was lower during the introduction and decline stages and higher at the growth and maturity stages of a firm’s life cycle. Moreover, the results of regression analysis revealed that mature firms enjoyed the highest level of investment efficiency followed by the growth firms. Overall, CIE exhibited an inverted U-shaped trend across FLCS. In addition, the findings corroborated the idea that the sample firms could not sustain their investment efficiency when they moved along different stages of the life cycle. Thus, policymakers are suggested to customize their investment policies for each stage of FLC to attain sustainable financial performance throughout the life of a firm.
    Schlagwörter firm life cycle ; investment efficiency ; non-financial firms ; Pakistan ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 338
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Fostering the Environmental Performance of Hotels in Pakistan: A Moderated Mediation Approach From the Perspective of Corporate Social Responsibility.

    Ahmed, Bilal / Xie, Hongming / Zia-Ud-Din, Malik / Zaheer, Muhammad / Ahmad, Naveed / Guo, Manman

    Frontiers in psychology

    2022  Band 13, Seite(n) 857906

    Abstract: The Islamic Republic of Pakistan has been a mere victim of climate change in recent years. The country needs emergency measures at every level to mitigate environmental dilapidation. The role of enterprises in the country's environmental efforts is ... ...

    Abstract The Islamic Republic of Pakistan has been a mere victim of climate change in recent years. The country needs emergency measures at every level to mitigate environmental dilapidation. The role of enterprises in the country's environmental efforts is critical. In this regard, the hotel sector is known for its outsized carbon footprint. Knowing this, the current study aims to improve a hotel enterprise's environmental performance (ENP) as an outcome of corporate social responsibility (CSR). The study also considers the mediating role of pro-environmental behavior (PEB) of employees and the moderating role of altruistic values (ALT). A hypothesized model was developed, which was validated by employing the structural equation modeling technique. The empirical results confirmed that CSR, directly and indirectly (through PEB), positively induces the ENP of a hotel enterprise. Whereas the conditional indirect role of ALT was also found significant. The study offers different implications for theory and practice, among which one important takeaway for the hotel sector is to realize the importance of employees to spur ENP of a hotel enterprise through their eco-friendly behavior. At the same time, the current work also advances the theory by highlighting the moderating role of ALT between the indirect relationship of CSR and ENP.
    Sprache Englisch
    Erscheinungsdatum 2022-05-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.857906
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Sustainability Reporting and Firm Performance

    Xie Hongming / Bilal Ahmed / Arif Hussain / Alam Rehman / Irfan Ullah / Farman Ullah Khan

    SAGE Open, Vol

    The Demonstration of Pakistani Firms

    2020  Band 10

    Abstract: The nexus between sustainability and firm performance is an area of debate among researchers and academicians. The objective of this study is to examine the level and extent of sustainable financial reporting for non-financial firms in Pakistan and to ... ...

    Abstract The nexus between sustainability and firm performance is an area of debate among researchers and academicians. The objective of this study is to examine the level and extent of sustainable financial reporting for non-financial firms in Pakistan and to assess the level of the impact of sustainable financial reporting on firm performance in Pakistan. This study is a novel research work as the sustainability practices are not mandatory in many Pakistani firms. Rather kinds of mix sustainability reporting practices are being practiced. The dilemma still exists whether sustainability practices affect the performance of Pakistani firms positively or not. We collect data from the sustainability reports as well as annual reports of 50 non-financial public limited companies listed in Pakistan Stock Exchange for the period 2013 to 2017. We calculate sustainability reporting index using content analysis procedure based on 42 indicators. The index is based on three subindices, namely, environmental, health and safety, and social indicators. We apply two regression models with a view to ascertain the individual effect of each indicator of the sustainability as well as the composite effect of sustainability reporting index on firm performance. The results confirm positive effects of all three individual indicators as well as the composite form of sustainability reporting index on firm performance. The findings of the study clearly outline the economic relevance for introducing the corporate sustainability reporting practices in corporate strategy.
    Schlagwörter History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
    Thema/Rubrik (Code) 690
    Sprache Englisch
    Erscheinungsdatum 2020-09-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Organoboron Compounds: Effective Antibacterial and Antiparasitic Agents.

    Coghi, Paolo Saul / Zhu, Yinghuai / Xie, Hongming / Hosmane, Narayan S / Zhang, Yingjun

    Molecules (Basel, Switzerland)

    2021  Band 26, Heft 11

    Abstract: The unique electron deficiency and coordination property of boron led to a wide range of applications in chemistry, energy research, materials science and the life sciences. The use of boron-containing compounds as pharmaceutical agents has a long ... ...

    Abstract The unique electron deficiency and coordination property of boron led to a wide range of applications in chemistry, energy research, materials science and the life sciences. The use of boron-containing compounds as pharmaceutical agents has a long history, and recent developments have produced encouraging strides. Boron agents have been used for both radiotherapy and chemotherapy. In radiotherapy, boron neutron capture therapy (BNCT) has been investigated to treat various types of tumors, such as glioblastoma multiforme (GBM) of brain, head and neck tumors, etc. Boron agents playing essential roles in such treatments and other well-established areas have been discussed elsewhere. Organoboron compounds used to treat various diseases besides tumor treatments through BNCT technology have also marked an important milestone. Following the clinical introduction of bortezomib as an anti-cancer agent, benzoxaborole drugs, tavaborole and crisaborole, have been approved for clinical use in the treatments of onychomycosis and atopic dermatitis. Some heterocyclic organoboron compounds represent potentially promising candidates for anti-infective drugs. This review highlights the clinical applications and perspectives of organoboron compounds with the natural boron atoms in disease treatments without neutron irradiation. The main topic focuses on the therapeutic applications of organoboron compounds in the diseases of tuberculosis and antifungal activity, malaria, neglected tropical diseases and cryptosporidiosis and toxoplasmosis.
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Antiparasitic Agents/pharmacology ; Boron/chemistry ; Boron/metabolism ; Boron/pharmacology ; Boron Neutron Capture Therapy/methods ; Boron Neutron Capture Therapy/trends ; Bortezomib/therapeutic use ; Brain Neoplasms/drug therapy ; Cryptosporidiosis/drug therapy ; Dermatitis, Atopic/drug therapy ; Eczema/drug therapy ; Glioblastoma/drug therapy ; Humans ; Malaria/drug therapy ; Onychomycosis/drug therapy ; Toxoplasmosis/drug therapy ; Tuberculosis/drug therapy
    Chemische Substanzen Anti-Bacterial Agents ; Antiparasitic Agents ; Bortezomib (69G8BD63PP) ; Boron (N9E3X5056Q)
    Sprache Englisch
    Erscheinungsdatum 2021-05-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26113309
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Population Pharmacokinetic Analysis of Yimitasvir in Chinese Healthy Volunteers and Patients With Chronic Hepatitis C Virus Infection.

    Guan, Xiao-Duo / Tang, Xian-Ge / Zhang, Ying-Jun / Xie, Hong-Ming / Luo, Lin / Wu, Dan / Chen, Rui / Hu, Pei

    Frontiers in pharmacology

    2021  Band 11, Seite(n) 617122

    Abstract: Yimitasvir is a novel, oral hepatitis C virus (HCV) non-structural protein 5A inhibitor for the treatment of chronic HCV genotype 1 infection. The objective of this analysis was to develop a population pharmacokinetic model of yimitasvir in Chinese ... ...

    Abstract Yimitasvir is a novel, oral hepatitis C virus (HCV) non-structural protein 5A inhibitor for the treatment of chronic HCV genotype 1 infection. The objective of this analysis was to develop a population pharmacokinetic model of yimitasvir in Chinese healthy volunteers and HCV infection patients. The model was performed using data from 219 subjects across six studies. Nonlinear mixed effects models were developed using Phoenix NLME software. The covariates were evaluated using a stepwise forward inclusion (
    Sprache Englisch
    Erscheinungsdatum 2021-01-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.617122
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Design, synthesis and biological evaluation of ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors.

    Xie, Hongming / Lin, Xinglong / Zhang, Yingjun / Tan, Fuxing / Chi, Bo / Peng, Zhihong / Dong, Wanrong / An, Delie

    Bioorganic & medicinal chemistry letters

    2020  Band 30, Heft 21, Seite(n) 127459

    Abstract: We report herein the synthesis of novel ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors and the evaluation of pharmaceutical activity against five cancer cell lines (MDA-MB-231, BXPC-3, NCI-H1975, DU145 and 786O). ... ...

    Abstract We report herein the synthesis of novel ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors and the evaluation of pharmaceutical activity against five cancer cell lines (MDA-MB-231, BXPC-3, NCI-H1975, DU145 and 786O). Generally, the majority of compounds displayed strong anti-FAK enzymatic potencies (IC
    Mesh-Begriff(e) Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Design ; Drug Screening Assays, Antitumor ; Focal Adhesion Kinase 1/antagonists & inhibitors ; Focal Adhesion Kinase 1/metabolism ; Humans ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Pyridines/chemistry ; Pyridines/pharmacology ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Structure-Activity Relationship
    Chemische Substanzen Antineoplastic Agents ; Protein Kinase Inhibitors ; Pyridines ; Pyrimidines ; Focal Adhesion Kinase 1 (EC 2.7.10.2) ; PTK2 protein, human (EC 2.7.10.2)
    Sprache Englisch
    Erscheinungsdatum 2020-08-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2020.127459
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: The Current Status and Perspectives of Delivery Strategy for Boronbased Drugs.

    Yinghuai, Zhu / Lin, Xinglong / Xie, Hongming / Li, Jianlin / Hosmane, Narayan S / Zhang, Yingjun

    Current medicinal chemistry

    2018  Band 26, Heft 26, Seite(n) 5019–5035

    Abstract: Boron-containing compounds are essential micronutrients for animals and plants despite their low-level natural occurrence. They can strengthen the cell walls of the plants and they play important role in supporting bone health. However, surprisingly, ... ...

    Abstract Boron-containing compounds are essential micronutrients for animals and plants despite their low-level natural occurrence. They can strengthen the cell walls of the plants and they play important role in supporting bone health. However, surprisingly, boron-containing compounds are seldom found in pharmaceutical drugs. In fact, there are no inherent disadvantages reported so far in terms of the incorporation of boron into medicines. Indeed, drugs based on boron-containing compounds, such as tavaborole (marked name Kerydin) and bortezomib (trade name Velcade) have been investigated and they are used in clinical treatment. In addition, following the advanced development of boron neutron capture therapy and a new emerging proton boron fusion therapy, more boron-containing medicinals are to be expected. This review discusses the current status and perspectives of delivery strategy for boron-containing drugs.
    Sprache Englisch
    Erscheinungsdatum 2018-10-06
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867325666180904105212
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Development of a diagonal-cut type beam position monitor for the booster ring in the High Intensity Heavy-Ion Accelerator Facility project.

    Du, Ze / He, Peilin / Zhu, Guangyu / Caspers, Fritz / Li, Zhixue / Wu, Junxia / Hu, Xuejing / Zhang, Zhaolong / Xie, Hongming / Ni, Fafu / Zhang, Yong / Yang, Yongliang / Yang, Jiancheng / Meng, Jun

    The Review of scientific instruments

    2021  Band 93, Heft 4, Seite(n) 43306

    Abstract: A diagonal-cut type beam position monitor (BPM) has been developed for the High Intensity Heavy-Ion Accelerator Facility (HIAF) project at the Institute of Modern Physics. Compared with other types of BPMs, the diagonal-cut type BPM has almost perfect ... ...

    Abstract A diagonal-cut type beam position monitor (BPM) has been developed for the High Intensity Heavy-Ion Accelerator Facility (HIAF) project at the Institute of Modern Physics. Compared with other types of BPMs, the diagonal-cut type BPM has almost perfect position linearity, i.e., no non-linear correction required, which is advantageous for beams that are transversally large and have a complex charge distribution. The key parameters for the diagonal-cut type BPM have been simulated and optimized in detail and systematically herein. It was found that the crosstalk is improved by ∼10 dB at 160 MHz by insertion of a separate ring between two horizontal or vertical electrodes of the BPM made of stainless steel with vacuum as a dielectric. Furthermore, the longitudinal and transverse numerical simulation to evaluate the beam impedance on the diagonal-cut type BPM has been performed. The results for the crosstalk, position sensitivity, and electrode capacitance to ground obtained from simulations and laboratory measurements agree well. The vacuum of the BPM prototype after baking out at 250 °C for 72 h is better than 1.0 × 10
    Sprache Englisch
    Erscheinungsdatum 2021-04-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0083344
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Proanthocyanidins attenuate breast cancer-induced bone metastasis by inhibiting Irf-3/c-jun activation.

    Guo, Shuangfei / Zhu, Wei / Yin, Ziqing / Xiao, Ding / Zhang, Qiang / Liu, Tang / Ni, Jiangdong / Ouyang, Zhengxiao / Xie, Hongming

    Anti-cancer drugs

    2019  Band 30, Heft 10, Seite(n) 998–1005

    Abstract: We have previously demonstrated the pivotal role of Jnk-mediated Irf-3/c-Jun in regulating nuclear factor kappa-Β ligand (RANKL)-induced osteoclastogenesis. Here, we demonstrated that proanthocyanidins (PACs) target Irf-3 to alleviate breast cancer- ... ...

    Abstract We have previously demonstrated the pivotal role of Jnk-mediated Irf-3/c-Jun in regulating nuclear factor kappa-Β ligand (RANKL)-induced osteoclastogenesis. Here, we demonstrated that proanthocyanidins (PACs) target Irf-3 to alleviate breast cancer-induced activation of osteoclasts. We also found that PACs induced apoptosis of osteoclast precursors by upregulating the ratio of bax/bcl-2 and activating caspase-3 activity. Such bone protective effect also could be observed in a bone metastasis model of breast cancer. These findings provided a novel therapeutic intervention targeting abnormal bone metabolism to alleviate bone metastasis of breast cancer.
    Mesh-Begriff(e) Animals ; Apoptosis/drug effects ; Bone Neoplasms/drug therapy ; Bone Neoplasms/metabolism ; Bone Neoplasms/secondary ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Culture Media, Conditioned/pharmacology ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Osteoclasts/drug effects ; Osteoclasts/metabolism ; Osteogenesis/drug effects ; Osteogenesis/physiology ; Proanthocyanidins/pharmacology ; Proto-Oncogene Proteins c-jun/genetics ; Proto-Oncogene Proteins c-jun/metabolism
    Chemische Substanzen Culture Media, Conditioned ; Interferon Regulatory Factor-3 ; Irf3 protein, mouse ; Proanthocyanidins ; Proto-Oncogene Proteins c-jun
    Sprache Englisch
    Erscheinungsdatum 2019-10-18
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1065301-6
    ISSN 1473-5741 ; 0959-4973
    ISSN (online) 1473-5741
    ISSN 0959-4973
    DOI 10.1097/CAD.0000000000000852
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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